AP2006003633A0 - Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-BETA-hydroxysteroid dehydrogenase type 1 (11-BETA-HSD-1) for the treatment of diabetes and obesity - Google Patents
Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-BETA-hydroxysteroid dehydrogenase type 1 (11-BETA-HSD-1) for the treatment of diabetes and obesityInfo
- Publication number
- AP2006003633A0 AP2006003633A0 AP2006003633A AP2006003633A AP2006003633A0 AP 2006003633 A0 AP2006003633 A0 AP 2006003633A0 AP 2006003633 A AP2006003633 A AP 2006003633A AP 2006003633 A AP2006003633 A AP 2006003633A AP 2006003633 A0 AP2006003633 A0 AP 2006003633A0
- Authority
- AP
- ARIPO
- Prior art keywords
- beta
- benzenesulfonylamino
- hsd
- pyridin
- obesity
- Prior art date
Links
- 102000008645 11-beta-Hydroxysteroid Dehydrogenase Type 1 Human genes 0.000 title 2
- 108010088011 11-beta-Hydroxysteroid Dehydrogenase Type 1 Proteins 0.000 title 2
- -1 Benzenesulfonylamino-pyridin-2-yl Chemical class 0.000 title 1
- 208000008589 Obesity Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 235000020824 obesity Nutrition 0.000 title 1
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53118603P | 2003-12-19 | 2003-12-19 | |
| US55692104P | 2004-03-26 | 2004-03-26 | |
| PCT/IB2004/004056 WO2005060963A1 (en) | 2003-12-19 | 2004-12-06 | Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-hsd-1) for the treatment of diabetes and obesity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AP2006003633A0 true AP2006003633A0 (en) | 2006-06-30 |
Family
ID=34713786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2006003633A AP2006003633A0 (en) | 2003-12-19 | 2004-12-06 | Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-BETA-hydroxysteroid dehydrogenase type 1 (11-BETA-HSD-1) for the treatment of diabetes and obesity |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20050148631A1 (pt) |
| EP (1) | EP1696915A1 (pt) |
| JP (1) | JP2007514731A (pt) |
| KR (1) | KR20060101772A (pt) |
| AP (1) | AP2006003633A0 (pt) |
| AR (1) | AR046767A1 (pt) |
| AU (1) | AU2004305321A1 (pt) |
| BR (1) | BRPI0417687A (pt) |
| CA (1) | CA2549651A1 (pt) |
| DO (1) | DOP2004001052A (pt) |
| EA (1) | EA200600990A1 (pt) |
| EC (1) | ECSP066653A (pt) |
| IL (1) | IL175949A0 (pt) |
| IS (1) | IS8473A (pt) |
| MA (1) | MA28271A1 (pt) |
| MX (1) | MXPA06007077A (pt) |
| NL (1) | NL1027811C2 (pt) |
| NO (1) | NO20063298L (pt) |
| OA (1) | OA13344A (pt) |
| PA (1) | PA8620301A1 (pt) |
| PE (1) | PE20050864A1 (pt) |
| TW (1) | TW200530185A (pt) |
| UY (1) | UY28674A1 (pt) |
| WO (1) | WO2005060963A1 (pt) |
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| US20100222316A1 (en) | 2004-04-29 | 2010-09-02 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| US8071624B2 (en) | 2004-06-24 | 2011-12-06 | Incyte Corporation | N-substituted piperidines and their use as pharmaceuticals |
| WO2006034804A1 (en) | 2004-09-29 | 2006-04-06 | F.Hoffmann-La Roche Ag | Indozolone derivatives as 11b-hsd1 inhibitors |
| EP1799647A1 (en) * | 2004-10-04 | 2007-06-27 | F.Hoffmann-La Roche Ag | Alkil-pyridines as 11-beta inhibitors for diabetes |
| EP1659113A1 (en) * | 2004-11-08 | 2006-05-24 | Evotec AG | Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1) |
| US8198331B2 (en) | 2005-01-05 | 2012-06-12 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| JP5133702B2 (ja) | 2005-01-05 | 2013-01-30 | アボット・ラボラトリーズ | 11−β−ヒドロキシステロイドデヒドロゲナーゼ1型酵素の阻害薬 |
| WO2006074244A2 (en) | 2005-01-05 | 2006-07-13 | Abbott Laboratories | Adamantyl derivatives as inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US20090192198A1 (en) | 2005-01-05 | 2009-07-30 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
