ZA974023B - Process for manufacturing simvastatin from lovastatin or mevinolinic acid. - Google Patents

Process for manufacturing simvastatin from lovastatin or mevinolinic acid.

Info

Publication number: ZA974023B
Authority: ZA; South Africa
Prior art keywords: formula; treating; iii; simvastatin; compound
Prior art date: 1997-03-13

Application number

ZA9704023A

Other languages

English (en)

Inventor

Yatendra Kumar

Rajesh K Thaper

Satyananda Misra

S M Dileep Kumar

Jag M Khanna

Original Assignee

Ranbaxy Lab Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-13

Filing date

1997-05-09

Publication date

1997-12-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25221004&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA974023(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-05-09 Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd

1997-12-10 Publication of ZA974023B publication Critical patent/ZA974023B/xx

Links

RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 title abstract 3
229960002855 simvastatin Drugs 0.000 title abstract 3
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 title abstract 3
QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 title 2
229960004844 lovastatin Drugs 0.000 title 1
PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
QLJODMDSTUBWDW-BXMDZJJMSA-N mevinolinic acid Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@@H](C)C=C21 QLJODMDSTUBWDW-BXMDZJJMSA-N 0.000 title 1
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
-1 alkyl amide Chemical class 0.000 abstract 2
239000012022 methylating agents‎ Substances 0.000 abstract 2
ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical group O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 abstract 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
239000000908 ammonium hydroxide Substances 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 abstract 1
FJDQVJUXXNIHNB-UHFFFAOYSA-N lithium;pyrrolidin-1-ide Chemical compound [Li+].C1CC[N-]C1 FJDQVJUXXNIHNB-UHFFFAOYSA-N 0.000 abstract 1
230000011987 methylation Effects 0.000 abstract 1
238000007069 methylation reaction Methods 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyrane Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ZA9704023A 1997-03-13 1997-05-09 Process for manufacturing simvastatin from lovastatin or mevinolinic acid. ZA974023B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/816,573 US5763646A (en)	1997-03-13	1997-03-13	Process for manufacturing simvastatin from lovastatin or mevinolinic acid

Publications (1)

Publication Number	Publication Date
ZA974023B true ZA974023B (en)	1997-12-10

Family

ID=25221004

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9704023A ZA974023B (en)	1997-03-13	1997-05-09	Process for manufacturing simvastatin from lovastatin or mevinolinic acid.

Country Status (7)

