AP2000001761A0 - Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase. - Google Patents

Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.

Info

Publication number: AP2000001761A0
Authority: AP; ARIPO
Prior art keywords: inhibitors; neutrophil elastase; pyrrolopyrrolone; derivatives; pyrrolopyrrolone derivatives
Prior art date: 1997-09-09

Application number

APAP/P/2000/001761A

Other languages

English (en)

Inventor

Geoffrey Duke Edward Clarke

Michael Dennis Dowle

Harry Finch

Lee Andrew Harrison

Graham George Adam Inglis

Martin Redpath Johnson

Simon John Fawcett Macdonald

Primton Shah

Robin Andrew Smith

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-09

Filing date

1998-09-07

Publication date

2000-03-31

1997-09-09 Priority claimed from GBGB9719189.4A external-priority patent/GB9719189D0/en

1997-09-09 Priority claimed from GBGB9719183.7A external-priority patent/GB9719183D0/en

1997-09-10 Priority claimed from GBGB9719290.0A external-priority patent/GB9719290D0/en

1998-02-21 Priority claimed from GBGB9803611.4A external-priority patent/GB9803611D0/en

1998-09-07 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2000-03-31 Publication of AP2000001761A0 publication Critical patent/AP2000001761A0/en

Links

ACJSMQZKXAMMRA-UHFFFAOYSA-N 1h-pyrrolo[3,2-b]pyrrol-5-one Chemical class N1C=CC2=NC(=O)C=C21 ACJSMQZKXAMMRA-UHFFFAOYSA-N 0.000 title 1
108010028275 Leukocyte Elastase Proteins 0.000 title 1
102000016799 Leukocyte elastase Human genes 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
208000027866 inflammatory disease Diseases 0.000 abstract 1
210000002345 respiratory system Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

APAP/P/2000/001761A 1997-09-09 1998-09-07 Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase. AP2000001761A0 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GBGB9719189.4A GB9719189D0 (en)	1997-09-09	1997-09-09	New therapeutic method
GBGB9719183.7A GB9719183D0 (en)	1997-09-09	1997-09-09	Compounds
GBGB9719290.0A GB9719290D0 (en)	1997-09-10	1997-09-10	Compounds
GBGB9803611.4A GB9803611D0 (en)	1998-02-21	1998-02-21	Compounds
PCT/EP1998/005609 WO1999012933A2 (en)	1997-09-09	1998-09-07	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

Publications (1)

Publication Number	Publication Date
AP2000001761A0 true AP2000001761A0 (en)	2000-03-31

Family

ID=27451698

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/2000/001761A AP2000001761A0 (en)	1997-09-09	1998-09-07	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.

Country Status (24)

