ZA919438B - Use of xanthines for the preparation of a medicament having immuno supressing activity - Google Patents

Use of xanthines for the preparation of a medicament having immuno supressing activity

Info

Publication number
ZA919438B
ZA919438B ZA919438A ZA919438A ZA919438B ZA 919438 B ZA919438 B ZA 919438B ZA 919438 A ZA919438 A ZA 919438A ZA 919438 A ZA919438 A ZA 919438A ZA 919438 B ZA919438 B ZA 919438B
Authority
ZA
South Africa
Prior art keywords
supressing
xanthines
immuno
medicament
activity
Prior art date
Application number
ZA919438A
Other languages
English (en)
Inventor
James A Bianco
A Bianco James
Jack W Singer
W Singer Jack
William J Novick Jr
J Novick William Jr
Original Assignee
Hoechst Roussel Pharma
Hutchinson Fred Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma, Hutchinson Fred Cancer Res filed Critical Hoechst Roussel Pharma
Publication of ZA919438B publication Critical patent/ZA919438B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA919438A 1990-11-30 1991-11-29 Use of xanthines for the preparation of a medicament having immuno supressing activity ZA919438B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62048090A 1990-11-30 1990-11-30

Publications (1)

Publication Number Publication Date
ZA919438B true ZA919438B (en) 1992-08-26

Family

ID=24486121

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA919438A ZA919438B (en) 1990-11-30 1991-11-29 Use of xanthines for the preparation of a medicament having immuno supressing activity

Country Status (10)

Country Link
EP (1) EP0490181A1 (de)
JP (1) JPH06100450A (de)
KR (1) KR920009399A (de)
CA (1) CA2056723A1 (de)
HU (1) HUT59825A (de)
IE (1) IE914163A1 (de)
IL (1) IL100195A0 (de)
PT (1) PT99659A (de)
TW (1) TW205507B (de)
ZA (1) ZA919438B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3566719B2 (ja) * 1991-05-24 2004-09-15 フレッド ハッチンソン キャンサー リサーチ センター 外来性刺激に対する細胞性応答の調整
DE4411660A1 (de) * 1994-04-05 1995-10-12 Hoechst Ag Verwendung von Xanthinderivaten zur Reduktion der pathologischen Hyperreagibilität eosinophiler Granulozyten, neue Xanthinverbindungen und Verfahren zu deren Herstellung
DE4430128A1 (de) * 1994-08-25 1996-02-29 Hoechst Ag Kombinationspräparat mit immunsuppressiven, kardiovaskulären und cerebralen Wirkungen
DE4430127A1 (de) * 1994-08-25 1996-03-14 Hoechst Ag Kombinationspräparat, enthaltend Cyclosporin A oder FK506 und ein Xanthinderivat
US6323201B1 (en) 1994-12-29 2001-11-27 The Regents Of The University Of California Compounds for inhibition of ceramide-mediated signal transduction
ES2189079T3 (es) * 1998-04-24 2003-07-01 Leuven K U Res & Dev Efectos inmunosupresores de derivados de xantina 8-sustituidos.
US6930101B1 (en) 1999-05-17 2005-08-16 The Regents Of The University Of California Thiazolopyrimidines useful as TNFα inhibitors
US7253176B1 (en) 2000-05-04 2007-08-07 K.U. Leuven Research & Development Immunosuppressive effects of 8-substituted xanthine derivatives
KR20100121527A (ko) 2008-02-29 2010-11-17 콘서트 파마슈티컬즈, 인크. 치환된 잔틴 유도체
US8952016B2 (en) 2009-02-27 2015-02-10 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
US20110053961A1 (en) 2009-02-27 2011-03-03 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
EP2611807A2 (de) 2010-09-01 2013-07-10 Concert Pharmaceuticals Inc. Polymorphe aus (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3-7-dimethyl-1h-purin-2,6(3h,7h)dion
WO2013013052A1 (en) 2011-07-19 2013-01-24 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
KR20150002779A (ko) 2012-04-13 2015-01-07 콘서트 파마슈티컬즈, 인크. 치환된 크산틴 유도체
WO2013159006A1 (en) 2012-04-20 2013-10-24 Concert Pharmaceuticals, Inc. Polymorphs of (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3,7-dimethyl-1h-purine-2,6(3h,7h)-dione
US9549869B2 (en) 2012-06-29 2017-01-24 Hill-Rom Canado Respiratory Ltd. Wearable thorax percussion device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0063827B1 (de) * 1980-05-02 1985-08-14 Societe Des Produits Nestle S.A. 1-Isopropyl- und 1-Isobutyl-3,7-dimethylxanthin als Arzneimittel
IL106859A (en) * 1986-12-31 1996-10-16 Hoechst Roussel Pharma Pentoxifilin metabolites and pharmaceutical preparations containing them for the treatment of VIH and similar diseases
US4965271A (en) * 1986-12-31 1990-10-23 Hoechst Roussel Pharmaceuticals, Inc. Method of inhibiting the activity of leukocyte derived cytokines
GB8918297D0 (en) * 1989-08-10 1989-09-20 Beecham Group Plc Novel treatment

Also Published As

Publication number Publication date
HU913721D0 (en) 1992-02-28
HUT59825A (en) 1992-07-28
IE914163A1 (en) 1992-06-03
CA2056723A1 (en) 1992-05-31
PT99659A (pt) 1992-10-30
IL100195A0 (en) 1992-08-18
TW205507B (de) 1993-05-11
KR920009399A (ko) 1992-06-25
JPH06100450A (ja) 1994-04-12
EP0490181A1 (de) 1992-06-17

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