ZA974578B - Asymmetric transformation of narwedine-type compounds - Google Patents

Asymmetric transformation of narwedine-type compounds

Info

Publication number: ZA974578B
Authority: ZA; South Africa
Prior art keywords: asymmetric transformation; narwedine; type compounds; carbon atoms; enantiomerically
Prior art date: 1996-05-24

Application number

ZA974578A

Other languages

English (en)

Inventor

Jane Marie Paul

Gerard Andrew Potter

Nicholas Bernard Johnson

David Andrew Chaplin

Original Assignee

Chiroscience Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-24

Filing date

1997-05-26

Publication date

1998-11-17

1997-05-26 Application filed by Chiroscience Ltd filed Critical Chiroscience Ltd

1998-11-17 Publication of ZA974578B publication Critical patent/ZA974578B/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 4
230000009466 transformation Effects 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
HPOIPOPJGBKXIR-UHFFFAOYSA-N 3,6-dimethoxy-10-methyl-galantham-1-ene Natural products O1C(C(=CC=2)OC)=C3C=2CN(C)CCC23C1CC(OC)C=C2 HPOIPOPJGBKXIR-UHFFFAOYSA-N 0.000 abstract 1
LPCKPBWOSNVCEL-UHFFFAOYSA-N Chlidanthine Natural products O1C(C(=CC=2)O)=C3C=2CN(C)CCC23C1CC(OC)C=C2 LPCKPBWOSNVCEL-UHFFFAOYSA-N 0.000 abstract 1
-1 R2 is H Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002877 alkyl aryl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
229960003980 galantamine Drugs 0.000 abstract 1
BGLNUNCBNALFOZ-WMLDXEAASA-N galanthamine Natural products COc1ccc2CCCC[C@@]34C=CCC[C@@H]3Oc1c24 BGLNUNCBNALFOZ-WMLDXEAASA-N 0.000 abstract 1
ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
IYVSXSLYJLAZAT-NOLJZWGESA-N lycoramine Natural products CN1CC[C@@]23CC[C@H](O)C[C@@H]2Oc4cccc(C1)c34 IYVSXSLYJLAZAT-NOLJZWGESA-N 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Optical Couplings Of Light Guides (AREA)
Glass Compositions (AREA)
Iron Core Of Rotating Electric Machines (AREA)

ZA974578A 1996-05-24 1997-05-26 Asymmetric transformation of narwedine-type compounds ZA974578B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9610887.3A GB9610887D0 (en)	1996-05-24	1996-05-24	Process

Publications (1)

Publication Number	Publication Date
ZA974578B true ZA974578B (en)	1998-11-17

Family

ID=10794242

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA974578A ZA974578B (en)	1996-05-24	1997-05-26	Asymmetric transformation of narwedine-type compounds

Country Status (11)

Country	Link
US (1)	US6346618B1 (de)
EP (1)	EP0906314B1 (de)
AT (1)	ATE224898T1 (de)
AU (1)	AU713946B2 (de)
DE (1)	DE69715846T2 (de)
DK (1)	DK0906314T3 (de)
ES (1)	ES2183175T3 (de)
GB (1)	GB9610887D0 (de)
PT (1)	PT906314E (de)
WO (1)	WO1997045431A1 (de)
ZA (1)	ZA974578B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005065662A1 (en) *	2003-12-31	2005-07-21	Actavis Group Hf	Solid dosage formulations of galantamine
CA2551946A1 (en) *	2003-12-31	2005-07-21	Actavis Group Hf	Immediate, controlled and sustained release formulations of galantamine
WO2006013546A2 (en) *	2004-07-28	2006-02-09	Ranbaxy Laboratories Limited	Process for the preparation of pure galantamine
WO2006018703A2 (en) *	2004-08-16	2006-02-23	Ranbaxy Laboratories Limited	Processes for preparation of narwedine and its use in the synthesis of galantamine
FR2879599B1 (fr) *	2004-12-16	2007-03-23	Centre Nat Rech Scient Cnrse	Utilisation de la chromatographie de partage centrifuge pour la purification de la galanthamine
EP2009015B1 (de)	2007-06-18	2012-01-11	Aurobindo Pharma Limited	Herstellungsprozess für Galantaminhydrobromid
US20110127879A1 (en) *	2009-12-01	2011-06-02	Kita Ronald J	Chiral gravitational shielding material
CN102304031A (zh) *	2011-05-13	2012-01-04	华东理工大学	苯甲醛衍生物及其在制备加兰他敏中的应用
CN119528922B (zh) *	2024-11-22	2025-12-09	泰安汉威集团有限公司	一种氢溴酸加兰他敏关键杂质-氢溴酸表加兰他敏的手性合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5428159A (en) *	1994-04-08	1995-06-27	Ciba-Geigy Corporation	Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine
WO1996012692A1 (de) *	1994-10-21	1996-05-02	Waldheim Pharmazeutika Gesellschaft M.B.H.	VERFAHREN ZUM HERSTELLEN VON DERIVATEN DES 4a,5,9,10,11,12,-HEXAHYDRO-6H-BENZOFURO[3a,3,2-ef][2]BENZAZEPINS

