ZA963870B - Fluorine-containing benzoylguanidines - Google Patents

Fluorine-containing benzoylguanidines

Info

Publication number: ZA963870B
Authority: ZA; South Africa
Prior art keywords: cnfmh2n; mop; opt; het; halo
Prior art date: 1995-05-16

Application number

ZA963870A

Other languages

English (en)

Inventor

Dieter Dorsch

Manfred Baumgarth

Rolf Gericke

Klaus-Otto Minck

Norbert Beier

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-16

Filing date

1996-05-15

Publication date

1996-11-21

1996-05-15 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1996-11-21 Publication of ZA963870B publication Critical patent/ZA963870B/xx

Links

229910052731 fluorine Inorganic materials 0.000 title abstract 2
AJDQRQQNNLZLPM-UHFFFAOYSA-N n-(diaminomethylidene)benzamide Chemical class NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 title abstract 2
YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title 1
239000011737 fluorine Substances 0.000 title 1
125000001475 halogen functional group Chemical group 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Obesity (AREA)
Endocrinology (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Phenolic Resins Or Amino Resins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ZA963870A 1995-05-16 1996-05-15 Fluorine-containing benzoylguanidines ZA963870B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19517848A DE19517848A1 (de)	1995-05-16	1995-05-16	Fluorhaltige Benzoylguanidine

Publications (1)

Publication Number	Publication Date
ZA963870B true ZA963870B (en)	1996-11-21

Family

ID=7761987

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA963870A ZA963870B (en)	1995-05-16	1996-05-15	Fluorine-containing benzoylguanidines

Country Status (23)

Country	Link
US (1)	US5747539A (da)
EP (1)	EP0743301B1 (da)
JP (1)	JPH08311011A (da)
KR (1)	KR960041154A (da)
CN (1)	CN1064955C (da)
AT (1)	ATE204856T1 (da)
AU (1)	AU713743B2 (da)
CA (1)	CA2176553A1 (da)
CZ (1)	CZ287750B6 (da)
DE (2)	DE19517848A1 (da)
DK (1)	DK0743301T3 (da)
ES (1)	ES2161936T3 (da)
GR (1)	GR3037033T3 (da)
HU (1)	HU223046B1 (da)
NO (1)	NO306157B1 (da)
PL (1)	PL184192B1 (da)
PT (1)	PT743301E (da)
RU (1)	RU2159230C2 (da)
SI (1)	SI0743301T1 (da)
SK (1)	SK282052B6 (da)
TW (1)	TW363052B (da)
UA (1)	UA44260C2 (da)
ZA (1)	ZA963870B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4328352A1 (de)	1993-08-24	1995-03-02	Hoechst Ag	Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19606509A1 (de) *	1996-02-22	1997-08-28	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19608161A1 (de) *	1996-03-04	1997-09-11	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US5747639A (en) *	1996-03-06	1998-05-05	Amgen Boulder Inc.	Use of hydrophobic interaction chromatography to purify polyethylene glycols
DE19713427A1 (de) *	1997-04-01	1998-10-08	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ID29523A (id) *	1998-11-26	2001-09-06	Marck Patent Gmbh	Penggunaan benzoilgunidin-benzoilguanidin untuk pengobatan diabetes melitus yang tidak bergantung pada insulin
DE10222192A1 (de) *	2002-05-18	2003-11-27	Aventis Pharma Gmbh	Pentafluorsulfuranyl-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US7375138B2 (en)	2002-05-18	2008-05-20	Sanofi-Aventis Deutschland Gmbh	Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them
DE10226462A1 (de) *	2002-06-13	2003-12-24	Aventis Pharma Gmbh	Fluorierte Cycloalkyl-derivatisierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament
US20050124666A1 (en) *	2003-11-13	2005-06-09	Aventis Pharma Deutschland Gmbh	Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same
DE10353204A1 (de) *	2003-11-13	2005-06-16	Aventis Pharma Deutschland Gmbh	Verfahren zur Herstellung von 4-Pentafluorsulfanyl-benzoylguanidinen
OA13285A (en) *	2003-11-13	2007-01-31	Sanofi Aventis Deutschland	Pentafluorosulfanyl benzoylguanidines, method for their production, their use as medicaments or diagnostic agents and medicament containing the same.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3929582A1 (de) *	1989-09-06	1991-03-07	Hoechst Ag	Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
EP0556674B1 (de) *	1992-02-15	1996-06-19	Hoechst Aktiengesellschaft	3,5-Substituierte Benzoylguanidine, mit antiarrythmischer Wirkung und inhibierender Wirkung auf die Proliferationen von Zellen
CZ284456B6 (cs) *	1992-02-15	1998-12-16	Hoechst Aktiengesellschaft	Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
ATE158278T1 (de) *	1992-02-15	1997-10-15	Hoechst Ag	Ortho-substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
EP0589336B1 (de) *	1992-09-22	1997-01-08	Hoechst Aktiengesellschaft	Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika
TW250479B (da) *	1992-12-15	1995-07-01	Hoechst Ag
TW250477B (da) *	1992-12-15	1995-07-01	Hoechst Ag
DE59403818D1 (de) *	1993-02-20	1997-10-02	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament
DE4318756A1 (de) *	1993-06-05	1994-12-08	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4328869A1 (de) *	1993-08-27	1995-03-02	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4417004A1 (de) *	1994-05-13	1995-11-16	Hoechst Ag	Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4430916A1 (de) *	1994-08-31	1996-03-07	Merck Patent Gmbh	Alkyl-benzoylguanidin-Derivate

