AP2000001735A0 - Treatment of diabetes with thiazolidinedione insulin secretagogue and alpha glucocidase inhibitor. - Google Patents

Treatment of diabetes with thiazolidinedione insulin secretagogue and alpha glucocidase inhibitor.

Info

Publication number: AP2000001735A0
Authority: AP; ARIPO
Prior art keywords: treatment; alpha; diabetes; glucocidase; inhibitor
Prior art date: 1997-07-18

Application number

APAP/P/2000/001735A

Other languages

English (en)

Inventor

Robin Edwin Buckingham

Stephen Alistair Smith

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-18

Filing date

2000-01-14

Publication date

2000-01-16

2000-01-14 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2000-01-16 Publication of AP2000001735A0 publication Critical patent/AP2000001735A0/en

Links

206010012601 diabetes mellitus Diseases 0.000 title abstract 3
ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 title 1
229940122199 Insulin secretagogue Drugs 0.000 title 1
229940123464 Thiazolidinedione Drugs 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
229940077274 Alpha glucosidase inhibitor Drugs 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
239000003888 alpha glucosidase inhibitor Substances 0.000 abstract 1
230000002058 anti-hyperglycaemic effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
231100000489 sensitizer Toxicity 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Emergency Medicine (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

APAP/P/2000/001735A 1997-07-18 2000-01-14 Treatment of diabetes with thiazolidinedione insulin secretagogue and alpha glucocidase inhibitor. AP2000001735A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9715298A GB9715298D0 (en)	1997-07-18	1997-07-18	Novel method of treatment
PCT/GB1998/002112 WO1999003478A1 (fr)	1997-07-18	1998-07-16	Traitement du diabete avec du thiazolidinedione, un secretagogue d'insuline et un inhibiteur d'alpha glucosidase

Publications (1)

Publication Number	Publication Date
AP2000001735A0 true AP2000001735A0 (en)	2000-01-16

Family

ID=10816170

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/2000/001735A AP2000001735A0 (en)	1997-07-18	2000-01-14	Treatment of diabetes with thiazolidinedione insulin secretagogue and alpha glucocidase inhibitor.

Country Status (27)

Country	Link
EP (1)	EP1001784A1 (fr)
JP (1)	JP2001510160A (fr)
KR (1)	KR20010021952A (fr)
CN (1)	CN1263467A (fr)
AP (1)	AP2000001735A0 (fr)
AR (2)	AR016350A1 (fr)
AU (1)	AU8449098A (fr)
BG (1)	BG104062A (fr)
BR (1)	BR9810292A (fr)
CA (1)	CA2297133A1 (fr)
CO (1)	CO4940489A1 (fr)
DZ (1)	DZ2563A1 (fr)
EA (1)	EA200000140A1 (fr)
GB (1)	GB9715298D0 (fr)
HU (1)	HUP0003626A3 (fr)
ID (1)	ID23804A (fr)
IL (1)	IL133907A0 (fr)
MA (1)	MA24608A1 (fr)
NO (1)	NO20000230D0 (fr)
OA (1)	OA11312A (fr)
PE (1)	PE99499A1 (fr)
PL (1)	PL338140A1 (fr)
SK (1)	SK612000A3 (fr)
TR (1)	TR200000133T2 (fr)
UY (1)	UY25101A1 (fr)
WO (1)	WO1999003478A1 (fr)
ZA (1)	ZA986364B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI238064B (en) *	1995-06-20	2005-08-21	Takeda Chemical Industries Ltd	A pharmaceutical composition for prophylaxis and treatment of diabetes
US7045519B2 (en)	1998-06-19	2006-05-16	Chiron Corporation	Inhibitors of glycogen synthase kinase 3
EP1849475A1 (fr)	1999-06-21	2007-10-31	Eli Lilly & Company	Utilisation synergique des thiazolidinediones avec peptide-1 comme glucagon et agonistes correspondants pour traiter les diabètes non dépendants de l'insuline
EP1743655B1 (fr) *	2000-01-21	2014-06-25	Novartis AG	Combinaisons à base d'inhibiteurs de DPP-IV et d'antidiabetiques
WO2001062295A1 (fr) *	2000-02-24	2001-08-30	Takeda Chemical Industries, Ltd.	Medicaments contenant des ingredients actifs combines
JP4917712B2 (ja) *	2000-02-24	2012-04-18	武田薬品工業株式会社	併用医薬
CA2434169C (fr)	2001-01-12	2011-03-15	Sun Pharmaceutical Industries Limited	Systeme de liberation espacee de medicaments
FR2832930A1 (fr) *	2001-12-03	2003-06-06	Lipha	Composition pharmaceutique comprenant un inhibiteur d'alpha-glucosidase et un derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete
CA2540225C (fr)	2003-10-31	2012-03-06	Takeda Pharmaceutical Company Limited	Preparation solide comprenant du pioglitazone, du glimepiride et un ester d'acide gras de polyoxyethylene sorbitan
CN101103993B (zh) *	2006-07-14	2011-03-30	北京华安佛医药研究中心有限公司	降糖药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0601001B1 (fr) *	1991-08-26	1997-04-16	PHARMACIA & UPJOHN COMPANY	Composition alimentaire liquide contenant de l'acide 3-guanidinopropionique
US5917052A (en) *	1994-09-28	1999-06-29	Shaman Pharmaceuticals, Inc.	Hypoglycemic agent from cryptolepis
TWI238064B (en) *	1995-06-20	2005-08-21	Takeda Chemical Industries Ltd	A pharmaceutical composition for prophylaxis and treatment of diabetes

