ZA948169B - Peptidyl derivatives and processes for their preparation - Google Patents

Peptidyl derivatives and processes for their preparation

Info

Publication number
ZA948169B
ZA948169B ZA948169A ZA948169A ZA948169B ZA 948169 B ZA948169 B ZA 948169B ZA 948169 A ZA948169 A ZA 948169A ZA 948169 A ZA948169 A ZA 948169A ZA 948169 B ZA948169 B ZA 948169B
Authority
ZA
South Africa
Prior art keywords
pct
derivatives
processes
preparation
sec
Prior art date
Application number
ZA948169A
Other languages
English (en)
Inventor
John Richard Morphy
Thomas Andrew Millicam
Original Assignee
Celltech Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939308696A external-priority patent/GB9308696D0/en
Priority to JP6524026A priority Critical patent/JPH08500124A/ja
Priority to ES94913709T priority patent/ES2134939T3/es
Priority to AT94913709T priority patent/ATE182137T1/de
Priority to EP94913709A priority patent/EP0648205B1/de
Priority to US08/356,315 priority patent/US5714491A/en
Priority to PCT/GB1994/000895 priority patent/WO1994025434A1/en
Priority to DE69419473T priority patent/DE69419473T2/de
Priority to AU65753/94A priority patent/AU6575394A/en
Priority to CA002139128A priority patent/CA2139128A1/en
Application filed by Celltech Therapeutics Ltd filed Critical Celltech Therapeutics Ltd
Priority to ZA948169A priority patent/ZA948169B/xx
Publication of ZA948169B publication Critical patent/ZA948169B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/38—Eight-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/61—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA948169A 1993-04-27 1994-10-18 Peptidyl derivatives and processes for their preparation ZA948169B (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CA002139128A CA2139128A1 (en) 1993-04-27 1994-04-27 Peptidyl derivatives as metalloproteinase inhibitors
ES94913709T ES2134939T3 (es) 1993-04-27 1994-04-27 Derivados de peptidilo como inhibidores de metaloproteinas.
AT94913709T ATE182137T1 (de) 1993-04-27 1994-04-27 Peptidylderivate als inhibitoren von metalloproteinase
EP94913709A EP0648205B1 (de) 1993-04-27 1994-04-27 Peptidylderivate als inhibitoren von metalloproteinase
US08/356,315 US5714491A (en) 1993-04-27 1994-04-27 Peptidyl derivatives as metalloproteinase inhibitors
JP6524026A JPH08500124A (ja) 1993-04-27 1994-04-27 メタロプロテイナーゼインヒビターとしてのペプチジル誘導体
PCT/GB1994/000895 WO1994025434A1 (en) 1993-04-27 1994-04-27 Peptidyl derivatives as metalloproteinase inhibitors
DE69419473T DE69419473T2 (de) 1993-04-27 1994-04-27 Peptidylderivate als inhibitoren von metalloproteinase
AU65753/94A AU6575394A (en) 1993-04-27 1994-04-27 Peptidyl derivatives as metalloproteinase inhibitors
ZA948169A ZA948169B (en) 1993-04-27 1994-10-18 Peptidyl derivatives and processes for their preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939308696A GB9308696D0 (en) 1993-04-27 1993-04-27 Peptidyl derivatives
ZA948169A ZA948169B (en) 1993-04-27 1994-10-18 Peptidyl derivatives and processes for their preparation

Publications (1)

Publication Number Publication Date
ZA948169B true ZA948169B (en) 1996-04-18

Family

ID=26302820

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA948169A ZA948169B (en) 1993-04-27 1994-10-18 Peptidyl derivatives and processes for their preparation

Country Status (10)

