ZA881426B - Crystalline quinapril and a process for producing the same - Google Patents

Crystalline quinapril and a process for producing the same

Info

Publication number: ZA881426B
Authority: ZA; South Africa
Prior art keywords: quinapril; producing; same; crystalline quinapril; novel
Prior art date: 1987-03-30

Application number

ZA881426A

Other languages

English (en)

Inventor

Om Prakash Goel

Prakash Goel Om

Uldis Krolls

Krolls Uldis

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-30

Filing date

1988-02-29

Publication date

1989-10-25

1988-02-29 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1989-10-25 Publication of ZA881426B publication Critical patent/ZA881426B/xx

Links

238000000034 method Methods 0.000 title abstract 3
JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 title abstract 3
229960001455 quinapril Drugs 0.000 title abstract 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
239000005541 ACE inhibitor Substances 0.000 abstract 1
229960000583 acetic acid Drugs 0.000 abstract 1
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 abstract 1
239000002775 capsule Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000012362 glacial acetic acid Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA881426A 1987-03-30 1988-02-29 Crystalline quinapril and a process for producing the same ZA881426B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/032,209 US4761479A (en)	1987-03-30	1987-03-30	Crystalline quinapril and a process for producing the same

Publications (1)

Publication Number	Publication Date
ZA881426B true ZA881426B (en)	1989-10-25

Family

ID=21863696

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA881426A ZA881426B (en)	1987-03-30	1988-02-29	Crystalline quinapril and a process for producing the same

Country Status (13)

Country	Link
US (1)	US4761479A (fr)
EP (1)	EP0285992B1 (fr)
JP (1)	JP2659990B2 (fr)
KR (1)	KR960007087B1 (fr)
AT (1)	ATE62229T1 (fr)
AU (1)	AU605555B2 (fr)
CA (1)	CA1291999C (fr)
DE (1)	DE3862227D1 (fr)
ES (1)	ES2021778B3 (fr)
GR (1)	GR3001736T3 (fr)
NZ (1)	NZ223671A (fr)
PH (1)	PH24986A (fr)
ZA (1)	ZA881426B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2122941B1 (es)	1997-05-29	1999-07-01	Esteve Quimica Sa	Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.
NZ333206A (en) *	1998-12-08	2000-07-28	Bernard Charles Sherman	Solid pharmaceutical compositions comprising a stable magnesium salt of quinapril that acts as a ACE (Angiotensin Converting Enzyme) inhibitor
US20030225124A1 (en) *	1999-08-31	2003-12-04	Spiridon Spireas	Stable formulations of ACE inhibitors, and methods for preparation thereof
AU2002361494A1 (en) *	2002-12-16	2004-07-09	Lupin Limited	Crystalline form of quinapril hydrochloride and process for preparing the same
CL2004000541A1 (es) *	2003-03-31	2005-02-04	Warner Lambert Co	Procedimiento de preparacion de clorhidrato de quinapril por reaccion entre una 2,5-dioxo-oxazolidina y un ester terbutilico de una tetrahidro isoquinolina, util como principio activo para tratar la hipertension y la insuficiencia cardiaca congestiva
WO2007069268A2 (fr) *	2005-10-14	2007-06-21	Sun Pharmaceutical Industries Limited	Procédé pour la préparation de dérivés de l'acide 1,2,3,4-tétrahydroisoquinoline-3-carboxylique pratiquement purs
WO2009113081A1 (fr) *	2008-03-10	2009-09-17	Lupin Limited	Sel de tris(hydroxyméthyl)aminométhane de quinapril et de ramipril

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4294832A (en) *	1979-04-28	1981-10-13	Tanabe Seiyaku Co., Ltd.	Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof
US4344949A (en) *	1980-10-03	1982-08-17	Warner-Lambert Company	Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids

1987
- 1987-03-30 US US07/032,209 patent/US4761479A/en not_active Expired - Lifetime
1988
- 1988-02-26 NZ NZ223671A patent/NZ223671A/xx unknown
- 1988-02-29 ZA ZA881426A patent/ZA881426B/xx unknown
- 1988-02-29 AU AU12383/88A patent/AU605555B2/en not_active Ceased
- 1988-03-04 CA CA000560594A patent/CA1291999C/fr not_active Expired - Lifetime
- 1988-03-25 PH PH36687A patent/PH24986A/en unknown
- 1988-03-29 AT AT88105131T patent/ATE62229T1/de not_active IP Right Cessation
- 1988-03-29 JP JP63073492A patent/JP2659990B2/ja not_active Expired - Lifetime
- 1988-03-29 ES ES88105131T patent/ES2021778B3/es not_active Expired - Lifetime
- 1988-03-29 EP EP88105131A patent/EP0285992B1/fr not_active Expired - Lifetime
- 1988-03-29 DE DE8888105131T patent/DE3862227D1/de not_active Expired - Lifetime
- 1988-03-30 KR KR1019880003494A patent/KR960007087B1/ko not_active Expired - Fee Related
1991
- 1991-04-04 GR GR91400309T patent/GR3001736T3/el unknown

Also Published As

Publication number	Publication date
AU1238388A (en)	1988-09-29
GR3001736T3 (en)	1992-11-23
NZ223671A (en)	1990-10-26
CA1291999C (fr)	1991-11-12
JP2659990B2 (ja)	1997-09-30
US4761479A (en)	1988-08-02
KR880011110A (ko)	1988-10-26
ATE62229T1 (de)	1991-04-15
PH24986A (en)	1990-12-26
JPS63258459A (ja)	1988-10-25
AU605555B2 (en)	1991-01-17
KR960007087B1 (ko)	1996-05-27
EP0285992A1 (fr)	1988-10-12
ES2021778B3 (es)	1991-11-16
EP0285992B1 (fr)	1991-04-03
DE3862227D1 (de)	1991-05-08

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