ZA946770B - Hybrid toxin - Google Patents

Hybrid toxin

Info

Publication number
ZA946770B
ZA946770B ZA946770A ZA946770A ZA946770B ZA 946770 B ZA946770 B ZA 946770B ZA 946770 A ZA946770 A ZA 946770A ZA 946770 A ZA946770 A ZA 946770A ZA 946770 B ZA946770 B ZA 946770B
Authority
ZA
South Africa
Prior art keywords
hybrid toxin
domain
region
protein
terminus
Prior art date
Application number
ZA946770A
Other languages
English (en)
Inventor
Hendrik Jan Bosch
Willem Johannes Stiekema
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of ZA946770B publication Critical patent/ZA946770B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ZA946770A 1993-09-02 1994-09-02 Hybrid toxin ZA946770B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939318207A GB9318207D0 (en) 1993-09-02 1993-09-02 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
ZA946770B true ZA946770B (en) 1996-03-04

Family

ID=10741404

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA946770A ZA946770B (en) 1993-09-02 1994-09-02 Hybrid toxin

Country Status (18)

Country Link
US (2) US5736131A (fr)
EP (1) EP0719335B1 (fr)
JP (1) JPH09502343A (fr)
KR (1) KR100360918B1 (fr)
AT (1) ATE329033T1 (fr)
AU (1) AU691522B2 (fr)
BR (1) BR9407377A (fr)
CA (1) CA2168011C (fr)
DE (1) DE69434758T2 (fr)
ES (1) ES2262136T3 (fr)
GB (1) GB9318207D0 (fr)
IL (1) IL110829A (fr)
PL (1) PL181408B1 (fr)
RU (1) RU2210593C2 (fr)
TW (1) TW430669B (fr)
UA (1) UA57698C2 (fr)
WO (1) WO1995006730A1 (fr)
ZA (1) ZA946770B (fr)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU638438B2 (en) 1989-02-24 1993-07-01 Monsanto Technology Llc Synthetic plant genes and method for preparation
GB9318207D0 (en) 1993-09-02 1993-10-20 Sandoz Ltd Improvements in or relating to organic compounds
US6780408B1 (en) 1993-09-02 2004-08-24 Syngenta Participations Ag Genes encoding hybrid bacillus thuringiensis toxins
US5593881A (en) * 1994-05-06 1997-01-14 Mycogen Corporation Bacillus thuringiensis delta-endotoxin
US6063756A (en) 1996-09-24 2000-05-16 Monsanto Company Bacillus thuringiensis cryET33 and cryET34 compositions and uses therefor
US6713063B1 (en) 1996-11-20 2004-03-30 Monsanto Technology, Llc Broad-spectrum δ-endotoxins
AP9901541A0 (en) 1996-11-20 1999-06-30 Ecogen Inc Broad-spectrum delta-endotoxins.
US6017534A (en) 1996-11-20 2000-01-25 Ecogen, Inc. Hybrid Bacillus thuringiensis δ-endotoxins with novel broad-spectrum insecticidal activity
US5942664A (en) * 1996-11-27 1999-08-24 Ecogen, Inc. Bacillus thuringiensis Cry1C compositions toxic to lepidopteran insects and methods for making Cry1C mutants
US6121436A (en) * 1996-12-13 2000-09-19 Monsanto Company Antifungal polypeptide and methods for controlling plant pathogenic fungi
EP1025244A2 (fr) * 1997-10-20 2000-08-09 Genzyme Transgenics Corporation SEQUENCES D'ACIDES NUCLEIQUES MSP-1 MODIFIES ET PROCEDES PERMETTANT D'ACCROITRE LES NIVEAUX D'ARNm ET L'EXPRESSION DES PROTEINES DANS LES SYSTEMES CELLULAIRES
US6218188B1 (en) * 1997-11-12 2001-04-17 Mycogen Corporation Plant-optimized genes encoding pesticidal toxins
AU774176B2 (en) * 1997-11-12 2004-06-17 Mycogen Corporation Plant-optimised genes encoding pesticidal toxins
US6121521A (en) * 1998-04-01 2000-09-19 Novartis Ag Chimeric insecticidal protein and DNA coding therefor
