ZA88464B - 11beta-alkynyl-estrenes and-estradienes,their production,and pharmaceutical preparations containing them - Google Patents

11beta-alkynyl-estrenes and-estradienes,their production,and pharmaceutical preparations containing them

Info

Publication number: ZA88464B
Authority: ZA; South Africa
Prior art keywords: phenyl; alkyl; optionally substituted; substituted; estradienes
Prior art date: 1987-01-23

Application number

ZA88464A

Other languages

English (en)

Inventor

Eckhard Ottow

Ottow Eckhard

Rudolf Wiechert

Wiechert Rudolf

Guenter Neef

Neef Guenter

Juergen Bardenhagen

Bardenhagen Juergen

Sybille Beier

Beier Sybille

Walter Elger

Elger Walter

David Henderson

Henderson David

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-01-23

Filing date

1988-01-22

Publication date

1988-09-28

1988-01-22 Application filed by Schering Ag filed Critical Schering Ag

1988-09-28 Publication of ZA88464B publication Critical patent/ZA88464B/xx

Links

238000004519 manufacturing process Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
-1 hydroximino Chemical group 0.000 abstract 3
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
JAOZTHAZZJCMAN-UHFFFAOYSA-N nitro cyanomethaneperoxoate Chemical compound [O-][N+](=O)OOC(=O)C#N JAOZTHAZZJCMAN-UHFFFAOYSA-N 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
229920002554 vinyl polymer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
- C07J21/003—Lactones at position 17
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Liquid Crystal Substances (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)

ZA88464A 1987-01-23 1988-01-22 11beta-alkynyl-estrenes and-estradienes,their production,and pharmaceutical preparations containing them ZA88464B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19873702383 DE3702383A1 (de)	1987-01-23	1987-01-23	11ss-alkinylestrene und -estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate

Publications (1)

Publication Number	Publication Date
ZA88464B true ZA88464B (en)	1988-09-28

Family

ID=6319636

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA88464A ZA88464B (en)	1987-01-23	1988-01-22	11beta-alkynyl-estrenes and-estradienes,their production,and pharmaceutical preparations containing them

Country Status (15)

Country	Link
US (1)	US4870069A (da)
EP (1)	EP0277089B1 (da)
JP (1)	JPS63201197A (da)
AT (1)	ATE64399T1 (da)
AU (1)	AU616395B2 (da)
CA (1)	CA1326014C (da)
DE (2)	DE3702383A1 (da)
DK (1)	DK2088A (da)
ES (1)	ES2038783T3 (da)
GR (1)	GR3002110T3 (da)
IE (1)	IE60321B1 (da)
NO (1)	NO169344C (da)
NZ (1)	NZ223269A (da)
PT (1)	PT86591B (da)
ZA (1)	ZA88464B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3633244A1 (de) *	1986-09-26	1988-03-31	Schering Ag	Antigestagene zur hemmung der uterinen prostaglandinsynthese
DE3921059A1 (de) *	1989-06-23	1991-01-10	Schering Ag	11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
DE4042007A1 (de) *	1990-12-22	1992-06-25	Schering Ag	6,7-modifizierte-11(beta)-aryl-4-estrene
EP0496520A1 (en) *	1991-01-22	1992-07-29	Merck & Co. Inc.	Novel bone acting agents
MX9301121A (es)	1992-03-02	1993-09-01	Schering Ag	Metodo y equipo para la contracepcion oral y regulacion de la menstruacion con estrogeno/progestina/aniprogestina.
CA2100514C (en) *	1992-07-29	2005-03-29	Johannes A. M. Hamersma	17-spiromethylene steroids
US5710144A (en) *	1993-02-08	1998-01-20	Akzo Nobel N.V.	C-11 substituted steroids for treating menopausal complaints
ZA94715B (en) *	1993-02-08	1994-10-24	Akzo Nv	Steroids for treating menopausal complaints
US6037339A (en)	1993-02-08	2000-03-14	Akzo Nobel N.V.	C-11 substituted steroids for treating menopausal complaints
US6407082B1 (en) *	1996-09-13	2002-06-18	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a vitamin D compound
US6034074A (en)	1996-09-13	2000-03-07	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a Vitamin D compound
US6765002B2 (en)	2000-03-21	2004-07-20	Gustavo Rodriguez	Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6028064A (en) *	1996-09-13	2000-02-22	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of progestin products
US6511970B1 (en)	1996-09-13	2003-01-28	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6090798A (en) *	1997-12-19	2000-07-18	Alcon Laboratories, Inc.	Treatment of GLC1A glaucoma with glucocorticoid antagonists
US6020328A (en) *	1998-03-06	2000-02-01	Research Triangle Institute	20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en)	1998-05-29	2001-07-17	Research Triangle Institute	17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) *	1998-05-29	1999-10-05	Research Triangle Institute	17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US20010044431A1 (en) *	2000-03-21	2001-11-22	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
DE102007063500A1 (de) *	2007-12-29	2009-07-02	Bayer Schering Pharma Aktiengesellschaft	17-(1'-Propenyl)-17-3'-oxidoestra-4-en-3-on-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007063496A1 (de) *	2007-12-29	2009-07-02	Bayer Schering Pharma Aktiengesellschaft	15,16-Methylen-17-(1'-propenyl)-17-3'-oxidoestra-4-en-3-on-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007063498A1 (de) *	2007-12-29	2009-07-02	Bayer Schering Pharma Aktiengesellschaft	15,16-Methylen-steroid-17,17-Lactol-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007063499A1 (de) *	2007-12-29	2009-07-02	Bayer Schering Pharma Aktiengesellschaft	Steroid-17,17-Lactol-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3236866A (en) *	1959-04-08	1966-02-22	Syntex Corp	21, 21-difluoro pregnenes
FR2377418A1 (fr) *	1977-01-13	1978-08-11	Roussel Uclaf	Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
NL7701384A (nl) *	1977-02-10	1978-08-14	Akzo Nv	Werkwijze voor het bereiden van nieuwe steroiden van de oestraanreeks.
DE3410880A1 (de) *	1984-03-21	1985-10-03	Schering AG, Berlin und Bergkamen, 1000 Berlin	17-substituierte estradiene und estratriene

