ZA866259B - Gamma-carbolines - Google Patents

Gamma-carbolines

Info

Publication number: ZA866259B
Authority: ZA; South Africa
Prior art keywords: sup; alkyl; hydrogen; halogen; carbolines
Prior art date: 1985-09-16

Application number

ZA866259A

Other languages

English (en)

Inventor

Magid Abdel-Megid Abou-Gharbia

Usha Rajni Patel

Reinhardt Peter Stein

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-09-16

Filing date

1986-08-19

Publication date

1988-03-30

1986-08-19 Application filed by American Home Prod filed Critical American Home Prod

1988-03-30 Publication of ZA866259B publication Critical patent/ZA866259B/xx

Links

125000000217 alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
230000000561 anti-psychotic effect Effects 0.000 abstract 1
239000000164 antipsychotic agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000004802 cyanophenyl group Chemical group 0.000 abstract 1
125000005059 halophenyl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000006501 nitrophenyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000003373 pyrazinyl group Chemical group 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000003944 tolyl group Chemical group 0.000 abstract 1
-1 trifluoromethylphenyl Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA866259A 1985-09-16 1986-08-19 Gamma-carbolines ZA866259B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/776,349 US4672117A (en)	1985-09-16	1985-09-16	Antipsychotic gamma-carbolines

Publications (1)

Publication Number	Publication Date
ZA866259B true ZA866259B (en)	1988-03-30

Family

ID=25107141

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA866259A ZA866259B (en)	1985-09-16	1986-08-19	Gamma-carbolines

Country Status (15)

Country	Link
US (1)	US4672117A (de)
EP (1)	EP0222474B1 (de)
JP (1)	JPS6270374A (de)
KR (1)	KR900002246B1 (de)
AT (1)	ATE57184T1 (de)
AU (1)	AU583941B2 (de)
CA (1)	CA1275100A (de)
DE (1)	DE3674721D1 (de)
DK (1)	DK440486A (de)
ES (1)	ES2002617A6 (de)
GB (1)	GB2180535B (de)
GR (1)	GR862344B (de)
HU (1)	HU194564B (de)
PT (1)	PT83345B (de)
ZA (1)	ZA866259B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4636563A (en) *	1985-09-16	1987-01-13	American Home Products Corporation	Antipsychotic γ-carbolines
US5360800A (en) *	1987-09-03	1994-11-01	Glaxo Group Limited	Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives
US4798896A (en) *	1988-01-19	1989-01-17	American Home Products Corporation	Antipsychotic gamma-carboline N-oxides
HU207078B (en) *	1988-08-02	1993-03-01	Glaxo Group Ltd	Process for producing lactam derivatives and pharmaceutical compositions comprising such compounds
EP0620222A3 (de) *	1993-04-14	1995-04-12	Lilly Co Eli	Tetrahydro-betacarboline.
WO1995018092A1 (en) *	1993-12-28	1995-07-06	Maruho Co., Ltd.	Amino ketone derivative
EP0905136A1 (de) *	1997-09-08	1999-03-31	Janssen Pharmaceutica N.V.	Tetrahydro gamma-Carboline
JP2004015286A (ja) *	2002-06-05	2004-01-15	Seiko Epson Corp	ディジタルカメラ
AU2005233456A1 (en) *	2004-04-12	2005-10-27	Taisho Pharmaceutical Co., Ltd.	Cyclic amine compound
RU2338537C2 (ru) *	2006-01-25	2008-11-20	Сергей Олегович Бачурин	СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
WO2009017836A1 (en) *	2007-08-01	2009-02-05	Medivation Neurology, Inc.	Methods and compositions for treating schizophrenia using antipsychotic combination therapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3522262A (en) *	1968-09-10	1970-07-28	Hoffmann La Roche	5-(pyridylalkyl)-pyridoindole derivatives
US3502688A (en) *	1968-09-10	1970-03-24	Hoffmann La Roche	5-(4-pyridylethyl)-pyridoindole derivatives
US4001263A (en) *	1974-04-01	1977-01-04	Pfizer Inc.	5-Aryl-1,2,3,4-tetrahydro-γ-carbolines
US4224329A (en) *	1979-01-23	1980-09-23	Pfizer Inc.	2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles
US4337250A (en) *	1979-07-30	1982-06-29	Pfizer Inc.	Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents
NZ226032A (en) *	1987-09-03	1991-12-23	Glaxo Group Ltd	2-(imidazolylmethyl)-pyrido or-azepino(4,3-b)indole-1(2h)-one derivatives; preparatory processes and pharmaceutical compositions

