ZA9290B - Phenylimidazolidines,process for their preparation,their use as medicaments and pharmaceutical compositions containing them - Google Patents

Phenylimidazolidines,process for their preparation,their use as medicaments and pharmaceutical compositions containing them

Info

Publication number: ZA9290B
Authority: ZA; South Africa
Prior art keywords: denotes; halogen; preparation; oxygen; phenylimidazolidines
Prior art date: 1991-01-09

Application number

ZA9290A

Other languages

English (en)

Inventor

Martine Gaillard-Kelly

Gaillard-Kelly Martine

Francois Goubet

Goubet Francois

Daniel Philbert

Philbert Daniel

Jean-Georges Teutsch

Teutsch Jean-Georges

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-09

Filing date

1992-01-07

Publication date

1993-03-31

1992-01-07 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1993-03-31 Publication of ZA9290B publication Critical patent/ZA9290B/xx

Links

239000003814 drug Substances 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical class 0.000 abstract 4
229910052760 oxygen Inorganic materials 0.000 abstract 4
239000001301 oxygen Substances 0.000 abstract 4
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
239000005864 Sulphur Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
230000002280 anti-androgenic effect Effects 0.000 abstract 1
239000000051 antiandrogen Substances 0.000 abstract 1
229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
238000002483 medication Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Plural Heterocyclic Compounds (AREA)

ZA9290A 1991-01-09 1992-01-07 Phenylimidazolidines,process for their preparation,their use as medicaments and pharmaceutical compositions containing them ZA9290B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9100185A FR2671348B1 (fr)	1991-01-09	1991-01-09	Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.

Publications (1)

Publication Number	Publication Date
ZA9290B true ZA9290B (en)	1993-03-31

Family

ID=9408539

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9290A ZA9290B (en)	1991-01-09	1992-01-07	Phenylimidazolidines,process for their preparation,their use as medicaments and pharmaceutical compositions containing them

Country Status (17)

