AP2014007400A0 - 4-Piperidinyl compounds for use as tankyrase inhibitors - Google Patents
4-Piperidinyl compounds for use as tankyrase inhibitorsInfo
- Publication number
- AP2014007400A0 AP2014007400A0 AP2014007400A AP2014007400A AP2014007400A0 AP 2014007400 A0 AP2014007400 A0 AP 2014007400A0 AP 2014007400 A AP2014007400 A AP 2014007400A AP 2014007400 A AP2014007400 A AP 2014007400A AP 2014007400 A0 AP2014007400 A0 AP 2014007400A0
- Authority
- AP
- ARIPO
- Prior art keywords
- piperidinyl compounds
- tankyrase inhibitors
- tankyrase
- inhibitors
- piperidinyl
- Prior art date
Links
- 102000004535 Tankyrases Human genes 0.000 title 1
- 108010017601 Tankyrases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161507321P | 2011-07-13 | 2011-07-13 | |
| PCT/IB2012/053613 WO2013008217A1 (fr) | 2011-07-13 | 2012-07-13 | Composés de 4-pipéridinyle utiles comme inhibiteurs de la tankyrase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AP2014007400A0 true AP2014007400A0 (en) | 2014-01-31 |
Family
ID=46604017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2014007400A AP2014007400A0 (en) | 2011-07-13 | 2012-07-13 | 4-Piperidinyl compounds for use as tankyrase inhibitors |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | USRE46942E1 (fr) |
| EP (1) | EP2731940B1 (fr) |
| JP (1) | JP5957077B2 (fr) |
| KR (1) | KR20140051944A (fr) |
| CN (1) | CN103797006B (fr) |
| AP (1) | AP2014007400A0 (fr) |
| AU (1) | AU2012282076A1 (fr) |
| BR (1) | BR112014000792A2 (fr) |
| CA (1) | CA2841932A1 (fr) |
| CO (1) | CO6880065A2 (fr) |
| CR (1) | CR20140071A (fr) |
| DO (1) | DOP2014000012A (fr) |
| EA (1) | EA201490272A1 (fr) |
| ES (1) | ES2548513T3 (fr) |
| IL (1) | IL230430A0 (fr) |
| MA (1) | MA35342B1 (fr) |
| MX (1) | MX2014000536A (fr) |
| PH (1) | PH12014500126A1 (fr) |
| TN (1) | TN2014000016A1 (fr) |
| WO (1) | WO2013008217A1 (fr) |
| ZA (1) | ZA201400374B (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9181266B2 (en) * | 2011-07-13 | 2015-11-10 | Novartis Ag | 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors |
| EP2822656B1 (fr) | 2012-03-07 | 2016-10-19 | Institute of Cancer Research: Royal Cancer Hospital (The) | Composés 3-aryl -5-substitué-isoquinolin -1-one et leur utilisation thérapeutique |
| EP2970121B1 (fr) * | 2013-03-15 | 2017-12-13 | Araxes Pharma LLC | Inhibiteurs covalents de k-ras g12c |
| PT3030554T (pt) * | 2013-08-07 | 2018-05-28 | Merck Patent Gmbh | Derivados de ureia de piperidina |
| US9611223B2 (en) | 2013-09-11 | 2017-04-04 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| CN105793264B (zh) * | 2014-03-10 | 2017-09-01 | 四川海思科制药有限公司 | 取代的二氢苯并呋喃‑哌啶‑甲酮衍生物、其制备及用途 |
| EP3140295B1 (fr) | 2014-05-07 | 2018-09-12 | Merck Patent GmbH | Dérivés hétérocyclyl-butanamides |
| KR101739003B1 (ko) | 2014-07-11 | 2017-05-23 | 에스티팜 주식회사 | 신규한 트리아졸로피리미디논 또는 트리아졸로피리디논 유도체, 및 이들의 용도 |
| WO2016006975A2 (fr) * | 2014-07-11 | 2016-01-14 | St Pharm Co., Ltd. | Nouveaux dérivés imidazotriazinone ou imidazopyrazinone et leur utilisation |
| WO2016006974A2 (fr) * | 2014-07-11 | 2016-01-14 | St Pharm Co., Ltd. | Nouveaux dérivés triazolopyrimidinone ou triazolopyridinone et leur utilisation |
| KR20160007347A (ko) | 2014-07-11 | 2016-01-20 | 에스티팜 주식회사 | 신규한 이미다조트리아지논 또는 이미다조피라지논 유도체, 및 이들의 용도 |
| CN108137556B (zh) * | 2015-11-02 | 2021-07-30 | 默克专利股份公司 | 1,4-二羰基-哌啶基衍生物 |
| KR101777475B1 (ko) * | 2015-12-08 | 2017-09-11 | 에스티팜 주식회사 | 신규한 디히드로피라노피리미디논 유도체 및 이들의 용도 |
| EP3394056B1 (fr) | 2015-12-22 | 2021-04-14 | Shy Therapeutics LLC | Composés pour le traitement du cancer et de maladies inflammatoires |
| WO2017156350A1 (fr) | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Méthodes de traitement du cancer |
