OA11312A - Treatment of diabetes with thiazolidinedione, insulin secretagogue and alpha glucocidase inhibitor. - Google Patents

Treatment of diabetes with thiazolidinedione, insulin secretagogue and alpha glucocidase inhibitor. Download PDF

Info

Publication number: OA11312A
Authority: OA; OAPI
Prior art keywords: composition according; compound; daims; insulin; theadministration
Prior art date: 1997-07-18

Application number

OA1200000013A

Other languages

English (en)

Inventor

Robin Edwin Buckingham

Stephen Alistair Smith

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-18

Filing date

2000-01-18

Publication date

2003-10-24

2000-01-18 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2003-10-24 Publication of OA11312A publication Critical patent/OA11312A/en

Links

229940122199 Insulin secretagogue Drugs 0.000 title claims abstract description 20
ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 title claims description 9
206010012601 diabetes mellitus Diseases 0.000 title abstract description 4
229940123464 Thiazolidinedione Drugs 0.000 title description 7
239000003112 inhibitor Substances 0.000 title description 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract description 74
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238000002156 mixing Methods 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
201000009925 nephrosclerosis Diseases 0.000 description 1
201000001119 neuropathy Diseases 0.000 description 1
230000007823 neuropathy Effects 0.000 description 1
239000002687 nonaqueous vehicle Substances 0.000 description 1
229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
239000005022 packaging material Substances 0.000 description 1
208000033808 peripheral neuropathy Diseases 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
201000010065 polycystic ovary syndrome Diseases 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
238000007789 sealing Methods 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
229940080313 sodium starch Drugs 0.000 description 1
239000007787 solid Substances 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
239000002278 tabletting lubricant Substances 0.000 description 1
230000002110 toxicologic effect Effects 0.000 description 1
231100000759 toxicological effect Toxicity 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Emergency Medicine (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

OA1200000013A 1997-07-18 2000-01-18 Treatment of diabetes with thiazolidinedione, insulin secretagogue and alpha glucocidase inhibitor. OA11312A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB9715298A GB9715298D0 (en)	1997-07-18	1997-07-18	Novel method of treatment

Publications (1)

Publication Number	Publication Date
OA11312A true OA11312A (en)	2003-10-24

Family

ID=10816170

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200000013A OA11312A (en)	1997-07-18	2000-01-18	Treatment of diabetes with thiazolidinedione, insulin secretagogue and alpha glucocidase inhibitor.

Country Status (27)