EP1099760A1 (fr) * 1999-11-09 2001-05-16 Centrum Voor Plantenveredelings- En Reproduktieonderzoek (Cpro) Toxines de Bacillus thuringiensis hybrides Cry1Ia-Cry1Ba
AU2001285900B2 (en) * 2000-08-25 2005-02-17 Syngenta Participations Ag Novel insecticidal toxins derived from bacillus thuringiensis insecticidal crystal proteins
WO2002089830A1 (fr) * 2001-05-04 2002-11-14 North Carolina State University Conjugues polymeres d'acides nucleiques ou de peptides insecticides et procedes d'utilisation correspondants
US20030108585A1 (en) * 2001-05-04 2003-06-12 Roe R. Michael Polymer conjugates of insecticidal peptides or nucleic acids or insecticides and methods of use thereof
EP1572902B1 (fr) * 2002-02-01 2014-06-11 Life Technologies Corporation Courts fragments d'arn interferant haute activite visant a reduire l'expression de genes cibles
ATE556714T1 (de) 2002-02-01 2012-05-15 Life Technologies Corp Doppelsträngige oligonukleotide
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US7053266B2 (en) * 2002-03-27 2006-05-30 Council Of Scientfic And Industrial Research Chimeric cry1E δendotoxin and methods of controlling insects
US7557186B2 (en) * 2002-03-27 2009-07-07 Council Of Scientific & Industrial Research Chimeric CrylE δ endotoxin and methods of controlling insects
US20040029275A1 (en) * 2002-08-10 2004-02-12 David Brown Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
US7393922B2 (en) * 2003-08-29 2008-07-01 The Ohio State University Research Foundation Insecticidal Cry4Ba proteins with enhanced toxicity
EA015908B1 (ru) 2005-08-31 2011-12-30 Монсанто Текнолоджи, Ллс Инсектицидный белок в.thuringiensis cry1a.105, кодирующий его полинуклеотид и их применение
CN100510081C (zh) * 2005-10-17 2009-07-08 华中农业大学 苏云金芽胞杆菌的杀虫晶体蛋白基因cry7Bal
PL1999141T3 (pl) * 2006-03-21 2011-10-31 Bayer Cropscience Nv Nowe geny kodujące białka owadobójcze
EP2021476B1 (fr) 2006-05-26 2014-07-09 Monsanto Technology, LLC Plant et semence de maïs correspondant au produit transgénique mon89034, procédés de détection et utilisation associés
US9522937B2 (en) 2007-03-28 2016-12-20 Syngenta Participations Ag Insecticidal proteins
ES2601577T3 (es) * 2007-03-28 2017-02-15 Syngenta Participations Ag Proteínas insecticidas
WO2008145406A1 (fr) * 2007-06-01 2008-12-04 Bayer Bioscience N.V. Nouveaux gènes codant pour des protéines insecticides
BRPI0922656A2 (pt) 2008-12-16 2015-08-04 Syngenta Participations Ag Semente de uma planta de milho transgênica, planta de milho transgênica, células e tecidos desta, molécula de ácido nucléico, amplicos, par de iniciadores de polinucleotídeos, método e kit de detecção da presença de uma molécula de ácido nucléico, molécula de dna, método para confirmar a ausência de uma molécula de ácido nucléico, amostra biológica e extrato derivados de planta, tecido, semente ou célula de milho do evento 5307, métodos de reprodução de uma planta de milho, de seleção auxiliada por marcadores para uma característica resistente a insetos em milho, e de produção de plantas de milho híbridas resistentes a insetos coleópteros, semente e plantas de milho híbridas, sítio-alvo de cromossomo de milho, e método de preparação de uma planta de milho transgênica
