ZA886125B - 5-amino or substituted amino 1,2,3-triazoles useful as antiproliferative agents - Google Patents

5-amino or substituted amino 1,2,3-triazoles useful as antiproliferative agents

Info

Publication number
ZA886125B
ZA886125B ZA886125A ZA886125A ZA886125B ZA 886125 B ZA886125 B ZA 886125B ZA 886125 A ZA886125 A ZA 886125A ZA 886125 A ZA886125 A ZA 886125A ZA 886125 B ZA886125 B ZA 886125B
Authority
ZA
South Africa
Prior art keywords
amino
antiproliferative agents
substituted amino
triazoles
triazoles useful
Prior art date
Application number
ZA886125A
Other languages
English (en)
Inventor
Donald Hupe
Hupe Donald
Barbara Ann Azzolina
Ann Azzolina Barbara
Lawrence Argenbright
Argenbright Lawrence
Nancy Behrens
Behrens Nancy
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA886125B publication Critical patent/ZA886125B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ZA886125A 1987-08-20 1988-08-18 5-amino or substituted amino 1,2,3-triazoles useful as antiproliferative agents ZA886125B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/087,494 US4847257A (en) 1987-08-20 1987-08-20 5-Amino or substituted amino 1,2,3,-triazoles useful as antiproliferative agents

Publications (1)

Publication Number Publication Date
ZA886125B true ZA886125B (en) 1989-04-26

Family

ID=22205528

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA886125A ZA886125B (en) 1987-08-20 1988-08-18 5-amino or substituted amino 1,2,3-triazoles useful as antiproliferative agents

Country Status (16)

Country Link
US (2) US4847257A (fr)
EP (1) EP0304221B1 (fr)
JP (1) JP2572115B2 (fr)
KR (1) KR960014871B1 (fr)
AT (1) ATE101513T1 (fr)
AU (1) AU612172B2 (fr)
CA (1) CA1325977C (fr)
CY (1) CY1954A (fr)
DE (1) DE3887793T2 (fr)
DK (1) DK175915B1 (fr)
HK (1) HK107596A (fr)
IE (1) IE61719B1 (fr)
IL (1) IL87421A (fr)
NZ (1) NZ225770A (fr)
PT (1) PT88275B (fr)
ZA (1) ZA886125B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5359078A (en) * 1989-05-19 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Signal transduction inhibitor compounds
US5880129A (en) * 1989-05-19 1999-03-09 The United States Of America As Represented By The Department Of Health And Human Services Methods of inhibiting invasion and metastasis of malignant solid tumors
US5498620A (en) * 1989-05-19 1996-03-12 The United States Of America As Represented By The Department Of Health And Human Services Signal transduction inhibitor 1,2,3-triazolo compounds
US5132315A (en) * 1989-05-19 1992-07-21 The United States Of America As Represented By The Department Of Health And Human Services Therapeutic application of an anti-invasive compound
WO1992012144A1 (fr) * 1990-12-28 1992-07-23 Teijin Limited Compose cyclique condense de benzoxa, son procede de production, et composition pharmaceutique le contenant
US5744492A (en) * 1993-09-17 1998-04-28 United States Of America Method for inhibiting angiogenesis
US5602156A (en) * 1993-09-17 1997-02-11 The United States Of America As Represented By The Department Of Health And Human Services Method for inhibiting metalloproteinase expression
US5728707A (en) * 1995-07-21 1998-03-17 Constantia Gruppe Treatment and prevention of primary and metastatic neoplasms with salts of aminoimidazole carboxamide
ATE278399T1 (de) * 1995-07-21 2004-10-15 Savvipharm Inc Orotatsalze von 5-amino- oder substituierten amino-1,2,3-triazolen zur behandlung von neoplasmen
US8198334B2 (en) * 1997-10-27 2012-06-12 Pathologica Llc Methods for modulating macrophage proliferation in ocular disease using polyamine analogs
US7087648B1 (en) * 1997-10-27 2006-08-08 The Regents Of The University Of California Methods for modulating macrophage proliferation using polyamine analogs
US5886038A (en) * 1998-03-24 1999-03-23 Panda Pharmaceuticals, L.L.C. Composition and method for treatment of psoriasis
US5990100A (en) * 1998-03-24 1999-11-23 Panda Pharmaceuticals, L.L.C. Composition and method for treatment of psoriasis
US6702801B2 (en) * 1998-05-07 2004-03-09 Kimberly-Clark Worldwide, Inc. Absorbent garment with an extensible backsheet
AU2005294514A1 (en) * 2004-10-04 2006-04-20 Cellgate, Inc. Polyamine analogs as therapeutic agents for ocular diseases
US7531560B2 (en) * 2004-11-10 2009-05-12 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
CN101164538B (zh) * 2006-10-16 2011-12-14 中国医学科学院基础医学研究所 羧胺三唑类化合物及其盐在制备治疗疼痛性疾病和/或炎症性疾病的药物中的应用
CA2772075C (fr) * 2009-09-04 2017-02-28 Rashida A. Karmali Nouvelles compositions et procedes de preparation de 5-amino ou amino substitue 1,2,3-triazoles et de formulations d'orotate de triazole
CN112358451B (zh) * 2021-01-11 2021-04-13 广东银珠医药科技有限公司 羧胺三唑的合成方法
CN113620892B (zh) * 2021-10-12 2022-02-22 广东银珠医药科技有限公司 羧胺三唑单晶、制备方法及其组合物和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4590201A (en) * 1984-02-02 1986-05-20 Merck & Co., Inc. 5-amino or substituted amino 1,2,3-triazoles

Also Published As

Publication number Publication date
KR960014871B1 (ko) 1996-10-21
DE3887793D1 (de) 1994-03-24
US4847257A (en) 1989-07-11
HK107596A (en) 1996-06-28
EP0304221A2 (fr) 1989-02-22
DK465488D0 (da) 1988-08-19
IE61719B1 (en) 1994-11-30
DK465488A (da) 1989-03-15
EP0304221A3 (en) 1990-09-05
EP0304221B1 (fr) 1994-02-16
JP2572115B2 (ja) 1997-01-16
IE882551L (en) 1989-02-20
ATE101513T1 (de) 1994-03-15
KR890003385A (ko) 1989-04-14
JPS6468321A (en) 1989-03-14
AU612172B2 (en) 1991-07-04
IL87421A0 (en) 1989-01-31
CY1954A (en) 1997-05-16
CA1325977C (fr) 1994-01-11
PT88275A (pt) 1989-06-30
DE3887793T2 (de) 1994-07-28
NZ225770A (en) 1991-11-26
AU2115988A (en) 1989-03-16
PT88275B (pt) 1995-03-01
US5045543A (en) 1991-09-03
DK175915B1 (da) 2005-06-27
IL87421A (en) 1992-12-01

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