Country	Link
EP (1)	EP1001784A1 (fr)
JP (1)	JP2001510160A (fr)
KR (1)	KR20010021952A (fr)
CN (1)	CN1263467A (fr)
AP (1)	AP2000001735A0 (fr)
AR (2)	AR016350A1 (fr)
AU (1)	AU8449098A (fr)
BG (1)	BG104062A (fr)
BR (1)	BR9810292A (fr)
CA (1)	CA2297133A1 (fr)
CO (1)	CO4940489A1 (fr)
DZ (1)	DZ2563A1 (fr)
EA (1)	EA200000140A1 (fr)
GB (1)	GB9715298D0 (fr)
HU (1)	HUP0003626A3 (fr)
ID (1)	ID23804A (fr)
IL (1)	IL133907A0 (fr)
MA (1)	MA24608A1 (fr)
NO (1)	NO20000230D0 (fr)
OA (1)	OA11312A (fr)
PE (1)	PE99499A1 (fr)
PL (1)	PL338140A1 (fr)
SK (1)	SK612000A3 (fr)
TR (1)	TR200000133T2 (fr)
UY (1)	UY25101A1 (fr)
WO (1)	WO1999003478A1 (fr)
ZA (1)	ZA986364B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI238064B (en) *	1995-06-20	2005-08-21	Takeda Chemical Industries Ltd	A pharmaceutical composition for prophylaxis and treatment of diabetes
US7045519B2 (en)	1998-06-19	2006-05-16	Chiron Corporation	Inhibitors of glycogen synthase kinase 3
EP1849475A1 (fr)	1999-06-21	2007-10-31	Eli Lilly & Company	Utilisation synergique des thiazolidinediones avec peptide-1 comme glucagon et agonistes correspondants pour traiter les diabètes non dépendants de l'insuline
EP1743655B1 (fr) *	2000-01-21	2014-06-25	Novartis AG	Combinaisons à base d'inhibiteurs de DPP-IV et d'antidiabetiques
WO2001062295A1 (fr) *	2000-02-24	2001-08-30	Takeda Chemical Industries, Ltd.	Medicaments contenant des ingredients actifs combines
JP4917712B2 (ja) *	2000-02-24	2012-04-18	武田薬品工業株式会社	併用医薬
CA2434169C (fr)	2001-01-12	2011-03-15	Sun Pharmaceutical Industries Limited	Systeme de liberation espacee de medicaments
FR2832930A1 (fr) *	2001-12-03	2003-06-06	Lipha	Composition pharmaceutique comprenant un inhibiteur d'alpha-glucosidase et un derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete
CA2540225C (fr)	2003-10-31	2012-03-06	Takeda Pharmaceutical Company Limited	Preparation solide comprenant du pioglitazone, du glimepiride et un ester d'acide gras de polyoxyethylene sorbitan
CN101103993B (zh) *	2006-07-14	2011-03-30	北京华安佛医药研究中心有限公司	降糖药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0601001B1 (fr) *	1991-08-26	1997-04-16	PHARMACIA & UPJOHN COMPANY	Composition alimentaire liquide contenant de l'acide 3-guanidinopropionique
US5917052A (en) *	1994-09-28	1999-06-29	Shaman Pharmaceuticals, Inc.	Hypoglycemic agent from cryptolepis
TWI238064B (en) *	1995-06-20	2005-08-21	Takeda Chemical Industries Ltd	A pharmaceutical composition for prophylaxis and treatment of diabetes

1997
- 1997-07-18 GB GB9715298A patent/GB9715298D0/en active Pending
1998
- 1998-07-15 DZ DZ980173A patent/DZ2563A1/fr active
- 1998-07-16 MA MA25172A patent/MA24608A1/fr unknown
- 1998-07-16 TR TR2000/00133T patent/TR200000133T2/xx unknown
- 1998-07-16 AR ARP980103482A patent/AR016350A1/es unknown
- 1998-07-16 IL IL13390798A patent/IL133907A0/xx unknown
- 1998-07-16 HU HU0003626A patent/HUP0003626A3/hu unknown
- 1998-07-16 JP JP2000502777A patent/JP2001510160A/ja active Pending
- 1998-07-16 EA EA200000140A patent/EA200000140A1/ru unknown
- 1998-07-16 EP EP98935129A patent/EP1001784A1/fr not_active Withdrawn
- 1998-07-16 PL PL98338140A patent/PL338140A1/xx unknown
- 1998-07-16 CA CA002297133A patent/CA2297133A1/fr not_active Abandoned
- 1998-07-16 SK SK61-2000A patent/SK612000A3/sk unknown
- 1998-07-16 BR BR9810292-3A patent/BR9810292A/pt not_active IP Right Cessation
- 1998-07-16 ID IDW20000077A patent/ID23804A/id unknown
- 1998-07-16 AU AU84490/98A patent/AU8449098A/en not_active Abandoned
- 1998-07-16 CN CN98807147A patent/CN1263467A/zh active Pending
- 1998-07-16 WO PCT/GB1998/002112 patent/WO1999003478A1/fr not_active Ceased
- 1998-07-16 PE PE1998000630A patent/PE99499A1/es not_active Application Discontinuation
- 1998-07-16 KR KR1020007000517A patent/KR20010021952A/ko not_active Withdrawn
- 1998-07-17 UY UY25101A patent/UY25101A1/es not_active Application Discontinuation
- 1998-07-17 ZA ZA9806364A patent/ZA986364B/xx unknown
- 1998-07-17 CO CO98040749A patent/CO4940489A1/es unknown
1999
- 1999-06-28 AR ARP990103110A patent/AR019724A2/es unknown
2000
- 2000-01-06 BG BG104062A patent/BG104062A/xx unknown
- 2000-01-14 AP APAP/P/2000/001735A patent/AP2000001735A0/en unknown
- 2000-01-17 NO NO20000230A patent/NO20000230D0/no not_active Application Discontinuation
- 2000-01-18 OA OA1200000013A patent/OA11312A/en unknown

