TR200000907T2 - Nötrofil elastaz inhibitörleri olarak pirolopirolon türevleri. - Google Patents

Nötrofil elastaz inhibitörleri olarak pirolopirolon türevleri.

Info

Publication number
TR200000907T2
TR200000907T2 TR2000/00907T TR200000907T TR200000907T2 TR 200000907 T2 TR200000907 T2 TR 200000907T2 TR 2000/00907 T TR2000/00907 T TR 2000/00907T TR 200000907 T TR200000907 T TR 200000907T TR 200000907 T2 TR200000907 T2 TR 200000907T2
Authority
TR
Turkey
Prior art keywords
pyrolopirolone
derivatives
neutrophil elastase
elastase inhibitors
compounds
Prior art date
Application number
TR2000/00907T
Other languages
English (en)
Inventor
Duke Edward Clarke Geoffrey
Dennis Dowle Michael
Finch Harry
Andrew Harrison Lee
George Adam Inglis Graham
Redpath Johnson Martin
John Fawcett Macdonald Simon
Shah Pritom
Andrew Smith Robin
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9719189.4A external-priority patent/GB9719189D0/en
Priority claimed from GBGB9719183.7A external-priority patent/GB9719183D0/en
Priority claimed from GBGB9719290.0A external-priority patent/GB9719290D0/en
Priority claimed from GBGB9803611.4A external-priority patent/GB9803611D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of TR200000907T2 publication Critical patent/TR200000907T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Bu bulusa göre (I) formülünün bilesikleri temin edilmektedir, bu formülde, R1,R2,ve R3 tarifnamede tanimlandigi gibidir. (I) formülü bilesikleri, diger yararlarinin yaninda, solunum yolunun ihtihapli bozukluklarinin tedavisinde yararli olmaktadir.
TR2000/00907T 1997-09-09 1998-09-07 Nötrofil elastaz inhibitörleri olarak pirolopirolon türevleri. TR200000907T2 (tr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9719189.4A GB9719189D0 (en) 1997-09-09 1997-09-09 New therapeutic method
GBGB9719183.7A GB9719183D0 (en) 1997-09-09 1997-09-09 Compounds
GBGB9719290.0A GB9719290D0 (en) 1997-09-10 1997-09-10 Compounds
GBGB9803611.4A GB9803611D0 (en) 1998-02-21 1998-02-21 Compounds

Publications (1)

Publication Number Publication Date
TR200000907T2 true TR200000907T2 (tr) 2000-11-21

Family

ID=27451698

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00907T TR200000907T2 (tr) 1997-09-09 1998-09-07 Nötrofil elastaz inhibitörleri olarak pirolopirolon türevleri.

Country Status (24)

Country Link
EP (1) EP1003748A2 (tr)
JP (1) JP2001515904A (tr)
KR (1) KR20010023766A (tr)
CN (1) CN1278820A (tr)
AP (1) AP2000001761A0 (tr)
AR (1) AR017072A1 (tr)
AU (1) AU9741298A (tr)
BR (1) BR9812062A (tr)
CA (1) CA2303176A1 (tr)
CO (1) CO4970719A1 (tr)
EA (1) EA200000204A1 (tr)
EE (1) EE200000138A (tr)
HU (1) HUP0004644A3 (tr)
ID (1) ID24452A (tr)
IL (1) IL134791A0 (tr)
IS (1) IS5391A (tr)
MA (1) MA26543A1 (tr)
NO (1) NO20001198L (tr)
NZ (1) NZ503130A (tr)
PE (1) PE107899A1 (tr)
PL (1) PL339176A1 (tr)
SK (1) SK3192000A3 (tr)
TR (1) TR200000907T2 (tr)
WO (1) WO1999012933A2 (tr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9905418D0 (en) * 1999-03-09 1999-05-05 Glaxo Group Ltd Process
DE602005025222D1 (de) 2004-03-31 2011-01-20 Janssen Pharmaceutica Nv Heterocyclische nichtimidazolverbindungen als modulatoren des histamin-h3-rezeptors
DE102004024772A1 (de) 2004-05-17 2005-12-22 Grünenthal GmbH Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide
JP4853759B2 (ja) * 2004-05-27 2012-01-11 日本農薬株式会社 置換ピラジンカルボン酸アニリド誘導体又はその塩類、その中間体及び農園芸用薬剤並びにその使用方法
TWI355380B (en) 2004-05-27 2012-01-01 Nihon Nohyaku Co Ltd Substituted pyrazinecarboxanilide derivatives or s
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
WO2006056845A1 (en) 2004-11-23 2006-06-01 Warner-Lambert Company Llc 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia
US8198288B2 (en) 2006-05-04 2012-06-12 Pulmagen Therapeutics (Inflammation) Limited Tetrahydropyrrolopyrimidinediones and their use in therapy
NZ572250A (en) 2006-05-04 2011-10-28 Pulmagen Therapeutics Inflammation Ltd Tetrahydropyrrolopyrimidinediones and their use as human neutrophil elastase inhibitors
GB2452696B (en) 2007-08-02 2009-09-23 Cambridge Entpr Ltd 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
US7662967B2 (en) 2007-08-02 2010-02-16 Cambridge Enterprise Limited Anti-inflammatory compounds and compositions
WO2009060206A1 (en) * 2007-11-07 2009-05-14 Argenta Discovery Limited 3,4,6,7-tetrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones and their therapeutic use
US20110212181A1 (en) * 2010-02-26 2011-09-01 The University Of Hong Kong Compositions and methods for treating chronic respiratory inflammation
CN114650819A (zh) 2019-09-17 2022-06-21 美莱奥生物制药第四有限公司 用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他
WO2021209740A1 (en) 2020-04-16 2021-10-21 Mereo Biopharma 4 Limited Methods involving neutrophil elastase inhibitor alvelestat for treating coronavirus infection
EP4419102A1 (en) 2021-10-20 2024-08-28 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211783D0 (en) * 1992-06-04 1992-07-15 Ici Plc Amide derivatives
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives
EE9800335A (et) * 1996-03-28 1999-04-15 Glaxo Group Limited Pürrolopürrolooni derivaadid kui neutrofiilelastaasi inhibiitorid

