ZA921328B - Hydrazone derivatives,their preparation and use - Google Patents

Hydrazone derivatives,their preparation and use

Info

Publication number: ZA921328B
Authority: ZA; South Africa
Prior art keywords: alkyl; hydrogen; independently; benzyl; so2nr
Prior art date: 1991-03-15

Application number

ZA921328A

Other languages

English (en)

Inventor

Bjarne Hugo Dahl

Hugo Dahl Bjarne

Frank Watjen

Watjen Frank

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-15

Filing date

1992-02-24

Publication date

1992-11-25

1992-02-24 Application filed by Neurosearch As filed Critical Neurosearch As

1992-11-25 Publication of ZA921328B publication Critical patent/ZA921328B/xx

Links

150000007857 hydrazones Chemical class 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
229910052739 hydrogen Inorganic materials 0.000 abstract 8
239000001257 hydrogen Substances 0.000 abstract 8
150000002431 hydrogen Chemical class 0.000 abstract 6
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical class 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
125000003627 8 membered carbocyclic group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
239000003257 excitatory amino acid Substances 0.000 abstract 1
230000002461 excitatory amino acid Effects 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Addiction (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Anesthesiology (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Cephalosporin Compounds (AREA)
Hydrogenated Pyridines (AREA)
Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Holo Graphy (AREA)

ZA921328A 1991-03-15 1992-02-24 Hydrazone derivatives,their preparation and use ZA921328B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/670,061 US5164404A (en)	1991-03-15	1991-03-15	Hydrazone derivatives and their use

Publications (1)

Publication Number	Publication Date
ZA921328B true ZA921328B (en)	1992-11-25

Family

ID=24688827

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA921328A ZA921328B (en)	1991-03-15	1992-02-24	Hydrazone derivatives,their preparation and use

Country Status (16)