Country	Link
EP (1)	EP0494819B1 (de)
JP (1)	JP3383320B2 (de)
KR (1)	KR100238385B1 (de)
CN (1)	CN1049214C (de)
AT (1)	ATE140218T1 (de)
AU (1)	AU648376B2 (de)
CA (1)	CA2059052C (de)
DE (1)	DE69212007T2 (de)
DK (1)	DK0494819T3 (de)
ES (1)	ES2089425T3 (de)
FR (1)	FR2671348B1 (de)
GR (1)	GR3020510T3 (de)
HU (1)	HU223310B1 (de)
IE (1)	IE76143B1 (de)
RU (1)	RU2076101C1 (de)
UA (1)	UA45299C2 (de)
ZA (1)	ZA9290B (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
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FR2693461B1 (fr) *	1992-07-08	1994-09-02	Roussel Uclaf	Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2706456B1 (fr) *	1993-06-18	1996-06-28	Rhone Poulenc Agrochimie	Dérivés optiquement actifs de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides.
FR2685328B1 (fr) *	1991-12-20	1995-12-01	Rhone Poulenc Agrochimie	Derives de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides.
US6002016A (en) *	1991-12-20	1999-12-14	Rhone-Poulenc Agrochimie	Fungicidal 2-imidazolin-5-ones and 2-imidazoline-5-thiones
FR2694290B1 (fr) *	1992-07-08	1994-09-02	Roussel Uclaf	Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
US6008370A (en) *	1992-11-25	1999-12-28	Rhone-Poulenc Agrochimie	Fungicidal-2-alkoxy/haloalkoxy-1-(mono- or disubstituted)amino-4,4-disubstituted-2-imidazolin-5-ones
DE4335438A1 (de) *	1993-10-18	1995-04-20	Bayer Ag	4-Cyanophenyliminoheterocyclen
FR2715402B1 (fr) *	1994-01-05	1996-10-04	Roussel Uclaf	Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2724169B1 (fr) *	1994-09-06	1997-01-03	Roussel Uclaf	Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
TW521073B (en) *	1994-01-05	2003-02-21	Hoechst Marion Roussel Inc	New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
FR2716110B1 (fr) *	1994-02-16	1996-04-05	Roussel Uclaf	Compositions cosmétiques ou pharmaceutiques comprenant des liposomes.
US5656651A (en) *	1995-06-16	1997-08-12	Biophysica Inc.	Androgenic directed compositions
FR2741342B1 (fr) *	1995-11-22	1998-02-06	Roussel Uclaf	Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
US7001911B2 (en)	2000-06-28	2006-02-21	Bristol-Myers Squibb Company	Fused cyclic modulators of nuclear hormone receptor function
JP2004509072A (ja) *	2000-06-28	2004-03-25	ブリストル−マイヤーズ　スクイブ　カンパニー	選択的アンドロゲン受容体モジュレーター並びにその同定、設計及び使用方法
US20040077605A1 (en)	2001-06-20	2004-04-22	Salvati Mark E.	Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6953679B2 (en)	2000-09-19	2005-10-11	Bristol-Myers Squibb Company	Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
EP1854798A3 (de)	2000-09-19	2007-11-28	Bristol-Myers Squibb Company	Kondensierte heterozyklische Succinimid-Verbindungen und Analoga daraus, Modulatoren der nuklearen Hormonrezeptorfunktion
US20040087548A1 (en)	2001-02-27	2004-05-06	Salvati Mark E.	Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
AU2002364082A1 (en)	2001-12-19	2003-07-09	Bristol-Myers Squibb Company	Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function
DE10322108B4 (de) *	2003-05-09	2008-12-11	Bayer Schering Pharma Aktiengesellschaft	Antiandrogene Pyrrolidine mit tumorhemmender Wirksamkeit
WO2004111012A1 (ja) *	2003-06-12	2004-12-23	Chugai Seiyaku Kabushiki Kaisha	イミダゾリジン誘導体
EP1709193B1 (de)	2003-12-19	2011-03-16	The Regents of The University of California	Verfahren und materialien zur beurteilung von prostatakrebstherapien
WO2005099693A2 (en)	2004-02-24	2005-10-27	The Regents Of The University Of California	Methods and materials for assessing prostate cancer therapies and compounds
EP1621536A1 (de)	2004-07-27	2006-02-01	Aventis Pharma S.A.	Amino zyklische Urea-Derivaten, ihre Herstellung und deren pharmazeutische Verwendungen als Kinase Inhibitoren
KR20070106969A (ko) *	2004-09-09	2007-11-06	추가이 세이야쿠 가부시키가이샤	신규 이미다졸리딘 유도체 및 그 용도
US7709517B2 (en)	2005-05-13	2010-05-04	The Regents Of The University Of California	Diarylhydantoin compounds
CA2608436C (en)	2005-05-13	2015-03-24	The Regents Of The University Of California	Diarylhydantoin compounds and their use in the treatment of hyperproliferative disorders
PT1891038E (pt) *	2005-05-13	2008-12-02	Lilly Co Eli	N-arilpirrolidinas substituídas como moduladores selectivos do receptor de androgénio
US7709516B2 (en)	2005-06-17	2010-05-04	Endorecherche, Inc.	Helix 12 directed non-steroidal antiandrogens
FR2896504B1 (fr) *	2006-01-23	2012-07-13	Aventis Pharma Sa	Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
ES2689292T3 (es)	2006-03-27	2018-11-13	The Regents Of The University Of California	Modulador del receptor de andrógenos para el tratamiento del cáncer de próstata y enfermedades asociadas con el receptor de andrógenos
NZ572374A (en)	2006-03-29	2011-12-22	Univ California	Diarylthiohydantoin compounds
US8168667B2 (en)	2006-05-31	2012-05-01	Galapagos Nv	Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
WO2008093838A1 (ja) *	2007-02-01	2008-08-07	Chugai Seiyaku Kabushiki Kaisha	スルファモイル基を有するピリジルイミダゾリジン誘導体、およびその医薬としての使用
US9284345B2 (en)	2007-04-12	2016-03-15	Endorecherche, Inc.	17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators
EP2220050A2 (de)	2007-10-26	2010-08-25	The Regents Of The University Of California	Diarylhydantoinverbindungen als androgenrezeptormodulatoren
WO2009097995A1 (de) *	2008-02-07	2009-08-13	Sanofi-Aventis	Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
FR2944524B1 (fr) *	2009-04-17	2012-11-30	Ipsen Pharma Sas	Derives d'imidazolidine-2,4-dione et leur utilisation comme medicament
TW201111378A (en)	2009-09-11	2011-04-01	Bayer Schering Pharma Ag	Substituted (heteroarylmethyl) thiohydantoins
SG10201907588XA (en)	2010-02-16	2019-09-27	Aragon Pharmaceuticals Inc	Androgen Receptor Modulators And Uses Thereof
CN115737643A (zh)	2012-09-26	2023-03-07	阿拉贡药品公司	用于治疗非转移性去势抵抗性前列腺癌的抗雄激素
DK2945628T3 (da)	2013-01-15	2020-05-04	Aragon Pharmaceuticals Inc	Androgen receptormodulator i kombination med abirateronacetat og prednison til behandling af prostatacancer
US9682960B2 (en)	2013-12-19	2017-06-20	Endorecherche, Inc.	Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
CN103965112A (zh) *	2014-05-13	2014-08-06	上海孚一生物科技有限公司	一种具有抗雄激素活性的化合物、制备方法及其应用
TWI726969B (zh)	2016-01-11	2021-05-11	比利時商健生藥品公司	用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
MX2020003845A (es)	2017-10-16	2020-11-06	Aragon Pharmaceuticals Inc	Antiandrógenos para el tratamiento de cáncer de próstata no metastásico resistente a la castración.
CN113024513A (zh) *	2021-03-22	2021-06-25	中国药科大学	新型雄激素受体降解剂、制备方法和医药用途