1985
- 1985-09-16 US US06/776,349 patent/US4672117A/en not_active Expired - Fee Related
1986
- 1986-08-19 ZA ZA866259A patent/ZA866259B/xx unknown
- 1986-08-25 AU AU61814/86A patent/AU583941B2/en not_active Ceased
- 1986-09-02 AT AT86306744T patent/ATE57184T1/de not_active IP Right Cessation
- 1986-09-02 EP EP86306744A patent/EP0222474B1/de not_active Expired - Lifetime
- 1986-09-02 DE DE8686306744T patent/DE3674721D1/de not_active Expired - Fee Related
- 1986-09-03 GB GB8621225A patent/GB2180535B/en not_active Expired
- 1986-09-10 PT PT83345A patent/PT83345B/pt not_active IP Right Cessation
- 1986-09-11 CA CA000518002A patent/CA1275100A/en not_active Expired - Fee Related
- 1986-09-12 ES ES8601848A patent/ES2002617A6/es not_active Expired
- 1986-09-12 JP JP61216965A patent/JPS6270374A/ja active Pending
- 1986-09-12 GR GR862344A patent/GR862344B/el unknown
- 1986-09-15 KR KR1019860007739A patent/KR900002246B1/ko not_active Expired
- 1986-09-15 DK DK440486A patent/DK440486A/da not_active Application Discontinuation
- 1986-09-15 HU HU863943A patent/HU194564B/hu not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU194564B (en)	1988-02-29
GB2180535B (en)	1989-04-05
AU583941B2 (en)	1989-05-11
CA1275100A (en)	1990-10-09
ATE57184T1 (de)	1990-10-15
HUT42480A (en)	1987-07-28
DK440486A (da)	1987-03-17
GB8621225D0 (en)	1986-10-08
ES2002617A6 (es)	1988-09-01
DK440486D0 (da)	1986-09-15
JPS6270374A (ja)	1987-03-31
AU6181486A (en)	1987-03-19
KR900002246B1 (ko)	1990-04-07
GB2180535A (en)	1987-04-01
EP0222474A1 (de)	1987-05-20
GR862344B (en)	1987-01-12
DE3674721D1 (en)	1990-11-08
US4672117A (en)	1987-06-09
PT83345B (pt)	1988-07-29
EP0222474B1 (de)	1990-10-03
PT83345A (pt)	1986-10-01
KR870003104A (ko)	1987-04-15

Publication	Publication Date	Title
ES2002656A6 (es)	1988-09-16	Un procedimiento para la produccion de gamma-carbolinas
IE832405L (en)	1984-04-13	1-phenyl-2-piperidinoalkanols.
ES8702907A1 (es)	1987-01-16	Procedimiento para la obtencion de acidos 7-amino-1-ciclopropil-6,8-dihalogeno-1,4-dihidro-4-oxo-3-quinolincarboxilico
DK177585A (da)	1985-11-11	Pyridazinoner
ES8701173A1 (es)	1986-12-01	Procedimiento para la fabricacion de derivados de pirazol tienil condensados
AU561450B2 (en)	1987-05-07	2-amino-3-acylamino-6-benzylamino pyridine derivatives
GR3015616T3 (en)	1995-06-30	Aryl-heteroaryl-carbinol derivatives having an analgesic activity.
GB2180535B (en)	1989-04-05	Gamma-carbolines
ATE25682T1 (de)	1987-03-15	Indol-3-carboxamid-derivate.
AU7748687A (en)	1988-03-03	Phenolic corrosion inhibitors for coating materials
ES8505927A1 (es)	1985-06-16	Procedimiento para la preparacion de derivados de 1-(fenil)-1-hidroxi-2-amino-3-fluoro-propano
ES8801545A1 (es)	1988-02-01	Un procedimiento para la preparacion de compuestos aminoheterociclicos
AU580373B2 (en)	1989-01-12	1-aryl-4-nitropyrazoles
GB1530415A (en)	1978-11-01	Pyridinylpyrimidine derivatives
JPS57163368A (en)	1982-10-07	4-aryloxy-1,2,3,4-tetrahydroisoquinoline and intermediate
GR851987B (de)	1985-12-10
ES8504768A1 (es)	1985-05-01	Un procedimiento para preparar derivados de pirimidona
ZA8312B (en)	1983-09-28	Substituted 1-benzoyl-2-phenyliminiomidazolidine derivatives
ATE138373T1 (de)	1996-06-15	N,n',n'-trisubstituierte-5-bisaminomethylen-1,3 dioxan-4,6-dione als acyl-coa:cholesterol- acyltransferasehemmer
ATE32339T1 (de)	1988-02-15	Imidazolkarbonsaeure derivate.
ES8507539A1 (es)	1985-10-01	Proceso para producir indolcarboxilato de benzoil
SE8105297L (sv)	1982-03-11	Imidazolderivat
AU561149B2 (en)	1987-04-30	Cardiotonic 4-semicarbazide quindyolines
MY102015A (en)	1992-02-29	Certain 2-(2-substituted benzoyl)-1, 3- cyclohexanadiones