ZA978602B - Novel NMDA (N-methyl-D-aspartate) antagonists. - Google Patents

Novel NMDA (N-methyl-D-aspartate) antagonists.

Info

Publication number: ZA978602B
Authority: ZA; South Africa
Prior art keywords: aspartate; antagonists; methyl; novel nmda; nmda
Prior art date: 1996-09-30

Application number

ZA9708602A

Other languages

English (en)

Inventor

Boyd L Harrison

Bruce M Baron

Raymond S Gross

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-30

Filing date

1997-09-25

Publication date

1998-03-30

1997-09-25 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1998-03-30 Publication of ZA978602B publication Critical patent/ZA978602B/xx

Links

HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title 2
239000005557 antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ZA9708602A 1996-09-30 1997-09-25 Novel NMDA (N-methyl-D-aspartate) antagonists. ZA978602B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US72317596A	1996-09-30	1996-09-30

Publications (1)

Publication Number	Publication Date
ZA978602B true ZA978602B (en)	1998-03-30

Family

ID=24905175

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9708602A ZA978602B (en)	1996-09-30	1997-09-25	Novel NMDA (N-methyl-D-aspartate) antagonists.

Country Status (18)

Country	Link
EP (1)	EP0929521B1 (de)
JP (1)	JP2001501221A (de)
KR (1)	KR20000048715A (de)
CN (1)	CN1139572C (de)
AR (1)	AR009374A1 (de)
AT (1)	ATE309215T1 (de)
AU (1)	AU732997B2 (de)
BR (1)	BR9712144A (de)
CA (1)	CA2266556C (de)
DE (1)	DE69734594T2 (de)
DK (1)	DK0929521T3 (de)
HU (1)	HUP0000882A3 (de)
IL (1)	IL129187A0 (de)
NO (1)	NO314080B1 (de)
NZ (1)	NZ334343A (de)
TW (1)	TW492958B (de)
WO (1)	WO1998014427A1 (de)
ZA (1)	ZA978602B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20010053849A1 (en) *	1999-06-16	2001-12-20	Mary Jeanne Kreek	Plural biological sample arrays, and preparation and uses thereof
KR20030060771A (ko)	2000-04-28	2003-07-16	메모리얼 슬로안-케터링 캔서 센터	국소용 마취제/아편양약물 제제 및 이들의 용도
HU227197B1 (en)	2000-10-24	2010-10-28	Richter Gedeon Nyrt	Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
US7820688B2 (en)	2001-04-27	2010-10-26	Memorial Sloan-Kettering Cancer Center	Topical anesthetic/opioid formulations and uses thereof
WO2003039540A2 (en) *	2001-11-09	2003-05-15	Sepracor Inc.	D-amino acid oxidase inhibitors for learning and memory
DE10306202A1 (de)	2003-02-13	2004-08-26	Grünenthal GmbH	Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
US7884124B2 (en)	2006-06-30	2011-02-08	Sepracor Inc.	Fluoro-substituted inhibitors of D-amino acid oxidase
AU2008315651B2 (en) *	2007-10-22	2012-12-13	Orchid Research Laboratories Limited	Histone deacetylase inhibitors
KR20120123089A (ko)	2010-02-16	2012-11-07	화이자 인코포레이티드	5-ＨＴ₄ 수용체의 부분 효능제인 (Ｒ)-4-((4-((4-(테트라히드로푸란-3-일옥시)벤조［ｄ］이속사졸-3-일옥시)메틸)피페리딘-1-일)메틸)테트라히드로-2Ｈ-피란-4-올
CA3146163A1 (en)	2019-07-08	2021-01-14	University Of Health Sciences & Pharmacy In St. Louis	G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
CN121695288A (zh)	2020-02-19	2026-03-20	Epizyme股份有限公司	Setd2抑制剂和相关方法和用途，包括组合疗法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU216787B (hu) *	1990-07-16	1999-08-30	Merrell Dow Pharmaceuticals Inc.	Eljárás excitátoros aminosav-antagonista hatású indolszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
GB9208492D0 (en) *	1992-04-16	1992-06-03	Glaxo Spa	Heterocyclic compounds
US5519048A (en) *	1993-05-27	1996-05-21	Merrell Pharmaceuticals Inc.	3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof
WO1994027964A1 (en) *	1993-05-27	1994-12-08	Merrell Dow Pharmaceuticals Inc.	3-(indol-3-yl) propenoic acid derivatives and as nmda antagonists
GB9319243D0 (en) *	1993-09-17	1993-11-03	Glaxo Spa	Heterocyclic compounds

