ATE349452T1 - Prodrug eines beta-lactamase-inhibitors - Google Patents

Prodrug eines beta-lactamase-inhibitors

Info

Publication number
ATE349452T1
ATE349452T1 AT03792574T AT03792574T ATE349452T1 AT E349452 T1 ATE349452 T1 AT E349452T1 AT 03792574 T AT03792574 T AT 03792574T AT 03792574 T AT03792574 T AT 03792574T AT E349452 T1 ATE349452 T1 AT E349452T1
Authority
AT
Austria
Prior art keywords
prodrug
beta
lactamase inhibitor
lactamase
inhibitor
Prior art date
Application number
AT03792574T
Other languages
English (en)
Inventor
Anthony Marfat
Dale Gordon Mcleod
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE349452T1 publication Critical patent/ATE349452T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT03792574T 2002-08-23 2003-08-11 Prodrug eines beta-lactamase-inhibitors ATE349452T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40564002P 2002-08-23 2002-08-23

Publications (1)

Publication Number Publication Date
ATE349452T1 true ATE349452T1 (de) 2007-01-15

Family

ID=31946909

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03792574T ATE349452T1 (de) 2002-08-23 2003-08-11 Prodrug eines beta-lactamase-inhibitors

Country Status (31)

Country Link
US (1) US7091197B2 (de)
EP (1) EP1534717B1 (de)
JP (1) JP2005539037A (de)
KR (1) KR20050037583A (de)
CN (1) CN1688589A (de)
AP (1) AP2005003231A0 (de)
AR (1) AR041028A1 (de)
AT (1) ATE349452T1 (de)
AU (1) AU2003250489A1 (de)
BR (1) BR0313683A (de)
CA (1) CA2494953A1 (de)
DE (1) DE60310733D1 (de)
EA (1) EA007540B1 (de)
EC (1) ECSP055625A (de)
GT (1) GT200300179A (de)
HR (1) HRP20050162A2 (de)
IL (1) IL166719A0 (de)
IS (1) IS7693A (de)
MA (1) MA27387A1 (de)
MX (1) MXPA05001446A (de)
NO (1) NO20051497L (de)
NZ (1) NZ538340A (de)
OA (1) OA12909A (de)
PA (1) PA8579701A1 (de)
PE (1) PE20040899A1 (de)
PL (1) PL375988A1 (de)
TN (1) TNSN05054A1 (de)
TW (1) TWI250162B (de)
UY (1) UY27947A1 (de)
WO (1) WO2004018484A1 (de)
ZA (1) ZA200501513B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006526612A (ja) * 2003-06-05 2006-11-24 ファイザー・プロダクツ・インク ベータ−ラクタマーゼ阻害剤・プロドラッグ
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
EP1913378A1 (de) * 2005-07-29 2008-04-23 Sigma-Aldrich Production GmbH Ionisierungsadditive enthaltende lc/ms-blends
WO2010118968A1 (en) 2009-04-16 2010-10-21 Nicox S.A. No-donor aspirin derivatives
WO2013056163A1 (en) 2011-10-14 2013-04-18 The Regents Of The University Of California Beta-lactamase inhibitors
EP2800568A4 (de) 2012-01-06 2015-06-10 Univ South Florida Zusammensetzungen, verwendungsverfahren dafür und behandlungsverfahren damit
CN109422765B (zh) * 2017-09-05 2020-08-28 香港理工大学深圳研究院 C类β-内酰胺酶抑制剂及其制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34011B1 (en) * 1969-03-13 1975-01-08 Leo Pharm Prod Ltd New penicillin esters
IE34019B1 (en) * 1969-03-18 1975-01-08 Leo Pharm Prod Ltd New semi-synthetic penicillin esters
GB1267936A (en) 1969-05-28 1972-03-22 Beecham Group Ltd DERIVATIVES OF alpha-AMINOPENICILLINS
US3957764A (en) * 1969-11-11 1976-05-18 Lovens Kemiske Fabrik Produktionsaktieselskab 6-aminopenicillanic acid derivatives
US3862181A (en) * 1970-10-28 1975-01-21 Squibb & Sons Inc Process for preparing cephalosporins
GB1315566A (en) 1970-11-06 1973-05-02 Leo Pharm Prod Ltd Penicillanic acid derivatives
CA996929A (en) 1971-04-05 1976-09-14 Kohzi Nakano Acyloxyalkyl ester derivatives of penicillin
GB1433131A (en) * 1972-03-13 1976-04-22 Astra Laekemedel Ab Penicillins
GB1426717A (en) 1972-03-13 1976-03-03 Astra Laekemedel Ab Penicillins
US4397783A (en) * 1979-03-05 1983-08-09 Pfizer Inc. Process for converting 6,6-disubstituted penicillanic acid derivatives to the 6-β-congeners
DE2927004A1 (de) * 1979-07-04 1981-05-27 Bayer Ag, 5090 Leverkusen Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel
US4287181A (en) * 1979-10-22 1981-09-01 Pfizer Inc. Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
GB2076812A (en) * 1980-05-22 1981-12-09 Ciba Geigy Ag Penam-dioxide compounds, processes for their manufacture, and their use
JPS5849387A (ja) 1981-09-17 1983-03-23 Sankyo Co Ltd ７−メトキシセフアロスポリン化合物およびその製法
EP0076066B1 (de) * 1981-09-22 1986-11-26 Kureha Kagaku Kogyo Kabushiki Kaisha Penicillin-Derivate
US4406887A (en) * 1981-10-13 1983-09-27 Bristol-Myers Company Method for treating resistant bacteria including anaerobes
US4428935A (en) * 1982-05-24 1984-01-31 Pfizer Inc. Penicillanic acid dioxide prodrug
US4521533A (en) * 1984-07-12 1985-06-04 Pfizer Inc. Salts of 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide esters and beta-lactam antibiotics
DE3901405A1 (de) 1989-01-19 1990-07-26 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
JPH03206038A (ja) 1990-01-08 1991-09-09 Yoshitomi Pharmaceut Ind Ltd 抗菌剤
GB9001405D0 (en) * 1990-01-22 1990-03-21 Leo Pharm Prod Ltd New intermediates,their production and use
GB9208492D0 (en) * 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
JP2006526612A (ja) * 2003-06-05 2006-11-24 ファイザー・プロダクツ・インク ベータ−ラクタマーゼ阻害剤・プロドラッグ