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| RU2008118350A (ru) | 2005-10-12 | 2009-11-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Бифенильные производные в качестве модуляторов потенциалзависимых ионных каналов |
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| WO2007084314A2 (en) | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| BRPI0710479A2 (pt) | 2006-01-18 | 2012-08-14 | Hoffmann La Roche | composto, processo para sua preparaÇço, composiÇço farmacÊutica, uso de um composto e mÉtodo de tratamento de doenÇa ou desosrdem metabàlica. |
| BRPI0707408A2 (pt) * | 2006-01-31 | 2011-05-03 | Incyte Corp | compostos de amido e seu uso como produtos farmacêuticos |
| WO2007114763A1 (en) * | 2006-03-31 | 2007-10-11 | Astrazeneca Ab | Sulphonamide derivates as modulators of the glucocorticoid receptor |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| JP2009537564A (ja) | 2006-05-17 | 2009-10-29 | インサイト・コーポレイション | 11−βヒドロキシルステロイドデヒドロゲナーゼタイプIの複素環阻害剤およびそれを用いる方法 |
| TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
| TW200829578A (en) | 2006-11-23 | 2008-07-16 | Astrazeneca Ab | Chemical compounds 537 |
| CN102838532A (zh) * | 2006-11-24 | 2012-12-26 | Ac免疫有限公司 | 用于治疗与淀粉样物质或淀粉样蛋白有关的疾病的吡唑胺和噻唑胺衍生物 |
| JO2754B1 (en) | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders |
| TW200836719A (en) | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
| GB0705400D0 (en) | 2007-03-21 | 2007-05-02 | Univ Aberdeen | Therapeutic compounds andm their use |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
| JP5736098B2 (ja) | 2007-08-21 | 2015-06-17 | アッヴィ・インコーポレイテッド | 中枢神経系障害を治療するための医薬組成物 |
| UY31832A (es) | 2008-05-20 | 2010-01-05 | Astrazeneca Ab | Derivados de indazol sustituidos con fenilo y benzodioxinilo |
| GB0817208D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | Therapeutic apsap compounds and their use |
| GB0817207D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
| ES2350077B1 (es) | 2009-06-04 | 2011-11-04 | Laboratorios Salvat, S.A. | Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1. |
| DE102010033690A1 (de) * | 2010-08-06 | 2012-02-09 | Saltigo Gmbh | Verfahren zur Herstellung vom Aminoarylalkylverbindungen |
| UA112418C2 (uk) | 2010-09-07 | 2016-09-12 | Астеллас Фарма Інк. | Терапевтичний болезаспокійливий засіб |
| EP2616450B1 (en) | 2010-09-17 | 2018-05-02 | Kancera AB | Sulfonamide compounds |
| WO2012124744A1 (ja) * | 2011-03-14 | 2012-09-20 | 大正製薬株式会社 | 含窒素縮合複素環化合物 |
| US10000449B2 (en) | 2011-12-22 | 2018-06-19 | Kancera Ab | Bisarylsulfonamides useful in the treatment of inflammation and cancer |
| CA2859586C (en) * | 2011-12-22 | 2020-03-31 | Kancera Ab | Bisarylsulfonamides useful in the treatment of inflammation and cancer |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
| GB201311361D0 (en) | 2013-06-26 | 2013-08-14 | Pimco 2664 Ltd | Compounds and their therapeutic use |
| EP3027590A1 (en) * | 2013-07-31 | 2016-06-08 | Minoryx Therapeutics S.L. | Di(hetero)arylamides and sulfonamides, methods for their preparation and therapeutic uses thereof |
| EP2940022B1 (en) * | 2014-04-30 | 2020-09-02 | Masarykova Univerzita | Furopyridines as inhibitors of protein kinases |
| SI3262028T1 (sl) | 2014-12-17 | 2022-02-28 | Pimco 2664 Limited | N-(4-hidroksi-4-metil-cikloheksil)-4-fenil-benzensulfonamidne in N-(-4hidroksi-4-metil-cikloheksil)-4-(2-piridil)-benzensulfonamidne spojine in njihova terapevtska uporaba |
| EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
| CN111801314B (zh) | 2018-01-02 | 2023-10-31 | 西尔洛克治疗公司 | Ask1抑制剂化合物及其用途 |
| CN113329754A (zh) | 2018-11-20 | 2021-08-31 | 麻雀制药股份有限公司 | 用于施用皮质类固醇的方法 |
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| CN114845709B (zh) | 2019-11-05 | 2024-10-01 | 德米拉公司 | 用于治疗炎性病症的mrgprx2拮抗剂 |
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| GB9409618D0 (en) * | 1994-05-13 | 1994-07-06 | Zeneca Ltd | Pyridine derivatives |