1997
- 1997-08-18 CN CNB97198400XA patent/CN1139572C/zh not_active Expired - Fee Related
- 1997-08-18 EP EP97938377A patent/EP0929521B1/de not_active Expired - Lifetime
- 1997-08-18 BR BR9712144-4A patent/BR9712144A/pt not_active IP Right Cessation
- 1997-08-18 KR KR1019990702680A patent/KR20000048715A/ko not_active Ceased
- 1997-08-18 DE DE69734594T patent/DE69734594T2/de not_active Expired - Fee Related
- 1997-08-18 CA CA002266556A patent/CA2266556C/en not_active Expired - Fee Related
- 1997-08-18 DK DK97938377T patent/DK0929521T3/da active
- 1997-08-18 IL IL12918797A patent/IL129187A0/xx not_active IP Right Cessation
- 1997-08-18 AT AT97938377T patent/ATE309215T1/de not_active IP Right Cessation
- 1997-08-18 AU AU40718/97A patent/AU732997B2/en not_active Ceased
- 1997-08-18 WO PCT/US1997/014486 patent/WO1998014427A1/en not_active Ceased
- 1997-08-18 NZ NZ334343A patent/NZ334343A/xx unknown
- 1997-08-18 JP JP10516523A patent/JP2001501221A/ja not_active Ceased
- 1997-08-18 HU HU0000882A patent/HUP0000882A3/hu unknown
- 1997-09-24 TW TW086113932A patent/TW492958B/zh not_active IP Right Cessation
- 1997-09-25 ZA ZA9708602A patent/ZA978602B/xx unknown
- 1997-09-29 AR ARP970104462A patent/AR009374A1/es unknown
1999
- 1999-03-29 NO NO19991533A patent/NO314080B1/no unknown

Also Published As

Publication number	Publication date
AU732997B2 (en)	2001-05-03
EP0929521B1 (de)	2005-11-09
TW492958B (en)	2002-07-01
CA2266556A1 (en)	1998-04-09
EP0929521A1 (de)	1999-07-21
AR009374A1 (es)	2000-04-12
WO1998014427A1 (en)	1998-04-09
AU4071897A (en)	1998-04-24
HUP0000882A3 (en)	2001-04-28
NO991533D0 (no)	1999-03-29
DK0929521T3 (da)	2006-03-27
ATE309215T1 (de)	2005-11-15
NO991533L (no)	1999-05-28
IL129187A0 (en)	2000-02-17
NO314080B1 (no)	2003-01-27
DE69734594D1 (en)	2005-12-15
CN1139572C (zh)	2004-02-25
NZ334343A (en)	2001-01-26
HUP0000882A2 (hu)	2000-09-28
CN1232452A (zh)	1999-10-20
CA2266556C (en)	2007-11-06
JP2001501221A (ja)	2001-01-30
KR20000048715A (ko)	2000-07-25
BR9712144A (pt)	1999-08-31
DE69734594T2 (de)	2006-07-06

Publication	Publication Date	Title
ZA985678B (en)	2000-01-10	1-amino-alkylcyclohexane NMDA receptor antagonists.
CY2410B1 (en)	2004-09-10	Novel device.
AU2524995A (en)	1995-11-29	Neurokinine (tachykinine) antagonists
ZA977086B (en)	1998-06-30	NAALADase inhibitors.
ZA977695B (en)	1998-02-23	1,4-heterocyclic metalloprotease inhibitors.
ZA977693B (en)	1998-02-23	1,3-diheterocyclic metalloprotease inhibitors.
ZA96940B (en)	1997-08-06	Substituted biphenyl sulfonamide edothelin antagonists.
ZA9811273B (en)	2000-06-09	Sprayhead.
ZA972056B (en)	1997-09-22	Substituted 1,2,3,4-tetrahydronaphthalene derivatives.
ZA996133B (en)	2000-04-06	Substituted benzamides.
AP9801212A0 (en)	1998-03-31	Tetrahydroquin olinesas NMDA antagonists
ZA987055B (en)	2000-02-07	Substituted 4-benzoylpyrazoles.
DE69734594D1 (en)	2005-12-15	Nmda (n-methyl-d-aspartate) antagonists
ZA97928B (en)	1997-08-05	Novel heteroaryl-oxazolidinones.
ZA972944B (en)	1997-10-15	Novel retinoids.
ZA971184B (en)	1997-08-27	Endothelin antagonists.
ZA974052B (en)	1998-01-14	New benzothiazolinones.
ZA973537B (en)	1997-10-27	Novel sulfonylurea compounds.
ZA9810554B (en)	1999-07-22	A dehusking apparatus.
ZA987B (en)	1999-07-02	Substituted 4-benzoylpyrazoles.
GR3015656T3 (en)	1995-07-31	NMDA antagonists.
ZA974056B (en)	1998-01-14	New thiazolopyridines.
HK1018954A (en)	2000-01-14	Nmda (n-methyl-d-aspartate) antagonists
ZA984307B (en)	1999-11-22	A slide apparatus.
ZA983795B (en)	1999-11-05	Substituted 4-benzoyl-pyrazoles.