Country	Link
EP (1)	EP1003748A2 (de)
JP (1)	JP2001515904A (de)
KR (1)	KR20010023766A (de)
CN (1)	CN1278820A (de)
AP (1)	AP2000001761A0 (de)
AR (1)	AR017072A1 (de)
AU (1)	AU9741298A (de)
BR (1)	BR9812062A (de)
CA (1)	CA2303176A1 (de)
CO (1)	CO4970719A1 (de)
EA (1)	EA200000204A1 (de)
EE (1)	EE200000138A (de)
HU (1)	HUP0004644A3 (de)
ID (1)	ID24452A (de)
IL (1)	IL134791A0 (de)
IS (1)	IS5391A (de)
MA (1)	MA26543A1 (de)
NO (1)	NO20001198L (de)
NZ (1)	NZ503130A (de)
PE (1)	PE107899A1 (de)
PL (1)	PL339176A1 (de)
SK (1)	SK3192000A3 (de)
TR (1)	TR200000907T2 (de)
WO (1)	WO1999012933A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9905418D0 (en) *	1999-03-09	1999-05-05	Glaxo Group Ltd	Process
MXPA06011410A (es)	2004-03-31	2007-04-20	Johnson & Johnson	Compuestos heterociclicos sin imidazol como moduladores de receptor de histamina h3.
DE102004024772A1 (de) *	2004-05-17	2005-12-22	Grünenthal GmbH	Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide
JP4853759B2 (ja) *	2004-05-27	2012-01-11	日本農薬株式会社	置換ピラジンカルボン酸アニリド誘導体又はその塩類、その中間体及び農園芸用薬剤並びにその使用方法
TWI355380B (en) *	2004-05-27	2012-01-01	Nihon Nohyaku Co Ltd	Substituted pyrazinecarboxanilide derivatives or s
GB2418427A (en)	2004-09-02	2006-03-29	Univ Cambridge Tech	Ligands for G-protein coupled receptors
ES2328384T3 (es)	2004-11-23	2009-11-12	Warner-Lambert Company Llc	Derivados del acido 7-(2h-pirazol-3-il)-3,5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de la lipidemia.
US8198288B2 (en)	2006-05-04	2012-06-12	Pulmagen Therapeutics (Inflammation) Limited	Tetrahydropyrrolopyrimidinediones and their use in therapy
DK2024367T3 (da)	2006-05-04	2011-01-03	Pulmagen Therapeutics Inflammation Ltd	Tetrahydropyrrolopyrimidindioner og deres anvendelse som inhibitorer af human neutrofil elastase
US7662967B2 (en)	2007-08-02	2010-02-16	Cambridge Enterprise Limited	Anti-inflammatory compounds and compositions
GB2452696B (en)	2007-08-02	2009-09-23	Cambridge Entpr Ltd	3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
WO2009060206A1 (en) *	2007-11-07	2009-05-14	Argenta Discovery Limited	3,4,6,7-tetrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones and their therapeutic use
US20110212181A1 (en) *	2010-02-26	2011-09-01	The University Of Hong Kong	Compositions and methods for treating chronic respiratory inflammation
AU2020349353A1 (en)	2019-09-17	2022-04-14	Duke University	Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
HUE064089T2 (hu)	2020-04-16	2024-02-28	Mereo Biopharma 4 Ltd	Alvelesztat neutrofil elasztáz inhibitort alkalmazó módszerek alfa-1-antitripszin hiány által közvetített légzõszervi megbetegedés kezelésére
AU2022373971A1 (en)	2021-10-20	2024-04-04	Mereo Biopharma 4 Limited	Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9211783D0 (en) *	1992-06-04	1992-07-15	Ici Plc	Amide derivatives
GB9402680D0 (en) *	1994-02-11	1994-04-06	Zeneca Ltd	Pyrrolidine derivatives
IL125859A0 (en) *	1996-03-28	1999-04-11	Glaxo Group Ltd	Pyrrolopyrrolone derivatives useful as inhibitors of neutrophil elastase

