ZA973793B - hGH-RH(1-29)NH2 analogues having antagonistic activity. - Google Patents

hGH-RH(1-29)NH2 analogues having antagonistic activity.

Info

Publication number: ZA973793B
Authority: ZA; South Africa
Prior art keywords: ala; abu; leu; arg; cit
Prior art date: 1996-05-03

Application number

ZA9703793A

Other languages

English (en)

Inventor

Andrew V Schally

Marta Zarandi

Katalin Toth

Original Assignee

Univ Tulane

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-03

Filing date

1997-05-02

Publication date

1997-11-19

1997-05-02 Application filed by Univ Tulane filed Critical Univ Tulane

1997-11-19 Publication of ZA973793B publication Critical patent/ZA973793B/xx

Links

125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 6
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical group OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 4
KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 abstract 4
-1 R3 is Asp Chemical compound 0.000 abstract 4
AHLPHDHHMVZTML-SCSAIBSYSA-N D-Ornithine Chemical compound NCCC[C@@H](N)C(O)=O AHLPHDHHMVZTML-SCSAIBSYSA-N 0.000 abstract 3
QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 3
ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical group OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 abstract 3
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 3
125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 abstract 3
DCXYFEDJOCDNAF-UWTATZPHSA-N D-Asparagine Chemical compound OC(=O)[C@H](N)CC(N)=O DCXYFEDJOCDNAF-UWTATZPHSA-N 0.000 abstract 2
CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 2
CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 abstract 2
ZDXPYRJPNDTMRX-GSVOUGTGSA-N D-glutamine Chemical compound OC(=O)[C@H](N)CCC(N)=O ZDXPYRJPNDTMRX-GSVOUGTGSA-N 0.000 abstract 2
ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 abstract 2
AYFVYJQAPQTCCC-STHAYSLISA-N D-threonine Chemical compound C[C@H](O)[C@@H](N)C(O)=O AYFVYJQAPQTCCC-STHAYSLISA-N 0.000 abstract 2
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 2
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical group C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 2
BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 2
QWCKQJZIFLGMSD-UHFFFAOYSA-N alpha-aminobutyric acid Chemical compound CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000002038 D-arginyl group Chemical group N[C@@H](C(=O)*)CCCNC(=N)N 0.000 abstract 1
WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 abstract 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical group OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
ULEBESPCVWBNIF-BYPYZUCNSA-N L-arginine amide Chemical compound NC(=O)[C@@H](N)CCCNC(N)=N ULEBESPCVWBNIF-BYPYZUCNSA-N 0.000 abstract 1
125000002059 L-arginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 abstract 1
125000000010 L-asparaginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C(=O)N([H])[H] 0.000 abstract 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical group OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 1
LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 abstract 1
125000000534 N(2)-L-lysino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C([H])([H])C(C([H])([H])N([H])[H])([H])[H] 0.000 abstract 1
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical compound CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
108010047254 alanyl-4-fluorophenylalanyl-arginyl-cyclohexylalanyl-citrulline-tyrosinamide Proteins 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
FXHCFPUEIDRTMR-UHFFFAOYSA-N hydron;1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;chloride Chemical compound Cl.C1=CC=C2CNC(C(=O)O)CC2=C1 FXHCFPUEIDRTMR-UHFFFAOYSA-N 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

ZA9703793A 1996-05-03 1997-05-02 hGH-RH(1-29)NH2 analogues having antagonistic activity. ZA973793B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/642,472 US5942489A (en)	1996-05-03	1996-05-03	HGH-RH(1-29)NH2 analogues having antagonistic activity

Publications (1)

Publication Number	Publication Date
ZA973793B true ZA973793B (en)	1997-11-19

Family

ID=24576702

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9703793A ZA973793B (en)	1996-05-03	1997-05-02	hGH-RH(1-29)NH2 analogues having antagonistic activity.