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US3823240A (en) *	1970-10-06	1974-07-09	Rhone Poulenc Sa	Fungicidal hydantoin derivatives
FR2329276A1 (fr) *	1975-10-29	1977-05-27	Roussel Uclaf	Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
MC1220A1 (fr) *	1977-10-28	1979-07-20	Hoffmann La Roche	Nouveaux derives d'imidazolidine
IL55774A (en) *	1977-10-28	1982-04-30	Sparamedica Ag	Pharmaceutical compositions containing urea derivatives,certain such novel derivatives and their manufacture
DE2933917A1 (de) *	1979-08-22	1981-03-26	Basf Ag, 67063 Ludwigshafen	5-imino-imidazolidin-2-one und diese enthaltende herbizide.
DE3444918A1 (de) *	1984-12-08	1986-06-12	Hoechst Ag, 6230 Frankfurt	1-phenyl-imidazol-5-carbonsaeure-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als wachstumsregulatoren
US4672101A (en) *	1985-09-09	1987-06-09	The Dow Chemical Company	Polyepoxy aromatic hydantoins
FR2619381B1 (fr) *	1987-08-13	1989-12-08	Roussel Uclaf	Nouvelles imidazolidines substituees par un radical hydroxymethyle et un radical phenyl substitue, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant et un intermediaire pour leur preparation

1991
- 1991-01-09 FR FR9100185A patent/FR2671348B1/fr not_active Expired - Fee Related
1992
- 1992-01-07 ZA ZA9290A patent/ZA9290B/xx unknown
- 1992-01-08 AU AU10106/92A patent/AU648376B2/en not_active Ceased
- 1992-01-08 CA CA002059052A patent/CA2059052C/fr not_active Expired - Fee Related
- 1992-01-08 EP EP92400038A patent/EP0494819B1/de not_active Expired - Lifetime
- 1992-01-08 DE DE69212007T patent/DE69212007T2/de not_active Expired - Fee Related
- 1992-01-08 KR KR1019920000124A patent/KR100238385B1/ko not_active Expired - Fee Related
- 1992-01-08 AT AT92400038T patent/ATE140218T1/de not_active IP Right Cessation
- 1992-01-08 RU SU925010932A patent/RU2076101C1/ru not_active IP Right Cessation
- 1992-01-08 DK DK92400038.3T patent/DK0494819T3/da active
- 1992-01-08 IE IE920059A patent/IE76143B1/en not_active IP Right Cessation
- 1992-01-08 HU HU9200065A patent/HU223310B1/hu not_active IP Right Cessation
- 1992-01-08 ES ES92400038T patent/ES2089425T3/es not_active Expired - Lifetime
- 1992-01-09 JP JP01935392A patent/JP3383320B2/ja not_active Expired - Fee Related
- 1992-01-09 CN CN92100140A patent/CN1049214C/zh not_active Expired - Fee Related
1993
- 1993-06-18 UA UA93003049A patent/UA45299C2/uk unknown
1996
- 1996-07-11 GR GR960400495T patent/GR3020510T3/el unknown

