ZA886727B - Azithromycin and derivatives as antiprotozoal agents - Google Patents

Azithromycin and derivatives as antiprotozoal agents

Info

Publication number: ZA886727B
Authority: ZA; South Africa
Prior art keywords: azithromycin; derivatives; antiprotozoal agents; sec; antiprotozoal
Prior art date: 1987-09-10

Application number

ZA886727A

Other languages

English (en)

Inventor

Jack Samuel Remington

Samuel Remington Jack

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-10

Filing date

1988-09-09

Publication date

1990-04-25

1988-09-09 Application filed by Pfizer filed Critical Pfizer

1990-04-25 Publication of ZA886727B publication Critical patent/ZA886727B/xx

Links

MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 title abstract 2
229960004099 azithromycin Drugs 0.000 title abstract 2
239000003904 antiprotozoal agent Substances 0.000 title 1
241000124008 Mammalia Species 0.000 abstract 1
206010037075 Protozoal infections Diseases 0.000 abstract 1
201000005485 Toxoplasmosis Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

ZA886727A 1987-09-10 1988-09-09 Azithromycin and derivatives as antiprotozoal agents ZA886727B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1987/002317 WO1989002271A1 (en)	1987-09-10	1987-09-10	Azithromycin and derivatives as antiprotozoal agents

Publications (1)

Publication Number	Publication Date
ZA886727B true ZA886727B (en)	1990-04-25

Family

ID=22202554

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA886727A ZA886727B (en)	1987-09-10	1988-09-09	Azithromycin and derivatives as antiprotozoal agents

Country Status (18)

Country	Link
US (1)	US4963531A (de)
EP (1)	EP0307128B1 (de)
JP (1)	JPH0667847B2 (de)
KR (1)	KR930011996B1 (de)
AT (1)	ATE74508T1 (de)
AU (1)	AU596029B2 (de)
CA (1)	CA1334574C (de)
DE (1)	DE3869880D1 (de)
DK (1)	DK175544B1 (de)
HU (1)	HUT47553A (de)
IE (1)	IE61507B1 (de)
IL (1)	IL87698A (de)
MY (1)	MY103388A (de)
NZ (1)	NZ226112A (de)
PH (1)	PH26229A (de)
PT (1)	PT88448B (de)
WO (1)	WO1989002271A1 (de)
ZA (1)	ZA886727B (de)

Families Citing this family (57)