Country Status (12)

Country	Link
US (1)	US5942489A (da)
EP (1)	EP0914340B1 (da)
JP (1)	JP2001501585A (da)
AT (1)	ATE244731T1 (da)
AU (1)	AU3117297A (da)
CA (1)	CA2253663C (da)
DE (1)	DE69723448T2 (da)
DK (1)	DK0914340T3 (da)
ES (1)	ES2200178T3 (da)
PT (1)	PT914340E (da)
WO (1)	WO1997042223A1 (da)
ZA (1)	ZA973793B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6057422A (en) *	1998-11-25	2000-05-02	The Administrators Of The Tulane Educational Fund	Antagonistic analogs of GH-RH inhibiting IGF-I and -II
US20040121407A1 (en) *	2002-09-06	2004-06-24	Elixir Pharmaceuticals, Inc.	Regulation of the growth hormone/IGF-1 axis
TW200517400A (en) *	2003-08-05	2005-06-01	Univ Tulane	Antagonistic analogs of GH-RH (2003)
WO2005090388A1 (en)	2004-03-19	2005-09-29	The University Of Queensland	Alpha helical mimics, their uses and methods for their production
CA2718146C (en) *	2008-03-28	2016-09-20	The University Of Miami	Novel n- and c-terminal substituted antagonistic analogs of gh-rh
US8691942B2 (en)	2008-03-28	2014-04-08	University Of Miami	N- and C- terminal substituted antagonistic analogs of GH-RH
CN102083451A (zh)	2008-06-12	2011-06-01	赛恩泰新公司	癌症的抑制
CA2727082C (en)	2008-06-12	2019-02-26	Syntaxin Limited	Fusion proteins for use in suppression of acromegaly
US8796216B2 (en)	2008-06-12	2014-08-05	Syntaxin Limited	Suppression of neuroendocrine diseases
GB0820970D0 (en)	2008-11-17	2008-12-24	Syntaxin Ltd	Suppression of cancer
US20100316639A1 (en)	2009-06-16	2010-12-16	Genentech, Inc.	Biomarkers for igf-1r inhibitor therapy
US9079974B2 (en) *	2011-12-21	2015-07-14	The University Of Miami	GH-RH analogs with potent agonistic effects
US9855312B2 (en)	2012-12-21	2018-01-02	University Of Miami	GHRH agonists for the treatment of ischemic disorders
WO2014100816A2 (en)	2012-12-21	2014-06-26	University Of Miami	Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
US9119832B2 (en)	2014-02-05	2015-09-01	The Regents Of The University Of California	Methods of treating mild brain injury
WO2016077620A1 (en)	2014-11-12	2016-05-19	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Treatment of hormonal disorders of growth
WO2017075535A1 (en)	2015-10-28	2017-05-04	Oxeia Biopharmaceuticals, Inc.	Methods of treating neurodegenerative conditions
CA3129405A1 (en)	2019-02-08	2020-08-13	United States Government As Represented By The Department Of Veterans Affairs	Growth hormone-releasing hormone antagonists and uses thereof
CN114126653B (zh)	2019-07-18	2024-02-20	迈阿密大学	用于治疗结节病的方法的ghrh拮抗剂
USD1085845S1 (en)	2022-10-24	2025-07-29	Gbrs Group Llc	Multi-accessory mount
USD1099256S1 (en)	2024-08-01	2025-10-21	Gbrs Group Llc	Multi-accessory mount
USD1098350S1 (en)	2024-08-01	2025-10-14	Gbrs Group Llc	Multi-accessory mount
USD1098349S1 (en)	2024-08-01	2025-10-14	Gbrs Group Llc	Multi-accessory mount

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4493934A (en) *	1979-10-01	1985-01-15	Merck & Co., Inc.	2(3-Amino-2-oxopyrrolidin-1-yl) acetic acid and n-acylated derivatives thereof
US4377515A (en) *	1979-10-01	1983-03-22	Merck & Co., Inc.	Long lasting agonists and antagonists of LH-RH
US5043322A (en) *	1988-07-22	1991-08-27	The Salk Institute For Biological Studies	Cyclic GRF analogs
US5084442A (en) *	1988-09-06	1992-01-28	Hoffmann-La Roche Inc.	Cyclic growth hormone releasing factor analogs and method for the manufacture thereof
CA2082059A1 (en) *	1990-05-04	1991-11-05	David H. Coy	Synthetic grf analogs
JP3401005B2 (ja) *	1992-12-11	2003-04-28	ユニバーシティオブフロリダ	有害生物の防除のための材料および方法
US5550212A (en) *	1993-12-17	1996-08-27	The Administrators Of The Tulane Educational Fund	Analogues of hGH-RH(1-29)NH2 having antagonistic activity
US5516759A (en) *	1994-12-08	1996-05-14	Tap Holdings Inc.	LHRH antagonists having lactam groups at the N-terminus
DE19514567A1 (de) *	1995-04-20	1996-10-24	Merck Patent Gmbh	Benzofurane

