ZA949246B - Use of,and method of treatment using , hydroxycarbazole compounds for inhibition of smooth muscle migration and proliferation. - Google Patents

Use of,and method of treatment using , hydroxycarbazole compounds for inhibition of smooth muscle migration and proliferation.

Info

Publication number: ZA949246B
Authority: ZA; South Africa
Prior art keywords: proliferation; smooth muscle; inhibition; treatment; hydroxycarbazole
Prior art date: 1993-11-24

Application number

ZA949246A

Other languages

English (en)

Inventor

Tian-Li Yue

Eliot H Ohlstein

Giora Z Feuerstein

Original Assignee

Boehringer Mannheim Pharm Corp

Smithkline Beecham Corp Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-24

Filing date

1994-11-22

Publication date

1995-07-04

1994-11-22 Application filed by Boehringer Mannheim Pharm Corp, Smithkline Beecham Corp Ltd filed Critical Boehringer Mannheim Pharm Corp

1995-07-04 Publication of ZA949246B publication Critical patent/ZA949246B/xx

Links

QBPAUIDFWFXLKB-UHFFFAOYSA-N 9h-carbazol-1-ol Chemical class N1C2=CC=CC=C2C2=C1C(O)=CC=C2 QBPAUIDFWFXLKB-UHFFFAOYSA-N 0.000 title abstract 3
238000013508 migration Methods 0.000 title abstract 2
230000005012 migration Effects 0.000 title abstract 2
230000035755 proliferation Effects 0.000 title abstract 2
230000005764 inhibitory process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
210000002460 smooth muscle Anatomy 0.000 title 1
230000002265 prevention Effects 0.000 abstract 2
201000001320 Atherosclerosis Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
206010072810 Vascular wall hypertrophy Diseases 0.000 abstract 1
OGHNVEJMJSYVRP-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=C1C1=CC=CC=C1N2 OGHNVEJMJSYVRP-UHFFFAOYSA-N 0.000 abstract 1
229960004195 carvedilol Drugs 0.000 abstract 1
238000007887 coronary angioplasty Methods 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000002207 metabolite Substances 0.000 abstract 1
208000037803 restenosis Diseases 0.000 abstract 1
210000000329 smooth muscle myocyte Anatomy 0.000 abstract 1
230000001629 suppression Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

ZA949246A 1993-11-24 1994-11-22 Use of,and method of treatment using , hydroxycarbazole compounds for inhibition of smooth muscle migration and proliferation. ZA949246B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/157,588 US5393772A (en)	1993-11-24	1993-11-24	Use of, and method of treatment using, hydroxycarbazole compounds for inhibition of smooth muscle migration and proliferation

Publications (1)

Publication Number	Publication Date
ZA949246B true ZA949246B (en)	1995-07-04

Family

ID=22564393

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA949246A ZA949246B (en)	1993-11-24	1994-11-22	Use of,and method of treatment using , hydroxycarbazole compounds for inhibition of smooth muscle migration and proliferation.

Country Status (12)

Country	Link
US (1)	US5393772A (ja)
EP (1)	EP0741567B1 (ja)
JP (1)	JPH09505809A (ja)
KR (1)	KR100386229B1 (ja)
CN (1)	CN1102388C (ja)
AT (1)	ATE226072T1 (ja)
AU (1)	AU686706B2 (ja)
CA (1)	CA2176377A1 (ja)
DE (1)	DE69431568T2 (ja)
ES (1)	ES2185691T3 (ja)
WO (1)	WO1995014384A1 (ja)
ZA (1)	ZA949246B (ja)