Country	Link
US (1)	US5164404A (de)
EP (1)	EP0503349B1 (de)
JP (1)	JP3407896B2 (de)
KR (1)	KR100192641B1 (de)
AT (1)	ATE116639T1 (de)
AU (1)	AU643877B2 (de)
CA (1)	CA2062853A1 (de)
DE (1)	DE69201068T2 (de)
DK (1)	DK0503349T3 (de)
ES (1)	ES2069330T3 (de)
FI (1)	FI103276B (de)
GR (1)	GR3015671T3 (de)
IE (1)	IE66111B1 (de)
NO (1)	NO180191C (de)
NZ (1)	NZ241752A (de)
ZA (1)	ZA921328B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9109007D0 (en) *	1991-04-26	1991-06-12	Merck Sharp & Dohme	Therapeutic method
AU655643B2 (en) *	1991-07-09	1995-01-05	Neurosearch A/S	Novel isatineoxime derivatives, their preparation and use
DK69693D0 (da) *	1993-06-14	1993-06-14	Neurosearch As	Farven lilla
US5565580A (en) *	1994-01-27	1996-10-15	Neurosearch A/S	Glutamate Antagonists
US5773434A (en) *	1995-08-30	1998-06-30	Gary A. Rogers	Facilitation of AMPA receptor-mediated synaptic transmission in brain as a treatment for schizophrenia
KR19980050063A (ko) *	1996-12-20	1998-09-15	이덕림	신규한 하이드라존 유도체
AR016384A1 (es) *	1997-07-30	2001-07-04	Smithkline Beecham Corp	Inhibidores de caspasas, composiciones farmaceuticas que comprenden dichos inhibidores de caspasas y uso de los inhibidores de caspasas para prepararun medicamento util para el tratamiento de apoptosis y desordenes asociados con excesiva actividad de la convertosa il-1 beta.
AR016551A1 (es) *	1997-07-30	2001-07-25	Smithkline Beecham Corp	Derivados de 2-oxindol, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos
GB9718913D0 (en)	1997-09-05	1997-11-12	Glaxo Group Ltd	Substituted oxindole derivatives
CA2320757A1 (en)	1998-03-06	1999-09-10	Astrazeneca Ab	New use
US6624171B1 (en)	1999-03-04	2003-09-23	Smithkline Beecham Corporation	Substituted aza-oxindole derivatives
US6492398B1 (en)	1999-03-04	2002-12-10	Smithkline Beechman Corporation	Thiazoloindolinone compounds
GB9904933D0 (en)	1999-03-04	1999-04-28	Glaxo Group Ltd	Compounds
EP1242081A4 (de) *	1999-09-30	2004-07-21	Smithkline Beecham Corp	Caspases und apoptose
US6620818B1 (en)	2000-03-01	2003-09-16	Smithkline Beecham Corporation	Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
US6589504B1 (en) *	2000-09-22	2003-07-08	Pharmacia & Upjohn Company	Compounds and methods for diagnosing and treating amyloid-related conditions
WO2002070478A1 (en)	2001-03-06	2002-09-12	Astrazeneca Ab	Indolone derivatives having vascular-damaging activity
CN100569076C (zh) *	2004-05-12	2009-12-16	拜尔作物科学有限公司	植物生长调节作用
WO2005118551A2 (en) *	2004-05-28	2005-12-15	Ligand Pharmaceuticals Inc.	Thrombopoietin activity modulating compounds and methods
MX2007004765A (es) *	2004-10-25	2007-07-09	Ligand Pharm Inc	Compuestos y metodos que modulan la actividad de la trombopoyetina.
EP2338492A1 (de)	2009-12-24	2011-06-29	Universidad del Pais Vasco	Verfahren und Zusammensetzung zur Behandlung von Alzheimer
CN115304536B (zh) *	2022-07-26	2023-09-22	合肥工业大学	一种吲哚啉-2-酮化合物衍生物的制备及用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3966900A (en)	1969-03-12	1976-06-29	Airwick Industries, Inc.	Evaporator system comprising a stabilized pesticidal phosphoric acid ester and method for stabilizing such ester enclosed in an evaporator
DE2314242A1 (de) *	1973-03-22	1974-09-26	Bayer Ag	Neue 3-substituierte 2-oxo-4-hydroxy1,2,3,4-tetrahydrochinazolin-4-carbonsaeurehydrazide
US4780477A (en) *	1985-06-08	1988-10-25	Kissei Pharmaceutical Co., Ltd.	Isatin compositions having anti-ulcer activities
US4988710A (en) *	1989-08-25	1991-01-29	Washington University	Aryl-cycloalkyl-alkanolamines for treatment of cholinergic neurotoxins
IE69677B1 (en) *	1989-12-11	1996-10-02	Neurosearch As	Isatine derivatives their preparation and use

1991
- 1991-03-15 US US07/670,061 patent/US5164404A/en not_active Expired - Fee Related
1992
- 1992-02-24 AT AT92103104T patent/ATE116639T1/de not_active IP Right Cessation
- 1992-02-24 EP EP92103104A patent/EP0503349B1/de not_active Expired - Lifetime
- 1992-02-24 DK DK92103104.3T patent/DK0503349T3/da active
- 1992-02-24 ES ES92103104T patent/ES2069330T3/es not_active Expired - Lifetime
- 1992-02-24 DE DE69201068T patent/DE69201068T2/de not_active Expired - Fee Related
- 1992-02-24 ZA ZA921328A patent/ZA921328B/xx unknown
- 1992-02-26 AU AU11225/92A patent/AU643877B2/en not_active Ceased
- 1992-02-26 NZ NZ241752A patent/NZ241752A/en unknown
- 1992-02-28 IE IE920643A patent/IE66111B1/en not_active IP Right Cessation
- 1992-03-11 FI FI921049A patent/FI103276B/fi not_active IP Right Cessation
- 1992-03-12 CA CA002062853A patent/CA2062853A1/en not_active Abandoned
- 1992-03-13 KR KR1019920004115A patent/KR100192641B1/ko not_active Expired - Fee Related
- 1992-03-13 NO NO921000A patent/NO180191C/no not_active IP Right Cessation
- 1992-03-13 JP JP05553192A patent/JP3407896B2/ja not_active Expired - Fee Related
1995
- 1995-04-03 GR GR950400815T patent/GR3015671T3/el unknown