Country	Link
US (1)	US5763646A (de)
EP (1)	EP0864569B1 (de)
AT (1)	ATE204271T1 (de)
AU (1)	AU693401B1 (de)
DE (1)	DE69706135T2 (de)
ES (1)	ES2162165T3 (de)
ZA (1)	ZA974023B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0940395A1 (de) *	1998-03-05	1999-09-08	Synthon B.V.	Verfahren zur Erzeugung von Simvatarin in und/oder deren Derivate
NO991045L (no) *	1998-03-05	1999-09-06	Synthon Bv	FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater
US20030078211A1 (en) *	1998-06-24	2003-04-24	Merck & Co., Inc.	Compositions and methods for inhibiting bone resorption
JP2002518448A (ja) *	1998-06-24	2002-06-25	メルクエンドカムパニーインコーポレーテッド	高血中コレステロールを治療する組成物および方法
AU757104B2 (en)	1998-06-24	2003-01-30	Merck & Co., Inc.	Compositions and methods for inhibiting bone resorption
SI20070A (sl) *	1998-09-18	2000-04-30	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Nove soli inhibitorjev HMG-CoA reduktaze
CN1122029C (zh) *	1998-12-10	2003-09-24	钟渊化学工业株式会社	制备辛伐他汀的方法
CO5140104A1 (es) *	1999-02-16	2002-03-22	Novartis Ag	Derivados de mevinolina y preparacion farmaceuticas que los contienen
AU2127500A (en)	1999-11-11	2001-06-06	Biocon India Limited	Process for manufacturing simvastatin and the novel intermediates
US6573385B1 (en)	1999-11-11	2003-06-03	Biocon India Limited	Process for manufacturing simvastatin and novel intermediates thereof
IN192861B (de) *	2000-06-30	2004-05-22	Ranbaxy Lab Ltd
US6472542B1 (en)	2001-11-29	2002-10-29	Fermic S.A. De C.V.	Method for alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin
SI21187A (sl)	2002-03-26	2003-10-31	Krka, Tovarna Zdravil D.D., Novo Mesto	Postopek za pripravo 4-oksitetrahidropiran-2-onov
US6603022B1 (en)	2002-05-10	2003-08-05	Biocon India Limited	Process for manufacturing Simvastatin and novel intermediates thereof
US20060019269A1 (en) *	2002-10-17	2006-01-26	Decode Genetics, Inc.	Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
US20080293750A1 (en) *	2002-10-17	2008-11-27	Anna Helgadottir	Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
ES2561354T3 (es) *	2003-10-31	2016-02-25	Sunshine Heart Company Pty Ltd	Sistema de control de sincronización
WO2005066150A1 (en) *	2004-01-02	2005-07-21	Hetero Drugs Limited	A novel process for the preparation of simvastatin
US8158362B2 (en) *	2005-03-30	2012-04-17	Decode Genetics Ehf.	Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
US20100216863A1 (en) *	2004-01-30	2010-08-26	Decode Genetics Ehf.	Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
DE602004023004D1 (de) *	2004-09-08	2009-10-15	Jubilant Organosys Ltd	Verbessertes verfahren zur lactonisierung bei der herstellung von statinen
CN1754870A (zh) *	2004-09-30	2006-04-05	淮北市辉克药业有限公司	辛伐他汀的制备方法
WO2006072963A1 (en) *	2005-01-10	2006-07-13	Concord Biotech Limited	Process for preparing simvastatin from lovastatin amine salts in three steps
WO2007020079A2 (en) *	2005-08-17	2007-02-22	Synthon B.V.	Orally disintegratable simvastatin tablets
US20070129437A1 (en) *	2005-12-06	2007-06-07	Ferenc Korodi	Process for preparing simvastatin and intermediates thereof
ES2343049B1 (es)	2008-10-15	2011-06-10	Neuron Biopharma, S.A.	Biosintesis de derivados de monacolina j.
CN102574896B (zh)	2009-09-30	2015-04-08	科德克希思公司	变异LovD多肽及其用途
CN102695792B (zh)	2009-10-08	2015-02-18	加利福尼亚大学董事会	对辛伐他汀合成表现出改善性质的LovD突变体
CN104744416A (zh) *	2015-03-25	2015-07-01	河南师范大学	一种辛伐他汀的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5612114B2 (de) *	1974-06-07	1981-03-18
US4231938A (en) *	1979-06-15	1980-11-04	Merck & Co., Inc.	Hypocholesteremic fermentation products and process of preparation
US4293496A (en) *	1980-02-04	1981-10-06	Merck & Co., Inc.	6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones
US4444784A (en) *	1980-08-05	1984-04-24	Merck & Co., Inc.	Antihypercholesterolemic compounds
US4450171A (en) *	1980-08-05	1984-05-22	Merck & Co., Inc.	Antihypercholesterolemic compounds
EP0137445B1 (de) *	1983-10-11	1990-01-03	Merck & Co. Inc.	Verfahren zur C-Methylierung von 2-Methylbutyraten
US4582915A (en) *	1983-10-11	1986-04-15	Merck & Co., Inc.	Process for C-methylation of 2-methylbutyrates
US4584389A (en) *	1983-10-11	1986-04-22	Merck & Co., Inc.	Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
US4611081A (en) *	1985-07-05	1986-09-09	Merck & Co., Inc.	Process for the preparation of HMG-CoA reductase inhibitors intermediates
US4820850A (en) *	1987-07-10	1989-04-11	Merck & Co., Inc.	Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US5177104A (en) *	1990-04-03	1993-01-05	E. R. Squibb & Sons, Inc.	6-α-hydroxy derivatives of mevinic acids
US5223415A (en) *	1990-10-15	1993-06-29	Merck & Co., Inc.	Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
US5159104A (en) *	1991-05-01	1992-10-27	Merck & Co., Inc.	Process to simvastatin ester
US5393893A (en) *	1993-11-08	1995-02-28	Apotex, Inc.	Process for producing simvastatin and analogs thereof

1997
- 1997-03-13 US US08/816,573 patent/US5763646A/en not_active Expired - Lifetime
- 1997-05-09 ZA ZA9704023A patent/ZA974023B/xx unknown
- 1997-05-14 AU AU21408/97A patent/AU693401B1/en not_active Ceased
- 1997-07-04 ES ES97111277T patent/ES2162165T3/es not_active Expired - Lifetime
- 1997-07-04 EP EP97111277A patent/EP0864569B1/de not_active Revoked
- 1997-07-04 DE DE69706135T patent/DE69706135T2/de not_active Expired - Fee Related
- 1997-07-04 AT AT97111277T patent/ATE204271T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2162165T3 (es)	2001-12-16
EP0864569B1 (de)	2001-08-16
EP0864569A1 (de)	1998-09-16
AU693401B1 (en)	1998-06-25
DE69706135D1 (de)	2001-09-20
DE69706135T2 (de)	2002-05-02
US5763646A (en)	1998-06-09
ATE204271T1 (de)	2001-09-15

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