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RO107257B1 (ro)	1987-07-09	1993-10-30	Pfizer	Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
SI9011409A (en) *	1990-07-18	1995-10-31	Pliva Pharm & Chem Works	O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
US5912331A (en) *	1991-03-15	1999-06-15	Merck & Co., Inc.	Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) *	1992-03-26	1999-11-16	Merck & Co., Inc.	Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) *	1992-04-02	1993-02-23	Merck & Co., Inc.	8a-AZA-8a-homoerythromycin cyclic iminoethers
US5215980A (en) *	1992-01-17	1993-06-01	Merck & Co., Inc.	10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
TW271400B (de) *	1992-07-30	1996-03-01	Pfizer
US5210235A (en) *	1992-08-26	1993-05-11	Merck & Co., Inc.	Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) *	1993-04-14	1994-07-26	Merck & Co., Inc.	Process of producing 8A- and 9A-azalide antibiotics
DE69400631T2 (de) *	1993-05-05	1997-02-27	Palo Alto Medical Foundation, Palo Alto, Calif.	Verwendung von rifamycinderivaten zur herstellung eines arzneimittels zur behandlung der toxoplasmose
US5529994A (en) *	1993-05-05	1996-06-25	Palo Alto Medical Foundation	Treatment for toxoplasmosis
CA2189001A1 (en) *	1994-04-26	1995-11-02	Nobuhiro Narita	Medicinal composition as a remedy for nonsmall cell lung cancer
US5605889A (en) *	1994-04-29	1997-02-25	Pfizer Inc.	Method of administering azithromycin
AU744318B2 (en) *	1994-04-29	2002-02-21	Pfizer Inc.	Method of administering azithromycin
EP0758244B2 (de) *	1994-05-06	2008-02-13	Pfizer Inc.	Azithromycin enthaltende arzneiverabreichungsformen mit gesteuerter wirkstoffabgabe
US20030212123A1 (en) *	1997-05-05	2003-11-13	Pfizer Inc.	COX-2 selective carprofen for treating pain and inflammation in dogs
US6407074B1 (en) *	1997-06-11	2002-06-18	Pfizer Inc	C-4″-substituted macrolide derivatives
JP2003512290A (ja) *	1997-09-10	2003-04-02	メルクエンドカムパニーインコーポレーテッド	家畜抗菌剤としての８ａ−アザライド
PT1437359E (pt) *	1997-10-16	2007-04-30	Glaxosmithkline Zagreb	Novos 3,6-hemicetais da classe dos 9a-azalidos
JP2002531409A (ja) *	1998-11-30	2002-09-24	テバファーマシューティカルインダストリーズリミティド	アジスロマイシンのエタノール付加物、その製造方法、及びその医薬製剤
US6555139B2 (en)	1999-06-28	2003-04-29	Wockhardt Europe Limited	Preparation of micron-size pharmaceutical particles by microfluidization
IT1313610B1 (it) *	1999-08-09	2002-09-09	S I F I Societa Ind Farmaceuti	Processo per la preparazione di formulazioni acquose per uso oftalmico
US6608033B1 (en) *	1999-08-27	2003-08-19	Pfizer Inc.	Treatment or prevention of coccidiosis
AU2928701A (en)	2000-01-04	2001-07-16	Teva Pharmaceutical Industries Ltd.	Preparation method of azithromycin dihydrate
WO2002007736A1 (en) *	2000-07-24	2002-01-31	Cadila Pharmaceuticals Limited	The process for manufacturing of clear liquid pharmaceutical composition of azithromycin
ATE320441T1 (de)	2000-07-25	2006-04-15	Silanes Sa De Cv Lab	Einstufiges verfahren zur herstellung von 7,16-
AU2001214115A1 (en) *	2000-08-01	2002-02-13	Habil F. Khorakiwala	Process for the preparation of anhydrous azithromycin
DE60114028T2 (de)	2000-08-23	2006-07-13	Wockhardt Ltd.	Verfahren zur herstellung von wasserfreiem azithromycin
CA2429639C (en) *	2000-11-27	2009-07-14	Biochemie S.A.	Stable azithromycin monohydrate
KR100491183B1 (ko) *	2001-03-21	2005-05-25	한미약품 주식회사	아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
EP1671979B1 (de)	2001-05-22	2008-08-13	Pfizer Products Inc.	Neue Kristallforme von Azithromycin
IL158591A0 (en) *	2001-05-22	2004-05-12	Pfizer Prod Inc	Crystal forms of azithromycin
US6861413B2 (en) *	2001-05-22	2005-03-01	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
HRP20040163A2 (en) *	2001-08-21	2005-02-28	Pfizer Products Inc.	Single dose azithromycin for treating respiratory infections
US20080149521A9 (en) *	2001-10-18	2008-06-26	Michael Pesachovich	Methods of stabilizing azithromycin
US6764997B2 (en) *	2001-10-18	2004-07-20	Teva Pharmaceutical Industries Ltd.	Stabilized azithromycin compositions
EP1455757A2 (de) *	2001-12-21	2004-09-15	Pfizer Products Inc.	Verfahren zur feuchtgranulierung von azithromycin
IL161996A0 (en) *	2001-12-21	2005-11-20	Pfizer Prod Inc	Directly compressible formulations of azithromycin
RU2212242C1 (ru) *	2001-12-24	2003-09-20	Закрытое акционерное общество "Брынцалов-А"	Антибиотик сумазид
BR0307331A (pt) *	2002-02-01	2004-12-07	Pfizer Prod Inc	Formulações granuladas a seco de azitromicina
ES2220229B1 (es) *	2003-05-29	2005-10-16	Quimica Sintetica, S.A.	Sales de adicion de azitromicina y acido citrico y procedimiento para su obtencion.
US20050013835A1 (en) *	2003-07-15	2005-01-20	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
JP2007513145A (ja)	2003-12-04	2007-05-24	ファイザー・プロダクツ・インク	医薬用多微粒子の製造方法
JP2007513139A (ja) *	2003-12-04	2007-05-24	ファイザー・プロダクツ・インク	安定性の改善した多粒子組成物
WO2005053652A1 (en)	2003-12-04	2005-06-16	Pfizer Products Inc.	Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
WO2005053639A2 (en) *	2003-12-04	2005-06-16	Pfizer Products Inc.	Controlled release multiparticulates formed with dissolution enhancers
JP2007513143A (ja) *	2003-12-04	2007-05-24	ファイザー・プロダクツ・インク	押出機を使用して好ましくはポロクサマーおよびグリセリドを含む多粒子アジスロマイシン組成物を製造するための噴霧凝固法
US6984403B2 (en) *	2003-12-04	2006-01-10	Pfizer Inc.	Azithromycin dosage forms with reduced side effects
CA2547239A1 (en) *	2003-12-04	2005-06-16	Pfizer Products Inc.	Azithromycin multiparticulate dosage forms by liquid-based processes
CA2549225A1 (en)	2003-12-04	2005-06-16	Pfizer Products Inc.	Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
CN1295719C (zh) *	2003-12-30	2007-01-17	郑玉庆	远程智能型变压器
WO2006115494A1 (en) *	2005-04-26	2006-11-02	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
US7468428B2 (en)	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
US20060046970A1 (en) *	2004-08-31	2006-03-02	Insite Vision Incorporated	Topical otic compositions and methods of topical treatment of prevention of otic infections
US20060198895A1 (en) *	2005-03-07	2006-09-07	Kotliar Eleonora M	Azithromycin powder for oral suspension compositions
CN100427499C (zh) *	2005-12-20	2008-10-22	山东诚创医药技术开发有限公司	一种阿奇霉素的可溶性盐及其制备方法
WO2013088274A1 (en)	2011-12-14	2013-06-20	Wockhardt Limited	Anhydrous amorphous azithromycin composition free of azithromycin dihydrate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI8110592A8 (en) *	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
ZA835204B (en) *	1982-07-19	1985-02-27	Pfizer	N-methyl 11-aza-10-deoxo-10-dihydroerythromycin a,intermediates therefor and processes for their preparation
US4526889A (en) *	1982-11-15	1985-07-02	Pfizer Inc.	Epimeric azahomoerythromycin A derivative, intermediates and method of use
PH19293A (en) *	1982-11-15	1986-03-04	Pfizer	Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
US4512982A (en) *	1984-04-13	1985-04-23	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
AU8280087A (en) *	1987-09-10	1989-04-17	Pfizer Inc.	Azithromycin and derivatives as antiprotozoal agents

