ZA895727B - Process for the conversion of daunorubicin into doxorubicin - Google Patents

Process for the conversion of daunorubicin into doxorubicin

Info

Publication number: ZA895727B
Authority: ZA; South Africa
Prior art keywords: daunorubicin; doxorubicin; conversion
Prior art date: 1988-10-11

Application number

ZA895727A

Other languages

English (en)

Inventor

Gaetano Palladino

Palladino Gaetano

Ettore Bigatti

Bigatti Ettore

Peter Macdonald

Macdonald Peter

Original Assignee

Sicor Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-11

Filing date

1989-07-27

Publication date

1990-04-25

1989-07-27 Application filed by Sicor Spa filed Critical Sicor Spa

1990-04-25 Publication of ZA895727B publication Critical patent/ZA895727B/xx

Links

AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 title 2
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 title 1
238000006243 chemical reaction Methods 0.000 title 1
229960000975 daunorubicin Drugs 0.000 title 1
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 title 1
229960004679 doxorubicin Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA895727A 1988-10-11 1989-07-27 Process for the conversion of daunorubicin into doxorubicin ZA895727B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8822260A IT1230505B (it)	1988-10-11	1988-10-11	Procedimento per la conversione della daunorubicina in doxorubicina.

Publications (1)

Publication Number	Publication Date
ZA895727B true ZA895727B (en)	1990-04-25

Family

ID=11193796

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA895727A ZA895727B (en)	1988-10-11	1989-07-27	Process for the conversion of daunorubicin into doxorubicin

Country Status (9)

Country	Link
US (1)	US5008380A (fr)
EP (1)	EP0363604A3 (fr)
JP (1)	JPH02129197A (fr)
KR (1)	KR900006357A (fr)
AU (1)	AU615774B2 (fr)
HU (1)	HUT52516A (fr)
IL (1)	IL91154A (fr)
IT (1)	IT1230505B (fr)
ZA (1)	ZA895727B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5976830A (en) *	1996-05-24	1999-11-02	The Ohio State University Research Foundation	Methods of producing doxorubicin
FR2753703B1 (fr) *	1996-09-20	1998-12-04		Procede de synthese de l'acide mercapto-3-propionique
PT848009E (pt) *	1996-12-16	2000-11-30	Pharmachemie Bv	Processo para a preparacao de epirubicina ou seus sais de adicao de acido a partir de daunorubicina
RU2211842C1 (ru) *	2002-01-31	2003-09-10	Закрытое акционерное общество "Фармсинтез"	Способ получения доксорубицина гидрохлорида
JP2015507019A (ja) *	2012-02-17	2015-03-05	セルシオンコーポレイション	感熱性ナノ粒子製剤およびその製造方法
WO2016159092A1 (fr) *	2015-03-30	2016-10-06	ＭｅｉｊｉＳｅｉｋａファルマ株式会社	Procédé de production d'épirubicine et nouvel intermédiaire de production associé
CN108350015A (zh) *	2015-11-05	2018-07-31	浙江海正药业股份有限公司	一种表柔比星或其盐酸盐的分离纯化方法
EP3509605A4 (fr)	2016-09-09	2020-05-27	Irisys, Inc.	Compositions anticancéreuses liposomales
CN106749447B (zh) *	2017-01-10	2018-02-13	鲁南制药集团股份有限公司	一种盐酸表柔比星中间体化合物
CN108484689B (zh) *	2018-03-06	2020-11-10	道中道（菏泽）制药有限公司	一种戊柔比星合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB691364A (en) *	1949-02-18	1953-05-13	Nat Starch Products Inc	Polysaccharide derivatives of substituted dicarboxylic acids
US3803124A (en) *	1968-04-12	1974-04-09	Farmaceutici It Soc	Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
GB1566330A (en) *	1977-02-16	1980-04-30	Farmaceutici Italia	Anthracycline glycosides
JPS56156300A (en) *	1980-04-26	1981-12-02	Microbial Chem Res Found	Novel preparative method of anthracyclin derivative
GB8413464D0 (en) *	1984-05-25	1984-07-04	Erba Farmitalia	Anthracycline-anionic polymer conjugates
FI860683A7 (fi) *	1984-06-14	1986-02-14	Biogal Gyogyszergyar	Menetelmä adriamysiinin ja sen halidisuolojen valmistamiseksi.
AU3774389A (en) *	1988-06-27	1990-01-23	Board Of Regents, The University Of Texas System	4'-deoxy-2'-halo-anthracycline antibiotics, methods for their use, and intermediates and methods for synthesis thereof

1988
- 1988-10-11 IT IT8822260A patent/IT1230505B/it active
- 1988-11-09 US US07/269,199 patent/US5008380A/en not_active Expired - Lifetime
1989
- 1989-07-20 HU HU893682A patent/HUT52516A/hu unknown
- 1989-07-27 AU AU39011/89A patent/AU615774B2/en not_active Ceased
- 1989-07-27 ZA ZA895727A patent/ZA895727B/xx unknown
- 1989-07-28 IL IL9115489A patent/IL91154A/en not_active IP Right Cessation
- 1989-08-07 JP JP1204524A patent/JPH02129197A/ja active Pending
- 1989-08-13 EP EP89114981A patent/EP0363604A3/fr not_active Ceased
- 1989-08-30 KR KR1019890012408A patent/KR900006357A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
AU3901189A (en)	1990-04-26
HUT52516A (en)	1990-07-28
AU615774B2 (en)	1991-10-10
IT1230505B (it)	1991-10-25
IL91154A0 (en)	1990-03-19
IL91154A (en)	1994-01-25
IT8822260A0 (it)	1988-10-11
JPH02129197A (ja)	1990-05-17
EP0363604A3 (fr)	1990-07-25
US5008380A (en)	1991-04-16
KR900006357A (ko)	1990-05-08
EP0363604A2 (fr)	1990-04-18

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