AP2006003632A0 - Pyridol[2,3-D] pyrimidine-2,4-Diamines as PDE 2 inhibitors - Google Patents

Pyridol[2,3-D] pyrimidine-2,4-Diamines as PDE 2 inhibitors

Info

Publication number
AP2006003632A0
AP2006003632A0 AP2006003632A AP2006003632A AP2006003632A0 AP 2006003632 A0 AP2006003632 A0 AP 2006003632A0 AP 2006003632 A AP2006003632 A AP 2006003632A AP 2006003632 A AP2006003632 A AP 2006003632A AP 2006003632 A0 AP2006003632 A0 AP 2006003632A0
Authority
AP
ARIPO
Prior art keywords
pyridol
pde
diamines
pyrimidine
inhibitors
Prior art date
Application number
AP2006003632A
Other languages
English (en)
Inventor
Thomas Arthur Beyer
Robert James Chambers
Kelvin Lam
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AP2006003632A0 publication Critical patent/AP2006003632A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AP2006003632A 2003-12-16 2004-12-06 Pyridol[2,3-D] pyrimidine-2,4-Diamines as PDE 2 inhibitors AP2006003632A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52999403P 2003-12-16 2003-12-16
PCT/IB2004/004013 WO2005061497A1 (en) 2003-12-16 2004-12-06 Pyrido[2,3-d]pyrimidine-2,4-diamines as pde 2 inhibitors

Publications (1)

Publication Number Publication Date
AP2006003632A0 true AP2006003632A0 (en) 2006-06-30

Family

ID=34710150

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2006003632A AP2006003632A0 (en) 2003-12-16 2004-12-06 Pyridol[2,3-D] pyrimidine-2,4-Diamines as PDE 2 inhibitors

Country Status (39)

Country Link
US (1) US20070135457A1 (de)
EP (1) EP1697356B1 (de)
JP (1) JP4073944B2 (de)
KR (1) KR100816179B1 (de)
CN (1) CN100439366C (de)
AP (1) AP2006003632A0 (de)
AR (1) AR046766A1 (de)
AT (1) ATE387446T1 (de)
AU (1) AU2004303609A1 (de)
BR (1) BRPI0417663A (de)
CA (1) CA2549510A1 (de)
CL (1) CL2008001920A1 (de)
DE (1) DE602004012154T2 (de)
DK (1) DK1697356T3 (de)
EA (1) EA010424B1 (de)
EC (1) ECSP066643A (de)
ES (1) ES2299888T3 (de)
GE (1) GEP20094720B (de)
GT (1) GT200400268A (de)
HN (1) HN2004000538A (de)
HR (1) HRP20080142T3 (de)
IL (1) IL175813A0 (de)
IS (1) IS8474A (de)
MA (1) MA28270A1 (de)
MX (1) MXPA06006777A (de)
NL (1) NL1027787C2 (de)
NO (1) NO20063231L (de)
PE (1) PE20050681A1 (de)
PL (1) PL1697356T3 (de)
PT (1) PT1697356E (de)
RS (1) RS50575B (de)
SI (1) SI1697356T1 (de)
SV (1) SV2005001979A (de)
TN (1) TNSN06186A1 (de)
TW (1) TWI291961B (de)
UA (1) UA83091C2 (de)
UY (1) UY28671A1 (de)
WO (1) WO2005061497A1 (de)
ZA (1) ZA200604970B (de)