1987
- 1987-09-10 WO PCT/US1987/002317 patent/WO1989002271A1/en not_active Ceased
1988
- 1988-08-16 US US07/359,676 patent/US4963531A/en not_active Expired - Lifetime
- 1988-08-29 MY MYPI88000970A patent/MY103388A/en unknown
- 1988-08-31 DE DE8888308024T patent/DE3869880D1/de not_active Expired - Lifetime
- 1988-08-31 AT AT88308024T patent/ATE74508T1/de not_active IP Right Cessation
- 1988-08-31 EP EP88308024A patent/EP0307128B1/de not_active Expired - Lifetime
- 1988-09-07 IL IL87698A patent/IL87698A/xx not_active IP Right Cessation
- 1988-09-07 PT PT88448A patent/PT88448B/pt not_active IP Right Cessation
- 1988-09-08 KR KR1019880011575A patent/KR930011996B1/ko not_active Expired - Lifetime
- 1988-09-08 CA CA000576732A patent/CA1334574C/en not_active Expired - Fee Related
- 1988-09-09 NZ NZ226112A patent/NZ226112A/en unknown
- 1988-09-09 DK DK198805028A patent/DK175544B1/da not_active IP Right Cessation
- 1988-09-09 HU HU884667A patent/HUT47553A/hu unknown
- 1988-09-09 ZA ZA886727A patent/ZA886727B/xx unknown
- 1988-09-09 PH PH37527A patent/PH26229A/en unknown
- 1988-09-09 IE IE276288A patent/IE61507B1/en not_active IP Right Cessation
- 1988-09-09 AU AU22061/88A patent/AU596029B2/en not_active Expired
- 1988-09-10 JP JP63227353A patent/JPH0667847B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK175544B1 (da)	2004-11-29
AU2206188A (en)	1989-05-11
PT88448B (pt)	1992-10-30
DK502888A (da)	1989-03-13
WO1989002271A1 (en)	1989-03-23
AU596029B2 (en)	1990-04-12
KR930011996B1 (ko)	1993-12-23
NZ226112A (en)	1997-03-24
EP0307128A3 (en)	1990-07-04
JPH0667847B2 (ja)	1994-08-31
US4963531A (en)	1990-10-16
IE882762L (en)	1989-03-10
IL87698A (en)	1992-12-01
KR890004709A (ko)	1989-05-09
ATE74508T1 (de)	1992-04-15
EP0307128A2 (de)	1989-03-15
MY103388A (en)	1993-06-30
CA1334574C (en)	1995-02-28
IL87698A0 (en)	1989-02-28
IE61507B1 (en)	1994-11-02
JPH0283326A (ja)	1990-03-23
PT88448A (pt)	1989-07-31
DE3869880D1 (de)	1992-05-14
EP0307128B1 (de)	1992-04-08
PH26229A (en)	1992-04-01
DK502888D0 (da)	1988-09-09
HUT47553A (en)	1989-03-28