1987
- 1987-01-23 DE DE19873702383 patent/DE3702383A1/de not_active Withdrawn
1988
- 1988-01-05 DK DK002088A patent/DK2088A/da not_active Application Discontinuation
- 1988-01-21 PT PT86591A patent/PT86591B/pt not_active IP Right Cessation
- 1988-01-22 EP EP88730017A patent/EP0277089B1/de not_active Expired - Lifetime
- 1988-01-22 NO NO880267A patent/NO169344C/no unknown
- 1988-01-22 ZA ZA88464A patent/ZA88464B/xx unknown
- 1988-01-22 ES ES198888730017T patent/ES2038783T3/es not_active Expired - Lifetime
- 1988-01-22 JP JP63011036A patent/JPS63201197A/ja active Pending
- 1988-01-22 CA CA000557191A patent/CA1326014C/en not_active Expired - Fee Related
- 1988-01-22 AT AT88730017T patent/ATE64399T1/de not_active IP Right Cessation
- 1988-01-22 DE DE8888730017T patent/DE3863182D1/de not_active Expired - Lifetime
- 1988-01-25 US US07/147,475 patent/US4870069A/en not_active Expired - Fee Related
- 1988-01-25 IE IE17188A patent/IE60321B1/en not_active IP Right Cessation
- 1988-01-26 NZ NZ223269A patent/NZ223269A/xx unknown
- 1988-01-27 AU AU11114/88A patent/AU616395B2/en not_active Ceased
1991
- 1991-07-03 GR GR90401114T patent/GR3002110T3/el unknown

Also Published As

Publication number	Publication date
DE3702383A1 (de)	1988-08-04
IE60321B1 (en)	1994-06-29
NO880267D0 (no)	1988-01-22
GR3002110T3 (en)	1992-12-30
US4870069A (en)	1989-09-26
NO169344C (no)	1992-06-10
EP0277089B1 (de)	1991-06-12
JPS63201197A (ja)	1988-08-19
NO169344B (no)	1992-03-02
DK2088A (da)	1988-07-24
CA1326014C (en)	1994-01-11
NZ223269A (en)	1990-09-26
DE3863182D1 (de)	1991-07-18
NO880267L (no)	1988-07-25
IE880171L (en)	1988-07-23
AU1111488A (en)	1988-07-28
ATE64399T1 (de)	1991-06-15
AU616395B2 (en)	1991-10-31
ES2038783T3 (es)	1993-08-01
EP0277089A1 (de)	1988-08-03
PT86591A (pt)	1988-02-01
PT86591B (pt)	1991-12-31
DK2088D0 (da)	1988-01-05

Publication	Publication Date	Title
AU1111488A (en)	1988-07-28	11B -alkynyl-estrenes and -estradienes, their production, and pharmaceutical preparations containing them
AP9801274A0 (en)	1998-06-30	Lactone derivatives of 17, beta.carboxy, carbothio and amide androstane derivatives.
UA5928A1 (uk)	1994-12-29	Спосіб отримання похідних дистаміцину а або їх гідрохлоридів
FI891806A0 (fi)	1989-04-17	Menetelmä valmistaa farmakologisesti arvokasta bentso/5,6/sykloheptapyridiiniä
FI102609B1 (fi)	1999-01-15	Menetelmä valmistaa farmakologisesti arvokas substituoidun bentso[5,6]sykloheptapyridiinin pyridiini-N-oksidi
DE3865863D1 (da)	1991-12-05
AU4415285A (en)	1986-01-02	Benzodiazepine derivatives
NZ223772A (en)	1991-09-25	Substituted benzodiazepine derivatives and pharmaceutical compositions
DE3460026D1 (en)	1986-03-13	N-phenyl-benzamide derivatives, process for their preparation and medicines containing them
IL73893A0 (en)	1985-03-31	11-beta arylestradienes,their production,and pharmaceutical preparations containing same
ES2000368A6 (es)	1988-02-16	Un procedimiento para preparar di-t-butilfenoles sustituidos
MY119192A (en)	2005-04-30	Intermediates useful for the production of morpholinyl derivatives of doxorubicin and process for their preparation.
HU891441D0 (en)	1990-01-28	Process for the preparation of novel 1,4-benzoxazine and 1,4-benzothiazine derivatives
GR3003079T3 (en)	1993-02-17	Six-membered heterocyclic derivatives of n'substituted-n,n'-diacylhydrazines
BG103271A (en)	2000-05-31	Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means
SI0736009T1 (en)	2003-04-30	N-oxides of 4-arylpiperazines and 4-arylpiperidines as antipsychotic drugs
FI894812A0 (fi)	1989-10-11	Menetelmä valmistaa farmakologisesti arvokkaita 2-karbonyylisubstituoituja N,N'-di(trimetoksibentsoyyli)piperatsiineja
ZA853017B (en)	1986-12-30	Antibacterial compounds
PH24971A (en)	1990-12-26	N2-thiocylcarbazate compounds and derivatives thereof