Also Published As

Publication number	Publication date
NO921000D0 (no)	1992-03-13
DK0503349T3 (da)	1995-05-08
US5164404A (en)	1992-11-17
FI103276B1 (fi)	1999-05-31
ES2069330T3 (es)	1995-05-01
KR920017650A (ko)	1992-10-21
NZ241752A (en)	1994-05-26
FI921049A0 (fi)	1992-03-11
NO180191B (no)	1996-11-25
EP0503349A1 (de)	1992-09-16
AU643877B2 (en)	1993-11-25
JP3407896B2 (ja)	2003-05-19
NO180191C (no)	1997-03-05
EP0503349B1 (de)	1995-01-04
NO921000L (no)	1992-09-16
DE69201068T2 (de)	1995-05-11
CA2062853A1 (en)	1992-09-16
IE66111B1 (en)	1995-12-13
KR100192641B1 (ko)	1999-06-15
ATE116639T1 (de)	1995-01-15
AU1122592A (en)	1992-09-17
GR3015671T3 (en)	1995-07-31
FI921049L (fi)	1992-09-16
DE69201068D1 (de)	1995-02-16
FI103276B (fi)	1999-05-31
JPH0578350A (ja)	1993-03-30
IE920643A1 (en)	1992-09-23

Publication	Publication Date	Title
GR3015671T3 (en)	1995-07-31	Hydrazone derivatives, their preparation and use.
DK46789D0 (da)	1989-02-02	3-indolpyrodruesyrederivater og farmaceutisk anvendelse deraf
SE8004002L (sv)	1981-11-30	Terapeutiskt anvendbara tetralinderivat
DK0432648T3 (da)	1995-11-06	Isatinderivater, deres fremstilling og anvendelse
ZA824453B (en)	1983-04-27	1-aryl 2-aminomethyl cyclopropane carboxamide (z) derivatives their preparation and their use as useful drugs in the treatment of disturbances of the central nervous system
IL83691A (en)	1993-08-18	Acylated quinolinamines, their preparation and pharmaceutical compositions containing them
BR9712321A (pt)	1999-08-31	Aminotiofenocarboxamidas
HUP0002830A2 (hu)	2001-09-28	Indol- és 2,3-dihidroindol-származékok, előállításuk és gyógyászati alkalmazásuk
IL81887A0 (en)	1987-10-20	Dihydroisoxazole derivatives,their preparation and pharmaceutical compositions containing them
PE20010205A1 (es)	2001-03-16	Derivados 3-sustituido de 2-carboxiciclopropil glicina como agonistas de glutamato
FI980471A0 (fi)	1998-03-02	1,3-substituoidut sykloalkeenit ja sykloalkaanit keskushermostoon vaikuttavina aineina
DE69313051D1 (de)	1997-09-18	Ethanolamin-derivate mit sympathomimetischer und anti-pollakiuria wirkung
ES2157565T3 (es)	2001-08-16	N-azacicloalquilalquildibenzotiofenocarboxamidas: ligandos especificos de un subtipo de receptor de la dopamina.
ES2058596T3 (es)	1994-11-01	Empleo de derivados de l-carnitina en el tratamiento terapeutico de alteraciones degenerativas del sistema nervioso.
IL104657A0 (en)	1993-06-10	Benzazepine derivatives,their preparation and pharmaceutical compositions containing them
PT1025101E (pt)	2003-04-30	Derivados de nafto-imidazo¬1,2-a\|piridina sua preparacao e uso no tratamento de perturbacoes do sistema nervoso central
DK0633262T3 (da)	2001-04-23	Hidtil ukendte isatinoximderivater samt fremstilling og anvendelse heraf
EP0334674A3 (en)	1990-09-12	Use of isoxazolinones as cerebro-active drugs
FR2781482B1 (fr)	2001-08-31	Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT8509443A0 (it)	1985-06-26	Interforometro per spettroscopia dell'ultravioletto e visibile del tipo trasformata di fourier, senza parti mobili
JPS53105474A (en)	1978-09-13	2-alkoxybenzamides