Publication	Publication Date	Title
EP0307128A3 (en)	1990-07-04	Azithromycin and derivatives as antiprotozoal agents
GR3005844T3 (de)	1993-06-07
EP0296573A3 (en)	1990-07-04	Novel nucleosides, their preparation and pharmaceutical novel nucleosides, their preparation and pharmaceutical compositions compositions
EP0293751A3 (en)	1990-07-25	Taurohyodeoxycholic acid for the therapy of calculosis of the biliary tract and of biliary dyspepsia
DE3686022D1 (de)	1992-08-20	Monosaccharide enthaltende zusammensetzung zum heilen von wunden.
PH27568A (en)	1993-08-18	Lactamimides in the treatment of drug-resistant protozoal infections
ZA938478B (en)	1994-05-20	Vitamin D3 analogs
GB8822546D0 (en)	1988-11-02	Antiviral combinations
JPS6419066A (en)	1989-01-23	Dihydropyridineamides
EP0378824A3 (en)	1990-09-19	Use of omega-3-fatty acids as anticachexia agents
IL90499A0 (en)	1990-01-18	Therapeutic uses of 2',5'-oligoadenylates
ZA88498B (en)	1989-10-25	Alkylmelatonins
GB2177398B (en)	1989-05-04	5,6-epoxy-7-oxabicycloheptane substituted ethers useful in the treatment of thrombotic disease
CA1268468C (en)	1990-05-01	PROSTAGLANDIN ANALOGS WITH SUBSTITUTE THIABICYCLOHEPTAN GROUP
DE3465014D1 (en)	1987-09-03	Podophyllotoxin preparations for use in the treatment of genital warts
PT87563A (pt)	1989-05-31	Process for the preparation of vinylcephalosporins useful as medicaments
EP0308792A3 (en)	1990-07-04	Azachromane derivatives
NZ228023A (en)	1991-10-25	24(r)-scymnol; preparatory processes and pharmaceutical compositions
GR3005231T3 (de)	1993-05-24
GR3000306T3 (en)	1991-06-07	Composition for the treatment of infections
EP0459176A3 (en)	1993-02-24	Oligophosphates with antiviral activity
JPS6452781A (en)	1989-02-28	Novel antitumoral and antiviral composition from mrine source
NZ214449A (en)	1989-01-06	13-alpha-alkylgonanes and pharmaceutical compositions
EP0188373A3 (en)	1986-10-29	Macrolide derivatives
ZA867888B (en)	1987-07-29	Composition for the treatment of infections