Also Published As

Publication number Publication date
PE107899A1 (es) 1999-11-17
CA2303176A1 (en) 1999-03-18
WO1999012933A2 (en) 1999-03-18
IL134791A0 (en) 2001-04-30
NO20001198L (no) 2000-05-08
BR9812062A (pt) 2000-09-26
PL339176A1 (en) 2000-12-04
IS5391A (is) 2000-02-29
MA26543A1 (fr) 2004-12-20
EA200000204A1 (ru) 2000-10-30
SK3192000A3 (en) 2001-03-12
WO1999012933A3 (en) 1999-05-27
EE200000138A (et) 2001-02-15
AP2000001761A0 (en) 2000-03-31
NO20001198D0 (no) 2000-03-08
AR017072A1 (es) 2001-08-22
AU9741298A (en) 1999-03-29
KR20010023766A (ko) 2001-03-26
JP2001515904A (ja) 2001-09-25
ID24452A (id) 2000-07-20
CO4970719A1 (es) 2000-11-07
HUP0004644A2 (hu) 2001-09-28
EP1003748A2 (en) 2000-05-31
HUP0004644A3 (en) 2002-01-28
NZ503130A (en) 2001-08-31
CN1278820A (zh) 2001-01-03

Similar Documents

Publication Publication Date Title
ATE264846T1 (de) Substituierte benzimidazol-derivaten und ihre verwendung zur behandlung retroviraler infektionen
DE60036726D1 (de) Harnstoff derivate als entzündungshemmende mittel
TR200000907T2 (tr) Nötrofil elastaz inhibitörleri olarak pirolopirolon türevleri.
ES2196396T3 (es) Compuestos heteroaromaticos de 5 miembros conteniendo oxigeno o azufre como inhibidores del factor xa.
TR200000059T2 (tr) Piridin türevleri
FI970246A7 (fi) Dihydrobentsofuraanit
TR200100805T2 (tr) Tetrahidropiridoeterler
TR200101709T2 (tr) İltihabik hastalıkların tedavisinde yararlı olan bileşikler
ATE230392T1 (de) Amidinophenyl-pyrrolidine, -pyrroline und - isoxazolidine und ihre derivate
TR200101499T1 (tr) Azepinoindol türevleri, hazırlanmaları ve kullanımları.
TR200201505T2 (tr) Terapötik maddeler olarak pirazolopirimidinler
TR199901191T2 (tr) Benzamidoaldehitlerin sistein proteazi inhibitörü olarak kullanimi.
ATE277929T1 (de) Immunsuppressive wirkungen von pteridinderivaten
IT1285770B1 (it) Composti corticoidei
ATE303384T1 (de) 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
ATE258930T1 (de) Dihydrobenzifurane
ATE311389T1 (de) Wirkstoffvorläufer von imidazopyridin-derivaten
TR200201128T2 (tr) PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
PT775118E (pt) Derivados de benzimidazole com actividade dopaminergica
SE9903290D0 (sv) Novel compounds
DK1377574T3 (da) 6-phenylbenzonaphtyridiner
AP2000001760A0 (en) Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.
ATE276259T1 (de) Dihydroporphyrinderivate und ihre verwendung
DK1244614T3 (da) Tryptase-inhibitorer
TR200001122T2 (tr) Farmasötikler olarak bifenil türevleri.