ZA959320B - Process for preparing 1-(2'-deoxy-2',2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one) hydrochloride - Google Patents

Process for preparing 1-(2'-deoxy-2',2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one) hydrochloride

Info

Publication number: ZA959320B
Authority: ZA; South Africa
Prior art keywords: aminopyrimidin; ribofuranosyl; deoxy; difluoro; hydrochloride
Prior art date: 1994-12-13

Application number

ZA959320A

Other languages

English (en)

Inventor

Richard Alan Berglund

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-13

Filing date

1995-11-03

Publication date

1997-05-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23397211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA959320(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-11-03 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1997-05-05 Publication of ZA959320B publication Critical patent/ZA959320B/xx

Links

VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA959320A 1994-12-13 1995-11-03 Process for preparing 1-(2'-deoxy-2',2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one) hydrochloride ZA959320B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/355,372 US5637688A (en)	1994-12-13	1994-12-13	Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride

Publications (1)

Publication Number	Publication Date
ZA959320B true ZA959320B (en)	1997-05-05

Family

ID=23397211

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA959320A ZA959320B (en)	1994-12-13	1995-11-03	Process for preparing 1-(2'-deoxy-2',2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one) hydrochloride

Country Status (31)

Country	Link
US (2)	US5637688A (de)
EP (1)	EP0719788B1 (de)
JP (1)	JPH10510806A (de)
KR (1)	KR100424991B1 (de)
CN (1)	CN1047177C (de)
AR (1)	AR001041A1 (de)
AT (1)	ATE179986T1 (de)
AU (1)	AU689674B2 (de)
BG (1)	BG62738B1 (de)
BR (1)	BR9509979A (de)
CO (1)	CO4520286A1 (de)
CZ (1)	CZ290941B6 (de)
DE (1)	DE69509624T2 (de)
DK (1)	DK0719788T3 (de)
ES (1)	ES2130542T3 (de)
GR (1)	GR3030265T3 (de)
HU (1)	HU219021B (de)
IL (1)	IL115852A (de)
MY (1)	MY112488A (de)
NO (1)	NO306783B1 (de)
NZ (1)	NZ296476A (de)
PE (1)	PE49296A1 (de)
PL (1)	PL181732B1 (de)
RO (1)	RO117327B1 (de)
RU (1)	RU2154648C2 (de)
SI (1)	SI0719788T1 (de)
TW (1)	TW379226B (de)
UA (1)	UA48152C2 (de)
WO (1)	WO1996018637A1 (de)
YU (1)	YU49314B (de)
ZA (1)	ZA959320B (de)

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US5637688A (en) *	1994-12-13	1997-06-10	Eli Lilly And Company	Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
EP0870506A1 (de) *	1997-04-11	1998-10-14	Eli Lilly And Company	Zusammentsetzungen enthaltend ein Cryptophycin Derivat in Kombination mit einem synchronisierten Wirkstoff oder Aktivierungsmittel zur Behandlung von Krebs
PT1041985E (pt) *	1997-12-22	2006-07-31	Schering Corp	Combinacao de compostos benzociclo-heptapiridina e farmacos antineoplasicos para tratar doencas proliferativas
US6376470B1 (en)	1999-09-23	2002-04-23	Enzon, Inc.	Polymer conjugates of ara-C and ara-C derivatives
WO2002028387A1 (en) *	2000-10-03	2002-04-11	Oncopharmaceutical, Inc.	Inhibitors of angiogenesis and tumor growth for local and systemic administration
WO2005014010A1 (en) *	2003-07-24	2005-02-17	Eli Lilly And Company	Pharmaceutical composition comprising gemcitabine and cyclodextrines
US7214791B2 (en) *	2004-07-01	2007-05-08	Shenzhen Hande Technology Co., Ltd.	Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
CN101076536A (zh) *	2004-07-30	2007-11-21	药华医药股份有限公司	β－核苷的立体选择性合成
WO2006070985A1 (en) *	2004-12-30	2006-07-06	Hanmi Pharm. Co., Ltd.	METHOD FOR THE PREPARATION OF 2&num;-DEOXY-2&num;,2&num;-DIFLUOROCYTIDINE
DE602005019626D1 (de) *	2005-03-04	2010-04-08	Fresenius Kabi Oncology Ltd	Zwischenprodukt und verfahren zur herstellung von an beta-anomeren angereicherten 2'-desoxy,2',2'-difluor-d-ribufuranosylnukleosiden
WO2006095359A1 (en) *	2005-03-10	2006-09-14	Sms Pharmaceuticals Limited	Synthesis of 2-deoxy-2, 2-di fluoro-d-ribo furanose-3, 5 di(4-methy/4-nitro-chloro)benzoate and its conversion to gemcitabine hydrochloride thereof
WO2006119347A1 (en) *	2005-05-02	2006-11-09	Pharmaessentia Corp.	STEREOSELECTIVE SYNTHESIS OF β-NUCLEOSIDES
CN100391966C (zh) *	2005-06-17	2008-06-04	华东师范大学	一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
WO2007049294A1 (en) *	2005-10-28	2007-05-03	Arch Pharmalabs Limited	An improved process for preparation of gemcitabine hydrochloride.
KR101259637B1 (ko) *	2005-12-14	2013-04-30	주식회사종근당	1-(2´-데옥시-2´,2´-디플루오로-디-리보푸라노실)-4-아미노피리미딘-2-온또는 그의 염산염의 제조방법
RU2345087C2 (ru) *	2006-02-06	2009-01-27	Др. Редди`С Лабораторис Лтд.	Способ получения и очистки гемцитабина гидрохлорида
WO2008045419A1 (en) *	2006-10-10	2008-04-17	Pharmasset, Inc.	Preparation of nucleosides ribofuranosyl pyrimidines
US20090069354A1 (en) *	2007-09-12	2009-03-12	Protia, Llc	Deuterium-enriched gemcitabine
JO2778B1 (en)	2007-10-16	2014-03-15	ايساي انك	Certain Compounds, Compositions and Methods
KR20100102107A (ko) *	2007-11-06	2010-09-20	파마이센시아 코퍼레이션	β-뉴클레오시드의 새로운 합성 방법
IT1393062B1 (it) *	2008-10-23	2012-04-11	Prime Europ Therapeuticals	Procedimento per la preparazione di gemcitabina cloridrato
UY32546A (es) *	2009-04-06	2010-10-29	Eisai Inc	Composiciones y metodos para tratar cancer
EP2416781B1 (de) *	2009-04-06	2017-03-08	Otsuka Pharmaceutical Co., Ltd.	Kombination von antineoplastischen arzneimitteln auf cytidin-basis mit cytidin-deaminase-inhibitor und ihre verwendung in der krebstherapie
TWI477508B (zh) *	2009-04-06	2015-03-21	Otsuka Pharma Co Ltd	用以治療癌症之組成物及方法
US8609631B2 (en)	2009-04-06	2013-12-17	Eisai Inc.	Compositions and methods for treating cancer
CN101525361B (zh) *	2009-04-21	2010-11-17	济南圣鲁金药物技术开发有限公司	基于吉西他滨结构的前药及其合成方法及应用
EP2431376B2 (de) *	2009-05-15	2024-02-07	Delta-Fly Pharma, Inc.	Neuer stabiler kristall aus 1-(2'-cyan-2'-desoxy-beta-d-arabinofuranosyl)cytosin-monohydrochlorid
CN101628927B (zh) *	2009-08-07	2012-10-10	卡硼瑞（北京）科技有限公司	以1,3,5-三-O-苯甲酰基-α-D-呋喃核糖为原料立体选择性制备β-二氟胞苷盐酸盐的方法
CN102453064B (zh) *	2011-06-30	2014-07-09	江苏豪森药业股份有限公司	制备吉西他滨盐酸盐的方法
CN102659884B (zh) *	2012-04-23	2014-07-02	南京臣功制药股份有限公司	盐酸吉西他滨的提纯方法
CN103224541B (zh) *	2013-04-27	2015-07-01	江苏豪森药业股份有限公司	吉西他滨α-异构体转化回收工艺
CN104402945A (zh) *	2014-11-27	2015-03-11	苏州乔纳森新材料科技有限公司	一种3-脱氧-1,2-o-异丙叉-d-呋喃木糖的合成方法

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US3817978A (en) *	1971-06-16	1974-06-18	Syntex Inc	4-fluoro nucleosides and sugar intermediates, and methods of preparing
JPS5924999B2 (ja) *	1978-06-10	1984-06-13	富山化学工業株式会社	新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体の製造法
US4526988A (en) *	1983-03-10	1985-07-02	Eli Lilly And Company	Difluoro antivirals and intermediate therefor
DE3587500T2 (de) *	1984-12-04	1993-12-16	Lilly Co Eli	Tumorbehandlung bei Säugetieren.
US5223608A (en) *	1987-08-28	1993-06-29	Eli Lilly And Company	Process for and intermediates of 2',2'-difluoronucleosides
US4965374A (en) *	1987-08-28	1990-10-23	Eli Lilly And Company	Process for and intermediates of 2',2'-difluoronucleosides
BR9302431A (pt) *	1992-06-22	1994-01-11	Lilly Co Eli	Processo de glicosilacao de anion estereosseletivo
AU4134793A (en) *	1992-06-22	1993-12-23	Eli Lilly And Company	2'-deoxy-2',2'-difluoro(2,6,8-substituted) purine nucleosides having anti-viral and anti-cancer activity and intermediates
UA41261C2 (uk) *	1992-06-22	2001-09-17	Елі Ліллі Енд Компані	Спосіб одержання збагачених бета-аномером нуклеозидів
CA2105112C (en) *	1992-09-01	2005-08-02	Thomas C. Britton	A process for anomerizing nucleosides
US5637688A (en) *	1994-12-13	1997-06-10	Eli Lilly And Company	Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride

1994
- 1994-12-13 US US08/355,372 patent/US5637688A/en not_active Expired - Lifetime
1995
- 1995-11-01 AR AR33407495A patent/AR001041A1/es unknown
- 1995-11-02 PE PE1995283631A patent/PE49296A1/es not_active IP Right Cessation
- 1995-11-02 IL IL11585295A patent/IL115852A/xx not_active IP Right Cessation
- 1995-11-03 ZA ZA959320A patent/ZA959320B/xx unknown
- 1995-11-09 DK DK95308030T patent/DK0719788T3/da active
- 1995-11-09 AT AT95308030T patent/ATE179986T1/de active
- 1995-11-09 SI SI9530272T patent/SI0719788T1/xx unknown
- 1995-11-09 ES ES95308030T patent/ES2130542T3/es not_active Expired - Lifetime
- 1995-11-09 DE DE69509624T patent/DE69509624T2/de not_active Expired - Lifetime
- 1995-11-09 EP EP95308030A patent/EP0719788B1/de not_active Expired - Lifetime
- 1995-11-10 CO CO95053319A patent/CO4520286A1/es unknown
- 1995-11-13 YU YU70895A patent/YU49314B/sh unknown
- 1995-11-14 NZ NZ296476A patent/NZ296476A/xx not_active IP Right Cessation
- 1995-11-14 CN CN95196792A patent/CN1047177C/zh not_active Expired - Fee Related
- 1995-11-14 KR KR1019970703880A patent/KR100424991B1/ko not_active Expired - Fee Related
- 1995-11-14 UA UA97062781A patent/UA48152C2/uk unknown
- 1995-11-14 RU RU97111801/04A patent/RU2154648C2/ru not_active IP Right Cessation
- 1995-11-14 HU HU9800673A patent/HU219021B/hu not_active IP Right Cessation
- 1995-11-14 BR BR9509979A patent/BR9509979A/pt not_active Application Discontinuation
- 1995-11-14 JP JP8518835A patent/JPH10510806A/ja active Pending
- 1995-11-14 CZ CZ19971798A patent/CZ290941B6/cs not_active IP Right Cessation
- 1995-11-14 PL PL95321046A patent/PL181732B1/pl unknown
- 1995-11-14 WO PCT/US1995/014864 patent/WO1996018637A1/en not_active Ceased
- 1995-11-14 TW TW084112041A patent/TW379226B/zh not_active IP Right Cessation
- 1995-11-14 RO RO97-01060A patent/RO117327B1/ro unknown
- 1995-11-14 AU AU41101/96A patent/AU689674B2/en not_active Ceased
- 1995-11-16 MY MYPI95003490A patent/MY112488A/en unknown
1997
- 1997-04-11 US US08/837,071 patent/US5808048A/en not_active Expired - Lifetime
- 1997-06-10 BG BG101591A patent/BG62738B1/bg unknown
- 1997-06-11 NO NO972679A patent/NO306783B1/no not_active IP Right Cessation
1999
- 1999-05-19 GR GR990401358T patent/GR3030265T3/el unknown

Also Published As

Publication number	Publication date
WO1996018637A1 (en)	1996-06-20
CZ179897A3 (en)	1997-09-17
BR9509979A (pt)	1998-06-09
AU4110196A (en)	1996-07-03
JPH10510806A (ja)	1998-10-20
EP0719788B1 (de)	1999-05-12
UA48152C2 (uk)	2002-08-15
IL115852A (en)	1999-09-22
SI0719788T1 (en)	1999-10-31
US5637688A (en)	1997-06-10
DE69509624D1 (de)	1999-06-17
CN1047177C (zh)	1999-12-08
ATE179986T1 (de)	1999-05-15
BG62738B1 (bg)	2000-06-30
PE49296A1 (es)	1996-11-21
CZ290941B6 (cs)	2002-11-13
KR100424991B1 (ko)	2004-05-20
HU219021B (hu)	2001-01-29
NO972679D0 (no)	1997-06-11
ES2130542T3 (es)	1999-07-01
AU689674B2 (en)	1998-04-02
NO306783B1 (no)	1999-12-20
NO972679L (no)	1997-06-11
RO117327B1 (ro)	2002-01-30
DK0719788T3 (da)	1999-11-01
MY112488A (en)	2001-06-30
GR3030265T3 (en)	1999-08-31
EP0719788A3 (de)	1996-09-25
YU49314B (sh)	2005-06-10
PL181732B1 (en)	2001-09-28
DE69509624T2 (de)	1999-10-07
PL321046A1 (en)	1997-11-24
TW379226B (en)	2000-01-11
US5808048A (en)	1998-09-15
AR001041A1 (es)	1997-09-24
NZ296476A (en)	1998-12-23
IL115852A0 (en)	1996-01-31
CO4520286A1 (es)	1997-10-15
RU2154648C2 (ru)	2000-08-20
EP0719788A2 (de)	1996-07-03
YU70895A (sh)	1998-09-18
CN1169728A (zh)	1998-01-07
MX9704322A (es)	1997-09-30
BG101591A (en)	1998-03-31
HUT77929A (hu)	1998-11-30

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