Country Link
US (1) US5714491A (de)
EP (1) EP0648205B1 (de)
JP (1) JPH08500124A (de)
AT (1) ATE182137T1 (de)
AU (1) AU6575394A (de)
CA (1) CA2139128A1 (de)
DE (1) DE69419473T2 (de)
ES (1) ES2134939T3 (de)
WO (1) WO1994025434A1 (de)
ZA (1) ZA948169B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
FI962905A0 (fi) * 1994-01-22 1996-07-19 British Biotech Pharm Metalloproteinaasi-inhibiittoreita
GB2300188B (en) * 1994-01-22 1998-07-01 British Biotech Pharm Metalloproteinase inhibitors
GB9423914D0 (en) * 1994-11-26 1995-01-11 British Biotech Pharm Polyether derivatives as metalloproteinase inhibitors
US5917090A (en) * 1995-06-30 1999-06-29 British Biotech Pharmaceuticals Ltd. Matrix metalloproteinase inhibitors
ES2164264T3 (es) 1995-11-23 2002-02-16 British Biotech Pharm Inhibidores de metaloproteinasas.
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
DE69624081T2 (de) * 1995-12-20 2003-06-12 Agouron Pharmaceuticals, Inc. Matrix-metalloprotease Inhibitoren
AU1812197A (en) * 1996-03-01 1997-09-16 Sankyo Company Limited Hydroxamic acid derivatives
WO1997041441A1 (en) * 1996-04-26 1997-11-06 Children's Medical Center Corporation Non-invasive enzyme screen for tissue remodelling-associated conditions
US6811995B1 (en) 1996-04-26 2004-11-02 Children's Medical Center Corporation Non-invasive enzyme screen for cancer
US5767274A (en) * 1996-06-28 1998-06-16 Biomeasure, Incorporated Prenyl transferase inhibitors
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
BR9712019A (pt) 1996-09-10 1999-08-24 British Biotech Pharm Derivados de cidos hirox-mico citoest ticos
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US20020099004A1 (en) * 1996-12-06 2002-07-25 Lund Leif Roge Inhibition of invasive remodelling
US5952320A (en) * 1997-01-07 1999-09-14 Abbott Laboratories Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
ATE258063T1 (de) * 1997-03-03 2004-02-15 Darwin Discovery Ltd Selektive mmp inhibitoren mit verringerten nebenwirkungen
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
GB9707333D0 (en) 1997-04-11 1997-05-28 British Biotech Pharm Metalloproteinase inhibitors
WO1999021583A1 (en) * 1997-10-29 1999-05-06 Warner-Lambert Company Method of inhibiting metastases of cancer cells
NZ504683A (en) 1998-01-09 2002-06-28 Pfizer Amide derivatives and pharmaceutical compositions thereof and their use as matrix metalloprotease inhibitors
GB9803005D0 (en) 1998-02-12 1998-04-08 British Biotech Pharm Anti-inflammatory agents
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
US6696456B1 (en) 1999-10-14 2004-02-24 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
EP1265864A1 (de) * 2000-03-21 2002-12-18 The Procter & Gamble Company Heterozyklische seitenkette enhaltende, n-substituierte metalloproteaseinhibitoren
IL151250A0 (en) * 2000-03-21 2003-04-10 Procter & Gamble Difluorobutyric acid metalloprotease inhibitors
PL357275A1 (en) * 2000-03-21 2004-07-26 The Procter & Gamble Company Carbocyclic side chain containing metalloprotease inhibitors
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
ES2283589T3 (es) 2001-06-15 2007-11-01 Vicuron Pharmaceuticals, Inc. Compuestos biciclicos de pirrolidina.
WO2004060425A2 (en) * 2002-12-27 2004-07-22 Angiotech International Ag Compositions and methods of using collagen and mmpi

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8919251D0 (en) * 1989-08-24 1989-10-04 British Bio Technology Compounds
WO1992009565A1 (en) * 1990-12-03 1992-06-11 Celltech Limited Peptidyl derivatives

Also Published As

Publication number Publication date
ES2134939T3 (es) 1999-10-16
EP0648205A1 (de) 1995-04-19
AU6575394A (en) 1994-11-21
EP0648205B1 (de) 1999-07-14
US5714491A (en) 1998-02-03
WO1994025434A1 (en) 1994-11-10
DE69419473T2 (de) 2000-03-16
ATE182137T1 (de) 1999-07-15
DE69419473D1 (de) 1999-08-19
JPH08500124A (ja) 1996-01-09
CA2139128A1 (en) 1994-11-10

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