ZA929761B - Enhancing the bioavailability of proteolytically labile therapeutic agents. - Google Patents

Enhancing the bioavailability of proteolytically labile therapeutic agents.

Info

Publication number
ZA929761B
ZA929761B ZA929761A ZA929761A ZA929761B ZA 929761 B ZA929761 B ZA 929761B ZA 929761 A ZA929761 A ZA 929761A ZA 929761 A ZA929761 A ZA 929761A ZA 929761 B ZA929761 B ZA 929761B
Authority
ZA
South Africa
Prior art keywords
bioavailability
enhancing
therapeutic agents
labile therapeutic
proteolytically labile
Prior art date
Application number
ZA929761A
Other languages
English (en)
Inventor
Gordon L Amidon
Glen D Leesman
Patrick J Sinko
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA929761B publication Critical patent/ZA929761B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2207—Gastrins; Cholecystokinins [CCK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
ZA929761A 1991-12-18 1992-12-17 Enhancing the bioavailability of proteolytically labile therapeutic agents. ZA929761B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81059391A 1991-12-18 1991-12-18

Publications (1)

Publication Number Publication Date
ZA929761B true ZA929761B (en) 1994-06-17

Family

ID=25204183

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA929761A ZA929761B (en) 1991-12-18 1992-12-17 Enhancing the bioavailability of proteolytically labile therapeutic agents.

Country Status (12)

Country Link
EP (1) EP0617626A1 (pt)
JP (1) JPH06510796A (pt)
AU (1) AU3058392A (pt)
CA (1) CA2125400A1 (pt)
FI (1) FI942938L (pt)
HU (1) HUT69785A (pt)
IL (1) IL104048A0 (pt)
MX (1) MX9207407A (pt)
NO (1) NO942323D0 (pt)
PT (1) PT101135A (pt)
WO (1) WO1993011799A1 (pt)
ZA (1) ZA929761B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2145763A1 (en) * 1992-10-02 1994-04-14 William J. Curatolo Pharmaceutical compositions containing nonionic surfactants
AU7273494A (en) * 1993-09-01 1995-03-22 Pfizer Inc. Pharmaceutical compositions containing anionic surfactants
DE19530865A1 (de) * 1995-08-22 1997-02-27 Michael Dr Med Nauck Wirkstoff sowie Mittel zur parenteralen Ernährung
US6852690B1 (en) 1995-08-22 2005-02-08 Amylin Pharmaceuticals, Inc. Method and composition for enhanced parenteral nutrition
AU2990401A (en) * 2000-01-27 2001-08-07 Peros Systemes Technologies Inc. Composition for intestinal delivery
GB0015921D0 (en) * 2000-06-30 2000-08-23 Nat Biolog Standards Board Improvements in or relating to stabilisation of substances
CL2008001640A1 (es) * 2007-06-08 2008-11-07 Bergen Teknologioverforing As Uso de hidroxiprolina para preparar una composicion de alemento destinada a promover el crecimiento de un animal, como peces, aves y mamiferos.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537769A (en) * 1982-04-06 1985-08-27 American Cyanamid Company Stabilization of influenza virus vaccine
IL68769A (en) * 1983-05-23 1986-02-28 Hadassah Med Org Pharmaceutical compositions containing insulin for oral administration
US4774089A (en) * 1985-06-14 1988-09-27 Albion International, Inc. Stimulation of gonadotropic hormones with mineral mixtures containing amino acid chelates
MY103189A (en) * 1986-10-31 1993-05-29 Pfizer Nor-statine and nor-cyclostatine polypeptides
GB2212062B (en) * 1987-11-13 1991-07-17 Isf Spa Pharmaceutical compositions containing a calcitonin and a glycyrrhizinate ab- sorption enhancer
IL90244A (en) * 1988-05-11 1993-05-13 Du Pont Merck Pharma Peptide-drug compositions, for buccal and nasal administration, containing :-aminoboronic acid derivatives
DD273980B5 (de) * 1988-07-12 1994-04-14 Berlin Chemie Ag Verfahren zur Herstellung von Insulin-Pr{paraten zur rektalen Anwendung
GB8822857D0 (en) * 1988-09-29 1988-11-02 Patralan Ltd Pharmaceutical formulations
DK546289D0 (da) * 1989-11-02 1989-11-02 Danochemo As Carotenoidpulvere

Also Published As

Publication number Publication date
FI942938A0 (fi) 1994-06-17
EP0617626A1 (en) 1994-10-05
HUT69785A (en) 1995-09-28
MX9207407A (es) 1993-06-01
HU9401824D0 (en) 1994-09-28
NO942323L (no) 1994-06-17
JPH06510796A (ja) 1994-12-01
FI942938A7 (fi) 1994-06-17
AU3058392A (en) 1993-07-19
WO1993011799A1 (en) 1993-06-24
CA2125400A1 (en) 1993-06-24
IL104048A0 (en) 1993-05-13
NO942323D0 (no) 1994-06-17
FI942938L (fi) 1994-06-17
PT101135A (pt) 1994-03-31

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