ZA982437B - Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid - Google Patents

Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid

Info

Publication number: ZA982437B
Authority: ZA; South Africa
Prior art keywords: clavulanic acid; alkali metal; metal salt; isolation; pharmaceutically acceptable
Prior art date: 1997-03-24

Application number

ZA982437A

Other languages

English (en)

Inventor

Joaquim P Cardoso

Original Assignee

Cipan Comp Ind Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-24

Filing date

1998-03-23

Publication date

1998-09-28

1998-03-23 Application filed by Cipan Comp Ind Prod filed Critical Cipan Comp Ind Prod

1998-09-28 Publication of ZA982437B publication Critical patent/ZA982437B/xx

Links

HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 title abstract 9
HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 title abstract 9
229960003324 clavulanic acid Drugs 0.000 title abstract 9
229910052783 alkali metal Inorganic materials 0.000 title abstract 7
-1 alkali metal salt Chemical class 0.000 title abstract 5
238000002955 isolation Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 5
150000001340 alkali metals Chemical class 0.000 abstract 2
238000001914 filtration Methods 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
239000008394 flocculating agent Substances 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Genetics & Genomics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA982437A 1997-03-24 1998-03-23 Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid ZA982437B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97104947A EP0867515B1 (de)	1997-03-24	1997-03-24	Verfahren zur Isolierung eines pharmazeutisch verträglichen Alkalimetallsalzes der Clavulansäure

Publications (1)

Publication Number	Publication Date
ZA982437B true ZA982437B (en)	1998-09-28

Family

ID=8226629

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA982437A ZA982437B (en)	1997-03-24	1998-03-23	Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid

Country Status (12)

Country	Link
US (1)	US6417352B1 (de)
EP (1)	EP0867515B1 (de)
JP (1)	JP3474204B2 (de)
AT (1)	ATE187498T1 (de)
AU (1)	AU740387B2 (de)
DE (1)	DE69700903T2 (de)
DK (1)	DK0867515T3 (de)
ES (1)	ES2142641T3 (de)
GR (1)	GR3032882T3 (de)
NZ (1)	NZ337476A (de)
PT (1)	PT867515E (de)
ZA (1)	ZA982437B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA01009808A (es) *	1999-04-01	2002-04-24	Dsm Nv	Aglomerados por cristalizacion.
GB0022841D0 (en) *	2000-09-18	2000-11-01	Smithkline Beecham Plc	Process
MX2009005773A (es) *	2006-12-01	2009-06-08	Dsm Ip Assets Bv	Proceso para la produccion de acido clavulanico.
JP5778161B2 (ja) *	2010-09-24	2015-09-16	第一三共株式会社	置換シクロアルケン誘導体の結晶
CN103833774A (zh) *	2014-03-21	2014-06-04	山东新时代药业有限公司	一种从克拉维酸钾混粉中回收有效成分的方法
CN109535183A (zh) *	2017-09-21	2019-03-29	联邦制药(内蒙古)有限公司	一种制备克拉维酸叔辛胺的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3770590A (en) *	1971-12-01	1973-11-06	Merck & Co Inc	Fermentation process
SE421796B (sv) *	1975-02-07	1982-02-01	Glaxo Lab Ltd	Forfarande for rening av klavulansyra och dess salter
SI9200139A (en) *	1992-07-08	1994-03-31	Lek Tovarna Farmacevtskih	New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
GB9401969D0 (en) *	1994-02-02	1994-03-30	Smithkline Beecham Plc	Process
SI9400107A (en) *	1994-03-02	1995-10-31	Lek Tovarna Farmacevtskih	New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
SI9500074A (en) *	1995-03-10	1996-10-31	Lek Tovarna Farmacevtskih	Process for preparation of alkani salts of clavulanic acid.
GB9515809D0 (en) *	1995-08-02	1995-10-04	Smithkline Beecham Plc	Process
GB9521173D0 (en)	1995-10-17	1995-12-20	Univ Southampton	Isolation of parasites

1997
- 1997-03-24 PT PT97104947T patent/PT867515E/pt unknown
- 1997-03-24 ES ES97104947T patent/ES2142641T3/es not_active Expired - Lifetime
- 1997-03-24 DK DK97104947T patent/DK0867515T3/da active
- 1997-03-24 EP EP97104947A patent/EP0867515B1/de not_active Expired - Lifetime
- 1997-03-24 AT AT97104947T patent/ATE187498T1/de not_active IP Right Cessation
- 1997-03-24 DE DE69700903T patent/DE69700903T2/de not_active Expired - Fee Related
1998
- 1998-03-20 US US09/381,884 patent/US6417352B1/en not_active Expired - Fee Related
- 1998-03-20 AU AU70389/98A patent/AU740387B2/en not_active Ceased
- 1998-03-20 JP JP54486598A patent/JP3474204B2/ja not_active Expired - Fee Related
- 1998-03-20 NZ NZ337476A patent/NZ337476A/xx unknown
- 1998-03-23 ZA ZA982437A patent/ZA982437B/xx unknown
2000
- 2000-03-07 GR GR20000400577T patent/GR3032882T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU740387B2 (en)	2001-11-01
DE69700903D1 (de)	2000-01-13
NZ337476A (en)	2001-03-30
US6417352B1 (en)	2002-07-09
DE69700903T2 (de)	2000-07-06
EP0867515B1 (de)	1999-12-08
JP3474204B2 (ja)	2003-12-08
ES2142641T3 (es)	2000-04-16
DK0867515T3 (da)	2000-06-13
PT867515E (pt)	2000-05-31
AU7038998A (en)	1998-10-20
EP0867515A1 (de)	1998-09-30
JP2001521393A (ja)	2001-11-06
ATE187498T1 (de)	1999-12-15
GR3032882T3 (en)	2000-07-31

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