AP2000001735A0 - Treatment of diabetes with thiazolidinedione insulin secretagogue and alpha glucocidase inhibitor. - Google Patents

Treatment of diabetes with thiazolidinedione insulin secretagogue and alpha glucocidase inhibitor.

Info

Publication number: AP2000001735A0
Authority: AP; ARIPO
Prior art keywords: treatment; alpha; diabetes; glucocidase; inhibitor
Prior art date: 1997-07-18

Application number

APAP/P/2000/001735A

Other languages

English (en)

Inventor

Robin Edwin Buckingham

Stephen Alistair Smith

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-18

Filing date

2000-01-14

Publication date

2000-01-16

2000-01-14 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2000-01-16 Publication of AP2000001735A0 publication Critical patent/AP2000001735A0/en

Links

206010012601 diabetes mellitus Diseases 0.000 title abstract 3
ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 title 1
229940122199 Insulin secretagogue Drugs 0.000 title 1
229940123464 Thiazolidinedione Drugs 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
229940077274 Alpha glucosidase inhibitor Drugs 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
239000003888 alpha glucosidase inhibitor Substances 0.000 abstract 1
230000002058 anti-hyperglycaemic effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
231100000489 sensitizer Toxicity 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

APAP/P/2000/001735A 1997-07-18 2000-01-14 Treatment of diabetes with thiazolidinedione insulin secretagogue and alpha glucocidase inhibitor. AP2000001735A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9715298A GB9715298D0 (en)	1997-07-18	1997-07-18	Novel method of treatment
PCT/GB1998/002112 WO1999003478A1 (fr)	1997-07-18	1998-07-16	Traitement du diabete avec du thiazolidinedione, un secretagogue d'insuline et un inhibiteur d'alpha glucosidase

Publications (1)

Publication Number	Publication Date
AP2000001735A0 true AP2000001735A0 (en)	2000-01-16

Family

ID=10816170

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/2000/001735A AP2000001735A0 (en)	1997-07-18	2000-01-14	Treatment of diabetes with thiazolidinedione insulin secretagogue and alpha glucocidase inhibitor.

Country Status (27)

Country	Link
EP (1)	EP1001784A1 (fr)
JP (1)	JP2001510160A (fr)
KR (1)	KR20010021952A (fr)
CN (1)	CN1263467A (fr)
AP (1)	AP2000001735A0 (fr)
AR (2)	AR016350A1 (fr)
AU (1)	AU8449098A (fr)
BG (1)	BG104062A (fr)
BR (1)	BR9810292A (fr)
CA (1)	CA2297133A1 (fr)
CO (1)	CO4940489A1 (fr)
DZ (1)	DZ2563A1 (fr)
EA (1)	EA200000140A1 (fr)
GB (1)	GB9715298D0 (fr)
HU (1)	HUP0003626A3 (fr)
ID (1)	ID23804A (fr)
IL (1)	IL133907A0 (fr)
MA (1)	MA24608A1 (fr)
NO (1)	NO20000230L (fr)
OA (1)	OA11312A (fr)
PE (1)	PE99499A1 (fr)
PL (1)	PL338140A1 (fr)
SK (1)	SK612000A3 (fr)
TR (1)	TR200000133T2 (fr)
UY (1)	UY25101A1 (fr)
WO (1)	WO1999003478A1 (fr)
ZA (1)	ZA986364B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI238064B (en) *	1995-06-20	2005-08-21	Takeda Chemical Industries Ltd	A pharmaceutical composition for prophylaxis and treatment of diabetes
US7045519B2 (en)	1998-06-19	2006-05-16	Chiron Corporation	Inhibitors of glycogen synthase kinase 3
CA2349865C (fr) *	1999-06-21	2014-08-19	Eli Lilly And Company	Utilisation combinee de thiazolidinediones et de peptide-1 de type glucagone et d'agonistes de ces derniers pour traiter l'instabilite metabolique associee aux diabetes non insulino-dependants
ES2487897T3 (es) *	2000-01-21	2014-08-25	Novartis Ag	Combinaciones que consisten de inhibidores de la dipeptidilpeptidasa-IV y agentes antidiabéticos
US20030040490A1 (en) *	2000-02-24	2003-02-27	Yasuo Sugiyama	Drugs containing combined active ingredients
JP4917712B2 (ja) *	2000-02-24	2012-04-18	武田薬品工業株式会社	併用医薬
EP1738751B1 (fr)	2001-01-12	2011-05-11	Sun Pharma Advanced Research Company Ltd	système de libération espacée de médicaments
FR2832930A1 (fr) *	2001-12-03	2003-06-06	Lipha	Composition pharmaceutique comprenant un inhibiteur d'alpha-glucosidase et un derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete
KR100952090B1 (ko)	2003-10-31	2010-04-13	다케다 야쿠힌 고교 가부시키가이샤	인슐린 감작제, 인슐린 분비촉진제 및 폴리옥시에틸렌소르비탄 지방산 에스테르를 함유하는 고체 제제
CN101103993B (zh) *	2006-07-14	2011-03-30	北京华安佛医药研究中心有限公司	降糖药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2479492A (en) *	1991-08-26	1993-03-16	Upjohn Company, The	Pharmaceutical composition containing 3-guanidinopropionic acid and pioglitazone glibenclamide or glimepiride
US5917052A (en) *	1994-09-28	1999-06-29	Shaman Pharmaceuticals, Inc.	Hypoglycemic agent from cryptolepis
TWI238064B (en) *	1995-06-20	2005-08-21	Takeda Chemical Industries Ltd	A pharmaceutical composition for prophylaxis and treatment of diabetes

