AP1878A - Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors. - Google Patents

Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors.

Info

Publication number: AP1878A
Authority: AP; ARIPO
Prior art keywords: broadspectrum; amino; protease inhibitors; hiv protease; benzothiazole sulfonamide
Prior art date: 2002-08-02

Application number

AP2005003242A

Other languages

English (en)

Other versions

AP2005003242A0 (en

Inventor

Dominique Louis Nestor Ghislain Surleraux

Piet Tom Bert Paul Wigerinck

Daniel P Getman

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-02

Filing date

2003-08-04

Publication date

2008-08-13

2003-08-04 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2005-03-31 Publication of AP2005003242A0 publication Critical patent/AP2005003242A0/xx

2008-08-13 Application granted granted Critical

2008-08-13 Publication of AP1878A publication Critical patent/AP1878A/xx

Links

XFMNXQKCYJXARU-UHFFFAOYSA-N 2-amino-3h-1,3-benzothiazole-2-sulfonamide Chemical compound C1=CC=C2SC(N)(S(N)(=O)=O)NC2=C1 XFMNXQKCYJXARU-UHFFFAOYSA-N 0.000 title 1
239000004030 hiv protease inhibitor Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)

AP2005003242A 2002-08-02 2003-08-04 Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors. AP1878A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP02078231		2002-08-02
US42786202P	2002-11-20	2002-11-20
PCT/EP2003/050359 WO2004014371A1 (fr)	2002-08-02	2003-08-04	Inhibiteurs broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors

Publications (2)

Publication Number	Publication Date
AP2005003242A0 AP2005003242A0 (en)	2005-03-31
AP1878A true AP1878A (en)	2008-08-13

Family

ID=31716850

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2005003242A AP1878A (en)	2002-08-02	2003-08-04	Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors.

Country Status (16)

Country	Link
US (2)	US20050267156A1 (fr)
EP (1)	EP1545518A1 (fr)
KR (1)	KR20050025647A (fr)
CN (1)	CN1671380B (fr)
AP (1)	AP1878A (fr)
AU (1)	AU2003262561B2 (fr)
BR (1)	BR0305717A (fr)
CA (1)	CA2492832C (fr)
EA (1)	EA008594B1 (fr)
HR (1)	HRP20050605A2 (fr)
IL (1)	IL166257A (fr)
MX (1)	MXPA05001275A (fr)
NO (1)	NO20051089L (fr)
NZ (1)	NZ538488A (fr)
PL (1)	PL374948A1 (fr)
WO (1)	WO2004014371A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2005244121B2 (en) *	2004-05-07	2012-01-19	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
JO2841B1 (en) *	2006-06-23	2014-09-15	تيبوتيك فارماسيوتيكالز ليمتد	2-(substituted-amino) -benzothiazole sulfonamide as protease inhibitors HIV (HIV)
US8267163B2 (en) *	2008-03-17	2012-09-18	Visteon Global Technologies, Inc.	Radiator tube dimple pattern
WO2011061590A1 (fr)	2009-11-17	2011-05-26	Hetero Research Foundation	Nouveaux dérivés carboxamides comme inhibiteurs du vih
EP2588455B1 (fr)	2010-07-02	2018-04-04	Gilead Sciences, Inc.	Dérivés de l'acide 2-quinolinyl-acétique en tant que composés antiviraux hiv
CN103140474A (zh)	2010-07-02	2013-06-05	吉里德科学公司	治疗aids的萘-2-基乙酸衍生物
US9024038B2 (en) *	2010-12-27	2015-05-05	Purdue Research Foundation	Compunds and methods for treating HIV
MX2013012266A (es)	2011-04-21	2013-11-22	Gilead Sciences Inc	Compuestos de benzotiazol y su uso farmaceutico.
US9376392B2 (en)	2012-01-04	2016-06-28	Gilead Sciences, Inc.	2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS
US9284323B2 (en)	2012-01-04	2016-03-15	Gilead Sciences, Inc.	Naphthalene acetic acid derivatives against HIV infection
ES2571479T3 (es)	2012-04-20	2016-05-25	Gilead Sciences Inc	Derivados del ácido benzotiazol-6-il acético y su uso para tratar una infección por VIH
IL322207A (en) *	2014-12-10	2025-09-01	Tricida Inc	Proton-binding polymers for oral administration

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995006030A1 (fr) *	1993-08-24	1995-03-02	G.D. Searle & Co.	Hydroxyethylamino-sulfonamides aptes a etre utilises comme inhibiteurs de protease retrovirale
WO1999067254A2 (fr) *	1998-06-23	1999-12-29	The United States Of America Represented By The Secretary, Department Of Health And Human Services	Inhibiteurs de protease retrovirale resistant a l'action de plusieurs medicaments et procedes associes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5968942A (en) *	1992-08-25	1999-10-19	G. D. Searle & Co.	α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
EP1370543B1 (fr) *	2001-02-14	2006-10-25	Tibotec Pharmaceuticals Ltd.	Sulfamides de 2-amino-benzothiazole substitue en tant qu'inhibiteurs de la protease du vih a large spectre

