AP2005003231A0 - Beta-lactamase inhibitor prodrug. - Google Patents

Beta-lactamase inhibitor prodrug.

Info

Publication number
AP2005003231A0
AP2005003231A0 AP2005003231A AP2005003231A AP2005003231A0 AP 2005003231 A0 AP2005003231 A0 AP 2005003231A0 AP 2005003231 A AP2005003231 A AP 2005003231A AP 2005003231 A AP2005003231 A AP 2005003231A AP 2005003231 A0 AP2005003231 A0 AP 2005003231A0
Authority
AP
ARIPO
Prior art keywords
beta
lactamase inhibitor
inhibitor prodrug
prodrug
lactamase
Prior art date
Application number
AP2005003231A
Other languages
English (en)
Inventor
Dale Gordon Mcleod
Anthony Marfat
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AP2005003231A0 publication Critical patent/AP2005003231A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AP2005003231A 2002-08-23 2003-08-11 Beta-lactamase inhibitor prodrug. AP2005003231A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40564002P 2002-08-23 2002-08-23
PCT/IB2003/003582 WO2004018484A1 (en) 2002-08-23 2003-08-11 Beta-lactamase inhibitor prodrug

Publications (1)

Publication Number Publication Date
AP2005003231A0 true AP2005003231A0 (en) 2005-03-31

Family

ID=31946909

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2005003231A AP2005003231A0 (en) 2002-08-23 2003-08-11 Beta-lactamase inhibitor prodrug.

Country Status (31)

Country Link
US (1) US7091197B2 (is)
EP (1) EP1534717B1 (is)
JP (1) JP2005539037A (is)
KR (1) KR20050037583A (is)
CN (1) CN1688589A (is)
AP (1) AP2005003231A0 (is)
AR (1) AR041028A1 (is)
AT (1) ATE349452T1 (is)
AU (1) AU2003250489A1 (is)
BR (1) BR0313683A (is)
CA (1) CA2494953A1 (is)
DE (1) DE60310733D1 (is)
EA (1) EA007540B1 (is)
EC (1) ECSP055625A (is)
GT (1) GT200300179A (is)
HR (1) HRP20050162A2 (is)
IL (1) IL166719A0 (is)
IS (1) IS7693A (is)
MA (1) MA27387A1 (is)
MX (1) MXPA05001446A (is)
NO (1) NO20051497D0 (is)
NZ (1) NZ538340A (is)
OA (1) OA12909A (is)
PA (1) PA8579701A1 (is)
PE (1) PE20040899A1 (is)
PL (1) PL375988A1 (is)
TN (1) TNSN05054A1 (is)
TW (1) TWI250162B (is)
UY (1) UY27947A1 (is)
WO (1) WO2004018484A1 (is)
ZA (1) ZA200501513B (is)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1636240A1 (en) * 2003-06-05 2006-03-22 Pfizer Products Inc. Beta-lactamase inhibitor prodrug
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
US20090306341A1 (en) * 2005-07-29 2009-12-10 Joachim Emmert LC/MS Blends Containing Ionizing Additives
WO2010118968A1 (en) 2009-04-16 2010-10-21 Nicox S.A. No-donor aspirin derivatives
WO2013056163A1 (en) 2011-10-14 2013-04-18 The Regents Of The University Of California Beta-lactamase inhibitors
CN104159587A (zh) * 2012-01-06 2014-11-19 南佛罗里达大学 组合物、使用方法、以及治疗方法
CN109422765B (zh) * 2017-09-05 2020-08-28 香港理工大学深圳研究院 C类β-内酰胺酶抑制剂及其制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34011B1 (en) 1969-03-13 1975-01-08 Leo Pharm Prod Ltd New penicillin esters
IE34019B1 (en) 1969-03-18 1975-01-08 Leo Pharm Prod Ltd New semi-synthetic penicillin esters
GB1267936A (en) 1969-05-28 1972-03-22 Beecham Group Ltd DERIVATIVES OF alpha-AMINOPENICILLINS
US3957764A (en) 1969-11-11 1976-05-18 Lovens Kemiske Fabrik Produktionsaktieselskab 6-aminopenicillanic acid derivatives
US3862181A (en) 1970-10-28 1975-01-21 Squibb & Sons Inc Process for preparing cephalosporins
GB1315566A (en) 1970-11-06 1973-05-02 Leo Pharm Prod Ltd Penicillanic acid derivatives
CA996929A (en) 1971-04-05 1976-09-14 Kohzi Nakano Acyloxyalkyl ester derivatives of penicillin
GB1433131A (en) 1972-03-13 1976-04-22 Astra Laekemedel Ab Penicillins
GB1426717A (en) 1972-03-13 1976-03-03 Astra Laekemedel Ab Penicillins
US4397783A (en) 1979-03-05 1983-08-09 Pfizer Inc. Process for converting 6,6-disubstituted penicillanic acid derivatives to the 6-β-congeners
DE2927004A1 (de) * 1979-07-04 1981-05-27 Bayer Ag, 5090 Leverkusen Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel
US4287181A (en) * 1979-10-22 1981-09-01 Pfizer Inc. Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors
US4432970A (en) 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
GB2076812A (en) * 1980-05-22 1981-12-09 Ciba Geigy Ag Penam-dioxide compounds, processes for their manufacture, and their use
JPS5849387A (ja) 1981-09-17 1983-03-23 Sankyo Co Ltd ７−メトキシセフアロスポリン化合物およびその製法
EP0076066B1 (en) * 1981-09-22 1986-11-26 Kureha Kagaku Kogyo Kabushiki Kaisha Penicillin derivatives
US4406887A (en) 1981-10-13 1983-09-27 Bristol-Myers Company Method for treating resistant bacteria including anaerobes
US4428935A (en) * 1982-05-24 1984-01-31 Pfizer Inc. Penicillanic acid dioxide prodrug
US4521533A (en) 1984-07-12 1985-06-04 Pfizer Inc. Salts of 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide esters and beta-lactam antibiotics
DE3901405A1 (de) 1989-01-19 1990-07-26 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
JPH03206038A (ja) 1990-01-08 1991-09-09 Yoshitomi Pharmaceut Ind Ltd 抗菌剤
GB9001405D0 (en) 1990-01-22 1990-03-21 Leo Pharm Prod Ltd New intermediates,their production and use
GB9208492D0 (en) 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
EP1636240A1 (en) 2003-06-05 2006-03-22 Pfizer Products Inc. Beta-lactamase inhibitor prodrug