1996
- 1996-05-24 GB GBGB9610887.3A patent/GB9610887D0/en active Pending
1997
- 1997-05-23 WO PCT/GB1997/001425 patent/WO1997045431A1/en not_active Ceased
- 1997-05-23 PT PT97923254T patent/PT906314E/pt unknown
- 1997-05-23 US US09/194,332 patent/US6346618B1/en not_active Expired - Lifetime
- 1997-05-23 AU AU29110/97A patent/AU713946B2/en not_active Expired
- 1997-05-23 DE DE69715846T patent/DE69715846T2/de not_active Expired - Lifetime
- 1997-05-23 DK DK97923254T patent/DK0906314T3/da active
- 1997-05-23 AT AT97923254T patent/ATE224898T1/de active
- 1997-05-23 ES ES97923254T patent/ES2183175T3/es not_active Expired - Lifetime
- 1997-05-23 EP EP97923254A patent/EP0906314B1/de not_active Expired - Lifetime
- 1997-05-26 ZA ZA974578A patent/ZA974578B/xx unknown

Also Published As

Publication number	Publication date
DE69715846D1 (de)	2002-10-31
WO1997045431A1 (en)	1997-12-04
EP0906314A1 (de)	1999-04-07
HK1022300A1 (en)	2000-08-04
GB9610887D0 (en)	1996-07-31
DK0906314T3 (da)	2002-12-23
AU713946B2 (en)	1999-12-16
US6346618B1 (en)	2002-02-12
AU2911097A (en)	1998-01-05
EP0906314B1 (de)	2002-09-25
ATE224898T1 (de)	2002-10-15
ES2183175T3 (es)	2003-03-16
DE69715846T2 (de)	2003-04-30
PT906314E (pt)	2003-01-31

Publication	Publication Date	Title
PT76316B (en)	1985-11-25	Process for the preparation of esters of substituted pyridino- 3,5-dicarboxylic and/or of pyrano-3,5-dicarboxylic acids having an hypotensive effect and application thereof for the preparation of pharmaceutical compositions having an hypotensive effect
ZA974578B (en)	1998-11-17	Asymmetric transformation of narwedine-type compounds
GB2175301B (en)	1989-09-13	Heterocyclic compounds
IL58506A (en)	1984-02-29	2-phenoxy-2-(1,2,4-triazol-1-yl)acetic acid derivatives,their manufacture and their use as fungicides
CA2256380A1 (en)	1997-12-04	Optical resolution of narwedine-type compounds
DE69800073D1 (de)	2000-03-09	Verfahren zur Herstellung von 2-Cyanobiphenyl-Verbindungen
ZA895254B (en)	1990-04-25	Process for the synthesis of optically active aminoacids
FR2669333B1 (fr)	1993-03-19	Procede de separation des enantiomeres des 5-aryl-5-alkylhydantouines.
GB2231570B (en)	1992-05-20	Naphthalenepropionic acid salts
ATE135693T1 (de)	1996-04-15	Halogeno-4-methylpyrazole und verfahren zu ihrer herstellung
ZA200702878B (en)	2009-10-28	Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and method of making them
ATE378319T1 (de)	2007-11-15	Verfahren zur herstellung von imidazolonen
ATE120740T1 (de)	1995-04-15	Verfahren und zwischenprodukte zur herstellung von optisch aktiven chromanderivaten.
DK161599C (da)	1992-01-13	Fremgangsmaade til fremstilling af lysergsyreestere
SE8302158D0 (sv)	1983-04-18	Verfahren zur herstellung von 1-alkyl-5-aroyl-pyrrol-2-essigseure-derivaten