1997
- 1997-07-18 GB GB9715298A patent/GB9715298D0/en active Pending
1998
- 1998-07-15 DZ DZ980173A patent/DZ2563A1/fr active
- 1998-07-16 MA MA25172A patent/MA24608A1/fr unknown
- 1998-07-16 PL PL98338140A patent/PL338140A1/xx unknown
- 1998-07-16 WO PCT/GB1998/002112 patent/WO1999003478A1/fr not_active Ceased
- 1998-07-16 AU AU84490/98A patent/AU8449098A/en not_active Abandoned
- 1998-07-16 HU HU0003626A patent/HUP0003626A3/hu unknown
- 1998-07-16 EP EP98935129A patent/EP1001784A1/fr not_active Withdrawn
- 1998-07-16 ID IDW20000077A patent/ID23804A/id unknown
- 1998-07-16 PE PE1998000630A patent/PE99499A1/es not_active Application Discontinuation
- 1998-07-16 AR ARP980103482A patent/AR016350A1/es unknown
- 1998-07-16 EA EA200000140A patent/EA200000140A1/ru unknown
- 1998-07-16 IL IL13390798A patent/IL133907A0/xx unknown
- 1998-07-16 KR KR1020007000517A patent/KR20010021952A/ko not_active Withdrawn
- 1998-07-16 CN CN98807147A patent/CN1263467A/zh active Pending
- 1998-07-16 JP JP2000502777A patent/JP2001510160A/ja active Pending
- 1998-07-16 CA CA002297133A patent/CA2297133A1/fr not_active Abandoned
- 1998-07-16 BR BR9810292-3A patent/BR9810292A/pt not_active IP Right Cessation
- 1998-07-16 SK SK61-2000A patent/SK612000A3/sk unknown
- 1998-07-16 TR TR2000/00133T patent/TR200000133T2/xx unknown
- 1998-07-17 UY UY25101A patent/UY25101A1/es not_active Application Discontinuation
- 1998-07-17 CO CO98040749A patent/CO4940489A1/es unknown
- 1998-07-17 ZA ZA9806364A patent/ZA986364B/xx unknown
1999
- 1999-06-28 AR ARP990103110A patent/AR019724A2/es unknown
2000
- 2000-01-06 BG BG104062A patent/BG104062A/xx unknown
- 2000-01-14 AP APAP/P/2000/001735A patent/AP2000001735A0/en unknown
- 2000-01-17 NO NO20000230A patent/NO20000230L/no not_active Application Discontinuation
- 2000-01-18 OA OA1200000013A patent/OA11312A/en unknown

