ZA851062B - Salts of oxazaphosphorine derivatives and process for their production - Google Patents

Salts of oxazaphosphorine derivatives and process for their production

Info

Publication number
ZA851062B
ZA851062B ZA851062A ZA851062A ZA851062B ZA 851062 B ZA851062 B ZA 851062B ZA 851062 A ZA851062 A ZA 851062A ZA 851062 A ZA851062 A ZA 851062A ZA 851062 B ZA851062 B ZA 851062B
Authority
ZA
South Africa
Prior art keywords
salts
production
oxazaphosphorine
derivatives
oxazaphosphorine derivatives
Prior art date
Application number
ZA851062A
Other languages
English (en)
Inventor
Juergen Engel
Axel Kleemann
Ulf Niemeyer
Joerg Pohl
Peter Hilgard
Original Assignee
Asta Werke Ag Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Werke Ag Chem Fab filed Critical Asta Werke Ag Chem Fab
Publication of ZA851062B publication Critical patent/ZA851062B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA851062A 1984-03-01 1985-02-12 Salts of oxazaphosphorine derivatives and process for their production ZA851062B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3407585 1984-03-01

Publications (1)

Publication Number Publication Date
ZA851062B true ZA851062B (en) 1985-11-27

Family

ID=6229317

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA851062A ZA851062B (en) 1984-03-01 1985-02-12 Salts of oxazaphosphorine derivatives and process for their production

Country Status (9)

Country Link
US (1) US4716242A (de)
JP (1) JPH072757B2 (de)
DD (1) DD234017A5 (de)
DK (1) DK93985A (de)
ES (1) ES540778A0 (de)
PL (2) PL146149B1 (de)
PT (1) PT80024B (de)
YU (2) YU31285A (de)
ZA (1) ZA851062B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE58900183D1 (de) * 1988-03-19 1991-08-29 Asta Pharma Ag Ifosfamid-mesna-lyophilisat und verfahren zu dessen herstellung.
DE3835772A1 (de) * 1988-10-20 1990-04-26 Deutsches Krebsforsch Tumorhemmende saccharid-konjugate
US5227373A (en) * 1991-10-23 1993-07-13 Bristol-Myers Squibb Co. Lyophilized ifosfamide compositions
US6828415B2 (en) 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
US5873584A (en) * 1995-01-17 1999-02-23 Rike Inline, Inc. In-line roller skate frame
DE102004031569A1 (de) * 2004-06-29 2006-02-02 Baxter International Inc., Deerfield Verfahren zur Herstellung von lagerstabiler Mafosfamid-Lysin-Salz Lyophilisat Bulkware und zu dessen Weiterverarbeitung zu Mafosfamid-Lysin-Salz Lyophilisat in dosierter Form
EP2336140B1 (de) * 2004-10-25 2016-01-27 Dekk-Tec, Inc. Salze aus isophosphoramid-mustard und analoge davon als antitumormittel
AU2010218109B2 (en) * 2009-02-24 2015-04-09 Dekk-Tec, Inc. Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5159886A (de) * 1974-11-20 1976-05-25 Shionogi Seiyaku Kk
US4220660A (en) * 1977-12-14 1980-09-02 Asta-werke Aktiengesellschaft, Chemische Farik Process for the treatment of humans suffering from undesired urotoxic side effects caused by cytostatically active alkylating agents
JPS54157580A (en) * 1978-05-29 1979-12-12 Otsuka Pharmaceut Co Ltd Optically active oxazaphosphorine derivative
JPS5651184A (en) * 1979-10-03 1981-05-08 Hitachi Ltd Color solid image pickup device
DE3133309A1 (de) * 1980-09-10 1982-04-15 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld 4-carbamoyloxy-oxazaphosphorine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DE3220432A1 (de) * 1981-03-24 1983-12-01 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorin-4-thio-alkansulfonsaeure, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate
DE3220672A1 (de) * 1981-03-24 1983-12-08 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Cis-oxazaphosphorin-4-thio-alkansulfonsaeuren, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate
DE3111428A1 (de) * 1981-03-24 1982-10-07 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DE3132221A1 (de) * 1981-08-14 1983-05-19 Behringwerke Ag, 3550 Marburg Neue cyclophosphamid-derivate, verfahren zu ihrer herstellung und ihre verwendung
DE3133077A1 (de) * 1981-08-21 1983-03-10 Henkel KGaA, 4000 Düsseldorf Neue cytostatisch wirksame epoxidgruppen tragende 1,3,2-oxazaphosphorin-verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung in pharmazeutischen zubereitungen
US4618692A (en) * 1981-09-03 1986-10-21 Asta-Werke Aktiengesellschaft 4-carbamoyloxy-oxazaphosphorins
DE3247436A1 (de) * 1981-12-31 1983-07-14 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld 4-sulfido-oxazaphosphorine und deren verwendung bei der krebsbekaempfung und zur immunsuppression
EP0083439B1 (de) * 1981-12-31 1989-07-26 ASTA Pharma AG 4-Sulfido-oxazaphosphorine und deren Verwendung bei der Krebsbekämpfung und zur Immunsuppression
DE3505482A1 (de) * 1984-03-01 1985-09-05 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Neue salze von oxazaphosphorin-derivaten

Also Published As

Publication number Publication date
ES8602831A1 (es) 1985-12-01
US4716242A (en) 1987-12-29
YU31285A (en) 1988-02-29
PT80024A (de) 1985-03-01
DK93985D0 (da) 1985-02-28
PL252161A1 (en) 1986-08-26
JPH072757B2 (ja) 1995-01-18
DD234017A5 (de) 1986-03-19
DK93985A (da) 1985-09-02
YU120287A (en) 1988-04-30
PT80024B (pt) 1987-09-18
JPS60222494A (ja) 1985-11-07
PL146149B1 (en) 1988-12-31
ES540778A0 (es) 1985-12-01
PL143712B1 (en) 1988-03-31

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