ZA978877B - 3-Alkoxyisoxazol-4-yl-substituted 2-amino carboxylic acid compounds. - Google Patents

3-Alkoxyisoxazol-4-yl-substituted 2-amino carboxylic acid compounds.

Info

Publication number: ZA978877B
Authority: ZA; South Africa
Prior art keywords: alkoxyisoxazol; substituted; carboxylic acid; acid compounds; amino carboxylic
Prior art date: 1996-10-04

Application number

ZA9708877A

Other languages

English (en)

Inventor

Benny Bang-Andersen

Klaus Peter Bogeso

Poul Krogsgaard-Larsen

Sibylle Moltzen Lenz

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-04

Filing date

1997-10-03

Publication date

1998-04-17

1997-10-03 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

1998-04-17 Publication of ZA978877B publication Critical patent/ZA978877B/xx

Links

GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical class NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 title 1
239000002253 acid Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

ZA9708877A 1996-10-04 1997-10-03 3-Alkoxyisoxazol-4-yl-substituted 2-amino carboxylic acid compounds. ZA978877B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK109296		1996-10-04

Publications (1)

Publication Number	Publication Date
ZA978877B true ZA978877B (en)	1998-04-17

Family

ID=8100908

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9708877A ZA978877B (en)	1996-10-04	1997-10-03	3-Alkoxyisoxazol-4-yl-substituted 2-amino carboxylic acid compounds.

Country Status (26)

Country	Link
US (1)	US6200999B1 (is)
EP (1)	EP0934286B1 (is)
JP (1)	JP2001501630A (is)
KR (1)	KR20000048908A (is)
CN (1)	CN1238766A (is)
AR (1)	AR008880A1 (is)
AT (1)	ATE230734T1 (is)
AU (1)	AU733004B2 (is)
BG (1)	BG103348A (is)
BR (1)	BR9712198A (is)
CA (1)	CA2268028C (is)
CZ (1)	CZ116899A3 (is)
DE (1)	DE69718338T2 (is)
EA (1)	EA001625B1 (is)
ES (1)	ES2189978T3 (is)
HU (1)	HUP0000084A3 (is)
IL (1)	IL129135A0 (is)
IS (1)	IS5009A (is)
NO (1)	NO312961B1 (is)
NZ (1)	NZ334798A (is)
PL (1)	PL332553A1 (is)
SK (1)	SK42899A3 (is)
TR (1)	TR199900724T2 (is)
UA (1)	UA52698C2 (is)
WO (1)	WO1998015542A1 (is)
ZA (1)	ZA978877B (is)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA73749C2 (en) *	1999-11-01	2005-09-15		Diarylenines
EP1317453B1 (en) *	2000-09-15	2006-08-09	Vertex Pharmaceuticals Incorporated	Isoxazoles and their use as inhibitors of erk
US20040106794A1 (en) *	2001-04-16	2004-06-03	Schering Corporation	3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
UA78529C2 (en)	2001-10-10	2007-04-10	Wyeth Corp	Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain
US20040152694A1 (en) *	2003-02-04	2004-08-05	Istvan Kurucz	Methods and compositions for treating inflammatory disorders of the airways
PT1611144E (pt)	2003-04-09	2010-11-12	Wyeth Llc	Derivados do ácido 2-(8,9-dioxo-2,6-diazabiciclo(5.2.0)- non-1(7)-eno-2-il)-alquil-fosfónico e sua utilização como antagonistas do receptor n-metil-d-aspartato (nmda)
GT200400213A (es)	2003-10-22	2007-09-05		Metodos para la preparacion del acido {2-[(8,9)-dioxo-2,6-diaza-biciclo[5.2.0]-non-1(7)-en-2-il]etil} fosfonico y esteres del mismo
BRPI0617306A2 (pt) *	2005-10-11	2011-07-19	Hoffmann La Roche	derivados de isoxazol
US8722714B2 (en)	2008-01-16	2014-05-13	The Honk Kong University of Science and Technology	Oxazolidine derivatives as NMDA antagonists
EP2338492A1 (en)	2009-12-24	2011-06-29	Universidad del Pais Vasco	Methods and compositions for the treatment of alzheimer
TW201609719A (zh) *	2014-05-28	2016-03-16	美國禮來大藥廠	作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物
JP6771775B2 (ja) *	2016-01-21	2020-10-21	アグロカネショウ株式会社	２−アミノニコチン酸ベンジルエステル誘導体の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0456519B1 (en)	1990-05-11	1994-07-13	Sankyo Company Limited	Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use
JPH08502508A (ja)	1992-10-23	1996-03-19	メルクシヤープエンドドームリミテツド	ドーパミンレセプターサブタイプリガンド
DK124393D0 (da) *	1993-11-03	1993-11-03	Lundbeck & Co As H	Compounds