WO2010102220A1 (fr) 2009-03-05 2010-09-10 Metabolix, Inc. Multiplication de plantes transgéniques
PL2419441T3 (pl) 2009-04-17 2015-06-30 Dow Agrosciences Llc Owadzie toksyny Cry obejmujące DIG-3
CA2775582A1 (fr) 2009-10-02 2011-04-07 Syngenta Participations Ag Proteines insecticides
MX343547B (es) * 2009-12-16 2016-11-09 Dow Agrosciences Llc Uso combinado de las proteínas insecticidas vip3ab y cry1fa para el manejo de insectos resistentes.
ES2598491T3 (es) * 2009-12-16 2017-01-27 Dow Agrosciences Llc Uso combinado de proteínas cry1ca y cry1ab para la gestión de la resistencia a insectos
CA2782546C (fr) * 2009-12-16 2023-03-21 Dow Agrosciences Llc Utilisation combinee des proteines cry1da et cry1fa pour la gestion de la resistance des insectes
US20120324605A1 (en) * 2009-12-16 2012-12-20 Dow Agrosciences Llc Insectcidal protein combinations for controlling fall armyworm and european corn borer, and methods for insect resistance management
PH12012501429B1 (en) 2009-12-16 2020-02-05 Dow Agrosciences Llc Modified cry1ca insecticidal cry proteins
US9499835B2 (en) * 2009-12-16 2016-11-22 Dow Agrosciences Llc Use of Cry1Da in combination with Cry1Be for management of resistant insects
UA113385C2 (xx) * 2009-12-16 2017-01-25 ТРАНСГЕННА РОСЛИНА, ЩО МІСТИТЬ ДНК, ЯКА КОДУЄ ІНСЕКТИЦИДНИЙ БІЛОК Сry1Be, І ДНК, ЯКА КОДУЄ ІНСЕКТИЦИДНИЙ БІЛОК Сry1Fa, ДЛЯ БОРОТЬБИ АБО ПОПЕРЕДЖЕННЯ ВИНИКНЕННЯ СТІЙКОСТІ У SPODOPTERA FRUGIPERDA ТА OSTRINIA NUBILALIS
BR112012014801B1 (pt) * 2009-12-16 2024-03-05 Dow Agrosciences Llc Métodos para controlar o desenvolvimento da resistência de um inseto à uma proteína inseticida derivada de um bacillus thuringiensis, e para o controle de pragas de lepidópteros, bem como composição para o controle de pragas de lepidópteros
EP2513316B1 (fr) * 2009-12-16 2018-11-28 Dow AgroSciences LLC Utilisation de cry1da en combinaison avec cry1ca pour la prise en charge d'insectes résistants
MX2012009632A (es) * 2010-02-18 2012-09-28 Athenix Corp Genes delta-endotoxinicos axmi221z, axmi222z, axmi223z, axmi224z, axmi225z y metodos para su uso.
US8735560B1 (en) * 2010-03-02 2014-05-27 Monsanto Technology Llc Multiple domain lepidopteran active toxin proteins
NZ603561A (en) * 2010-04-23 2015-06-26 Dow Agrosciences Llc Combinations including cry34ab/35ab and cry3aa proteins to prevent development of resistance in corn rootworms (diabrotica spp.)
US9234208B1 (en) 2010-05-10 2016-01-12 Dow Agrosciences Llc DIG-13 insecticidal cry toxins
UA111592C2 (uk) * 2010-07-07 2016-05-25 Сінгента Партісіпейшнс Аг Спосіб контролю над твердокрилими комахами-шкідниками
US9045766B2 (en) * 2010-12-16 2015-06-02 Dow Agrosciences Llc Combined use of Vip3Ab and Cry1Ab for management of resistant insects
WO2012131619A1 (fr) * 2011-03-30 2012-10-04 Metahelix Life Sciences Limited Séquence nucléotidique, cassette d'expression, évènements transgéniques, cellules et procédés associés
US10119149B2 (en) 2011-08-05 2018-11-06 Dow Agrosciences Llc Use of DIG3 insecticidal crystal protein in combination with cry1Ab for management of resistance in european cornborer
WO2013022743A1 (fr) * 2011-08-05 2013-02-14 Dow Agrosciences Llc Utilisation d'une protéine dig3 cristalline insecticide en combinaison avec crylab
