ZA914830B - Novel,protracted insulin analogues - Google Patents

Novel,protracted insulin analogues

Info

Publication number
ZA914830B
ZA914830B ZA914830A ZA914830A ZA914830B ZA 914830 B ZA914830 B ZA 914830B ZA 914830 A ZA914830 A ZA 914830A ZA 914830 A ZA914830 A ZA 914830A ZA 914830 B ZA914830 B ZA 914830B
Authority
ZA
South Africa
Prior art keywords
novel
insulin analogues
protracted insulin
protracted
analogues
Prior art date
Application number
ZA914830A
Inventor
Jan Markussen
Markussen Jan
Liselotte Langkjaer
Langkjaer Liselotte
Kjeld Norris
Norris Kjeld
Leo Boye Snel
Boye Snel Leo
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of ZA914830B publication Critical patent/ZA914830B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
ZA914830A 1990-06-28 1991-06-24 Novel,protracted insulin analogues ZA914830B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK155690A DK155690D0 (en) 1990-06-28 1990-06-28 NEW PEPTIDES

Publications (1)

Publication Number Publication Date
ZA914830B true ZA914830B (en) 1992-03-25

Family

ID=8106031

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA914830A ZA914830B (en) 1990-06-28 1991-06-24 Novel,protracted insulin analogues

Country Status (10)

Country Link
EP (1) EP0536245A1 (en)
JP (1) JPH05508406A (en)
AU (1) AU8054391A (en)
DK (1) DK155690D0 (en)
IE (1) IE912247A1 (en)
IL (1) IL98596A0 (en)
NZ (1) NZ238718A (en)
PT (1) PT98124A (en)
WO (1) WO1992000321A1 (en)
ZA (1) ZA914830B (en)

Families Citing this family (56)

