ZA9010219B - 5-ht3 antagonists for treat of nausea,bradycardia of hypotension associated with myocardial instability - Google Patents

5-ht3 antagonists for treat of nausea,bradycardia of hypotension associated with myocardial instability

Info

Publication number
ZA9010219B
ZA9010219B ZA9010219A ZA9010219A ZA9010219B ZA 9010219 B ZA9010219 B ZA 9010219B ZA 9010219 A ZA9010219 A ZA 9010219A ZA 9010219 A ZA9010219 A ZA 9010219A ZA 9010219 B ZA9010219 B ZA 9010219B
Authority
ZA
South Africa
Prior art keywords
bradycardia
nausea
antagonists
treat
hypotension associated
Prior art date
Application number
ZA9010219A
Other languages
English (en)
Inventor
Edward Stewart Johnson
Stewart Johnson Edward
Thomas Conway Hamilton
Conway Hamilton Thomas
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of ZA9010219B publication Critical patent/ZA9010219B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
ZA9010219A 1989-12-21 1990-12-19 5-ht3 antagonists for treat of nausea,bradycardia of hypotension associated with myocardial instability ZA9010219B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898928837A GB8928837D0 (en) 1989-12-21 1989-12-21 Pharmaceuticals

Publications (1)

Publication Number Publication Date
ZA9010219B true ZA9010219B (en) 1991-11-27

Family

ID=10668280

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9010219A ZA9010219B (en) 1989-12-21 1990-12-19 5-ht3 antagonists for treat of nausea,bradycardia of hypotension associated with myocardial instability

Country Status (9)

Country Link
EP (1) EP0506813A1 (fr)
JP (1) JPH05502872A (fr)
KR (1) KR920703037A (fr)
AU (1) AU7051691A (fr)
CA (1) CA2071994A1 (fr)
GB (1) GB8928837D0 (fr)
IE (1) IE904603A1 (fr)
WO (1) WO1991009593A2 (fr)
ZA (1) ZA9010219B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2699794B2 (ja) * 1992-03-12 1998-01-19 三菱化学株式会社 チエノ〔３，２−ｂ〕ピリジン誘導体
GB9305593D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Pharmaceuticals
PE20021019A1 (es) 2001-04-19 2002-11-13 Upjohn Co Grupos azabiciclicos sustituidos
AR036041A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
AR036040A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
CA2462453C (fr) 2001-10-02 2009-07-28 Pharmacia & Upjohn Company Composes d'heteoraryle fusionne substitues par azabicyclo utiles pour le traitement de maladies
US6849620B2 (en) 2001-10-26 2005-02-01 Pfizer Inc N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
MXPA04004373A (es) 2001-11-09 2004-08-11 Upjohn Co Compuestos heterociclicos condensados con fenilo azabiciclo para el tratamiento de enfermedades.
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
EP1480977A2 (fr) 2002-02-15 2004-12-01 PHARMACIA & UPJOHN COMPANY Composes aryle substitues permettant de traiter une maladie
CA2476624A1 (fr) 2002-02-19 2003-08-28 Pharmacia & Upjohn Company Composes azabicycliques servant a traiter des maladies
CA2476681A1 (fr) 2002-02-19 2003-08-28 Bruce N. Rogers Carboxamides hetero-aromatiques n-pontes bicycliques condenses destines au traitement de maladies
MXPA05003317A (es) 2002-09-25 2005-07-05 Memory Pharm Corp Indazoles, benzotiazoles y benzoisotiazoles asi como preparacion y usos de los mismos.
RU2389729C2 (ru) 2003-12-22 2010-05-20 Мемори Фармасьютиклз Корпорейшн 1н-индазолы, 1, 2-бензизоксазолы и 1, 2-бензизотиазолы, их получение и применение
EP1735306A2 (fr) 2004-03-25 2006-12-27 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, et leur preparation et leurs utilisations
CA2567977A1 (fr) 2004-04-22 2006-01-05 Memory Pharmaceutical Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, leur preparation et leurs utilisations
NZ551712A (en) 2004-05-07 2010-07-30 Memory Pharm Corp 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparations and uses thereof
AU2005316739A1 (en) 2004-12-13 2006-06-22 Galileo Pharmaceuticals, Inc. Spiro derivatives as lipoxygenase inhibitors
CA2591817A1 (fr) 2004-12-22 2006-06-29 Memory Pharmaceuticals Corporation Ligands du recepteur alpha-7 nicotinique ainsi que preparation et utilisations de ceux-ci
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
PE20170923A1 (es) * 2010-05-17 2017-07-12 Forum Pharmaceuticals Inc Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida monohidratado
EP3461481A1 (fr) 2012-05-08 2019-04-03 Forum Pharmaceuticals Inc. Procédés de maintien, de traitement ou d'amélioration de la fonction cognitive

