ZA913033B - N-(3-fluoro-2-phosphonylmethoxypropyl)derivatives of purine and pyrimidine heterocyclic basis,their preparation and use - Google Patents

N-(3-fluoro-2-phosphonylmethoxypropyl)derivatives of purine and pyrimidine heterocyclic basis,their preparation and use

Info

Publication number
ZA913033B
ZA913033B ZA913033A ZA913033A ZA913033B ZA 913033 B ZA913033 B ZA 913033B ZA 913033 A ZA913033 A ZA 913033A ZA 913033 A ZA913033 A ZA 913033A ZA 913033 B ZA913033 B ZA 913033B
Authority
ZA
South Africa
Prior art keywords
phosphonylmethoxypropyl
purine
fluoro
derivatives
preparation
Prior art date
Application number
ZA913033A
Other languages
English (en)
Inventor
Antonin Holy
Holy Antonin
Jindrich Jindrich
Jan Balzarini
Balzarini Jan
Erik De Clercq
De Clercq Erik
Original Assignee
Ceskoslovenska Akademie Ved
Univ Rega Katholieke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ceskoslovenska Akademie Ved, Univ Rega Katholieke filed Critical Ceskoslovenska Akademie Ved
Publication of ZA913033B publication Critical patent/ZA913033B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA913033A 1990-04-24 1991-04-23 N-(3-fluoro-2-phosphonylmethoxypropyl)derivatives of purine and pyrimidine heterocyclic basis,their preparation and use ZA913033B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS902047A CZ285420B6 (cs) 1990-04-24 1990-04-24 N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití

Publications (1)

Publication Number Publication Date
ZA913033B true ZA913033B (en) 1992-01-29

Family

ID=5356430

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA913033A ZA913033B (en) 1990-04-24 1991-04-23 N-(3-fluoro-2-phosphonylmethoxypropyl)derivatives of purine and pyrimidine heterocyclic basis,their preparation and use

Country Status (15)

Country Link
US (1) US5733896A (pt)
EP (1) EP0454427B1 (pt)
JP (1) JP2937532B2 (pt)
AT (1) ATE131171T1 (pt)
AU (1) AU7533091A (pt)
CA (1) CA2040982C (pt)
CZ (1) CZ285420B6 (pt)
DE (1) DE69115108T2 (pt)
FI (1) FI911980A7 (pt)
IE (1) IE911356A1 (pt)
IL (1) IL98110A0 (pt)
NO (1) NO911600L (pt)
PT (1) PT97478B (pt)
SK (1) SK280313B6 (pt)
ZA (1) ZA913033B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ284678B6 (cs) * 1991-05-20 1999-01-13 Ústav Organické Chemie A Biochemie Avčr Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
US6093816A (en) 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
IL137164A0 (en) 1998-01-23 2001-07-24 Newbiotics Inc Enzyme catalyzed therapeutic agents
BR0012676A (pt) 1999-07-22 2003-07-01 Newbiotics Inc Métodos para tratamento de tumores resistentes a terapia
US6683061B1 (en) * 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
AU2583901A (en) * 1999-12-17 2001-06-25 Ariad Pharmaceuticals, Inc. Proton pump inhibitors
US20020119443A1 (en) 2000-07-21 2002-08-29 Gilead Sciences, Inc. Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
US6747132B2 (en) 2000-11-29 2004-06-08 Apex Biosciences, Inc. Methods for the synthesis of a modified hemoglobin solution
EP1406911B1 (en) 2001-06-29 2016-01-06 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic 6-[2-(phosphonomethoxy)alkoxy] pyrimidine derivatives having antiviral activity
NZ543864A (en) 2003-06-16 2009-10-30 Leuven K U Res & Dev Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
ES2401285T3 (es) 2004-12-16 2013-04-18 The Regents Of The University Of California Fármacos con el pulmón como diana
US20090156545A1 (en) * 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
EP1906971A2 (en) * 2005-07-27 2008-04-09 Gilead Sciences, Inc. Antiviral compounds
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
TR201802083T4 (tr) * 2008-10-24 2018-03-21 Glaxosmithkline Biologicals Sa Lipidatlı imidazokinolin türevleri.
EP3578563B1 (en) 2011-12-22 2021-04-14 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
SG10201800188SA (en) 2013-03-15 2018-02-27 Univ California Acyclic nucleoside phosphonate diesters
CN111808136B (zh) 2014-09-15 2024-06-11 加利福尼亚大学董事会 核苷酸类似物
EP3350191B9 (en) 2015-09-15 2021-12-22 The Regents of the University of California Nucleotide analogs
CN117186092A (zh) * 2018-11-07 2023-12-08 四川科伦博泰生物医药股份有限公司 并环化合物、其制备方法及用途
KR20250052378A (ko) 2022-07-21 2025-04-18 안티바 바이오사이언시즈, 인크. Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
IL64501A (en) * 1980-12-22 1985-07-31 Astra Laekemedel Ab 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
AU8092587A (en) * 1986-11-18 1988-05-19 Bristol-Myers Squibb Company Synthesis of purin-9-ylalkylenoxymethyl phosphonic acids
NZ222553A (en) * 1986-11-18 1991-07-26 Bristol Myers Co Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions
US4808419A (en) * 1987-02-02 1989-02-28 Hsu Edward J Automated method for a semi-solid fermentation used in the production of ancient quality rice vinegar and/or rice wine
EP0338168A1 (en) * 1988-04-19 1989-10-25 Merrell Dow Pharmaceuticals Inc. Phosphonoalkylpurine derivatives
EP0338887B1 (en) * 1988-04-19 1993-12-08 Merrell Dow Pharmaceuticals Inc. Phosphonoalkylpurine derivatives
JPH0296589A (ja) * 1988-09-30 1990-04-09 Asahi Glass Co Ltd ヌクレオシド類

