ZA945045B - Derivatives of imidazo (1,2-a) pyrazin-4-one their preparation and medicaments containing them - Google Patents

Derivatives of imidazo (1,2-a) pyrazin-4-one their preparation and medicaments containing them

Info

Publication number: ZA945045B
Authority: ZA; South Africa
Prior art keywords: alk; alkyl; het; phenyl; receptor
Prior art date: 1993-07-16

Application number

ZA945045A

Other languages

English (en)

Inventor

Jean-Claude Aloup

Dominique Damour

Patrick Jimonet

Yves Ribeill

Francois Audiau

Arielle Genevois-Borella

Serge Mignani

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-16

Filing date

1994-07-12

Publication date

1995-02-22

1994-07-12 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1995-02-22 Publication of ZA945045B publication Critical patent/ZA945045B/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ZA945045A 1993-07-16 1994-07-12 Derivatives of imidazo (1,2-a) pyrazin-4-one their preparation and medicaments containing them ZA945045B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9308754A FR2707643B1 (fr)	1993-07-16	1993-07-16	Dérivés d'imidazo[1,2-a]pyrazine-4-one, leur préparation et les médicaments les contenant.

Publications (1)

Publication Number	Publication Date
ZA945045B true ZA945045B (en)	1995-02-22

Family

ID=9449312

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA945045A ZA945045B (en)	1993-07-16	1994-07-12	Derivatives of imidazo (1,2-a) pyrazin-4-one their preparation and medicaments containing them

Country Status (18)

Country	Link
US (1)	US5753657A (de)
EP (1)	EP0708774B1 (de)
JP (1)	JPH09500873A (de)
AT (1)	ATE177746T1 (de)
AU (1)	AU681688B2 (de)
CA (1)	CA2167169A1 (de)
DE (1)	DE69417235T2 (de)
DK (1)	DK0708774T3 (de)
ES (1)	ES2130438T3 (de)
FI (1)	FI960160A0 (de)
FR (1)	FR2707643B1 (de)
GR (1)	GR3029713T3 (de)
HU (1)	HUT74678A (de)
IL (1)	IL110329A0 (de)
NO (1)	NO955192D0 (de)
PL (1)	PL312571A1 (de)
WO (1)	WO1995002601A1 (de)
ZA (1)	ZA945045B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2717805B1 (fr) *	1994-03-28	1996-05-10	Rhone Poulenc Rorer Sa	Dérivés de 5H-indeno[1,2-b]pyrazine-2,3-dione, leur préparation et les médicaments les contenant .
FR2717813B1 (fr) *	1994-03-28	1996-05-10	Rhone Poulenc Rorer Sa	Dérivés d'imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant .
FR2717812B1 (fr) *	1994-03-28	1996-05-10	Rhone Poulenc Rorer Sa	Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant.
FR2726275B1 (fr) *	1994-11-02	1996-12-06	Rhone Poulenc Rorer Sa	Spiro heterocycle-imidazo(1,2-a)indeno(1,2-e)pyrazine)-4'- ones, leur preparation et les medicaments les contenants
FR2738821B1 (fr) *	1995-09-15	1997-11-21	Rhone Poulenc Rorer Sa	Indeno[1,2-e]pyrazin-4-ones, leur preparation et les medicaments les contenant
WO2002072542A2 (en) *	2001-03-08	2002-09-19	Emory University	Ph-dependent nmda receptor antagonists
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
WO2008053301A2 (en) *	2006-10-30	2008-05-08	Hybrigenics Sa	Novel tetracyclic inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
JP5523107B2 (ja)	2006-11-30	2014-06-18	プロビオドルグエージー	グルタミニルシクラーゼの新規阻害剤
EP2481408A3 (de)	2007-03-01	2013-01-09	Probiodrug AG	Neue Verwendung von Inhibitoren der Glutaminyl Cyclase
WO2008128985A1 (en)	2007-04-18	2008-10-30	Probiodrug Ag	Thiourea derivatives as glutaminyl cyclase inhibitors
CN103058957A (zh)	2007-06-29	2013-04-24	埃莫里大学	用于神经保护的nmda受体拮抗剂
MX2012002993A (es)	2009-09-11	2012-04-19	Probiodrug Ag	Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
US8269019B2 (en)	2010-03-10	2012-09-18	Probiodrug Ag	Inhibitors
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
ES2570167T3 (es)	2011-03-16	2016-05-17	Probiodrug Ag	Derivados de benzimidazol como inhibidores de glutaminil ciclasa
PL3461819T3 (pl)	2017-09-29	2020-11-30	Probiodrug Ag	Inhibitory cyklazy glutaminylowej

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU9049391A (en) *	1990-12-20	1992-07-22	Warner-Lambert Company	2-acylamido derivatives of 3,4-dihydro-3-oxo-quinoxaline having pharmaceutical activity
US5196421A (en)	1991-06-05	1993-03-23	Eli Lilly And Company	Excitatory amino acid receptor antagonists in methods for the use thereof
US5153196A (en) *	1991-06-05	1992-10-06	Eli Lilly And Company	Excitatory amino acid receptor antagonists and methods for the use thereof
FR2696466B1 (fr) *	1992-10-02	1994-11-25	Rhone Poulenc Rorer Sa	Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant.