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US6251920B1 (en)	1993-05-13	2001-06-26	Neorx Corporation	Prevention and treatment of cardiovascular pathologies
US6395494B1 (en) *	1993-05-13	2002-05-28	Neorx Corporation	Method to determine TGF-β
US6306421B1 (en)	1992-09-25	2001-10-23	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5770609A (en)	1993-01-28	1998-06-23	Neorx Corporation	Prevention and treatment of cardiovascular pathologies
US5981568A (en)	1993-01-28	1999-11-09	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en)	1993-05-13	2002-12-10	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5595722A (en) *	1993-01-28	1997-01-21	Neorx Corporation	Method for identifying an agent which increases TGF-beta levels
US6663881B2 (en)	1993-01-28	2003-12-16	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
WO1994026303A1 (en) *	1993-05-13	1994-11-24	Neorx Corporation	Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
US20030083733A1 (en) *	1997-10-10	2003-05-01	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US20020091433A1 (en) *	1995-04-19	2002-07-11	Ni Ding	Drug release coated stent
US6099562A (en) *	1996-06-13	2000-08-08	Schneider (Usa) Inc.	Drug coating with topcoat
US5837313A (en) *	1995-04-19	1998-11-17	Schneider (Usa) Inc	Drug release stent coating process
JPH11510479A (ja) *	1995-06-07	1999-09-14	ネオルックスコーポレイション	タモキシフェン類似体による心臓血管疾病の予防及び治療
US7611533B2 (en) *	1995-06-07	2009-11-03	Cook Incorporated	Coated implantable medical device
ZA967892B (en) *	1995-09-21	1998-03-18	Lilly Co Eli	Selective β3 adrenergic agonists.
AU4083097A (en) *	1996-08-23	1998-03-06	Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership No. 1	Method for inhibiting the expression of fas
DE69711519T2 (de)	1996-09-05	2002-10-31	Eli Lilly And Co., Indianapolis	Carbazolanaloge als selektive beta3-adrenergische Agonisten
US5808080A (en) *	1996-09-05	1998-09-15	Eli Lilly And Company	Selective β3 adrenergic agonists
WO1998015272A1 (en) *	1996-10-09	1998-04-16	BOEHRINGER MANNHEIM PHARMACEUTICALS CORP. - SMITHKLINE BEECHAM CORPORATION, LIMITED PARTNERSHIP No.1	Method for inhibiting stress-activated protein kinases
AU765934B2 (en) *	1996-10-09	2003-10-02	Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership No. 1	Method for inhibiting stress-activated protein kinases
US6273913B1 (en)	1997-04-18	2001-08-14	Cordis Corporation	Modified stent useful for delivery of drugs along stent strut
CO5011072A1 (es) *	1997-12-05	2001-02-28	Lilly Co Eli	Etanolaminas pirazinil substituidas como agfonistas de los receptores
DE19830472B4 (de) *	1998-07-08	2013-06-27	Robert Bosch Gmbh	Externe Komponente für ein Mikroprozessorsystem und Betriebsverfahren
US6776796B2 (en)	2000-05-12	2004-08-17	Cordis Corportation	Antiinflammatory drug and delivery device
US20040243097A1 (en) *	2000-05-12	2004-12-02	Robert Falotico	Antiproliferative drug and delivery device
US7300662B2 (en)	2000-05-12	2007-11-27	Cordis Corporation	Drug/drug delivery systems for the prevention and treatment of vascular disease
US20050002986A1 (en) *	2000-05-12	2005-01-06	Robert Falotico	Drug/drug delivery systems for the prevention and treatment of vascular disease
US8236048B2 (en) *	2000-05-12	2012-08-07	Cordis Corporation	Drug/drug delivery systems for the prevention and treatment of vascular disease
US20020111590A1 (en) *	2000-09-29	2002-08-15	Davila Luis A.	Medical devices, drug coatings and methods for maintaining the drug coatings thereon
US20020051730A1 (en) *	2000-09-29	2002-05-02	Stanko Bodnar	Coated medical devices and sterilization thereof
US7261735B2 (en) *	2001-05-07	2007-08-28	Cordis Corporation	Local drug delivery devices and methods for maintaining the drug coatings thereon
AU9486901A (en) *	2000-09-29	2002-04-08	Cordis Corp	Coated medical devices
US6613083B2 (en) *	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
US7195640B2 (en) *	2001-09-25	2007-03-27	Cordis Corporation	Coated medical devices for the treatment of vulnerable plaque
WO2003029214A1 (en) *	2001-09-28	2003-04-10	F. Hoffmann-La Roche Ag	Pseudopolymorphic forms of carvedilol
US7108701B2 (en) *	2001-09-28	2006-09-19	Ethicon, Inc.	Drug releasing anastomosis devices and methods for treating anastomotic sites
US20030065377A1 (en) *	2001-09-28	2003-04-03	Davila Luis A.	Coated medical devices
US20030065345A1 (en) *	2001-09-28	2003-04-03	Kevin Weadock	Anastomosis devices and methods for treating anastomotic sites
US8101209B2 (en) *	2001-10-09	2012-01-24	Flamel Technologies	Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
JP2006500320A (ja) *	2002-04-30	2006-01-05	エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド	カルベジロール一クエン酸塩一水和物
MXPA04012923A (es) *	2002-06-27	2005-03-31	Sb Pharmco Inc	Sales de fosfato de carvedilol y/o solvatos de las mismas, composiciones correspondientes y/o metodos de tratamiento.
AU2003251627A1 (en) *	2002-06-27	2004-01-19	Sb Pharmco Puerto Rico Inc.	Carvedilol hydrobromide
US20050169994A1 (en) *	2003-11-25	2005-08-04	Burke Matthew D.	Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods
WO2005051322A2 (en) *	2003-11-25	2005-06-09	Sb Pharmco Puerto Rico Inc.	Controlled release pharmaceutical formulations comprising carvedilol, free based and its salts
JP2007512372A (ja) *	2003-11-25	2007-05-17	エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド	カルベジロール塩、対応する組成物、送達および／または治療方法
US10281374B2 (en) *	2015-11-04	2019-05-07	Diagnostic Biosystems	Method of pretreatment of biological samples for an analyte-staining assay method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2815926A1 (de) *	1978-04-13	1979-10-18	Boehringer Mannheim Gmbh	Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5308862A (en) *	1993-03-05	1994-05-03	Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beecham Corp., Ltd. Partnership No. 1	Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation

