ZA911925B - Novel pyrazole derivatives which are angiotensin ii receptor antagonists;their methods of preparation and pharmaceutical compositions in which they are present - Google Patents

Novel pyrazole derivatives which are angiotensin ii receptor antagonists;their methods of preparation and pharmaceutical compositions in which they are present

Info

Publication number
ZA911925B
ZA911925B ZA911925A ZA911925A ZA911925B ZA 911925 B ZA911925 B ZA 911925B ZA 911925 A ZA911925 A ZA 911925A ZA 911925 A ZA911925 A ZA 911925A ZA 911925 B ZA911925 B ZA 911925B
Authority
ZA
South Africa
Prior art keywords
angiotensin
preparation
methods
pharmaceutical compositions
present
Prior art date
Application number
ZA911925A
Inventor
Nicole Bru-Magniez
Bru-Magniez Nicole
Eric Nicolai
Nicolai Eric
Jean-Marie Teulon
Teulon Jean-Marie
Original Assignee
Union Pharma Scient Appl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Pharma Scient Appl filed Critical Union Pharma Scient Appl
Publication of ZA911925B publication Critical patent/ZA911925B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA911925A 1990-03-19 1991-03-15 Novel pyrazole derivatives which are angiotensin ii receptor antagonists;their methods of preparation and pharmaceutical compositions in which they are present ZA911925B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9003485A FR2659655B1 (en) 1990-03-19 1990-03-19 NOVEL ANGIOTENSIN II RECEPTOR ANTAGONIST OXYPYRAZOLE DERIVATIVES; THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Publications (1)

Publication Number Publication Date
ZA911925B true ZA911925B (en) 1992-03-25

Family

ID=9394876

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA911925A ZA911925B (en) 1990-03-19 1991-03-15 Novel pyrazole derivatives which are angiotensin ii receptor antagonists;their methods of preparation and pharmaceutical compositions in which they are present

Country Status (11)

Country Link
EP (1) EP0449699A3 (en)
JP (1) JPH04234851A (en)
KR (1) KR910016708A (en)
AU (1) AU7359191A (en)
CA (1) CA2038428A1 (en)
FR (1) FR2659655B1 (en)
IE (1) IE910766A1 (en)
IL (1) IL97576A0 (en)
NZ (1) NZ237445A (en)
PT (1) PT97056A (en)
ZA (1) ZA911925B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2079343A1 (en) * 1990-03-30 1991-10-01 Eric E. Allen Substituted pyrazoles, isoxazoles and isothiazoles
GB9110623D0 (en) * 1991-05-16 1991-07-03 Glaxo Group Ltd Chemical compounds
AP254A (en) * 1991-09-05 1993-05-05 Glaxo Group Ltd C-Linked pyrazole derivatives.
WO1993005025A1 (en) * 1991-09-06 1993-03-18 Glaxo Group Limited C-linked pyrazole derivatives
FR2685697B1 (en) * 1991-12-30 1994-02-04 Synthelabo NOVEL 2- (TETRAZOL-5-YL) - (1,1'-BIPHENYL) DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SYNTHESIS INTERMEDIATES.
EP0550313A1 (en) * 1991-12-30 1993-07-07 Synthelabo 2-(Tetranol-5-yl)-(1,1'-biphenyl)derivatives, their preparation and use as intermediates
US5264451A (en) * 1992-04-07 1993-11-23 American Home Products Corporation Process for treating hyperglycemia using trifluoromethyl substituted 3H-pyrazol-3-ones
GB9218449D0 (en) 1992-08-29 1992-10-14 Boots Co Plc Therapeutic agents
TW348175B (en) * 1993-01-06 1998-12-21 Hoechst Ag Process for the preparation of biphenyl derivatives
US5262412A (en) * 1993-03-10 1993-11-16 Merck & Co., Inc. Substituted pyrazoles, compositions and use
US5338740A (en) * 1993-07-13 1994-08-16 Pfizer Inc. Angiotensin II receptor antagonists
FR2740135B1 (en) * 1995-10-20 1997-12-19 Roussel Uclaf NOVEL ACID PYRAZOLES DERIVATIVES, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS, THEIR NEW USE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AU751139B2 (en) 1997-10-13 2002-08-08 Astellas Pharma Inc. Amide derivative
DE19830431A1 (en) 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Sulfonylamino-carboxylic acid N-arylamides as guanylate cyclase activators
SE9903028D0 (en) 1999-08-27 1999-08-27 Astra Ab New use
PL209375B1 (en) 2000-12-28 2011-08-31 Kissei Pharmaceutical Glucopyranosyloxypyrazole derivatives and use thereof in medicines
CA2438593C (en) * 2001-02-26 2010-09-21 Kissei Pharmaceutical Co., Ltd. Glucopyranosyloxypyrazole derivatives and medicinal use thereof
CA2438595C (en) * 2001-02-27 2011-08-09 Kissei Pharmaceutical Co., Ltd. Glucopyranosyloxypyrazole derivatives and medicinal use thereof
KR100459938B1 (en) * 2001-10-16 2004-12-03 한국화학연구원 Fluorine-substituted heterocyclic compounds as intermediate for synthesis of agrochemical and medicinal antagonist and method for preparing thereof
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2527360B1 (en) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2013155422A1 (en) * 2012-04-12 2013-10-17 Ironwood Pharmaceuticals, Inc. Methods of treating alopecia and acne
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
SI3004138T1 (en) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2319281A1 (en) * 1973-04-17 1974-11-07 Bayer Ag DIURETIC AND ANTIHYPERTENSIVE AGENT
DE2347015C2 (en) * 1973-09-14 1985-12-12 Schering AG, 1000 Berlin und 4709 Bergkamen New pyrazolyloxyacetic acid derivatives, processes for their preparation and compositions containing them
DE2828529A1 (en) * 1978-06-29 1980-01-17 Kali Chemie Pharma Gmbh NEW 5-PHENYLPYRAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS
CA1211111A (en) * 1982-02-15 1986-09-09 Isao Yanagisawa Process for preparing novel pyrimidone compounds
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
GB9005354D0 (en) * 1990-03-09 1990-05-02 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
FR2659655B1 (en) 1992-07-24
EP0449699A3 (en) 1993-04-07
JPH04234851A (en) 1992-08-24
KR910016708A (en) 1991-11-05
CA2038428A1 (en) 1991-09-20
PT97056A (en) 1991-10-31
EP0449699A2 (en) 1991-10-02
FR2659655A1 (en) 1991-09-20
AU7359191A (en) 1991-09-19
IL97576A0 (en) 1992-06-21
NZ237445A (en) 1993-04-28
IE910766A1 (en) 1991-09-25

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