1997
- 1997-07-18 GB GB9715298A patent/GB9715298D0/en active Pending
1998
- 1998-07-15 DZ DZ980173A patent/DZ2563A1/fr active
- 1998-07-16 MA MA25172A patent/MA24608A1/fr unknown
- 1998-07-16 TR TR2000/00133T patent/TR200000133T2/xx unknown
- 1998-07-16 AR ARP980103482A patent/AR016350A1/es unknown
- 1998-07-16 IL IL13390798A patent/IL133907A0/xx unknown
- 1998-07-16 HU HU0003626A patent/HUP0003626A3/hu unknown
- 1998-07-16 JP JP2000502777A patent/JP2001510160A/ja active Pending
- 1998-07-16 EA EA200000140A patent/EA200000140A1/ru unknown
- 1998-07-16 EP EP98935129A patent/EP1001784A1/fr not_active Withdrawn
- 1998-07-16 PL PL98338140A patent/PL338140A1/xx unknown
- 1998-07-16 CA CA002297133A patent/CA2297133A1/fr not_active Abandoned
- 1998-07-16 SK SK61-2000A patent/SK612000A3/sk unknown
- 1998-07-16 BR BR9810292-3A patent/BR9810292A/pt not_active IP Right Cessation
- 1998-07-16 ID IDW20000077A patent/ID23804A/id unknown
- 1998-07-16 AU AU84490/98A patent/AU8449098A/en not_active Abandoned
- 1998-07-16 CN CN98807147A patent/CN1263467A/zh active Pending
- 1998-07-16 WO PCT/GB1998/002112 patent/WO1999003478A1/fr not_active Ceased
- 1998-07-16 PE PE1998000630A patent/PE99499A1/es not_active Application Discontinuation
- 1998-07-16 KR KR1020007000517A patent/KR20010021952A/ko not_active Withdrawn
- 1998-07-17 UY UY25101A patent/UY25101A1/es not_active Application Discontinuation
- 1998-07-17 ZA ZA9806364A patent/ZA986364B/xx unknown
- 1998-07-17 CO CO98040749A patent/CO4940489A1/es unknown
1999
- 1999-06-28 AR ARP990103110A patent/AR019724A2/es unknown
2000
- 2000-01-06 BG BG104062A patent/BG104062A/xx unknown
- 2000-01-14 AP APAP/P/2000/001735A patent/AP2000001735A0/en unknown
- 2000-01-17 NO NO20000230A patent/NO20000230D0/no not_active Application Discontinuation
- 2000-01-18 OA OA1200000013A patent/OA11312A/en unknown