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531083B1 (fr) * 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
SE460359B (sv) * 1984-01-25 1989-10-02 Glaxo Group Ltd 3-imidazolylmetyltetrahydrokarbazoloner, foerfarande foer framstaellning av dessa och en farmaceutisk komposition
EP0191562B1 (fr) * 1985-01-23 1991-07-10 Glaxo Group Limited Dérivés de tétrahydrocarbazolones
DE3650772T2 (de) * 1985-04-27 2003-04-03 F. Hoffmann-La Roche Ag, Basel Derivate von Indazole-3-carboxamide und -3-carboxylsäure
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518745D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
DE3687980T2 (de) * 1986-01-07 1993-06-17 Beecham Group Plc Indolderivate mit einer azabicyclischen seitenkette, verfahren zu ihrer herstellung, zwischenprodukte und pharmazeutische zusammensetzungen.
GB8701494D0 (en) * 1987-01-23 1987-02-25 Glaxo Group Ltd Chemical compounds
ZA878096B (en) * 1986-11-03 1988-04-26 Merrell Dow Pharmaceuticals Inc. Esters of hexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one and related compounds
GB8628475D0 (en) * 1986-11-28 1987-01-07 Glaxo Group Ltd Medicaments
FR2616149B1 (fr) * 1987-06-04 1990-10-19 Adir Nouveau derive de l'acide benzo (b) thiophene - 7 carboxylique, son procede de preparation et les compositions pharmaceutiques qui le contiennent
EP0306323B1 (fr) * 1987-09-03 1994-09-21 Glaxo Group Limited Dérivés de lactames
GB8723157D0 (en) * 1987-10-02 1987-11-04 Beecham Group Plc Compounds
EP0315390B1 (fr) * 1987-11-04 1994-07-20 Beecham Group Plc Composés nouveaux de 4-oxobenzotriazine et 4-oxoquinazoline
DE3740984A1 (de) * 1987-12-03 1989-06-15 Sandoz Ag N-oxide von heterocyclischen carbonsaeurederivaten bzw. verfahren zu deren herstellung und deren verwendung
NZ227229A (en) * 1987-12-10 1991-03-26 Duphar Int Res Indole derivatives and pharmaceutical compositions
DE3810552A1 (de) * 1988-03-29 1989-10-19 Sandoz Ag Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
EP0336759A1 (fr) * 1988-04-07 1989-10-11 Glaxo Group Limited Dérivés d'imidazole
EP0350129A1 (fr) * 1988-07-07 1990-01-10 Duphar International Research B.V Indole cétones annelées avec un substituant imidazolylalkyle
IT1226389B (it) * 1988-07-12 1991-01-15 Angeli Inst Spa Nuovi derivati ammidinici e guanidinici
FR2639944B1 (fr) * 1988-12-06 1991-01-18 Adir Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2004911A1 (fr) * 1988-12-22 1990-06-22 Mitsuaki Ohta Derives de 4,5,6,7-tetrahydrobenzimidazole
IT1228288B (it) * 1989-01-09 1991-06-07 Zambon Spa Composti ad attivita' antiserotoninica