Also Published As

Publication number Publication date
PL375988A1 (en) 2005-12-12
NO20051497L (no) 2005-03-21
AU2003250489A1 (en) 2004-03-11
IS7693A (is) 2005-02-10
KR20050037583A (ko) 2005-04-22
TWI250162B (en) 2006-03-01
EP1534717A1 (en) 2005-06-01
TNSN05054A1 (fr) 2007-05-14
NZ538340A (en) 2006-10-27
ECSP055625A (es) 2005-04-18
EA200500398A1 (ru) 2005-08-25
JP2005539037A (ja) 2005-12-22
CN1688589A (zh) 2005-10-26
AR041028A1 (es) 2005-04-27
US20040110740A1 (en) 2004-06-10
CA2494953A1 (en) 2004-03-04
NO20051497D0 (no) 2005-03-21
MA27387A1 (fr) 2005-06-01
HRP20050162A2 (en) 2005-06-30
ZA200501513B (en) 2006-09-27
TW200417548A (en) 2004-09-16
ATE349452T1 (de) 2007-01-15
PA8579701A1 (es) 2005-05-24
UY27947A1 (es) 2004-03-31
EP1534717B1 (en) 2006-12-27
PE20040899A1 (es) 2004-12-28
MXPA05001446A (es) 2005-06-06
BR0313683A (pt) 2005-06-21
IL166719A0 (en) 2006-01-15
GT200300179A (es) 2004-05-18
US7091197B2 (en) 2006-08-15
OA12909A (en) 2006-10-13
DE60310733D1 (de) 2007-02-08
EA007540B1 (ru) 2006-10-27
WO2004018484A1 (en) 2004-03-04

Similar Documents

Publication Publication Date Title
EG25482A (en) Inhibitors
AU2003202263A1 (en) Roh-kinase inhibitors
AP2005003198A0 (en) Spiroindolinepiperidine derivatives.
ZA200500170B (en) Indole-3-sulphur derivatives.
EP1483254A4 (en) INHIBITORS OF ANTI-RESISTANCE RETROVIRAL PROTEASE
AU2003249683A1 (en) Nf-:b inhibitors
AU2003249477A1 (en) Heterobicylcic metalloproteinase inhibitors
AU2003230392A1 (en) Beta-secretase inhibitors
IL164898A0 (en) Heterotricyclyl 6-alkylidene-penems as beta-lactamase inhibitors
AU2003302588A1 (en) Phosphodiesterase 10a inhibitors
AU2003244080A1 (en) Phosphodiesterase inhibitor
AP2005003242A0 (en) Broadspectrum 2-aminobenzothiazole sulfonamide HIVprotease inhibitors.
ZA200408511B (en) Plasma carboxypeptidase B inhibitors.
AUPS282002A0 (en) Metalloproteinase inhibitors
IL166719A0 (en) Beta-lactamase inhibitor prodrug
NL1026340A1 (nl) Beta-lactamaseremmerprodrug.
AU2002950577A0 (en) Drilling arrangement
AU2003298513A8 (en) Sterically-awkward beta-lactamase inhibitors
AU2003252417A1 (en) Protease inhibitor
HK1069391A (en) Heterotricyclyl 6-alkylidene-penems as beta-lactamase inhibitors
ZA200207924B (en) Combination tool.
EG23241A (en) Beshob.
GB0208094D0 (en) Inhibitors
GB0206031D0 (en) Inhibitors
GB0217330D0 (en) Inhibitors