Also Published As

Publication number Publication date
EP1534717B1 (de) 2006-12-27
JP2005539037A (ja) 2005-12-22
PE20040899A1 (es) 2004-12-28
CA2494953A1 (en) 2004-03-04
NO20051497D0 (no) 2005-03-21
ECSP055625A (es) 2005-04-18
EA007540B1 (ru) 2006-10-27
AU2003250489A1 (en) 2004-03-11
HRP20050162A2 (en) 2005-06-30
MA27387A1 (fr) 2005-06-01
TWI250162B (en) 2006-03-01
AP2005003231A0 (en) 2005-03-31
OA12909A (en) 2006-10-13
UY27947A1 (es) 2004-03-31
MXPA05001446A (es) 2005-06-06
PL375988A1 (en) 2005-12-12
BR0313683A (pt) 2005-06-21
EA200500398A1 (ru) 2005-08-25
IS7693A (is) 2005-02-10
AR041028A1 (es) 2005-04-27
NZ538340A (en) 2006-10-27
IL166719A0 (en) 2006-01-15
ZA200501513B (en) 2006-09-27
GT200300179A (es) 2004-05-18
WO2004018484A1 (en) 2004-03-04
TW200417548A (en) 2004-09-16
TNSN05054A1 (fr) 2007-05-14
CN1688589A (zh) 2005-10-26
PA8579701A1 (es) 2005-05-24
KR20050037583A (ko) 2005-04-22
DE60310733D1 (de) 2007-02-08
US20040110740A1 (en) 2004-06-10
US7091197B2 (en) 2006-08-15
EP1534717A1 (de) 2005-06-01
NO20051497L (no) 2005-03-21

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties