ZA844004B - Pharmaceutical peptides,preparation,use and intermediates - Google Patents

Pharmaceutical peptides,preparation,use and intermediates

Info

Publication number: ZA844004B
Authority: ZA; South Africa
Prior art keywords: sup; hydrogen; carbamyl; alkyl; carbon atoms
Prior art date: 1983-05-26

Application number

ZA844004A

Other languages

English (en)

Inventor

George William Hardy

Lawrence Alfred Lowe

Terence William Smith

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-05-26

Filing date

1984-05-25

Publication date

1986-01-29

1984-05-25 Application filed by Wellcome Found filed Critical Wellcome Found

1986-01-29 Publication of ZA844004B publication Critical patent/ZA844004B/xx

Links

102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
206010011224 Cough Diseases 0.000 abstract 1
206010012735 Diarrhoea Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000001142 anti-diarrhea Effects 0.000 abstract 1
229940124537 antidiarrhoeal agent Drugs 0.000 abstract 1
125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
208000001848 dysentery Diseases 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
230000002093 peripheral effect Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001629 suppression Effects 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
230000000294 tussive effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/70—Enkephalins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Zoology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

ZA844004A 1983-05-26 1984-05-25 Pharmaceutical peptides,preparation,use and intermediates ZA844004B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB838314646A GB8314646D0 (en)	1983-05-26	1983-05-26	Pharmaceutical amides

Publications (1)

Publication Number	Publication Date
ZA844004B true ZA844004B (en)	1986-01-29

Family

ID=10543432

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA844004A ZA844004B (en)	1983-05-26	1984-05-25	Pharmaceutical peptides,preparation,use and intermediates

Country Status (17)

Country	Link
US (1)	US4540682A (fr)
EP (1)	EP0127154B1 (fr)
JP (1)	JPS59231053A (fr)
KR (1)	KR850000467A (fr)
AT (1)	ATE57188T1 (fr)
AU (1)	AU575324B2 (fr)
CA (1)	CA1251898A (fr)
DE (1)	DE3483338D1 (fr)
DK (1)	DK258884A (fr)
ES (2)	ES8606395A1 (fr)
FI (1)	FI82254C (fr)
GB (1)	GB8314646D0 (fr)
GR (1)	GR81890B (fr)
HU (1)	HU193569B (fr)
IL (1)	IL71932A (fr)
NZ (1)	NZ208283A (fr)
ZA (1)	ZA844004B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8622090D0 (en) *	1986-09-12	1986-10-22	Wellcome Found	Pharmacologically active compounds
US5663146A (en) *	1991-08-22	1997-09-02	Administrators Of The Tulane Educational Fund	Polypeptide analogues having growth hormone releasing activity
US5928896A (en) *	1993-04-23	1999-07-27	Virginia Commonwealth University	Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
AU6770794A (en) *	1993-04-23	1994-11-21	Herbert J. Evans	Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US6258550B1 (en)	1993-04-23	2001-07-10	Virginia Commonwealth University	Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5965698A (en) *	1993-04-23	1999-10-12	Virginia Commonwealth University	Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US5952465A (en) *	1993-04-23	1999-09-14	Virginia Commonwealth University	Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US6084066A (en) *	1993-10-29	2000-07-04	Virginia Commonwealth University	Polypetides that include conformation-constraining groups which flank a protein-protein interaction site
US6190691B1 (en)	1994-04-12	2001-02-20	Adolor Corporation	Methods for treating inflammatory conditions
US5962477A (en) *	1994-04-12	1999-10-05	Adolor Corporation	Screening methods for cytokine inhibitors
US5849761A (en)	1995-09-12	1998-12-15	Regents Of The University Of California	Peripherally active anti-hyperalgesic opiates
US6573282B1 (en)	1995-09-12	2003-06-03	Adolor Corporation	Peripherally active anti-hyperalgesic opiates
US6027890A (en)	1996-01-23	2000-02-22	Rapigene, Inc.	Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US6613508B1 (en)	1996-01-23	2003-09-02	Qiagen Genomics, Inc.	Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US6312893B1 (en)	1996-01-23	2001-11-06	Qiagen Genomics, Inc.	Methods and compositions for determining the sequence of nucleic acid molecules
US6372717B1 (en) *	1996-08-23	2002-04-16	Sederma S.A.	Synthetic peptides and their use in cosmetic or dermopharmaceutical compositions
CN101506225A (zh) *	2006-08-17	2009-08-12	埃里比斯药品公司	心脏保护化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4178371A (en) *	1977-12-15	1979-12-11	Reckitt & Colman Products Limited	Tetrapeptide derivatives
US4288432A (en) *	1979-06-12	1981-09-08	Richter Gedeon Vegyeszeti Gyar Rt.	Novel enkephalin analogs and process for the preparation thereof
US4265808A (en) *	1979-12-17	1981-05-05	Eli Lilly And Company	Pharmacologically active peptides
US4322339A (en) *	1980-10-20	1982-03-30	Eli Lilly And Company	Pharmacologically active peptides