Also Published As

Publication number	Publication date
EA200000140A1 (ru)	2000-06-26
IL133907A0 (en)	2001-04-30
NO20000230L (no)	2000-01-17
WO1999003478A1 (fr)	1999-01-28
OA11312A (en)	2003-10-24
GB9715298D0 (en)	1997-09-24
PL338140A1 (en)	2000-09-25
TR200000133T2 (tr)	2000-09-21
AR019724A2 (es)	2002-03-13
BR9810292A (pt)	2000-09-19
NO20000230D0 (no)	2000-01-17
HUP0003626A2 (hu)	2001-05-28
KR20010021952A (ko)	2001-03-15
CO4940489A1 (es)	2000-07-24
AR016350A1 (es)	2001-07-04
MA24608A1 (fr)	1999-04-01
DZ2563A1 (fr)	2003-02-15
BG104062A (en)	2000-11-30
AU8449098A (en)	1999-02-10
PE99499A1 (es)	1999-12-18
CN1263467A (zh)	2000-08-16
ZA986364B (en)	2000-01-17
CA2297133A1 (fr)	1999-01-28
HUP0003626A3 (en)	2001-12-28
UY25101A1 (es)	2000-12-29
JP2001510160A (ja)	2001-07-31
EP1001784A1 (fr)	2000-05-24
SK612000A3 (en)	2000-07-11
ID23804A (id)	2000-05-11

Publication	Publication Date	Title
MXPA02012763A (es)	2003-04-25	Combinaciones de inhibidores de dipeptidil peptidasa iv y otros agentes antidiabeticos para el tratamiento de diabetes mellitus.
MY155219A (en)	2015-09-30	Treatment of diabetes with thiazolidinedione, insulin secretagogue and biguanide
CA2294582A1 (fr)	1998-12-23	Traitement du diabete a l'aide de thiazolidinedione et de metformine
MY124695A (en)	2006-06-30	Novel composition and use.
AP2001002291A0 (en)	2001-12-31	Novel method of treatment.
AP2000001735A0 (en)	2000-01-16	Treatment of diabetes with thiazolidinedione insulin secretagogue and alpha glucocidase inhibitor.
TR199903095T2 (xx)	2000-08-21	Diabetin roziglitazon ve ins�lin ile tedavisi.
AP9901720A0 (en)	1999-12-31	Treatment of diabetes with thiazolidinedione and alpha-glucosidase inhibitors.
MY125855A (en)	2006-08-30	Treatment of diabetes with a thiazolidinedione and sulphonylurea
MY138246A (en)	2009-05-29	Treatment of diabetes with thiazolidione and sulphonylurea.
HK1041201A1 (zh)	2002-07-05	貝塔激動劑和抗糖尿病製劑的配伍
WO2001047509A3 (fr)	2002-09-12	Procede de traitement
IL143088A0 (en)	2002-11-10	A method for the treatment of type 2 diabetes mellitus and conditions associated therewith, and a pharmaceutical composition comprising an insulin sensitiser for use in such a method
ECSP982592A (es)	1999-02-22	Nuevo metodo de tratamiento v
ECSP982591A (es)	1999-02-22	Nuevo metodo de tratamiento iv
AP2000001787A0 (en)	2000-06-30	Use of thiazolidinediones for the treatment of hyperglycaemia.
ECSP982542A (es)	1999-02-11	Nuevo metodo de tratamiento iii
ECSP982534A (es)	1999-02-11	Nuevo metodo de tratamiento
ECSP982593A (es)	1999-02-22	Nuevo metodo de tratamiento vi
ECSP982535A (es)	1999-04-13	Nuevo metodo de tratamiento (i)