ZA921660B - Antiviral nucleoside combination - Google Patents

Antiviral nucleoside combination

Info

Publication number
ZA921660B
ZA921660B ZA921660A ZA921660A ZA921660B ZA 921660 B ZA921660 B ZA 921660B ZA 921660 A ZA921660 A ZA 921660A ZA 921660 A ZA921660 A ZA 921660A ZA 921660 B ZA921660 B ZA 921660B
Authority
ZA
South Africa
Prior art keywords
antiviral nucleoside
combinations
combination
nucleoside combination
antiviral
Prior art date
Application number
ZA921660A
Other languages
English (en)
Inventor
George Robert Painter Iii
Phillip Allen Furman
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of ZA921660B publication Critical patent/ZA921660B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ZA921660A 1991-03-06 1992-03-05 Antiviral nucleoside combination ZA921660B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919104740A GB9104740D0 (en) 1991-03-06 1991-03-06 Antiviral nucleoside combination

Publications (1)

Publication Number Publication Date
ZA921660B true ZA921660B (en) 1993-09-06

Family

ID=10691101

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA921660A ZA921660B (en) 1991-03-06 1992-03-05 Antiviral nucleoside combination

Country Status (25)

Country Link
US (2) US5234913A (fr)
EP (1) EP0574457B1 (fr)
JP (1) JP3442773B2 (fr)
KR (1) KR100225986B1 (fr)
AT (1) ATE185483T1 (fr)
AU (1) AU668860B2 (fr)
CA (1) CA2105487C (fr)
CZ (1) CZ283185B6 (fr)
DE (1) DE69230140T2 (fr)
DK (1) DK0574457T3 (fr)
ES (1) ES2138969T3 (fr)
GB (1) GB9104740D0 (fr)
GR (1) GR3032299T3 (fr)
HU (1) HU219492B (fr)
IE (1) IE920702A1 (fr)
IL (1) IL101145A (fr)
MY (1) MY108638A (fr)
NZ (1) NZ241842A (fr)
PT (1) PT100199B (fr)
RU (1) RU2110993C1 (fr)
SK (1) SK279767B6 (fr)
TW (1) TW199861B (fr)
UA (1) UA29429C2 (fr)
WO (1) WO1992015309A1 (fr)
ZA (1) ZA921660B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6903224B2 (en) 1988-04-11 2005-06-07 Biochem Pharma Inc. Substituted 1,3-oxathiolanes
SE464168B (sv) * 1989-07-19 1991-03-18 Bo Fredrik Oeberg Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt)
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US5827727A (en) * 1990-02-01 1998-10-27 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5914331A (en) * 1990-02-01 1999-06-22 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5925643A (en) * 1990-12-05 1999-07-20 Emory University Enantiomerically pure β-D-dioxolane-nucleosides
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
US6812233B1 (en) * 1991-03-06 2004-11-02 Emory University Therapeutic nucleosides
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
WO1992020344A1 (fr) * 1991-05-16 1992-11-26 Glaxo Group Limited Combinaisons antivirales contenant des analogues de nucleosides
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
US20020120130A1 (en) * 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
WO1995024904A1 (fr) * 1994-03-16 1995-09-21 Tanox Biosystems, Inc. Inhibition synergique d'infections par vih-1 au moyen d'un inhibiteur de transcriptase inverse de nucleosides et d'anticorps anti vih-1
IL115156A (en) * 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US5703058A (en) 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
MY115461A (en) * 1995-03-30 2003-06-30 Wellcome Found Synergistic combinations of zidovudine, 1592u89 and 3tc
EP0831852B1 (fr) * 1995-06-07 2006-11-29 Emory University Nucleosides ayant une activite anti-virus de l'hepatite b
NZ333099A (en) * 1996-06-25 2000-06-23 Glaxo Group Ltd synergistic combinations comprising 141W94, zidovudine and 3TC for use in the treatment of HIV
CZ429398A3 (cs) * 1996-06-25 1999-05-12 Glaxo Group Limited Kombinace účinných látek a farmaceutický prostředek
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
ATE267198T1 (de) * 1997-03-19 2004-06-15 Univ Emory Synthese und anti-hiv und anti-hepatitis virus aktivität von 1,3-oxaselenolan nucleosiden
EP0986375A2 (fr) 1997-04-07 2000-03-22 Triangle Pharmaceuticals Inc. Utilisation de mkc-442 en combinaison avec d'autres agents antiviraux
US6040434A (en) * 1997-12-01 2000-03-21 Inaba; Tadanobu Aldehyde oxidase inhibitors for treatment of aids
MXPA00012842A (es) * 1998-06-24 2004-06-22 Univ Emory Uso de 3'-azido-2',3'-didesoxiuridina en combinacion de drogas adicionales contra el vih para la manufactura de un medicamento para el tratamiento del vih.
CA2340214C (fr) 1998-08-12 2007-10-30 Triangle Pharmaceuticals, Inc. Methode de production de nucleosides de 1,3-oxathiolane
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
DK1382343T3 (da) 1998-11-02 2010-04-26 Gilead Sciences Inc Kombinationsterapi til behandling af hepatitis B-virus
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts
KR101150250B1 (ko) * 2001-03-01 2012-06-12 아보트 래버러토리즈 시스-ｆｔｃ의 다형 및 기타 결정형
UA93354C2 (ru) * 2004-07-09 2011-02-10 Гилиад Сайенсиз, Инк. Местный противовирусный препарат

