ZA893971B - Aromatic steroid 5-alpha-reductase inhibitors - Google Patents

Aromatic steroid 5-alpha-reductase inhibitors

Info

Publication number: ZA893971B
Authority: ZA; South Africa
Prior art keywords: alpha; beta; reductase inhibitors; steroid; preparation
Prior art date: 1988-05-25

Application number

ZA893971A

Other languages

English (en)

Inventor

Dennis Alan Holt

Alan Holt Dennis

Mark Alan Levy

Alan Levy Mark

Brian Walter Metcalf

Walter Metcalf Brian

Original Assignee

Smithkline Beckman Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-05-25

Filing date

1989-05-25

Publication date

1990-05-30

1989-05-25 Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp

1990-05-30 Publication of ZA893971B publication Critical patent/ZA893971B/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0095—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 carbon in position 21 is part of carboxylic group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ZA893971A 1988-05-25 1989-05-25 Aromatic steroid 5-alpha-reductase inhibitors ZA893971B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US19853488A	1988-05-25	1988-05-25

Publications (1)

Publication Number	Publication Date
ZA893971B true ZA893971B (en)	1990-05-30

Family

ID=22733779

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA893971A ZA893971B (en)	1988-05-25	1989-05-25	Aromatic steroid 5-alpha-reductase inhibitors

Country Status (16)

Country	Link
EP (1)	EP0343954B1 (de)
JP (1)	JP2675418B2 (de)
AT (1)	ATE114665T1 (de)
AU (1)	AU627466B2 (de)
CA (1)	CA1331457C (de)
DE (1)	DE68919537T2 (de)
DK (2)	DK168295B1 (de)
ES (1)	ES2065378T3 (de)
GR (1)	GR3015135T3 (de)
HK (1)	HK1006461A1 (de)
IE (1)	IE68858B1 (de)
IL (1)	IL91968A (de)
NO (1)	NO174964C (de)
PT (1)	PT90656B (de)
WO (1)	WO1989011282A1 (de)
ZA (1)	ZA893971B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5571817A (en) *	1984-02-27	1996-11-05	Merck & Co., Inc.	Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones]
US5138063A (en) *	1984-02-27	1992-08-11	Merck & Co., Inc.	17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones
US5151430A (en) *	1990-06-20	1992-09-29	Merck & Co., Inc.	Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents
US5061802A (en) *	1990-06-20	1991-10-29	Merck & Co. Inc.	17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents
US5162332A (en) *	1990-06-20	1992-11-10	Merck & Co., Inc.	Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors
US5098908A (en) *	1990-06-20	1992-03-24	Merck & Co., Inc.	17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors
US5091380A (en) *	1990-06-28	1992-02-25	Merck & Co., Inc.	N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors
IL101243A (en) *	1991-03-20	1999-12-22	Merck & Co Inc	Pharmaceutical preparations for the treatment of benign prostatic hyperplasia containing steroid history
FI945105A7 (fi) *	1992-04-30	1994-10-31	Smithkline Beecham Corp	17alfa- ja 17beta-substituoitu estra-1,3,5(10)-trieeni-3-karboksyyliha ppo
CA2135173A1 (en) *	1992-05-20	1993-11-25	Bruce E. Witzel	Ester derivatives of 4-aza-steroids
CZ283894A3 (en) *	1992-05-20	1995-09-13	Merck & Co Inc	7beta-substituted 4-aza-5alpha-cholestanones, their use for the preparation of pharmaceutical preparations and pharmaceutical compositions containing thereof
EP0641204B1 (de) *	1992-05-20	2000-08-16	Merck & Co. Inc.	17-ether und thioether von 4-aza-steroiden
US5237064A (en) *	1992-05-20	1993-08-17	Merck & Co., Inc.	Process for producing 7β-substituted-aza-5αandrostan-3-ones
ATE195129T1 (de) *	1992-05-20	2000-08-15	Merck & Co Inc	4-azasteroide als 5-alpha-reduktase
DE69326008T2 (de) *	1992-05-20	2000-03-02	Merck & Co., Inc.	17-amino-substituierte 4-azasteroide als 5-alpha-reductase inhibitoren
US5324734A (en) *	1992-09-15	1994-06-28	Merck & Co., Inc.	Oxidization metabolites of 5-α-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione
US5278159A (en) *	1992-10-06	1994-01-11	Merck & Co., Inc.	Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors
US5683995A (en) *	1992-11-18	1997-11-04	Smithkline Beecham Corporation	17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
US5641765A (en) *	1992-11-18	1997-06-24	Smithkline Beecham Corporation	17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
US5359071A (en) *	1993-03-12	1994-10-25	Merck & Co., Inc.	15-substituted 4-azasteroids
US5621104A (en) *	1993-03-24	1997-04-15	Merck & Co., Inc.	Substituted 3-phenanthridinone derivatives as 5-alpha-reductase inhibitors
DE69405760T2 (de) *	1993-06-28	1998-04-09	Merck & Co Inc	4-aza-pregnan-5-alpha-reductase isozym 1 inhibitoren
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5430157A (en) *	1993-12-13	1995-07-04	Eli Lilly And Company	Reduced phenanthrenes
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
US5595996A (en) *	1994-10-25	1997-01-21	Merck & Co., Inc.	7-substituted 4-aza cholanic acid derivatives and their use
GB201102913D0 (en)	2011-02-18	2011-04-06	Univ Birmingham	Novel therapeutic

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1107664B (de) *	1959-11-05	1961-05-31	Schering Ag	Verfahren zur Herstellung neuer in 3-Stellung substituierter OEstratriene
US3622670A (en) *	1969-08-22	1971-11-23	American Home Prod	Method of inducing ovulation
US4185101A (en) *	1977-08-11	1980-01-22	Schering Corporation	1,3,5(10),6,8-19-Nor-pregnapentaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
US4191759A (en) *	1978-04-13	1980-03-04	Merck & Co., Inc.	N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors
US4340602A (en) *	1978-10-18	1982-07-20	Wayne State University	Compositions inhibiting estrogen sulfotransferase activity
US4910226A (en) *	1987-04-29	1990-03-20	Smithkline Beckman Corporation	Steroid 5-alpha-reductase inhibitors

1989
- 1989-05-23 AU AU37487/89A patent/AU627466B2/en not_active Ceased
- 1989-05-23 CA CA000600335A patent/CA1331457C/en not_active Expired - Fee Related
- 1989-05-23 WO PCT/US1989/002269 patent/WO1989011282A1/en not_active Ceased
- 1989-05-23 JP JP1506391A patent/JP2675418B2/ja not_active Expired - Lifetime
- 1989-05-24 ES ES89305246T patent/ES2065378T3/es not_active Expired - Lifetime
- 1989-05-24 DE DE68919537T patent/DE68919537T2/de not_active Expired - Fee Related
- 1989-05-24 EP EP89305246A patent/EP0343954B1/de not_active Expired - Lifetime
- 1989-05-24 PT PT90656A patent/PT90656B/pt not_active IP Right Cessation
- 1989-05-24 AT AT89305246T patent/ATE114665T1/de not_active IP Right Cessation
- 1989-05-25 ZA ZA893971A patent/ZA893971B/xx unknown
- 1989-06-12 IE IE173289A patent/IE68858B1/en not_active IP Right Cessation
- 1989-10-11 NO NO894065A patent/NO174964C/no unknown
- 1989-10-12 IL IL9196889A patent/IL91968A/en not_active IP Right Cessation
1990
- 1990-11-23 DK DK279790A patent/DK168295B1/da not_active IP Right Cessation
1993
- 1993-11-19 DK DK130393A patent/DK169787B1/da active
1995
- 1995-02-22 GR GR950400355T patent/GR3015135T3/el unknown
1998
- 1998-06-18 HK HK98105689A patent/HK1006461A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE68919537D1 (de)	1995-01-12
EP0343954B1 (de)	1994-11-30
DK130393A (da)	1993-11-19
EP0343954A3 (en)	1990-05-16
DK169787B1 (da)	1995-02-27
PT90656B (pt)	1994-10-31
ATE114665T1 (de)	1994-12-15
JP2675418B2 (ja)	1997-11-12
PT90656A (pt)	1989-11-30
IE68858B1 (en)	1996-07-24
EP0343954A2 (de)	1989-11-29
ES2065378T3 (es)	1995-02-16
NO894065L (no)	1991-04-12
AU3748789A (en)	1989-12-12
CA1331457C (en)	1994-08-16
HK1006461A1 (en)	1999-02-26
DK168295B1 (da)	1994-03-07
JPH03504498A (ja)	1991-10-03
NO174964C (no)	1994-08-10
DE68919537T2 (de)	1995-05-11
NO174964B (no)	1994-05-02
GR3015135T3 (en)	1995-05-31
AU627466B2 (en)	1992-08-27
DK279790D0 (da)	1990-11-23
WO1989011282A1 (en)	1989-11-30
DK279790A (da)	1990-11-23
IE891732L (en)	1989-11-25
NO894065D0 (no)	1989-10-11
DK130393D0 (da)	1993-11-19
IL91968A (en)	1994-10-21

Publication	Publication Date	Title
GR3015135T3 (en)	1995-05-31	Aromatic steroid 5-alpha-reductase inhibitors.
GR3015039T3 (en)	1995-05-31	Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5alpha-reductase.
IE894109L (en)	1990-06-23	Phosphinic acid substituted aromatic steroids as inhibitors¹of steroid 5ó-reductase
AU4700589A (en)	1990-06-28	Sulfonic acid substituted aromatic steroids as inhibitors of steroids 5 alpha-reductase
GB8827988D0 (en)	1989-01-05	Chemical compounds
NZ221663A (en)	1989-08-29	4-aminoquinoline derivatives and pharmaceutical compositions containing such
ZA891389B (en)	1990-10-31	L-amino-3-acylquinoline derivatives their use as inhibitors of gastric secretion
GR3017662T3 (en)	1996-01-31	Carboximidamide derivatives.
EP0301466A3 (en)	1990-09-12	Uricosuric composition
GB1471546A (en)	1977-04-27	1-acyl-4-substituted alkyl-piperazine or homopiperazine derivatives nad process for preparation thereof
IE891187L (en)	1989-10-14	Carbocyclic compounds