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NZ273285A (en) * 1993-09-17 1997-10-24 Novo Nordisk As Insulin derivatives and compositions thereof
US5559094A (en) * 1994-08-02 1996-09-24 Eli Lilly And Company AspB1 insulin analogs
CA2215694A1 (en) * 1995-03-17 1996-09-26 Novo Nordisk A/S Insulin derivatives
US6251856B1 (en) 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
DE19726167B4 (en) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, process for its preparation and pharmaceutical preparation containing it
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
DE10114178A1 (en) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinc-free and low-zinc insulin preparations with improved stability
DE10227232A1 (en) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Sour insulin preparations with improved stability
EP2033662B1 (en) 2004-01-21 2012-10-17 Novo Nordisk Health Care AG Transglutaminase mediated conjugation of peptides
CN101573133B (en) 2006-07-31 2014-08-27 诺沃-诺迪斯克有限公司 PEGylated, extended insulins
CN101541830A (en) 2006-09-22 2009-09-23 诺沃-诺迪斯克有限公司 Protease resistant insulin analogues
WO2008132224A2 (en) 2007-04-30 2008-11-06 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
RU2524423C2 (en) 2008-01-09 2014-07-27 Санофи-Авентис Дойчланд Гмбх Novel insulin derivatives with extremely delayed time/action profile
CN101970477B (en) 2008-03-14 2014-12-31 诺沃-诺迪斯克有限公司 Protease-stabilized insulin analogues
HUE032284T2 (en) 2008-03-18 2017-09-28 Novo Nordisk As Protease stabilized, acylated insulin analogues
DE102008053048A1 (en) 2008-10-24 2010-04-29 Sanofi-Aventis Deutschland Gmbh Medicament, useful e.g. for treating diabetes, controlling fasting, postprandial or postabsorptive blood glucose concentration in diabetic patients and improving glucose tolerance, comprises insulin and glucagon-like peptide-1 agonist
DE102008051834A1 (en) 2008-10-17 2010-04-22 Sanofi-Aventis Deutschland Gmbh Drug, useful e.g. for treating diabetes, preferably type-I or II and for controlling fasting, postprandial and/or postabsorptive plasma glucose concentration, comprises insulin and glucagon-like peptide-1 agonist
DE102009038210A1 (en) 2009-08-20 2011-03-03 Sanofi-Aventis Deutschland Gmbh Combination of an insulin and a GLP-1 agonist
PT3228320T (en) 2008-10-17 2020-03-26 Sanofi Aventis Deutschland Combination of an insulin and a glp-1 agonist
DE102008064270A1 (en) * 2008-12-20 2010-07-01 Voith Patent Gmbh Flotation method for removing contaminants from aqueous fibrous material suspension by gas bubbles, involves supplying stream of fibrous material suspension along interference body after supplying stream of gas
EP2451471A1 (en) 2009-07-06 2012-05-16 Sanofi-Aventis Deutschland GmbH Slow-acting insulin preparations
WO2011003820A1 (en) 2009-07-06 2011-01-13 Sanofi-Aventis Deutschland Gmbh Heat- and vibration-stable insulin preparations
PH12011502708B1 (en) 2009-07-06 2017-11-10 Sanofi Aventis Deutschland Insulin preparations containing methionine
KR20120089843A (en) 2009-07-31 2012-08-14 사노피-아벤티스 도이칠란트 게엠베하 Prodrugs comprising an insulin linker conjugate
DK2459171T3 (en) 2009-07-31 2017-09-25 Sanofi Aventis Deutschland Long-acting insulin composition
SG10201500871TA (en) 2009-11-13 2015-04-29 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine
JP5832439B2 (en) 2009-11-13 2015-12-16 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Pharmaceutical composition comprising a GLP-1 agonist, insulin and methionine
EP2585484A1 (en) * 2010-06-23 2013-05-01 Novo Nordisk A/S Insulin analogues containing additional disulfide bonds
CA2802510A1 (en) 2010-06-23 2011-12-29 Novo Nordisk A/S Insulin derivatives containing additional disulfide bonds
EP2585483A1 (en) 2010-06-23 2013-05-01 Novo Nordisk A/S Human insulin containing additional disulfide bonds
CN103179978A (en) 2010-08-30 2013-06-26 赛诺菲-安万特德国有限公司 Use of AVE0010 for the manufacture of a medicament for the treatment of type 2 diabetes
EP2438930A1 (en) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrugs comprising an exendin linker conjugate
CN103533952B (en) 2011-03-15 2017-02-15 诺沃—诺迪斯克有限公司 Human insulin analogues and derivatives comprising cysteine substitutions
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
JP6367115B2 (en) 2011-08-29 2018-08-01 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Combination medicine used for blood glucose control in patients with type 2 diabetes
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
EP2836508B1 (en) 2012-04-11 2016-06-29 Novo Nordisk A/S Insulin formulations
US20130315891A1 (en) 2012-05-25 2013-11-28 Matthew Charles Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
US20130323222A1 (en) 2012-06-04 2013-12-05 Matthew Charles Human tissue kallikrein 1 glycosylation isoforms
MX360420B (en) 2012-12-19 2018-10-31 Wockhardt Ltd A stable aqueous composition comprising human insulin or an analogue or derivative thereof.
MX2015006997A (en) 2012-12-26 2015-09-23 Wockhardt Ltd Pharmaceutical composition.
TWI780236B (en) 2013-02-04 2022-10-11 法商賽諾菲公司 Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
EP3052114A1 (en) 2013-09-30 2016-08-10 Wockhardt Limited Pharmaceutical composition
CA2926701A1 (en) 2013-10-07 2015-04-16 Novo Nordisk A/S Novel derivative of an insulin analogue
JP6641280B2 (en) 2014-01-09 2020-02-05 サノフイＳａｎｏｆｉ Stabilized pharmaceutical formulations of insulin analogues and / or insulin derivatives
CA2932873A1 (en) 2014-01-09 2015-07-16 Sanofi Stabilized pharmaceutical formulations of insulin aspart
KR20160104726A (en) 2014-01-09 2016-09-05 사노피 Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives
WO2016001862A1 (en) 2014-07-04 2016-01-07 Wockhardt Limited Extended release formulations of insulins
CN107206058A (en) 2014-12-12 2017-09-26 赛诺菲-安万特德国有限公司 Insulin glargine/lixisenatide fixed ratio preparaton
TWI748945B (en) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 Treatment type 2 diabetes mellitus patients
TW201705975A (en) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 Treatment of type 2 diabetes mellitus patients
ES2886837T3 (en) 2016-12-16 2021-12-21 Novo Nordisk As Pharmaceutical compositions containing insulin
AU2018230478B2 (en) 2017-03-09 2025-01-23 Diamedica Inc. Dosage forms of tissue kallikrein 1
CA3071686A1 (en) 2017-08-17 2019-02-21 Novo Nordisk A/S Novel acylated insulin analogues and uses thereof
CN109646396A (en) * 2018-12-29 2019-04-19 江苏万邦医药科技有限公司 A kind of stable insulin analog injection and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2536040A1 (en) * 1975-08-13 1977-02-24 Hoechst Ag Prolonged action insulin analogues - with A1-glycine replaced by D-alanine or D-serine
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK257988D0 (en) * 1988-05-11 1988-05-11 Novo Industri As NEW PEPTIDES
HUT56857A (en) * 1988-12-23 1991-10-28 Novo Nordisk As Human insulin analogues

Also Published As

Publication number Publication date
IL98596A0 (en) 1992-07-15
JPH05508406A (en) 1993-11-25
DK155690D0 (en) 1990-06-28
AU8054391A (en) 1992-01-23
WO1992000321A1 (en) 1992-01-09
IE912247A1 (en) 1992-01-01
NZ238718A (en) 1992-06-25
PT98124A (en) 1992-04-30
EP0536245A1 (en) 1993-04-14

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