Also Published As

Publication number Publication date
WO1991009593A3 (fr) 1991-09-05
EP0506813A1 (fr) 1992-10-07
IE904603A1 (en) 1991-07-03
JPH05502872A (ja) 1993-05-20
WO1991009593A2 (fr) 1991-07-11
AU7051691A (en) 1991-07-24
CA2071994A1 (fr) 1991-06-22
GB8928837D0 (en) 1990-02-28
KR920703037A (ko) 1992-12-17

Similar Documents

Publication Publication Date Title
ZA9010219B (en) 5-ht3 antagonists for treat of nausea,bradycardia of hypotension associated with myocardial instability
FI872379A7 (fi) Menetelmä farmakologisesti vaikuttavien 1,5-diaryyli-3-(w-substituoitu-alempi-alkyyli)-pyratsolien valmistamiseksi
FI902661A0 (fi) Menetelmä angiotensiini-II-antagonisteina aktiivisten 3-(2'-(substituoitu)bifen-4-yyli)metyyli-3H-imidatso/4,5-b/pyridiiniyhdisteiden valmistamiseksi
FI20000085L (fi) Menetelmä terapeuttisesti aktiivisten 4-amino-substituoitujen 2-azabicyklo/3.3.1/nonaanijohdannaisten valmistamiseksi
HUT49791A (en) Fungicide composition containing quinazoline derivative as active component and process for producing the active component
EP0597830A4 (fr) Emploi de polyamines en tant qu'agents regulateurs de canaux ioniques.
HUT51610A (en) Process for producing toco-pherol-analogues having cardio-protective activity and pharmaceutic preparations containing these compounds as active agents
NO177096C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte isokinoliner
FI905855L (fi) Menetelmä terapeuttisesti käyttökelpoisten /(3aS-cis)-1,2,3,3a,8,8a-heksahydropyrrolo/2,3-b/indol-5-yyli/aminokarbonyyli/karbamaattijohdannaisten valmistamiseksi
GR3035827T3 (en) Process for preparing new fibrinogen receptor antagonists
AU4668289A (en) Heteroazabenzobicyclic carboxamide 5-ht3, antagonists
FI891200A7 (fi) Menetelmä terapeuttisesti käyttökelpoisten 5-substituoitujen /4,5-c/imidatsopyridiinijohdannaisten valmistamiseksi
MY105128A (en) Bu-3608 derivatives.
NO174200C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-imino-6-polyfluoralkoksybenzotiazol-forbindelser
DE58907381D1 (de) Ungesättigte Derivate von 2,2,6,6-Tetramethylpiperidin.
FI893682L (fi) Menetelmä terapeuttisesti käyttökelpoisten 1,2,5-ditiatsosiinijohdannaisten valmistamiseksi
PT85153A (en) Process for the preparation of benzimidazol derivatives
NO175565C (no) Fremgangsmåte for fremstilling av et parenteralt anvendbart, farmasöytisk preparat inneholdende et bis-indolalkaloid
ZA842335B (en) New five-membered nitrogen-containing heterocyclic compounds,processes for their preparation and their use as pets-combating agents
FI893121L (fi) Menetelmä farmakologisesti aktiivisten 6,21-dimetyyli-19-norprogesteronijohdannaisten valmistamiseksi
ZA894097B (en) Alpha-adrenergic receptor antagonists
FI896178A7 (fi) Menetelmä tekstiilien substituoitujen imidatsoliinivalmennusaineiden valmistamiseksi
MY103414A (en) Process for preparing 3, 3-disubstituted indolines
EG19360A (en) Process for preparing of therapeutically active fluro substituted benzimidazoles
AU5041793A (en) Method for treating myocardial ischemia employing serotonin receptor antagonists