ZA891439B - 4-amino-3-acylquinoline derivatives and their use as inhibitors of gastric secretion - Google Patents

4-amino-3-acylquinoline derivatives and their use as inhibitors of gastric secretion

Info

Publication number
ZA891439B
ZA891439B ZA891439A ZA891439A ZA891439B ZA 891439 B ZA891439 B ZA 891439B ZA 891439 A ZA891439 A ZA 891439A ZA 891439 A ZA891439 A ZA 891439A ZA 891439 B ZA891439 B ZA 891439B
Authority
ZA
South Africa
Prior art keywords
inhibitors
amino
gastric secretion
acylquinoline
derivatives
Prior art date
Application number
ZA891439A
Other languages
English (en)
Inventor
Robert John Ife
John Ife Robert
Thomas Henry Brown
Henry Brown Thomas
Colin Andrew Leach
Andrew Leach Colin
Original Assignee
Smithkline Beckman Intercredit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Intercredit filed Critical Smithkline Beckman Intercredit
Publication of ZA891439B publication Critical patent/ZA891439B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
ZA891439A 1988-02-25 1989-02-24 4-amino-3-acylquinoline derivatives and their use as inhibitors of gastric secretion ZA891439B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888804445A GB8804445D0 (en) 1988-02-25 1988-02-25 Compounds

Publications (1)

Publication Number Publication Date
ZA891439B true ZA891439B (en) 1990-06-27

Family

ID=10632377

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA891439A ZA891439B (en) 1988-02-25 1989-02-24 4-amino-3-acylquinoline derivatives and their use as inhibitors of gastric secretion

Country Status (8)

Country Link
US (1) US5089498A (de)
EP (1) EP0339768A1 (de)
JP (1) JPH01261374A (de)
AU (1) AU3011789A (de)
DK (1) DK81989A (de)
GB (1) GB8804445D0 (de)
PT (1) PT89790B (de)
ZA (1) ZA891439B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8804444D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
CA2011086A1 (en) * 1989-03-17 1990-09-17 Karl-Heinz Geiss 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom
GB8918265D0 (en) * 1989-08-10 1989-09-20 Smithkline Beckman Intercredit Compounds
JPH04211661A (ja) * 1990-03-28 1992-08-03 Otsuka Pharmaceut Co Ltd キノリン誘導体及び該誘導体を含有する抗潰瘍剤
GB9201694D0 (en) * 1992-01-27 1992-03-11 Smithkline Beecham Intercredit Compounds
US5362743A (en) * 1993-03-09 1994-11-08 Pfizer Inc. Aminoquinoline derivatives
IS4164A (is) * 1993-06-11 1994-12-12 Ab Astra Efnasambönd sem hindra flæði magasýru
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
US5650415A (en) * 1995-06-07 1997-07-22 Sugen, Inc. Quinoline compounds
KR0169813B1 (ko) * 1995-07-12 1999-01-15 김종인 4-아미노-3-아실나프티리딘 유도체
SI2396307T1 (sl) * 2009-02-11 2015-02-27 Merck Patent Gmbh Novi amino azaheterockliäśni karboksamidi
AU2011282684B2 (en) * 2010-07-29 2015-05-21 Merck Patent Gmbh Cyclic amine azaheterocyclic carboxamides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2652398A (en) * 1949-11-17 1953-09-15 Endo Products Inc N-substituted-2-amino (methyl) quinolines
US3391146A (en) * 1964-11-10 1968-07-02 Bristol Myers Co Nu-substituted carbamates and thiocarbamates of 2-quinolinemethanols
US3470186A (en) * 1967-06-02 1969-09-30 American Cyanamid Co Substituted 4-anilino-3-quinolinecarboxylic acids and esters
CA942748A (en) * 1970-09-18 1974-02-26 Venkatachala L. Narayanan 1-aziridinylcarbonyl substituted-3-quinolinecarboxylic acid compounds
US4343804A (en) * 1979-03-26 1982-08-10 A. H. Robins Company, Inc. 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
ES295403Y (es) * 1986-06-25 1987-11-01 Martinez Sanchez Miguel Barrera de proteccion para cocinas domesticas
US4839380A (en) * 1986-08-25 1989-06-13 Granik Vladimir G 1-Thiocarbamoylmethylpyrrolidine-2-thione, medical compositions of, and anti-hypoxic and nootropic use thereof
US4789678A (en) * 1986-08-25 1988-12-06 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds

Also Published As

Publication number Publication date
AU3011789A (en) 1989-08-31
DK81989D0 (da) 1989-02-22
PT89790A (pt) 1989-10-04
US5089498A (en) 1992-02-18
DK81989A (da) 1989-08-26
JPH01261374A (ja) 1989-10-18
PT89790B (pt) 1994-05-31
GB8804445D0 (en) 1988-03-23
EP0339768A1 (de) 1989-11-02

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