ZA937085B - e derivatives active on the cardiovascular system 17-Aryl and 17-heterocyclyl-5Beta-14Beta androstanprocesses for their preparation and pharmaceutical compositions containing same - Google Patents

e derivatives active on the cardiovascular system 17-Aryl and 17-heterocyclyl-5Beta-14Beta androstanprocesses for their preparation and pharmaceutical compositions containing same

Info

Publication number
ZA937085B
ZA937085B ZA937085A ZA937085A ZA937085B ZA 937085 B ZA937085 B ZA 937085B ZA 937085 A ZA937085 A ZA 937085A ZA 937085 A ZA937085 A ZA 937085A ZA 937085 B ZA937085 B ZA 937085B
Authority
ZA
South Africa
Prior art keywords
heterocyclyl
aryl
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
ZA937085A
Other languages
English (en)
Inventor
Nicoletta Almirante
Luigi Bernardi
Alberto Cerri
Piero Melloni
Gloria Padoani
Luisa Quadri
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ZA937085B publication Critical patent/ZA937085B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA937085A 1992-09-29 1993-09-24 e derivatives active on the cardiovascular system 17-Aryl and 17-heterocyclyl-5Beta-14Beta androstanprocesses for their preparation and pharmaceutical compositions containing same ZA937085B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4232638A DE4232638C2 (de) 1992-09-29 1992-09-29 17-Phenyl-5beta-14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number Publication Date
ZA937085B true ZA937085B (en) 1994-08-11

Family

ID=6469142

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA937085A ZA937085B (en) 1992-09-29 1993-09-24 e derivatives active on the cardiovascular system 17-Aryl and 17-heterocyclyl-5Beta-14Beta androstanprocesses for their preparation and pharmaceutical compositions containing same

Country Status (12)

Country Link
US (1) US5567694A (de)
EP (1) EP0590272B1 (de)
JP (1) JPH06192286A (de)
KR (1) KR940007055A (de)
AT (1) ATE147077T1 (de)
CA (1) CA2106917A1 (de)
DE (2) DE4232638C2 (de)
DK (1) DK0590272T3 (de)
ES (1) ES2095531T3 (de)
GR (1) GR3022376T3 (de)
HK (1) HK1005878A1 (de)
ZA (1) ZA937085B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510340A (en) * 1992-06-12 1996-04-23 Sri International Antihypercholesterolemic compounds and related pharmaceutical compositions and methods of use
DE4232681C2 (de) * 1992-09-29 1994-11-24 Sigma Tau Ind Farmaceuti 17-Phenyl- und 17-Furyl-14beta,5alpha-androstan- und androsten- Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung
CA2522784C (en) 2003-04-01 2012-06-19 Hollis-Eden Pharmaceuticals, Inc. Antiandrogens with marginal agonist activity and methods of use
WO2007031833A2 (en) * 2005-09-15 2007-03-22 Council Of Scientific And Industrial Research Novel series of imidazolyl substituted steroidal and indan-1-one derivatives
KR101530019B1 (ko) * 2007-06-07 2015-06-18 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. 혈관성형술 또는 동맥내막절제술 후 재협착 및 장기 섬유증으로 인한 질환의 치료에 유용한 5베타, 14베타-안드로스테인 유도체
EP2411015B1 (de) 2009-03-23 2015-12-23 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. 5-beta, 14-beta-androstan-derivative zur behandlung von proteinurie, glomerulosklerose und nierenversagen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2614046C2 (de) * 1976-04-01 1984-08-02 Boehringer Mannheim Gmbh, 6800 Mannheim Neue 17α-Hydroxy-Cardenolid-Glykoside, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
FR2407940A1 (fr) * 1977-11-08 1979-06-01 Roussel Uclaf Nouveaux derives steroides 17 a-aryle, ou 17 a-heteroaryle, leur procede de preparation et leur application comme medicament
DE3223735A1 (de) * 1982-06-25 1983-12-29 Boehringer Mannheim Gmbh, 6800 Mannheim Neue derivate von 17(alpha)-hydroxy-digitoxigenin-digitoxosiden, verfahren zu ihrer herstellung und ihre verwendung als arzneitmittel
JPH0368596A (ja) * 1989-08-09 1991-03-25 Snow Brand Milk Prod Co Ltd １４α‐ヒドロキシ‐４‐アンドロステン‐３，６，１７‐トリオンの製造方法

Also Published As

Publication number Publication date
ATE147077T1 (de) 1997-01-15
EP0590272A3 (en) 1994-07-06
KR940007055A (ko) 1994-04-26
EP0590272A2 (de) 1994-04-06
HK1005878A1 (en) 1999-01-29
GR3022376T3 (en) 1997-04-30
EP0590272B1 (de) 1997-01-02
DE69307071D1 (de) 1997-02-13
DE4232638A1 (de) 1994-03-31
CA2106917A1 (en) 1994-03-30
DE4232638C2 (de) 1994-11-17
US5567694A (en) 1996-10-22
JPH06192286A (ja) 1994-07-12
DE69307071T2 (de) 1997-05-22
DK0590272T3 (da) 1997-04-14
ES2095531T3 (es) 1997-02-16

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