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL78158A (en) * 1985-03-16 1988-04-29 Wellcome Found Pharmaceutical compositions containing 3'-azido-3'-deoxythymidine
US4874751A (en) * 1985-03-16 1989-10-17 Burroughs Wellcome Co. Antibacterial treatment
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
ATE108794T1 (de) * 1985-05-15 1994-08-15 Wellcome Found Therapeutische nucleoside und deren herstellung.
ZA878877B (en) * 1986-11-29 1988-05-24 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Treatment of diseases caused by viruses
US5159067A (en) * 1987-01-28 1992-10-27 University Of Georgia Research Foundation Inc. 5'-Diphosphohexose nucleoside pharmaceutical compositions
US4837311A (en) * 1987-06-22 1989-06-06 Hoffman-La Roche Inc. Anti-retroviral compounds
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
NZ228645A (en) * 1988-04-11 1991-09-25 Iaf Biochem Int 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections
US5041449A (en) * 1988-04-11 1991-08-20 Iaf Biochem International, Inc. 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
CA2055433A1 (fr) * 1989-05-15 1990-11-16 Jay H. Hoofnagle Methode de traitement de l'hepatite
US5071983A (en) * 1989-10-06 1991-12-10 Burroughs Wellcome Co. Therapeutic nucleosides
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
IT1249019B (it) * 1990-06-28 1995-02-11 Lamberti S P A L Emulsione acquosa di resine filmogene per la finitura di pelli, cuoio e croste di pelle e relativo procedimento di applicazione
EP0560794B1 (fr) * 1990-11-13 1996-09-18 Biochem Pharma Inc 1,3-oxathiolanes substitues ayant des proprietes antivirales
IL100502A (en) * 1991-01-03 1995-12-08 Iaf Biochem Int PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
WO1992020344A1 (fr) * 1991-05-16 1992-11-26 Glaxo Group Limited Combinaisons antivirales contenant des analogues de nucleosides

Also Published As

Publication number Publication date
HU219492B (hu) 2001-04-28
EP0574457A1 (fr) 1993-12-22
CA2105487C (fr) 2002-09-24
HK1004189A1 (en) 1998-11-20
NZ241842A (en) 1994-08-26
CA2105487A1 (fr) 1992-09-07
IL101145A (en) 1996-08-04
CZ183693A3 (en) 1994-06-15
UA29429C2 (uk) 2000-11-15
IE920702A1 (en) 1992-09-09
DK0574457T3 (da) 2000-04-17
JPH06506199A (ja) 1994-07-14
IL101145A0 (en) 1992-11-15
WO1992015309A1 (fr) 1992-09-17
JP3442773B2 (ja) 2003-09-02
ES2138969T3 (es) 2000-02-01
EP0574457B1 (fr) 1999-10-13
AU668860B2 (en) 1996-05-23
SK279767B6 (sk) 1999-03-12
HU9302496D0 (en) 1993-11-29
RU2110993C1 (ru) 1998-05-20
TW199861B (fr) 1993-02-11
DE69230140D1 (de) 1999-11-18
PT100199A (pt) 1993-07-30
KR100225986B1 (ko) 1999-10-15
CZ283185B6 (cs) 1998-01-14
GB9104740D0 (en) 1991-04-17
GR3032299T3 (en) 2000-04-27
SK95193A3 (en) 1994-01-12
PT100199B (pt) 1999-06-30
US6107288A (en) 2000-08-22
MY108638A (en) 1996-10-31
HUT72460A (en) 1996-04-29
DE69230140T2 (de) 2000-04-06
AU1351292A (en) 1992-10-06
ATE185483T1 (de) 1999-10-15
US5234913A (en) 1993-08-10

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