ZA979573B - (Alpha-aminophosphino) peptide derivatives, process for their preparation and their therapeutic applications. - Google Patents

(Alpha-aminophosphino) peptide derivatives, process for their preparation and their therapeutic applications.

Info

Publication number
ZA979573B
ZA979573B ZA9709573A ZA979573A ZA979573B ZA 979573 B ZA979573 B ZA 979573B ZA 9709573 A ZA9709573 A ZA 9709573A ZA 979573 A ZA979573 A ZA 979573A ZA 979573 B ZA979573 B ZA 979573B
Authority
ZA
South Africa
Prior art keywords
aminophosphino
alpha
preparation
therapeutic applications
peptide derivatives
Prior art date
Application number
ZA9709573A
Other languages
English (en)
Inventor
Marie-Claude Fournie-Zaluski
Huixiong Chen
Bernard Pierre Roques
Original Assignee
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med filed Critical Inst Nat Sante Rech Med
Publication of ZA979573B publication Critical patent/ZA979573B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA9709573A 1996-10-25 1997-10-24 (Alpha-aminophosphino) peptide derivatives, process for their preparation and their therapeutic applications. ZA979573B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9613082A FR2755135B1 (fr) 1996-10-25 1996-10-25 Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent

Publications (1)

Publication Number Publication Date
ZA979573B true ZA979573B (en) 1998-05-21

Family

ID=9497061

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9709573A ZA979573B (en) 1996-10-25 1997-10-24 (Alpha-aminophosphino) peptide derivatives, process for their preparation and their therapeutic applications.

Country Status (13)

Country Link
US (1) US6518260B1 (de)
EP (1) EP1009750B1 (de)
JP (1) JP2001504815A (de)
AR (1) AR009129A1 (de)
AT (1) ATE221537T1 (de)
AU (1) AU4873197A (de)
CA (1) CA2266514A1 (de)
DE (1) DE69714475T2 (de)
DK (1) DK1009750T3 (de)
ES (1) ES2180950T3 (de)
FR (1) FR2755135B1 (de)
WO (1) WO1998018803A1 (de)
ZA (1) ZA979573B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2777780B1 (fr) * 1998-04-22 2001-05-04 Inst Nat Sante Rech Med Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent
FR2781230B1 (fr) 1998-07-02 2000-09-01 Commissariat Energie Atomique Derives de peptides utilisables comme inhibiteur selectif du site n-terminal de l'enzyme de conversion de l'angiotensine humaine
FR2823212B1 (fr) * 2001-04-10 2005-12-02 Inst Nat Sante Rech Med Inhibiteurs de la toxine botulique de type b
FR2882752B1 (fr) * 2005-03-01 2007-05-04 Servier Lab Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2931151A1 (fr) 2008-05-13 2009-11-20 Pharmaleads Soc Par Actions Si Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
FR2934267B1 (fr) 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
EP2435402B1 (de) 2009-05-28 2016-04-13 Novartis AG Substituierte aminobuttersäurederivate als neprilysininhibitoren
CN103896796B (zh) 2009-05-28 2016-04-27 诺华股份有限公司 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
FR2997081B1 (fr) 2012-10-23 2015-11-27 Pharmaleads Inhibiteurs mixtes de l'aminopeptidase n et de la neprilysine
CU24330B1 (es) 2013-02-14 2018-03-13 Novartis Ag Derivados del ácido 4-((1,1) bifenil-4-il)-3-(3-fosfonopropanamido) butanoico, activos como inhibidores de nep (endopeptidasa neutral)
US9102635B2 (en) 2013-02-14 2015-08-11 Novartis Ag Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy
GR1008310B (el) * 2013-10-03 2014-10-02 Εκεφε Δημοκριτος, Φωσφινικα ψευδοπεπτιδικα παραγωγα για την αποτελεσματικη αναστολη αμινοπεπτιδασων της υπο-οικογενειας οκυτοκινασων της οικογενειας μ1 αμινοπεπτιδασων
JP6938817B2 (ja) * 2015-11-30 2021-09-22 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． Ｍｍｐ−１２阻害剤としての使用のためのホスフィンペプチド誘導体
FR3044227B1 (fr) * 2015-11-30 2017-11-24 Pharmaleads Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires
TWI771386B (zh) 2017-03-09 2022-07-21 法商領先藥物公司 用於預防及治療眼發炎的氨基膦衍生物
FR3063635B1 (fr) * 2017-03-09 2019-06-07 Pharmaleads Derives aminophosphiniques pour la prevention et le traitement de l'inflammation oculaire
FR3077201B1 (fr) 2018-01-26 2020-01-17 Pharmaleads Derives aminoacides contenant un groupement disulfanyle sous forme d'un inhibiteur de nep et d'apn pour la prevention et le traitement des douleurs relatives au nerf trijumeau
FR3098217B1 (fr) 2019-07-05 2023-04-21 Pharmaleads N-Formylhydroxylamines en tant qu’inhibiteurs mixtes de l’aminopeptidase N (APN) et de la néprilysine (NEP)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2651229B1 (fr) * 1989-08-24 1991-12-13 Inst Nat Sante Rech Med Nouveaux derives d'amino-acides, leur procede de preparation et leur application therapeutique.
IT1270260B (it) * 1994-06-21 1997-04-29 Zambon Spa Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi
FR2730235A1 (fr) * 1995-02-06 1996-08-09 Commissariat Energie Atomique Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15

Also Published As

Publication number Publication date
AU4873197A (en) 1998-05-22
CA2266514A1 (en) 1998-05-07
FR2755135B1 (fr) 2002-12-27
WO1998018803A1 (fr) 1998-05-07
AR009129A1 (es) 2000-03-08
DE69714475T2 (de) 2003-04-10
US6518260B1 (en) 2003-02-11
DE69714475D1 (de) 2002-09-05
EP1009750B1 (de) 2002-07-31
FR2755135A1 (fr) 1998-04-30
EP1009750A1 (de) 2000-06-21
ATE221537T1 (de) 2002-08-15
DK1009750T3 (da) 2002-12-16
JP2001504815A (ja) 2001-04-10
ES2180950T3 (es) 2003-02-16

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