2003
- 2003-08-04 BR BR0305717-8A patent/BR0305717A/pt not_active Application Discontinuation
- 2003-08-04 CA CA2492832A patent/CA2492832C/fr not_active Expired - Fee Related
- 2003-08-04 CN CN038184044A patent/CN1671380B/zh not_active Expired - Fee Related
- 2003-08-04 KR KR1020057001206A patent/KR20050025647A/ko not_active Ceased
- 2003-08-04 PL PL03374948A patent/PL374948A1/xx not_active Application Discontinuation
- 2003-08-04 HR HR20050605A patent/HRP20050605A2/hr not_active Application Discontinuation
- 2003-08-04 EA EA200500298A patent/EA008594B1/ru not_active IP Right Cessation
- 2003-08-04 WO PCT/EP2003/050359 patent/WO2004014371A1/fr not_active Ceased
- 2003-08-04 NZ NZ538488A patent/NZ538488A/en not_active IP Right Cessation
- 2003-08-04 AP AP2005003242A patent/AP1878A/xx active
- 2003-08-04 EP EP03784205A patent/EP1545518A1/fr not_active Ceased
- 2003-08-04 AU AU2003262561A patent/AU2003262561B2/en not_active Ceased
- 2003-08-04 US US10/523,445 patent/US20050267156A1/en not_active Abandoned
- 2003-08-04 MX MXPA05001275A patent/MXPA05001275A/es active IP Right Grant
2005
- 2005-01-12 IL IL166257A patent/IL166257A/en not_active IP Right Cessation
- 2005-03-01 NO NO20051089A patent/NO20051089L/no not_active Application Discontinuation
2009
- 2009-04-20 US US12/426,730 patent/US20090203742A1/en not_active Abandoned

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995006030A1 (fr) *	1993-08-24	1995-03-02	G.D. Searle & Co.	Hydroxyethylamino-sulfonamides aptes a etre utilises comme inhibiteurs de protease retrovirale
WO1999067254A2 (fr) *	1998-06-23	1999-12-29	The United States Of America Represented By The Secretary, Department Of Health And Human Services	Inhibiteurs de protease retrovirale resistant a l'action de plusieurs medicaments et procedes associes

Also Published As

Publication number	Publication date
AU2003262561A1 (en)	2004-02-25
WO2004014371A1 (fr)	2004-02-19
IL166257A (en)	2013-04-30
NZ538488A (en)	2007-10-26
EP1545518A1 (fr)	2005-06-29
EA200500298A1 (ru)	2005-08-25
CN1671380B (zh)	2010-05-26
US20050267156A1 (en)	2005-12-01
MXPA05001275A (es)	2005-04-28
CN1671380A (zh)	2005-09-21
NO20051089L (no)	2005-05-02
IL166257A0 (en)	2006-01-15
KR20050025647A (ko)	2005-03-14
PL374948A1 (en)	2005-11-14
AU2003262561B2 (en)	2008-10-16
EA008594B1 (ru)	2007-06-29
CA2492832C (fr)	2012-05-22
CA2492832A1 (fr)	2004-02-19
US20090203742A1 (en)	2009-08-13
HRP20050605A2 (en)	2006-02-28
AP2005003242A0 (en)	2005-03-31
BR0305717A (pt)	2004-09-28

Publication	Publication Date	Title
EP1499336A4 (fr)	2005-06-01	Inhibiteurs de protease
EP1483254A4 (fr)	2005-06-08	Inhibiteurs de protease retrovirale anti-resistance
AP2003002856A0 (en)	2003-09-30	Broadspectrum 2-(substitutted-amino)-benzothiazolesulphonamide HIV protease inhibitors.
IL179056A0 (en)	2007-03-08	An hiv protease inhibitor
DK1466962T3 (da)	2011-11-21	Alkalisk protease
AP2003002904A0 (en)	2003-12-31	Broadspectrum 2-amino-benzoxazole sulfonamide HIV protease inhibitors.
DK1466970T3 (da)	2009-04-06	Alkalisk protease
EP1704142A4 (fr)	2008-08-20	Inhibiteurs de la protease
AU2003234630A1 (en)	2003-12-02	Cysteine protease inhibitors
IL166257A0 (en)	2006-01-15	Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors
DK1347044T3 (da)	2014-01-13	Alkalisk protease
PL375307A1 (en)	2005-11-28	Broadspectrum substituted oxindole sulfonamide hiv protease inhibitors
IL165043A0 (en)	2005-12-18	broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
AU2003269984A8 (en)	2004-03-11	Protease inhibitors
AP2003002882A0 (en)	2003-12-31	Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors.
AP2004003151A0 (en)	2004-12-31	Broadspectrum substituted benzimidazole sulfonamide HIV protease inhibitors
ZA200500926B (en)	2006-03-29	Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors
AU2003263738A1 (en)	2003-12-02	Protease inhibitors
AU2003287325A8 (en)	2004-06-03	N-cycloalkylglycines as hiv protease inhibitors
HK1079684A (en)	2006-04-13	Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors
BR0317312B8 (pt)	2013-02-19	adaptador.
EP1534292A4 (fr)	2008-04-02	Inhibiteurs de protease
AU2003252417A1 (en)	2004-03-03	Protease inhibitor
AU2003265240A8 (en)	2003-12-22	Protease inhibitors
EP1532115A4 (fr)	2006-01-11	Inhibiteurs de la protease