1993
- 1993-11-24 US US08/157,588 patent/US5393772A/en not_active Expired - Lifetime
1994
- 1994-11-22 CA CA002176377A patent/CA2176377A1/en not_active Abandoned
- 1994-11-22 AT AT95902689T patent/ATE226072T1/de not_active IP Right Cessation
- 1994-11-22 EP EP95902689A patent/EP0741567B1/en not_active Expired - Lifetime
- 1994-11-22 KR KR1019960702460A patent/KR100386229B1/ko not_active Expired - Fee Related
- 1994-11-22 CN CN94194188A patent/CN1102388C/zh not_active Expired - Fee Related
- 1994-11-22 JP JP7515231A patent/JPH09505809A/ja active Pending
- 1994-11-22 ZA ZA949246A patent/ZA949246B/xx unknown
- 1994-11-22 ES ES95902689T patent/ES2185691T3/es not_active Expired - Lifetime
- 1994-11-22 DE DE69431568T patent/DE69431568T2/de not_active Expired - Fee Related
- 1994-11-22 AU AU11867/95A patent/AU686706B2/en not_active Ceased
- 1994-11-22 WO PCT/US1994/013561 patent/WO1995014384A1/en not_active Ceased

Also Published As

Publication number	Publication date
CN1102388C (zh)	2003-03-05
CA2176377A1 (en)	1995-06-01
JPH09505809A (ja)	1997-06-10
AU686706B2 (en)	1998-02-12
CN1135161A (zh)	1996-11-06
KR100386229B1 (ko)	2003-08-21
WO1995014384A1 (en)	1995-06-01
AU1186795A (en)	1995-06-13
EP0741567A1 (en)	1996-11-13
EP0741567B1 (en)	2002-10-16
DE69431568T2 (de)	2003-06-26
ATE226072T1 (de)	2002-11-15
US5393772A (en)	1995-02-28
DE69431568D1 (de)	2002-11-21
EP0741567A4 (ja)	1996-12-04
ES2185691T3 (es)	2003-05-01

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EP0741567A4 (ja)	1996-12-04
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HU9500704D0 (en)	1995-04-28	Use of cytochrome p450 inhibitors for inhibiting the metabolism of nitrogen substituted acridine
NO994903L (no)	1999-12-09	Behandling eller profylakse av prostatakreft og benign prostatahyperplasi med selektive östrogenreseptormodulatorer
WO1996035805A3 (fr)	1997-01-30	Inhibiteurs de tripeptidylpeptidases
DE69405760D1 (de)	1997-10-23	4-aza-pregnan-5-alpha-reductase isozym 1 inhibitoren