Also Published As

Publication number	Publication date
NO20000230D0 (no)	2000-01-17
AR019724A2 (es)	2002-03-13
PL338140A1 (en)	2000-09-25
IL133907A0 (en)	2001-04-30
NO20000230L (no)	2000-01-17
OA11312A (en)	2003-10-24
BR9810292A (pt)	2000-09-19
SK612000A3 (en)	2000-07-11
CN1263467A (zh)	2000-08-16
UY25101A1 (es)	2000-12-29
DZ2563A1 (fr)	2003-02-15
AU8449098A (en)	1999-02-10
KR20010021952A (ko)	2001-03-15
HUP0003626A2 (hu)	2001-05-28
EP1001784A1 (fr)	2000-05-24
WO1999003478A1 (fr)	1999-01-28
JP2001510160A (ja)	2001-07-31
HUP0003626A3 (en)	2001-12-28
ID23804A (id)	2000-05-11
GB9715298D0 (en)	1997-09-24
TR200000133T2 (tr)	2000-09-21
PE99499A1 (es)	1999-12-18
BG104062A (en)	2000-11-30
AR016350A1 (es)	2001-07-04
EA200000140A1 (ru)	2000-06-26
ZA986364B (en)	2000-01-17
CA2297133A1 (fr)	1999-01-28
CO4940489A1 (es)	2000-07-24
MA24608A1 (fr)	1999-04-01

Publication	Publication Date	Title
MXPA02012763A (es)	2003-04-25	Combinaciones de inhibidores de dipeptidil peptidasa iv y otros agentes antidiabeticos para el tratamiento de diabetes mellitus.
MY155219A (en)	2015-09-30	Treatment of diabetes with thiazolidinedione, insulin secretagogue and biguanide
CA2294582A1 (fr)	1998-12-23	Traitement du diabete a l'aide de thiazolidinedione et de metformine
MY124695A (en)	2006-06-30	Novel composition and use.
AP2001002291A0 (en)	2001-12-31	Novel method of treatment.
AP2000001735A0 (en)	2000-01-16	Treatment of diabetes with thiazolidinedione insulin secretagogue and alpha glucocidase inhibitor.
TR199903095T2 (xx)	2000-08-21	Diabetin roziglitazon ve ins�lin ile tedavisi.
AP9901720A0 (en)	1999-12-31	Treatment of diabetes with thiazolidinedione and alpha-glucosidase inhibitors.
MY125855A (en)	2006-08-30	Treatment of diabetes with a thiazolidinedione and sulphonylurea
MY138246A (en)	2009-05-29	Treatment of diabetes with thiazolidione and sulphonylurea.
HK1041201A1 (zh)	2002-07-05	貝塔激動劑和抗糖尿病製劑的配伍
WO2001047509A3 (fr)	2002-09-12	Procede de traitement
IL143088A0 (en)	2002-11-10	A method for the treatment of type 2 diabetes mellitus and conditions associated therewith, and a pharmaceutical composition comprising an insulin sensitiser for use in such a method
ECSP982591A (es)	1999-02-22	Nuevo metodo de tratamiento iv
AP2000001787A0 (en)	2000-06-30	Use of thiazolidinediones for the treatment of hyperglycaemia.
ECSP982534A (es)	1999-02-11	Nuevo metodo de tratamiento
ECSP982593A (es)	1999-02-22	Nuevo metodo de tratamiento vi
ECSP982535A (es)	1999-04-13	Nuevo metodo de tratamiento (i)
HK1028551A (en)	2001-02-23	Treatment of diabetes with thiazolidinedione, insulin secretagogue and alpha glucosidase inhibitor