Also Published As

Publication number	Publication date
EP0494819A1 (de)	1992-07-15
AU1010692A (en)	1992-07-16
ATE140218T1 (de)	1996-07-15
KR920014786A (ko)	1992-08-25
FR2671348B1 (fr)	1993-03-26
AU648376B2 (en)	1994-04-21
HUT60250A (en)	1992-08-28
CA2059052A1 (fr)	1992-07-10
UA45299C2 (uk)	2002-04-15
CA2059052C (fr)	2004-11-23
DK0494819T3 (da)	1996-08-12
DE69212007D1 (de)	1996-08-14
CN1063102A (zh)	1992-07-29
HU223310B1 (hu)	2004-05-28
EP0494819B1 (de)	1996-07-10
FR2671348A1 (fr)	1992-07-10
KR100238385B1 (ko)	2000-03-02
HU9200065D0 (en)	1992-03-30
DE69212007T2 (de)	1997-01-09
CN1049214C (zh)	2000-02-09
JP3383320B2 (ja)	2003-03-04
IE76143B1 (en)	1997-10-08
IE920059A1 (en)	1992-07-15
GR3020510T3 (en)	1996-10-31
JPH04308579A (ja)	1992-10-30
ES2089425T3 (es)	1996-10-01
RU2076101C1 (ru)	1997-03-27

Publication	Publication Date	Title
GR3020510T3 (en)	1996-10-31	Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them
GR3035768T3 (en)	2001-07-31	Substituted Phenylimidazolidins, process for their preparation, their use as medicaments and their pharmaceutical compositions containing them.
ATE73776T1 (de)	1992-04-15	4-aminochinolin-derivate und ihre verwendung als arzneimittel.
MY102866A (en)	1993-03-31	Amide derivatives.
IL145277A0 (en)	2002-06-30	Amide derivatives
IL80437A0 (en)	1987-01-30	Benzimidazole derivatives and pharmaceutical compositions containing them
ZA926328B (en)	1993-03-11	Naphthylethylureas and naphthylethylthioureas process for the preparation thereof and pharmaceutical compositions containing them.
IL109610A0 (en)	1994-08-26	Amide derivatives, their preparation and pharmaceutical compositions containing them
ZA898842B (en)	1991-07-31	Anti-atherosclerotic diaryl compounds
IL147149A0 (en)	2002-08-14	Novel diphenyl-piperidine derivate
IL114833A (en)	2003-07-31	Anthracyclinone derivatives for use as medicaments or for the manufacture of a medicament and pharmaceutical compositions comprising said derivatives for the treatment of amyloidosis, some such derivatives and processes for their preparation
ATE91682T1 (de)	1993-08-15	Alkansulfonanilid-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
DE69102477D1 (de)	1994-07-21	3-Aminochroman-Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen.
ZA984114B (en)	1998-11-24	Substituted heterocyclic compounds a process for the preparation thereof and pharmaceutical compositions containing them
SE8600658D0 (sv)	1986-02-14	Novel composition of matter
EP0270046A3 (en)	1990-06-13	Pharmaceutical composition for treatment of cataract
IL87197A0 (en)	1988-12-30	Leukotriene antagonists,precursors of same,processes for the preparation thereof and pharmaceutical compositions containing same
MX25922A (es)	1993-10-01	Pirido (3,4-b) pirrolo (1,2-e)(1,4,5)oxadiazepinasy compuestos analogos relacionados un procedimiento para su preparacion y su uso como medicamentos