1998
- 1998-09-04 PE PE1998000828A patent/PE107899A1/es not_active Application Discontinuation
- 1998-09-07 ID IDW20000445A patent/ID24452A/id unknown
- 1998-09-07 HU HU0004644A patent/HUP0004644A3/hu unknown
- 1998-09-07 WO PCT/EP1998/005609 patent/WO1999012933A2/en not_active Ceased
- 1998-09-07 AU AU97412/98A patent/AU9741298A/en not_active Abandoned
- 1998-09-07 TR TR2000/00907T patent/TR200000907T2/xx unknown
- 1998-09-07 CN CN98810954A patent/CN1278820A/zh active Pending
- 1998-09-07 MA MA25243A patent/MA26543A1/fr unknown
- 1998-09-07 IL IL13479198A patent/IL134791A0/xx unknown
- 1998-09-07 AR ARP980104458A patent/AR017072A1/es unknown
- 1998-09-07 CA CA002303176A patent/CA2303176A1/en not_active Abandoned
- 1998-09-07 EA EA200000204A patent/EA200000204A1/ru unknown
- 1998-09-07 KR KR1020007002422A patent/KR20010023766A/ko not_active Withdrawn
- 1998-09-07 BR BR9812062-0A patent/BR9812062A/pt not_active Application Discontinuation
- 1998-09-07 SK SK319-2000A patent/SK3192000A3/sk unknown
- 1998-09-07 PL PL98339176A patent/PL339176A1/xx not_active Application Discontinuation
- 1998-09-07 NZ NZ503130A patent/NZ503130A/en unknown
- 1998-09-07 EE EEP200000138A patent/EE200000138A/xx unknown
- 1998-09-07 JP JP2000510740A patent/JP2001515904A/ja active Pending
- 1998-09-07 AP APAP/P/2000/001761A patent/AP2000001761A0/en unknown
- 1998-09-07 EP EP98951348A patent/EP1003748A2/de not_active Withdrawn
- 1998-09-08 CO CO98051488A patent/CO4970719A1/es unknown
2000
- 2000-02-29 IS IS5391A patent/IS5391A/is unknown
- 2000-03-08 NO NO20001198A patent/NO20001198L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO1999012933A2 (en)	1999-03-18
ID24452A (id)	2000-07-20
BR9812062A (pt)	2000-09-26
HUP0004644A3 (en)	2002-01-28
IS5391A (is)	2000-02-29
EE200000138A (et)	2001-02-15
CN1278820A (zh)	2001-01-03
CA2303176A1 (en)	1999-03-18
CO4970719A1 (es)	2000-11-07
EP1003748A2 (de)	2000-05-31
SK3192000A3 (en)	2001-03-12
WO1999012933A3 (en)	1999-05-27
NO20001198D0 (no)	2000-03-08
NZ503130A (en)	2001-08-31
NO20001198L (no)	2000-05-08
HUP0004644A2 (hu)	2001-09-28
EA200000204A1 (ru)	2000-10-30
IL134791A0 (en)	2001-04-30
TR200000907T2 (tr)	2000-11-21
AR017072A1 (es)	2001-08-22
PL339176A1 (en)	2000-12-04
KR20010023766A (ko)	2001-03-26
AU9741298A (en)	1999-03-29
JP2001515904A (ja)	2001-09-25
MA26543A1 (fr)	2004-12-20
PE107899A1 (es)	1999-11-17

Publication	Publication Date	Title
JO2311B1 (en)	2005-09-12	Alkyl inhibitors Ariel phosphodiesterase-4
AU1617901A (en)	2001-05-30	Urea derivatives as anti-inflammatory agents
BG106586A (en)	2003-01-31	Pyrazolopyramidines as therapeutic agents
TR200000059T2 (tr)	2000-06-21	Piridin türevleri
NO20025601L (no)	2003-01-06	Arylmetylaminderivater for anvendelse som tryptaseinhibitorer
BG105783A (en)	2002-03-29	Triazole compounds with dopamine-d3-receptor affinity
MY121294A (en)	2006-01-28	Novel hexanoic acid derivatives.
AP2002002637A0 (en)	2002-09-30	Novel piperazine
MX9707980A (es)	1998-04-30	Derivados de 4-aminoquinazolina, composiciones que los contienen, y uso de los mismos.
AU6645998A (en)	1998-07-17	Oxygen or sulfur containing heteroaromatics as factor xa inhibitors
WO2001066564A3 (en)	2002-01-03	Gamma-secretase inhibitors
BG106444A (en)	2002-09-30	Benzodiazepin derivatives, the production and use thereof
BG105650A (en)	2002-02-28	Azepinoindole derivatives, the production and use thereof
TR200200068T2 (tr)	2002-05-21	Nematisital triflüorobütenler
AU4064597A (en)	1998-03-06	Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
YU87202A (sh)	2006-05-25	Derivati arilmetilamina koji se koriste kao inhibitori triptaze
GB0011203D0 (en)	2000-06-28	Chemical compounds
IT1285770B1 (it)	1998-06-18	Composti corticoidei
TR199802060T2 (xx)	1999-01-18	Aminoisokinolinler ve aminopiridin t�revlerinin iltihap �nleyiciler olarak kullan�m�.
WO1999012933A3 (en)	1999-05-27	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase
ATE303384T1 (de)	2005-09-15	1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
DE69924292D1 (de)	2005-04-21	Pyrazol verbindungen und ihre verwendung
SE9803518D0 (sv)	1998-10-15	Novel compounds
MXPA04004372A (es)	2004-08-11	Derivados heterociclicos de glicinamida y su uso medico.
AP2001002191A0 (en)	2001-06-01	3,3- Biarylpiperine and 2,2-biarylmorpholine derivatives.