Also Published As

Publication number Publication date
US5733896A (en) 1998-03-31
FI911980A0 (fi) 1991-04-24
CA2040982A1 (en) 1991-10-25
NO911600D0 (no) 1991-04-23
FI911980L (fi) 1991-10-25
DE69115108D1 (de) 1996-01-18
IL98110A0 (en) 1992-06-21
CS9002047A2 (en) 1991-11-12
SK280313B6 (sk) 1999-11-08
PT97478A (pt) 1992-01-31
ATE131171T1 (de) 1995-12-15
FI911980A7 (fi) 1991-10-25
PT97478B (pt) 1998-08-31
JP2937532B2 (ja) 1999-08-23
IE911356A1 (en) 1991-11-06
EP0454427B1 (en) 1995-12-06
NO911600L (no) 1991-10-25
EP0454427A1 (en) 1991-10-30
AU7533091A (en) 1991-11-07
JPH06206888A (ja) 1994-07-26
DE69115108T2 (de) 1996-07-04
CA2040982C (en) 2001-12-04
CZ285420B6 (cs) 1999-08-11

Similar Documents

Publication Publication Date Title
ZA913033B (en) N-(3-fluoro-2-phosphonylmethoxypropyl)derivatives of purine and pyrimidine heterocyclic basis,their preparation and use
DK224286A (da) 2',3'-dideoxy-nucleosider
DK1002534T3 (da) Anvendelse af fire K-252a-derivater
MY109606A (en) Substituted phthalides and heterocyclic phthalides.
DK172089D0 (da) 1,3-dioxolanderivater samt fremgangsmaade til fremstilling deraf
ATE157095T1 (de) Hydroxymethyl(methylencyclopentyl)purinen und pyrimidinen
DE69133397D1 (de) Benzoylderivate
DK0574457T3 (da) Antiviral nucleosidkombination
NZ233735A (en) Heterocyclic substituted aminophenol derivatives
DK0509398T3 (da) Quinoxaliner, fremgangsmåder til deres fremstilling samt deres anvendelse
ATE105297T1 (de) Derivate von 2'-halomethyliden, 2'-ethenyliden und 2'-ethynylcytidin, uridin und guanosin.
DE3887014D1 (de) Nukleoside, ihre Herstellung und pharmazeutische Zusammenstellungen.
GR1001511B (el) Στεροειδείς συν?έσεις.
GB8822546D0 (en) Antiviral combinations
CA2086756A1 (en) Penciclovir and famciclovir and related guanine derivatives for the treatment of the hiv-1 infections
TR23373A (tr) N'-suebstitueye-n,n'-diasilhidrazinlerin 5 ueyeli heterosiklik tuerevleri
FI912963A0 (fi) Hjaernverksamheten oekande pyrimidinylderivat.
EE02942B1 (et) Metüülpiperasinoasepiini derivaadid, nende valmistamine ja kasutamine
CZ281393B6 (cs) Způsob výroby 6-(substituovaných amino)-propionyl derivátů forskolinu
ATE89732T1 (de) Bakterientoetende gemische.
DE69015411D1 (de) 5,11-Dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one und -thione und deren Verwendung bei der Vorbeugung und und Behandlung von AIDS.
FI890173L (fi) Isoxazoler med nootropisk verkan.
DK0483063T3 (da) Ergolinderivater
DK514686A (da) 5-naphthyl-2,4-dialkyl-3h-1,2,4-triazol-3-thioner og tautomer deraf, deres fremstilling og anvendelse som antidepressive midler
SU1602007A1 (ru) 6-(4,5-Дифенилтиенил-2)-3-тиа-1,2,4-триазин-5-он, проявляющий противовоспалительную и антимикробную активность