1983
- 1983-05-26 GB GB838314646A patent/GB8314646D0/en active Pending
1984
- 1984-05-23 US US06/613,868 patent/US4540682A/en not_active Expired - Lifetime
- 1984-05-25 CA CA000455145A patent/CA1251898A/fr not_active Expired
- 1984-05-25 NZ NZ208283A patent/NZ208283A/xx unknown
- 1984-05-25 AT AT84105981T patent/ATE57188T1/de not_active IP Right Cessation
- 1984-05-25 JP JP59106325A patent/JPS59231053A/ja active Pending
- 1984-05-25 EP EP84105981A patent/EP0127154B1/fr not_active Expired - Lifetime
- 1984-05-25 GR GR74826A patent/GR81890B/el unknown
- 1984-05-25 DE DE8484105981T patent/DE3483338D1/de not_active Expired - Fee Related
- 1984-05-25 AU AU28701/84A patent/AU575324B2/en not_active Ceased
- 1984-05-25 ES ES532813A patent/ES8606395A1/es not_active Expired
- 1984-05-25 ZA ZA844004A patent/ZA844004B/xx unknown
- 1984-05-25 KR KR1019840002863A patent/KR850000467A/ko not_active Ceased
- 1984-05-25 FI FI842104A patent/FI82254C/fi not_active IP Right Cessation
- 1984-05-25 IL IL71932A patent/IL71932A/xx unknown
- 1984-05-25 HU HU842048A patent/HU193569B/hu not_active IP Right Cessation
- 1984-05-25 DK DK258884A patent/DK258884A/da not_active Application Discontinuation
1985
- 1985-07-15 ES ES545189A patent/ES8604991A1/es not_active Expired

Also Published As

Publication number	Publication date
CA1251898A (fr)	1989-03-28
JPS59231053A (ja)	1984-12-25
IL71932A (en)	1987-10-20
FI842104A0 (fi)	1984-05-25
DE3483338D1 (de)	1990-11-08
GR81890B (fr)	1984-12-12
US4540682A (en)	1985-09-10
HU193569B (en)	1987-10-28
KR850000467A (ko)	1985-02-27
EP0127154A2 (fr)	1984-12-05
ES8604991A1 (es)	1986-03-01
FI842104L (fi)	1984-11-27
FI82254B (fi)	1990-10-31
AU2870184A (en)	1984-11-29
EP0127154A3 (en)	1987-05-06
ES545189A0 (es)	1986-03-01
DK258884A (da)	1984-11-27
HUT34764A (en)	1985-04-28
ES532813A0 (es)	1986-04-01
GB8314646D0 (en)	1983-06-29
AU575324B2 (en)	1988-07-28
NZ208283A (en)	1988-07-28
ATE57188T1 (de)	1990-10-15
ES8606395A1 (es)	1986-04-01
EP0127154B1 (fr)	1990-10-03
FI82254C (fi)	1991-02-11
IL71932A0 (en)	1984-09-30
DK258884D0 (da)	1984-05-25

Publication	Publication Date	Title
EP0127154A3 (en)	1987-05-06	Pharmaceutical peptides, preparation, use and intermediates
MY100343A (en)	1990-08-28	Amide derivative and external medicament comprising same
IL76932A (en)	1989-07-31	Synergistic pharmaceutical analgesic compositions containing dihydrocodeine and ibuprofen
MY119403A (en)	2005-05-31	Novel compounds with analgesic effect.
NZ333373A (en)	2000-07-28	Use of amino acid derivatives for preparing compositions with improved multi-drug resistance activity
MY101791A (en)	1992-01-31	New benzimidazole derivatives
IT1170214B (it)	1987-06-03	Composizione farmaceutica per la cura delle arteriopatie periferiche
ES2060173T3 (es)	1994-11-16	Derivados de lisolecitina para el tratamiento de enfermedades autoinmunologicas.
SE8801513D0 (sv)	1988-04-22	Farmaceutisk komposition
CA2139385A1 (fr)	1995-08-05	Produits renfermant une proteine liante de g-csf et de tnf
MY115805A (en)	2003-09-30	Substituted benzyloxycarbonylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
GB9108629D0 (en)	1991-06-12	Heterocyclic pharmaceutical compounds,preparation and use
DE3369327D1 (en)	1987-02-26	Pharmaceutical compounds, preparation, use and intermediates therefor and their preparation
GEP20032968B (en)	2003-05-27	Use of Ketolides in Pharmaceutical Compositions for Preventing Thrombotic Arterial Complications Linked to Atherosclerosis
HUT41025A (en)	1987-03-30	Process for preparing octahydro-indolizine derivatives and pharmaceutical compositions containing such compounds as active ingredients
ATE45958T1 (de)	1989-09-15	Peptide, diese enthaltende zusammensetzungen und verfahren zu ihrer herstellung.
ES8605800A1 (es)	1986-04-01	Procedimiento para la fabricacion de nuevos compuestos cina-moicos
GB8804188D0 (en)	1988-03-23	Pharmaceutical compositions
CA2090234A1 (fr)	1992-03-12	Methode permettant d'obtenir un effet analgesique ameliore
EP0158312A3 (en)	1987-03-11	1-cyclohexyl-3,4-dihydroisoquinoline derivatives, process for their preparation and medicament containing them
EP0204172A3 (en)	1987-09-30	Phenylpyrazine derivatives, processes for preparing them, pharmaceutical composition and use
SE9203296D0 (sv)	1992-11-05	The use of inositoltrisphate for the preparing of medicaments
ES2131331T3 (es)	1999-07-16	Uso de benzotiofenos para la preparacion de un medicamento para reducir la formacion de cicatrices en la curacion de heridas.
JPS5634624A (en)	1981-04-06	Central nervous system depressant
MX9804798A (es)	1998-10-31	Nuevos compuestos con efecto analgesico.