Also Published As

Publication number	Publication date
EA200000140A1 (ru)	2000-06-26
IL133907A0 (en)	2001-04-30
NO20000230L (no)	2000-01-17
WO1999003478A1 (fr)	1999-01-28
GB9715298D0 (en)	1997-09-24
PL338140A1 (en)	2000-09-25
AP2000001735A0 (en)	2000-01-16
TR200000133T2 (tr)	2000-09-21
AR019724A2 (es)	2002-03-13
BR9810292A (pt)	2000-09-19
NO20000230D0 (no)	2000-01-17
HUP0003626A2 (hu)	2001-05-28
KR20010021952A (ko)	2001-03-15
CO4940489A1 (es)	2000-07-24
AR016350A1 (es)	2001-07-04
MA24608A1 (fr)	1999-04-01
DZ2563A1 (fr)	2003-02-15
BG104062A (en)	2000-11-30
AU8449098A (en)	1999-02-10
PE99499A1 (es)	1999-12-18
CN1263467A (zh)	2000-08-16
ZA986364B (en)	2000-01-17
CA2297133A1 (fr)	1999-01-28
HUP0003626A3 (en)	2001-12-28
UY25101A1 (es)	2000-12-29
JP2001510160A (ja)	2001-07-31
EP1001784A1 (fr)	2000-05-24
SK612000A3 (en)	2000-07-11
ID23804A (id)	2000-05-11

Publication	Publication Date	Title
OA11516A (en)	2004-02-04	Treatment of diabetes with thiazolidinedione and metformin.
EP1001783B1 (fr)	2005-10-05	Traitement du diabete avec du thiazolidinedione, un secretagogue d'insuline et du biguanide
US20080058388A1 (en)	2008-03-06	Treatment of diabetes with thiazolidinedione and sulphonylurea
OA11312A (en)	2003-10-24	Treatment of diabetes with thiazolidinedione, insulin secretagogue and alpha glucocidase inhibitor.
AU743269B2 (en)	2002-01-24	Treatment of diabetes with thiazolidinedione and sulphonylurea
AU8539298A (en)	1999-01-04	Treatment of diabetes with thiazolidinedione and sulphonylurea
AU8799998A (en)	1999-01-04	Treatment of diabetes with thiazolidinedione and alpha-glucosidase inhibitor
US20020016287A1 (en)	2002-02-07	Treatment of diabetes with thiazolidinedione, insulin secretagogue and diguanide
US20030073645A1 (en)	2003-04-17	Treatment of diabetes with thiazolidinedione and alpha-glucosidase inhibitor
AU1540002A (en)	2002-03-21	Treatment of diabetes with thiazolidinedione and sulphonylurea
US20030092750A1 (en)	2003-05-15	Treatment of diabetes with thiazolidinedione, insulin secretagogue and alpha glucocidase inhibitor
HK1091393A (en)	2007-01-19	Treatment of diabetes with thiazolidinedione and sulphonylurea
AU2928002A (en)	2002-05-16	Treatment of diabetes with thiazolidinedione, insulin secretagogue and diguanide
HK1028550B (en)	2006-05-19	Treatment of diabetes with thiazolidinedione, insulin secretagogue and diguanide
AU2005227371A1 (en)	2005-11-24	Treatment of diabetes with thiazolidinedione, insulin secretagogue and diguanide