ZA981392B - Tetrodotoxin-sensitivie sodium channel alpha-subunit - Google Patents

Tetrodotoxin-sensitivie sodium channel alpha-subunit

Info

Publication number
ZA981392B
ZA981392B ZA981392A ZA981392A ZA981392B ZA 981392 B ZA981392 B ZA 981392B ZA 981392 A ZA981392 A ZA 981392A ZA 981392 A ZA981392 A ZA 981392A ZA 981392 B ZA981392 B ZA 981392B
Authority
ZA
South Africa
Prior art keywords
sensitivie
tetrodotoxin
subunit
sodium channel
channel alpha
Prior art date
Application number
ZA981392A
Other languages
English (en)
Inventor
Stephen Gregory Delgado
Paul Shartzer Dietrich
Linda Marie Fish
Ronald Charles Herman
Lakshmi Sangameswaran
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA981392B publication Critical patent/ZA981392B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA981392A 1997-02-26 1998-02-19 Tetrodotoxin-sensitivie sodium channel alpha-subunit ZA981392B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3944797P 1997-02-26 1997-02-26

Publications (1)

Publication Number Publication Date
ZA981392B true ZA981392B (en) 1998-08-26

Family

ID=21905505

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA981392A ZA981392B (en) 1997-02-26 1998-02-19 Tetrodotoxin-sensitivie sodium channel alpha-subunit

Country Status (4)

Country Link
US (2) US6030810A (fr)
AU (1) AU6723298A (fr)
WO (1) WO1998038302A2 (fr)
ZA (1) ZA981392B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1252330T1 (de) * 1999-11-26 2003-11-27 Mcgill University, Montreal Loci der idiopathischen epilepsie, mutationen derselben und verfahren zu deren verwendung zur feststellung, prognose und behandlung von epilepsie
JP2001327294A (ja) * 2000-05-23 2001-11-27 Japan Science & Technology Corp ヒト・ナトリウムチャンネルｓｃｎ１２ａ
DE60129688T2 (de) 2000-06-07 2008-04-30 Ortho-Mcneil Pharmaceutical, Inc. Die menschliche beta-1a-untereinheit des potential-abhängigen natriumkanals und deren verwendungen
CA2477043A1 (fr) * 2001-02-27 2002-09-06 Eos Biotechnology, Inc. Nouveaux procedes de diagnostic du cancer colorectal metastatique, compositions et procedes de criblage des modulateurs du cancer colorectal metastatique
EP1418834A4 (fr) * 2001-07-20 2007-04-04 Sinai School Medicine Procedes servant a diagnostiquer et a traiter la maladie d'alzheimer et la maladie de parkinson
CA2474751A1 (fr) 2002-02-25 2003-09-04 Vanderbilt University Systeme d'expression pour canal sodique dependant d'un potentiel d'action specifique au cerveau humain de type 1
WO2004012668A2 (fr) * 2002-08-02 2004-02-12 Wisconsin Alumni Research Foundation Variants de la sous-unite alpha du canal sodique
AU2003259846A1 (en) * 2002-08-16 2004-03-03 The General Hospital Corporation Non-invasive functional imaging of peripheral nervous system activation in humans and animals
US7531523B2 (en) * 2005-02-17 2009-05-12 Vertex Pharmaceuticals Incorporated Sodium channel protein type III alpha-subunit splice variant
US7972813B2 (en) * 2005-09-30 2011-07-05 Vertex Pharmaceuticals Incorporated Tetrodotoxin-resistant sodium channel alpha subunit
US20080200408A1 (en) * 2005-09-30 2008-08-21 Mccormack Kenneth Deletion mutants of tetrodotoxin-resistant sodium channel alpha subunit

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340597C (fr) * 1984-08-27 1999-06-22 Haim Aviv Vecteurs d'expression renfermant le promoteur pl et site de restriction synthetique facilitant le remplacement du site de liaison aux ribosomes; plasmides contenant les vecteurs, hotes contenant les plasmides et methodes connexes
US5132296A (en) * 1987-08-14 1992-07-21 Cherksey Bruce D Membrane NA+ channel protein and related therapeutic compounds
US5380836A (en) * 1989-02-13 1995-01-10 Arch Development Corporation Nucleic acid encoding sodium channel protein
US5439808A (en) * 1993-07-23 1995-08-08 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
CA2204355C (fr) * 1994-11-02 2001-01-16 Gail Mandel Canaux sodium specifiques du systeme nerveux peripherique, adn les codant, cristallisation, diffraction par les rayons x, modelisation moleculaire informatique, composition medicamenteuse rationnelle, criblage medicamenteux et procede de fabrication et d'utilisation de ces canaux
GB9513180D0 (en) * 1995-06-28 1995-08-30 Univ London Ion channel

Also Published As

Publication number Publication date
WO1998038302A2 (fr) 1998-09-03
US6335172B1 (en) 2002-01-01
WO1998038302A3 (fr) 1998-12-03
US6030810A (en) 2000-02-29
AU6723298A (en) 1998-09-18

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