1996
- 1996-05-03 US US08/642,472 patent/US5942489A/en not_active Expired - Fee Related
1997
- 1997-05-02 JP JP09540054A patent/JP2001501585A/ja not_active Ceased
- 1997-05-02 PT PT97926399T patent/PT914340E/pt unknown
- 1997-05-02 AT AT97926399T patent/ATE244731T1/de not_active IP Right Cessation
- 1997-05-02 ZA ZA9703793A patent/ZA973793B/xx unknown
- 1997-05-02 WO PCT/US1997/007452 patent/WO1997042223A1/en not_active Ceased
- 1997-05-02 AU AU31172/97A patent/AU3117297A/en not_active Abandoned
- 1997-05-02 CA CA002253663A patent/CA2253663C/en not_active Expired - Fee Related
- 1997-05-02 DE DE69723448T patent/DE69723448T2/de not_active Expired - Fee Related
- 1997-05-02 EP EP97926399A patent/EP0914340B1/en not_active Expired - Lifetime
- 1997-05-02 ES ES97926399T patent/ES2200178T3/es not_active Expired - Lifetime
- 1997-05-02 DK DK97926399T patent/DK0914340T3/da active

Also Published As

Publication number	Publication date
CA2253663C (en)	2002-07-16
DE69723448D1 (de)	2003-08-14
DE69723448T2 (de)	2004-05-19
WO1997042223A1 (en)	1997-11-13
US5942489A (en)	1999-08-24
EP0914340A1 (en)	1999-05-12
AU3117297A (en)	1997-11-26
EP0914340B1 (en)	2003-07-09
ATE244731T1 (de)	2003-07-15
CA2253663A1 (en)	1997-11-13
PT914340E (pt)	2003-11-28
ES2200178T3 (es)	2004-03-01
JP2001501585A (ja)	2001-02-06
DK0914340T3 (da)	2003-10-27

Publication	Publication Date	Title
ZA973793B (en)	1997-11-19	hGH-RH(1-29)NH2 analogues having antagonistic activity.
AU693143B2 (en)	1998-06-25	CS-1 peptidomimetics, compositions and methods of using the same
AU707094B2 (en)	1999-07-01	Analogs of parathyroid hormone
ES8900167A1 (es)	1988-04-16	Un metodo para preparar un peptido o una sal no toxica del mismo
CO5180565A1 (es)	2002-07-30	Analogos antagonistas de gh-rh que inhiben igf-i y ii
RU2008104802A (ru)	2009-08-20	Лиганды рецепторов меланокортинов
ES2152380T3 (es)	2001-02-01	Analogos de hgh-rh(1-29)nh2 con actividad antagonista.
PT70936B (en)	1981-06-24	New tripeptides and methods
Dutta et al.	2000	Potent cyclic monomeric and dimeric peptide inhibitors of VLA‐4 (α4β1 integrin)‐mediated cell adhesion based on the Ile‐Leu‐Asp‐Val tetrapeptide
EP0151016A3 (en)	1987-04-01	Arginine vasopressin antagonists
IE800743L (en)	1980-10-12	Peptides having thymopoietin-like activity
EP0189326A3 (en)	1988-10-26	Derivatives of arginine vasopressin antagonists
IL72789A (en)	1988-10-31	Basic hexa and heptapeptide vasopressin antagonists and their preparation
ABIKO et al.	1979	Synthesis and effects of two peptide fragments of thymopoietin II on E-rosette forming cells in the uremic state
EP0138604A3 (en)	1987-04-01	Arginine vasopressin antagonists
DE69315849D1 (de)	1998-01-29	Peptide als lungensurfactant und therapeutisch wirksame mischungen
ES8707740A1 (es)	1987-08-16	Un procedimiento para preparar octapeptidos ciclicos
EP0273645A3 (en)	1990-07-18	Novel derivatives of arginine vasopressin antagonists
HUT61033A (en)	1992-11-30	Process for producing intermediates of lh-rh-antagonist peptides