1997
- 1997-03-10 UA UA99042300A patent/UA52698C2/uk unknown
- 1997-10-03 JP JP10517096A patent/JP2001501630A/ja active Pending
- 1997-10-03 WO PCT/DK1997/000426 patent/WO1998015542A1/en not_active Ceased
- 1997-10-03 US US09/269,356 patent/US6200999B1/en not_active Expired - Fee Related
- 1997-10-03 CN CN97180167A patent/CN1238766A/zh active Pending
- 1997-10-03 ES ES97942821T patent/ES2189978T3/es not_active Expired - Lifetime
- 1997-10-03 DE DE69718338T patent/DE69718338T2/de not_active Expired - Fee Related
- 1997-10-03 ZA ZA9708877A patent/ZA978877B/xx unknown
- 1997-10-03 KR KR1019990702938A patent/KR20000048908A/ko not_active Ceased
- 1997-10-03 HU HU0000084A patent/HUP0000084A3/hu unknown
- 1997-10-03 CA CA002268028A patent/CA2268028C/en not_active Expired - Fee Related
- 1997-10-03 IL IL12913597A patent/IL129135A0/xx unknown
- 1997-10-03 AU AU44517/97A patent/AU733004B2/en not_active Ceased
- 1997-10-03 PL PL97332553A patent/PL332553A1/xx unknown
- 1997-10-03 NZ NZ334798A patent/NZ334798A/en unknown
- 1997-10-03 EP EP97942821A patent/EP0934286B1/en not_active Expired - Lifetime
- 1997-10-03 SK SK428-99A patent/SK42899A3/sk unknown
- 1997-10-03 BR BR9712198-3A patent/BR9712198A/pt unknown
- 1997-10-03 EA EA199900358A patent/EA001625B1/ru not_active IP Right Cessation
- 1997-10-03 AT AT97942821T patent/ATE230734T1/de not_active IP Right Cessation
- 1997-10-03 AR ARP970104586A patent/AR008880A1/es not_active Application Discontinuation
- 1997-10-03 TR TR1999/00724T patent/TR199900724T2/xx unknown
- 1997-10-03 CZ CZ991168A patent/CZ116899A3/cs unknown
1999
- 1999-03-20 BG BG103348A patent/BG103348A/xx unknown
- 1999-03-23 IS IS5009A patent/IS5009A/is unknown
- 1999-03-30 NO NO19991561A patent/NO312961B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69718338D1 (de)	2003-02-13
ATE230734T1 (de)	2003-01-15
TR199900724T2 (xx)	1999-06-21
DE69718338T2 (de)	2003-10-16
NO991561D0 (no)	1999-03-30
BG103348A (en)	1999-11-30
PL332553A1 (en)	1999-09-13
NZ334798A (en)	2000-06-23
ES2189978T3 (es)	2003-07-16
BR9712198A (pt)	1999-08-31
AU733004B2 (en)	2001-05-03
CA2268028A1 (en)	1998-04-16
IS5009A (is)	1999-03-23
HUP0000084A3 (en)	2001-12-28
EP0934286A1 (en)	1999-08-11
AU4451797A (en)	1998-05-05
EA199900358A1 (ru)	1999-10-28
SK42899A3 (en)	1999-08-06
CA2268028C (en)	2003-03-18
JP2001501630A (ja)	2001-02-06
EP0934286B1 (en)	2003-01-08
CN1238766A (zh)	1999-12-15
EA001625B1 (ru)	2001-06-25
AR008880A1 (es)	2000-02-23
US6200999B1 (en)	2001-03-13
NO991561L (no)	1999-06-04
NO312961B1 (no)	2002-07-22
WO1998015542A1 (en)	1998-04-16
KR20000048908A (ko)	2000-07-25
IL129135A0 (en)	2000-02-17
UA52698C2 (uk)	2003-01-15
HUP0000084A2 (hu)	2000-06-28
CZ116899A3 (cs)	1999-09-15

Publication	Publication Date	Title
ZA981602B (en)	1999-09-21	Novel hexanoic acid derivatives.
ZA99567B (en)	1999-07-26	Aryl-acrylic acid esters.
GB9626637D0 (en)	1997-02-12	Percarboxyilic acid solutions
ZA987126B (en)	2000-02-07	Aryloxyarylsulfonylamino hydroxamic acid derivatives.
ZA9811898B (en)	2000-06-28	Anti-Inflammatory Compounds.
ZA97912B (en)	1997-08-05	Heterocyclic compounds.
ZA992629B (en)	2000-10-09	(4-arylsulfonylamino)-tetrahydropyran-4-caboxylic acid hydroxamides.
ZA97927B (en)	1997-08-19	New substituted oxazolidinones.
HU9801045D0 (en)	1998-07-28	Substituted diamino-carboxylic acids
ZA99680B (en)	1999-07-28	Ester compounds.
ZA9711567B (en)	1998-06-24	Compounds.
ZA99873B (en)	2000-08-04	Novel dihydroxyhexanoic acid derivatives.
IL129135A0 (en)	2000-02-17	3-Alkoxyisoxazol-4- YL-substituted 2-amino carboxylic acid compounds
ZA978226B (en)	1998-05-11	Fatty acid treatment.
ZA948631B (en)	1995-07-10	5-arylisoxazol-4-yl-substituted 2-amino carboxylic acid compounds
ZA97928B (en)	1997-08-05	Novel heteroaryl-oxazolidinones.
IL123213A0 (en)	1998-09-24	Carboxylic acid derivatives
ZA966396B (en)	1998-01-26	Boronic acid derivatives.
ZA965713B (en)	1998-01-05	5-pyrazolylbenzoic acid derivatives.
ZA993642B (en)	1999-11-29	Ester compounds.
SI0934286T1 (en)	2003-06-30	3-alkoxyisoxazol-4-yl-substituted 2-amino carboxylic acid compounds
AU5319898A (en)	1998-06-10	Glyoxylic acid amides
ZA972928B (en)	1997-11-03	Improved process for pyrimidinone compounds.
AU8214498A (en)	1999-01-04	Glyoxylic acid amides
ZA976429B (en)	1998-02-18	Benzoylpropionic acid ester derivatives.