CN103923204B (zh) * 2014-04-04 2016-06-08 湖北省生物农药工程研究中心 杀南方根结线虫的苏云金芽胞杆菌的活性物质及其应用
US10487123B2 (en) 2014-10-16 2019-11-26 Monsanto Technology Llc Chimeric insecticidal proteins toxic or inhibitory to lepidopteran pests
JP6626102B2 (ja) 2014-10-16 2019-12-25 モンサント テクノロジー エルエルシー 鱗翅目害虫に有毒または阻害性の新規キメラ殺虫性タンパク質
TW201615095A (zh) 2014-10-31 2016-05-01 陶氏農業科學公司 Ｄｉｇ－３０３殺蟲ｃｒｙ毒素
CA3192494A1 (fr) 2014-12-30 2016-07-07 Corteva Agriscience Llc Toxines cry1ca modifiees pour lutter contre les insectes nuisibles
AU2017342921B2 (en) 2016-10-10 2023-06-15 Monsanto Technology Llc Novel insect inhibitory proteins
US11008371B2 (en) 2016-10-19 2021-05-18 Pioneer Hi-Bred International, Inc. Broad spectrum insecticidal polypeptide against lepidopteran pests and methods of use thereof
US11692013B2 (en) * 2016-10-19 2023-07-04 Pioneer Hi-Bred International, Inc. Broad spectrum insecticidal polypeptide against lepidopteran pests and methods of use thereof
US11714090B2 (en) 2017-12-15 2023-08-01 Syngenta Participations Ag Non-antibody ligands for detecting target proteins
WO2020046701A1 (fr) * 2018-08-29 2020-03-05 Pioneer Hi-Bred International, Inc. Protéines insecticides et leurs procédés d'utilisation
CN120476134A (zh) * 2022-11-04 2025-08-12 巴西农业研究公司-恩布拉帕 截短的嵌合杀虫蛋白
CN119504958B (zh) * 2025-01-20 2025-03-25 中国农业科学院植物保护研究所 一种突变的杀虫蛋白及其在防治美国白蛾中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341092C (fr) 1985-12-12 2000-09-05 David L. Edwards Procede de modification de la gamme d'hotes des toxines de bacillus thuringiensis, ainsi que de nouvelles toxines obtenues par ce procede
ATE120801T1 (de) * 1988-09-06 1995-04-15 Plant Genetic Systems Nv Pflanzen, die mit einer lepidopteralen dns- sequenz aus bazillus thuringiensis transformiert werden.
IT1231157B (it) * 1989-07-20 1991-11-19 Crc Ricerca Chim Nuovi geni ibridi funzionali di bacillus thuringiensis ottenuti mediante ricombinazione in vivo.
WO1991010725A1 (fr) * 1990-01-22 1991-07-25 Dekalb Plant Genetics Plantes de mais transgeniques fertiles
GB9318207D0 (en) 1993-09-02 1993-10-20 Sandoz Ltd Improvements in or relating to organic compounds
US5593881A (en) * 1994-05-06 1997-01-14 Mycogen Corporation Bacillus thuringiensis delta-endotoxin
US5527883A (en) 1994-05-06 1996-06-18 Mycogen Corporation Delta-endotoxin expression in pseudomonas fluorescens
US5508264A (en) 1994-12-06 1996-04-16 Mycogen Corporation Pesticidal compositions

Also Published As

Publication number Publication date
US6204246B1 (en) 2001-03-20
BR9407377A (pt) 1996-07-16
PL313317A1 (en) 1996-06-24
EP0719335A1 (fr) 1996-07-03
KR100360918B1 (ko) 2005-01-15
ES2262136T3 (es) 2006-11-16
IL110829A0 (en) 1994-11-11
ATE329033T1 (de) 2006-06-15
UA57698C2 (uk) 2003-07-15
AU691522B2 (en) 1998-05-21
CA2168011A1 (fr) 1995-03-09
WO1995006730A1 (fr) 1995-03-09
RU2210593C2 (ru) 2003-08-20
JPH09502343A (ja) 1997-03-11
DE69434758D1 (de) 2006-07-20
AU7693294A (en) 1995-03-22
CA2168011C (fr) 2007-11-06
EP0719335B1 (fr) 2006-06-07
DE69434758T2 (de) 2006-11-09
US5736131A (en) 1998-04-07
IL110829A (en) 2006-08-20
GB9318207D0 (en) 1993-10-20
PL181408B1 (pl) 2001-07-31
TW430669B (en) 2001-04-21

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