| WO1996036595A1 (en) * | 1995-05-19 | 1996-11-21 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| US5939451A (en) * | 1996-06-28 | 1999-08-17 | Hoffmann-La Roche Inc. | Use of sulfonamides |
| GB9805520D0 (en) * | 1998-03-17 | 1998-05-13 | Zeneca Ltd | Chemical compounds |
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| US6506754B1 (en) * | 2000-04-14 | 2003-01-14 | Corvas International, Inc. | Non-covalent thrombin inhibitors |
| SE0001899D0 (sv) * | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| AU2002353718B2 (en) * | 2001-11-22 | 2007-05-10 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| RS44304A (sr) * | 2001-11-22 | 2007-06-04 | Biovitrum Ab., | Inhibitori 11-beta- hidroksistereoidne dehidrogenaze tipa 1 |
| EP2399903A1 (en) * | 2002-05-24 | 2011-12-28 | Millennium Pharmaceuticals, Inc. | Ccr9 inhibitors and methods of use thereof |
| WO2004056744A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| WO2004103980A1 (en) * | 2003-05-21 | 2004-12-02 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type i |
-
2004
- 2004-12-06 AP AP2006003633A patent/AP2006003633A0/xx unknown
- 2004-12-06 EA EA200600990A patent/EA200600990A1/ru unknown
- 2004-12-06 KR KR1020067012036A patent/KR20060101772A/ko not_active Ceased
- 2004-12-06 EP EP04801352A patent/EP1696915A1/en not_active Withdrawn
- 2004-12-06 CA CA002549651A patent/CA2549651A1/en not_active Abandoned
- 2004-12-06 WO PCT/IB2004/004056 patent/WO2005060963A1/en not_active Ceased
- 2004-12-06 BR BRPI0417687-1A patent/BRPI0417687A/pt not_active IP Right Cessation
- 2004-12-06 JP JP2006544581A patent/JP2007514731A/ja active Pending
- 2004-12-06 OA OA1200600201A patent/OA13344A/en unknown
- 2004-12-06 MX MXPA06007077A patent/MXPA06007077A/es not_active Application Discontinuation
- 2004-12-06 AU AU2004305321A patent/AU2004305321A1/en not_active Abandoned
- 2004-12-10 PE PE2004001240A patent/PE20050864A1/es not_active Application Discontinuation
- 2004-12-15 AR ARP040104669A patent/AR046767A1/es unknown
- 2004-12-16 DO DO2004001052A patent/DOP2004001052A/es unknown
- 2004-12-16 UY UY28674A patent/UY28674A1/es not_active Application Discontinuation
- 2004-12-17 NL NL1027811A patent/NL1027811C2/nl not_active IP Right Cessation
- 2004-12-17 TW TW093139461A patent/TW200530185A/zh unknown
- 2004-12-17 US US11/016,152 patent/US20050148631A1/en not_active Abandoned
- 2004-12-17 PA PA20048620301A patent/PA8620301A1/es unknown
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2006
- 2006-05-18 IS IS8473A patent/IS8473A/is unknown
- 2006-05-25 IL IL175949A patent/IL175949A0/en unknown
- 2006-06-16 EC EC2006006653A patent/ECSP066653A/es unknown
- 2006-06-19 MA MA29114A patent/MA28271A1/fr unknown
- 2006-07-17 NO NO20063298A patent/NO20063298L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DOP2004001052A (es) | 2005-06-30 |
| JP2007514731A (ja) | 2007-06-07 |
| ECSP066653A (es) | 2006-10-25 |
| MXPA06007077A (es) | 2006-08-23 |
| AU2004305321A1 (en) | 2005-07-07 |
| US20050148631A1 (en) | 2005-07-07 |
| KR20060101772A (ko) | 2006-09-26 |
| NL1027811C2 (nl) | 2006-03-06 |
| EA200600990A1 (ru) | 2006-10-27 |
| UY28674A1 (es) | 2005-07-29 |
| BRPI0417687A (pt) | 2007-04-03 |
| IL175949A0 (en) | 2006-10-05 |
| AR046767A1 (es) | 2005-12-21 |
| WO2005060963A8 (en) | 2005-12-01 |
| TW200530185A (en) | 2005-09-16 |
| NL1027811A1 (nl) | 2005-06-21 |
| IS8473A (is) | 2006-05-18 |
| PA8620301A1 (es) | 2005-08-04 |
| EP1696915A1 (en) | 2006-09-06 |
| NO20063298L (no) | 2006-09-14 |
| MA28271A1 (fr) | 2006-11-01 |
| CA2549651A1 (en) | 2005-07-07 |
| OA13344A (en) | 2007-04-13 |
| WO2005060963A1 (en) | 2005-07-07 |
| PE20050864A1 (es) | 2005-10-31 |
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