1993
- 1993-07-16 FR FR9308754A patent/FR2707643B1/fr not_active Expired - Fee Related
1994
- 1994-07-11 DK DK94922904T patent/DK0708774T3/da active
- 1994-07-11 HU HU9503955A patent/HUT74678A/hu unknown
- 1994-07-11 DE DE69417235T patent/DE69417235T2/de not_active Expired - Fee Related
- 1994-07-11 ES ES94922904T patent/ES2130438T3/es not_active Expired - Lifetime
- 1994-07-11 US US08/583,126 patent/US5753657A/en not_active Expired - Fee Related
- 1994-07-11 AT AT94922904T patent/ATE177746T1/de not_active IP Right Cessation
- 1994-07-11 WO PCT/FR1994/000866 patent/WO1995002601A1/fr not_active Ceased
- 1994-07-11 AU AU72652/94A patent/AU681688B2/en not_active Withdrawn - After Issue
- 1994-07-11 PL PL94312571A patent/PL312571A1/xx unknown
- 1994-07-11 JP JP7504376A patent/JPH09500873A/ja active Pending
- 1994-07-11 EP EP94922904A patent/EP0708774B1/de not_active Expired - Lifetime
- 1994-07-11 CA CA002167169A patent/CA2167169A1/fr not_active Abandoned
- 1994-07-12 ZA ZA945045A patent/ZA945045B/xx unknown
- 1994-07-14 IL IL11032994A patent/IL110329A0/xx unknown
1995
- 1995-12-20 NO NO955192A patent/NO955192D0/no unknown
1996
- 1996-01-12 FI FI960160A patent/FI960160A0/fi not_active Application Discontinuation
1999
- 1999-03-18 GR GR980402654T patent/GR3029713T3/el unknown

Also Published As

Publication number	Publication date
AU7265294A (en)	1995-02-13
FR2707643A1 (fr)	1995-01-20
FI960160A7 (fi)	1996-01-12
ES2130438T3 (es)	1999-07-01
EP0708774B1 (de)	1999-03-17
HUT74678A (en)	1997-01-28
ATE177746T1 (de)	1999-04-15
HU9503955D0 (en)	1996-03-28
DE69417235D1 (de)	1999-04-22
CA2167169A1 (fr)	1995-01-26
GR3029713T3 (en)	1999-06-30
WO1995002601A1 (fr)	1995-01-26
IL110329A0 (en)	1994-10-21
FR2707643B1 (fr)	1995-08-11
NO955192L (no)	1995-12-20
AU681688B2 (en)	1997-09-04
US5753657A (en)	1998-05-19
PL312571A1 (en)	1996-04-29
NO955192D0 (no)	1995-12-20
DE69417235T2 (de)	1999-07-08
FI960160A0 (fi)	1996-01-12
DK0708774T3 (da)	1999-10-11
EP0708774A1 (de)	1996-05-01
JPH09500873A (ja)	1997-01-28

Publication	Publication Date	Title
AU681688B2 (en)	1997-09-04	Imidazo(1,2-a)pyrazine-4-one, preparation thereof and drugs containing same
GR3022498T3 (en)	1997-05-31	Imidazo[1,2-a]pyrazin-4-one derivatives for use as ampa and nmda receptor antagonists
ZA952525B (en)	1996-01-15	5h-indeno[1,2-b]pyrazine-2,3-dione derivatives and preparation thereof
EP0309422A3 (de)	1990-01-10	Amidinotricyclische Derivate
MX9806171A (es)	1998-10-31	Derivados 2,3-benzodiazepina y sus usos como inhibidores del receptor-ampa.
GR3031693T3 (en)	2000-02-29	Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase
GR3001356T3 (en)	1992-09-11	3-vinyl and 3-ethinyl-beta-carboline derivatives, their preparation and their use as medicaments
HU9500959D0 (en)	1995-05-29	Derivatives of 5h,10h-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, preparation thereof and medicaments containing them
DE69509888D1 (de)	1999-07-01	IMIDAZO[1,2-a]INDENO [1,2-e] PYRAZINONE ANTAGONISTEN DER AMPA UND NMDA REZEPTOREN
ZA952529B (en)	1996-01-22	Imidazo[1,2-a]-indeno[1,2-e]pyrazin-4-one derivatives and preparation thereof
DE69431471D1 (de)	2002-11-07	Amide derivate als 5-ht1a liganden