MA35342B1 - Composés de-pipéridinyle utiles comme inhibiteurs de la tankyrase - Google Patents

Composés de-pipéridinyle utiles comme inhibiteurs de la tankyrase

Info

Publication number
MA35342B1
MA35342B1 MA36745A MA36745A MA35342B1 MA 35342 B1 MA35342 B1 MA 35342B1 MA 36745 A MA36745 A MA 36745A MA 36745 A MA36745 A MA 36745A MA 35342 B1 MA35342 B1 MA 35342B1
Authority
MA
Morocco
Prior art keywords
tankyrase
inhibitors
compounds useful
piperidinyl compounds
formula
Prior art date
Application number
MA36745A
Other languages
English (en)
Inventor
Christine Hiu-Tung Chen
Noel Chin Chin
Lucian V Dipietro
Jianme Fan
Mark G Palermo
Michael David Shultz
Bakary-Barry Toure
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA35342B1 publication Critical patent/MA35342B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des composés représentés par la formule (i). L'invention concerne aussi des compositions pharmaceutiques et des combinaisons comprenant un composé représenté par la formule (i), ainsi que l'utilisation de tels composés comme inhibiteurs de la tankyrase et dans le traitement de troubles liés à la signalisation de wnt et à la signalisation des tankyrases 1 et 2, lesdits troubles comprenant notamment, mais pas exclusivement, le cancer.
MA36745A 2011-07-13 2014-02-10 Composés de-pipéridinyle utiles comme inhibiteurs de la tankyrase MA35342B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161507321P 2011-07-13 2011-07-13
PCT/IB2012/053613 WO2013008217A1 (fr) 2011-07-13 2012-07-13 Composés de 4-pipéridinyle utiles comme inhibiteurs de la tankyrase

Publications (1)

Publication Number Publication Date
MA35342B1 true MA35342B1 (fr) 2014-08-01

Family

ID=46604017

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36745A MA35342B1 (fr) 2011-07-13 2014-02-10 Composés de-pipéridinyle utiles comme inhibiteurs de la tankyrase

Country Status (21)

Country Link
US (2) USRE46942E1 (fr)
EP (1) EP2731940B1 (fr)
JP (1) JP5957077B2 (fr)
KR (1) KR20140051944A (fr)
CN (1) CN103797006B (fr)
AP (1) AP2014007400A0 (fr)
AU (1) AU2012282076A1 (fr)
BR (1) BR112014000792A2 (fr)
CA (1) CA2841932A1 (fr)
CO (1) CO6880065A2 (fr)
CR (1) CR20140071A (fr)
DO (1) DOP2014000012A (fr)
EA (1) EA201490272A1 (fr)
ES (1) ES2548513T3 (fr)
IL (1) IL230430A0 (fr)
MA (1) MA35342B1 (fr)
MX (1) MX2014000536A (fr)
PH (1) PH12014500126A1 (fr)
TN (1) TN2014000016A1 (fr)
WO (1) WO2013008217A1 (fr)
ZA (1) ZA201400374B (fr)

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US9181266B2 (en) * 2011-07-13 2015-11-10 Novartis Ag 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
EP2822656B1 (fr) 2012-03-07 2016-10-19 Institute of Cancer Research: Royal Cancer Hospital (The) Composés 3-aryl -5-substitué-isoquinolin -1-one et leur utilisation thérapeutique
EP2970121B1 (fr) * 2013-03-15 2017-12-13 Araxes Pharma LLC Inhibiteurs covalents de k-ras g12c
PT3030554T (pt) * 2013-08-07 2018-05-28 Merck Patent Gmbh Derivados de ureia de piperidina
US9611223B2 (en) 2013-09-11 2017-04-04 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
CN105793264B (zh) * 2014-03-10 2017-09-01 四川海思科制药有限公司 取代的二氢苯并呋喃‑哌啶‑甲酮衍生物、其制备及用途
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KR101777475B1 (ko) * 2015-12-08 2017-09-11 에스티팜 주식회사 신규한 디히드로피라노피리미디논 유도체 및 이들의 용도
EP3394056B1 (fr) 2015-12-22 2021-04-14 Shy Therapeutics LLC Composés pour le traitement du cancer et de maladies inflammatoires
WO2017156350A1 (fr) 2016-03-09 2017-09-14 K-Gen, Inc. Méthodes de traitement du cancer
CA3066939A1 (fr) 2017-06-21 2018-12-27 SHY Therapeutics LLC Composes interagissant avec la superfamille ras destines a etre utilises dans le traitement de cancers, de maladies inflammatoires, de rasopathies et de maladies fibrotiques
EP3891136B1 (fr) 2018-12-03 2023-07-19 Merck Patent GmbH 4-hétéroarylcarbonyl-n-(phényle ou hétéroaryl) pipéridine-1-carboxamides servant d'inhibiteurs de tankyrases
US12391705B2 (en) 2018-12-19 2025-08-19 Shy Therapeutics, Llc Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
WO2021030711A1 (fr) * 2019-08-15 2021-02-18 Black Diamond Therapeutics, Inc. Composés d'alcynyle quinazoline
US20240041859A1 (en) * 2020-12-03 2024-02-08 Washington University Methods of treating and preventing kidney disease

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US9181266B2 (en) * 2011-07-13 2015-11-10 Novartis Ag 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors

Also Published As

Publication number Publication date
ES2548513T3 (es) 2015-10-19
USRE46942E1 (en) 2018-07-10
JP5957077B2 (ja) 2016-07-27
JP2014522855A (ja) 2014-09-08
CN103797006A (zh) 2014-05-14
CR20140071A (es) 2014-10-16
AU2012282076A1 (en) 2014-02-27
KR20140051944A (ko) 2014-05-02
US9163003B2 (en) 2015-10-20
EA201490272A1 (ru) 2014-05-30
MX2014000536A (es) 2014-12-05
PH12014500126A1 (en) 2014-02-24
EP2731940A1 (fr) 2014-05-21
CO6880065A2 (es) 2014-02-28
CA2841932A1 (fr) 2013-01-17
NZ620426A (en) 2015-08-28
IL230430A0 (en) 2014-03-31
DOP2014000012A (es) 2014-07-31
US20150126513A1 (en) 2015-05-07
WO2013008217A1 (fr) 2013-01-17
BR112014000792A2 (pt) 2017-10-31
EP2731940B1 (fr) 2015-08-19
ZA201400374B (en) 2014-10-29
AP2014007400A0 (en) 2014-01-31
CN103797006B (zh) 2016-01-27
TN2014000016A1 (en) 2015-07-01

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