| CA3066939A1 (fr) | 2017-06-21 | 2018-12-27 | SHY Therapeutics LLC | Composes interagissant avec la superfamille ras destines a etre utilises dans le traitement de cancers, de maladies inflammatoires, de rasopathies et de maladies fibrotiques |
| EP3891136B1 (fr) | 2018-12-03 | 2023-07-19 | Merck Patent GmbH | 4-hétéroarylcarbonyl-n-(phényle ou hétéroaryl) pipéridine-1-carboxamides servant d'inhibiteurs de tankyrases |
| US12391705B2 (en) | 2018-12-19 | 2025-08-19 | Shy Therapeutics, Llc | Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
| WO2021030711A1 (fr) * | 2019-08-15 | 2021-02-18 | Black Diamond Therapeutics, Inc. | Composés d'alcynyle quinazoline |
| US20240041859A1 (en) * | 2020-12-03 | 2024-02-08 | Washington University | Methods of treating and preventing kidney disease |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020022636A1 (en) | 1997-09-03 | 2002-02-21 | Jia-He Li | Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity |
| AU2004200A (en) | 1999-01-14 | 2000-08-01 | Meiji Seika Kaisha Ltd. | Poly(adp-ribose) polymerase inhibitors consisting of pyrimidine derivatives |
| US6710058B2 (en) * | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| DE10056312A1 (de) | 2000-11-14 | 2002-05-16 | Bayer Ag | Substituierte Amidoalkyluracile und ihre Verwendung |
| AUPR201600A0 (en) | 2000-12-11 | 2001-01-11 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivative |
| US20040176361A1 (en) | 2001-05-23 | 2004-09-09 | Masakazu Fujio | Fused heterocyclic compound and medicinal use thereof |
| JP4391825B2 (ja) | 2001-12-06 | 2009-12-24 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン阻害剤 |
| DE10201240A1 (de) | 2002-01-15 | 2003-07-24 | Bayer Ag | Substituierte Alkyluracile und ihre Verwendung |
| AUPS019702A0 (en) | 2002-01-29 | 2002-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Condensed heterocyclic compounds |
| PL372171A1 (en) | 2002-02-19 | 2005-07-11 | Ono Pharmaceutical Co, Ltd. | Fused pyridazine derivative compounds and drugs containing the compounds as the active ingredient |
| AUPS137402A0 (en) | 2002-03-26 | 2002-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Novel tricyclic compounds |
| TWI275390B (en) | 2002-04-30 | 2007-03-11 | Wyeth Corp | Process for the preparation of 7-substituted-3- quinolinecarbonitriles |
| US7183287B2 (en) | 2003-04-03 | 2007-02-27 | Pharmacia Corporation | Substituted pyrimidinones |
| EP1646615B1 (fr) | 2003-06-06 | 2009-08-26 | Vertex Pharmaceuticals Incorporated | Derives de pyrimidne utilises en tant que modulateurs de transporteurs de cassette de liaison a l'atp |
| CL2004002050A1 (es) | 2003-08-13 | 2005-06-03 | Pharmacia Corp Sa Organizada B | Compuestos derivados de piridinonas sustituidas; su uso en el tratamiento de afecciones causadas o exacerbadas por actividad p38 map kinasa y/o tnf no regulada, tales como inflamaciones, tumores, sida y otros. |
| JP2007513154A (ja) | 2003-12-08 | 2007-05-24 | サイトキネティクス・インコーポレーテッド | 化合物、組成物及び方法 |
| GB0405101D0 (en) * | 2004-03-06 | 2004-04-07 | Astrazeneca Ab | Compounds |
| US7375102B2 (en) | 2004-06-28 | 2008-05-20 | Amgen Sf, Llc | Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use |
| KR101286969B1 (ko) | 2004-06-30 | 2013-07-23 | 얀센 파마슈티카 엔.브이. | Ｐａｒｐ 저해제로서의 퀴나졸리논 유도체 |
| KR20170001725A (ko) | 2004-09-02 | 2017-01-04 | 제넨테크, 인크. | 헤지호그 신호전달에 대한 피리딜 억제제 |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| ATE474829T1 (de) | 2005-06-27 | 2010-08-15 | Amgen Inc | Entzündungshemmende arylnitrilverbindungen |
| PL2021337T3 (pl) * | 2006-04-25 | 2010-06-30 | Lilly Co Eli | Inhibitory dehydrogenazy 11-beta-hydroksysteroidowej typu 1 |