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WO2007070872A1 (en) * 2005-12-15 2007-06-21 Rigel Pharmaceuticals, Inc. Kinase inhibitors and their uses
EP2070541A4 (de) * 2006-09-21 2011-04-13 Toshiki Oguro Mittel zur förderung der regeneration von hartem gewebe
JP5472638B2 (ja) * 2008-03-18 2014-04-16 日産化学工業株式会社 1−(置換フェニル)−1−置換シリルエーテル、アルコールまたはケトンの製造方法および中間体
US20120065165A1 (en) * 2008-10-31 2012-03-15 Arginetix, Inc Compositions and methods of treating endothelial disorders
US8680116B2 (en) 2009-07-22 2014-03-25 Merck Sharp & Dohme Corp. Quinolinone PDE2 inhibitors
US8440710B2 (en) 2009-10-15 2013-05-14 Hoffmann-La Roche Inc. HSL inhibitors useful in the treatment of diabetes
US9540379B2 (en) 2011-01-31 2017-01-10 Boehringer Ingelheim International Gmbh (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases
CN103596958A (zh) 2011-04-20 2014-02-19 葛兰素集团有限公司 用作抗结核病化合物的四氢吡唑并[1,5-a]嘧啶
NZ631258A (en) 2012-04-25 2016-11-25 Takeda Pharmaceuticals Co Nitrogenated heterocyclic compound
WO2014010732A1 (ja) 2012-07-13 2014-01-16 武田薬品工業株式会社 複素環化合物
US20140045856A1 (en) 2012-07-31 2014-02-13 Boehringer Ingelheim International Gmbh 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes
EP2975031A4 (de) 2013-03-14 2017-04-19 Takeda Pharmaceutical Company Limited Heterocyclische verbindung
JP6427491B2 (ja) 2013-07-03 2018-11-21 武田薬品工業株式会社 複素環化合物
EP3018123B1 (de) 2013-07-03 2023-05-10 Takeda Pharmaceutical Company Limited Amidverbindung
JPWO2015012328A1 (ja) * 2013-07-24 2017-03-02 武田薬品工業株式会社 複素環化合物
WO2015096651A1 (en) 2013-12-23 2015-07-02 Merck Sharp & Dohme Corp. Pyrimidone carboxamide compounds as pde2 inhibitors
JP6696904B2 (ja) 2014-01-08 2020-05-20 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 製剤および医薬組成物
EP3174408B1 (de) * 2014-08-01 2018-12-05 Firmenich SA Feste dispersion von amidaromaverbindungen
CA2969594A1 (en) 2014-12-06 2016-06-09 Intra-Cellular Therapies, Inc. Pde2 inhibiting organic compounds
HK1244427A1 (zh) 2014-12-06 2018-08-10 Intra-Cellular Therapies, Inc. 有机化合物
WO2016145614A1 (en) 2015-03-17 2016-09-22 Merck Sharp & Dohme Corp. Triazolyl pyrimidinone compounds as pde2 inhibitors
WO2016154081A1 (en) 2015-03-26 2016-09-29 Merck Sharp & Dohme Corp. Pyrazolyl pyrimidinone compounds as pde2 inhibitors
WO2016179059A1 (en) 2015-05-05 2016-11-10 Merck Sharp & Dohme Corp. Heteroaryl-pyrimidinone compounds as pde2 inhibitors
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
WO2016191935A1 (en) 2015-05-29 2016-12-08 Merck Sharp & Dohme Corp. 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors
WO2016192083A1 (en) 2015-06-04 2016-12-08 Merck Sharp & Dohme Corp. Dihydropyrazolopyrimidinone compounds as pde2 inhibitors
US10647727B2 (en) 2015-06-25 2020-05-12 Merck Sharp & Dohme Corp. Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors
WO2017000276A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Bicyclic heterocyclic compounds as pde2 inhibitors
WO2017000277A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Substituted triazolo bicycliccompounds as pde2 inhibitors
EP3156405A1 (de) 2015-10-13 2017-04-19 Boehringer Ingelheim International GmbH Spirocyclische etherderivate von pyrazolo[1,5-a]pyrimidin-3-carboxamid
GB201700814D0 (en) * 2017-01-17 2017-03-01 Liverpool School Tropical Medicine Compounds
AU2018371216B2 (en) 2017-11-23 2024-09-19 Oslo University Hospital Hf Treatment of tachycardia
CN109758458B (zh) * 2019-03-05 2021-02-23 中国人民解放军陆军军医大学第二附属医院 抑制Crif1与PKA相互作用的化合物的应用
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Also Published As

Publication number Publication date
AU2004303609A1 (en) 2005-07-07
UA83091C2 (en) 2008-06-10
PT1697356E (pt) 2008-05-05
HN2004000538A (es) 2008-02-21
TWI291961B (en) 2008-01-01
MA28270A1 (fr) 2006-11-01
JP4073944B2 (ja) 2008-04-09
EP1697356A1 (de) 2006-09-06
TNSN06186A1 (fr) 2007-11-15
TW200522952A (en) 2005-07-16
CN100439366C (zh) 2008-12-03
HRP20080142T3 (en) 2008-06-30
IS8474A (is) 2006-05-18
KR100816179B1 (ko) 2008-03-28
JP2007513996A (ja) 2007-05-31
IL175813A0 (en) 2006-10-05
PL1697356T3 (pl) 2008-07-31
WO2005061497A1 (en) 2005-07-07
EA200600973A1 (ru) 2006-10-27
ES2299888T3 (es) 2008-06-01
ZA200604970B (en) 2007-11-28
DK1697356T3 (da) 2009-01-12
NL1027787C2 (nl) 2006-03-09
PE20050681A1 (es) 2005-10-04
US20070135457A1 (en) 2007-06-14
GEP20094720B (en) 2009-06-25
NO20063231L (no) 2006-07-11
MXPA06006777A (es) 2006-08-23
EA010424B1 (ru) 2008-08-29
ECSP066643A (es) 2006-10-25
KR20060105776A (ko) 2006-10-11
GT200400268A (es) 2005-09-20
SV2005001979A (es) 2005-12-13
BRPI0417663A (pt) 2007-04-03
NL1027787A1 (nl) 2005-06-21
DE602004012154D1 (de) 2008-04-10
RS50575B (sr) 2010-05-07
DE602004012154T2 (de) 2009-03-12
AR046766A1 (es) 2005-12-21
ATE387446T1 (de) 2008-03-15
SI1697356T1 (sl) 2008-06-30
EP1697356B1 (de) 2008-02-27
CA2549510A1 (en) 2005-07-07
CN1894245A (zh) 2007-01-10
CL2008001920A1 (es) 2008-10-17
UY28671A1 (es) 2005-07-29

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