1995
- 1995-05-16 DE DE19517848A patent/DE19517848A1/de not_active Withdrawn
1996
- 1996-03-25 TW TW085103561A patent/TW363052B/zh active
- 1996-05-02 DK DK96106881T patent/DK0743301T3/da active
- 1996-05-02 EP EP96106881A patent/EP0743301B1/de not_active Expired - Lifetime
- 1996-05-02 ES ES96106881T patent/ES2161936T3/es not_active Expired - Lifetime
- 1996-05-02 PT PT96106881T patent/PT743301E/pt unknown
- 1996-05-02 AT AT96106881T patent/ATE204856T1/de not_active IP Right Cessation
- 1996-05-02 SI SI9630361T patent/SI0743301T1/xx unknown
- 1996-05-02 DE DE59607559T patent/DE59607559D1/de not_active Expired - Fee Related
- 1996-05-09 SK SK590-96A patent/SK282052B6/sk unknown
- 1996-05-13 CN CN961058854A patent/CN1064955C/zh not_active Expired - Fee Related
- 1996-05-13 AU AU52252/96A patent/AU713743B2/en not_active Ceased
- 1996-05-13 UA UA96051860A patent/UA44260C2/uk unknown
- 1996-05-14 CA CA002176553A patent/CA2176553A1/en not_active Abandoned
- 1996-05-15 HU HU9601305A patent/HU223046B1/hu not_active IP Right Cessation
- 1996-05-15 PL PL96314259A patent/PL184192B1/pl unknown
- 1996-05-15 US US08/647,789 patent/US5747539A/en not_active Expired - Fee Related
- 1996-05-15 ZA ZA963870A patent/ZA963870B/xx unknown
- 1996-05-15 RU RU96109204/04A patent/RU2159230C2/ru not_active IP Right Cessation
- 1996-05-15 KR KR1019960016096A patent/KR960041154A/ko not_active Abandoned
- 1996-05-15 CZ CZ19961408A patent/CZ287750B6/cs not_active IP Right Cessation
- 1996-05-15 NO NO961997A patent/NO306157B1/no not_active IP Right Cessation
- 1996-05-16 JP JP8144881A patent/JPH08311011A/ja active Pending
2001
- 2001-10-30 GR GR20010401903T patent/GR3037033T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
UA44260C2 (uk)	2002-02-15
HUP9601305A3 (en)	1997-11-28
EP0743301A2 (de)	1996-11-20
RU2159230C2 (ru)	2000-11-20
CZ140896A3 (en)	1997-02-12
HU223046B1 (hu)	2004-03-01
NO961997L (no)	1996-11-18
SK282052B6 (sk)	2001-10-08
DK0743301T3 (da)	2001-11-26
JPH08311011A (ja)	1996-11-26
AU713743B2 (en)	1999-12-09
EP0743301A3 (de)	1997-06-11
PL184192B1 (pl)	2002-09-30
US5747539A (en)	1998-05-05
NO306157B1 (no)	1999-09-27
CN1143632A (zh)	1997-02-26
HUP9601305A2 (en)	1997-05-28
CZ287750B6 (en)	2001-01-17
ATE204856T1 (de)	2001-09-15
NO961997D0 (no)	1996-05-15
HU9601305D0 (en)	1996-07-29
DE19517848A1 (de)	1996-11-21
AU5225296A (en)	1996-11-28
SK59096A3 (en)	1996-12-04
TW363052B (en)	1999-07-01
ES2161936T3 (es)	2001-12-16
KR960041154A (ko)	1996-12-19
PL314259A1 (en)	1996-11-25
DE59607559D1 (de)	2001-10-04
GR3037033T3 (en)	2002-01-31
PT743301E (pt)	2002-01-30
CN1064955C (zh)	2001-04-25
SI0743301T1 (en)	2002-02-28
EP0743301B1 (de)	2001-08-29
CA2176553A1 (en)	1996-11-17

Publication	Publication Date	Title
AU5225296A (en)	1996-11-28	Fluorine-containing benzoylguanidines
IL119698A0 (en)	1997-02-18	Novel 9- ([haloacyl) amido]-6-demethyl-6-deoxytetracycline intermediates
PT618190E (pt)	2004-08-31	9-¬glicil substituido)amido\|-6-(substituido)-5-hidroxi-6-desoxitetraciclinas
TW267927B (da)	1996-01-11
IL109658A0 (en)	1994-08-26	Herbicides
NO931917D0 (no)	1993-05-26	Farmasoeytiske forbindelser
AU1642488A (en)	1989-11-23	Antiarrhythmic agents
AU657397B2 (en)	1995-03-09	3,4-diaryl-(5H)-furan-2-one based compounds with fungicidal activity
MY129992A (en)	2007-05-31	Benzanilide herbicides and process for the preparation thereof
GB9325618D0 (en)	1994-02-16	New herbicides
ZA958909B (en)	1996-05-29	Alkyl-5-methylsulfonyl-benzoylguanidin-derivate
GB9520092D0 (en)	1995-12-06	Chemical compounds
BR9303455A (pt)	1994-03-22	Emprego de compostos,dispositivos e agentes de combate de baratas,compostos e processo para sua preparacao
RU1816770C (ru)	1993-05-23	Полисульфид-5-аминосалициловой кислоты в качестве светостабилизатора лакокрасочной композиции на основе битума
EP0645374A4 (en)	1995-02-14	5-AMINO-2-PHENOXYSULFONANILIDE DERIVATIVES.
CA2110132A1 (en)	1994-06-19	Inorganic/organic inhibitor for corrosion of iron containing materials in sulfur environment
MY103529A (en)	1993-07-31	Antiarrhythmic agents
ITPG910013A0 (it)	1991-09-04	L'autorotante con cannocchiale, molle, senza attrito
ES2025201B3 (es)	1992-03-16	Preparacion de intermediarios fosforados para uso herbicida.
ATE159253T1 (de)	1997-11-15	2-thiazolylpyrroleakrylate mit fungizider wirkung