| US8466150B2 (en) | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
| CA2699202C (fr) | 2007-09-12 | 2016-09-27 | F. Hoffmann-La Roche Ag | Combinaisons de composes inhibiteurs des phosphoinositide 3-kinases et agents chimiotherapeutiques, et leurs procedes d'utilisation |
| EP2214675B1 (fr) | 2007-10-25 | 2013-11-20 | Genentech, Inc. | Procédé de préparation de composés de thiénopyrimidine |
| US20100267626A1 (en) | 2007-11-05 | 2010-10-21 | Novartis Ag | Methods and compositions for measuring wnt activation and for treating wnt-related cancers |
| KR101179753B1 (ko) | 2007-11-06 | 2012-09-04 | 제일약품주식회사 | 신규한 트리시클릭 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 포함하는 약학조성물 |
| US8642660B2 (en) * | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| RU2490260C2 (ru) | 2008-03-27 | 2013-08-20 | Янссен Фармацевтика Нв | Тетрагидрофенантридиноны и тетрагидроциклопентахинолиноны в качестве ингибиторов parp и ингибиторов полимеризации тубулина |
| US9181266B2 (en) * | 2011-07-13 | 2015-11-10 | Novartis Ag | 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors |
-
2012
- 2012-07-13 MX MX2014000536A patent/MX2014000536A/es not_active Application Discontinuation
- 2012-07-13 WO PCT/IB2012/053613 patent/WO2013008217A1/fr not_active Ceased
- 2012-07-13 US US15/786,125 patent/USRE46942E1/en active Active
- 2012-07-13 AU AU2012282076A patent/AU2012282076A1/en not_active Abandoned
- 2012-07-13 EP EP12742957.9A patent/EP2731940B1/fr not_active Not-in-force
- 2012-07-13 KR KR20147003628A patent/KR20140051944A/ko not_active Withdrawn
- 2012-07-13 AP AP2014007400A patent/AP2014007400A0/xx unknown
- 2012-07-13 ES ES12742957.9T patent/ES2548513T3/es active Active
- 2012-07-13 BR BR112014000792A patent/BR112014000792A2/pt not_active IP Right Cessation
- 2012-07-13 EA EA201490272A patent/EA201490272A1/ru unknown
- 2012-07-13 JP JP2014519688A patent/JP5957077B2/ja not_active Expired - Fee Related
- 2012-07-13 CN CN201280043558.7A patent/CN103797006B/zh not_active Expired - Fee Related
- 2012-07-13 US US14/154,173 patent/US9163003B2/en not_active Ceased
- 2012-07-13 CA CA 2841932 patent/CA2841932A1/fr not_active Abandoned
- 2012-07-13 PH PH1/2014/500126A patent/PH12014500126A1/en unknown
-
2014
- 2014-01-13 IL IL230430A patent/IL230430A0/en unknown
- 2014-01-15 TN TNP2014000016A patent/TN2014000016A1/en unknown
- 2014-01-17 ZA ZA2014/00374A patent/ZA201400374B/en unknown
- 2014-01-22 DO DO2014000012A patent/DOP2014000012A/es unknown
- 2014-02-10 MA MA36745A patent/MA35342B1/fr unknown
- 2014-02-12 CR CR20140071A patent/CR20140071A/es unknown
- 2014-02-13 CO CO14031176A patent/CO6880065A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2548513T3 (es) | 2015-10-19 |
| USRE46942E1 (en) | 2018-07-10 |
| JP5957077B2 (ja) | 2016-07-27 |
| JP2014522855A (ja) | 2014-09-08 |
| CN103797006A (zh) | 2014-05-14 |
| CR20140071A (es) | 2014-10-16 |
| AU2012282076A1 (en) | 2014-02-27 |
| KR20140051944A (ko) | 2014-05-02 |
| US9163003B2 (en) | 2015-10-20 |
| EA201490272A1 (ru) | 2014-05-30 |
| MA35342B1 (fr) | 2014-08-01 |
| MX2014000536A (es) | 2014-12-05 |
| PH12014500126A1 (en) | 2014-02-24 |
| EP2731940A1 (fr) | 2014-05-21 |
| CO6880065A2 (es) | 2014-02-28 |
| CA2841932A1 (fr) | 2013-01-17 |
| NZ620426A (en) | 2015-08-28 |
| IL230430A0 (en) | 2014-03-31 |
| DOP2014000012A (es) | 2014-07-31 |
| US20150126513A1 (en) | 2015-05-07 |
| WO2013008217A1 (fr) | 2013-01-17 |
| BR112014000792A2 (pt) | 2017-10-31 |
| EP2731940B1 (fr) | 2015-08-19 |
| ZA201400374B (en) | 2014-10-29 |
| CN103797006B (zh) | 2016-01-27 |
| TN2014000016A1 (en) | 2015-07-01 |
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