AP2014007401A0 - Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma - Google Patents
Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthmaInfo
- Publication number
- AP2014007401A0 AP2014007401A0 AP2014007401A AP2014007401A AP2014007401A0 AP 2014007401 A0 AP2014007401 A0 AP 2014007401A0 AP 2014007401 A AP2014007401 A AP 2014007401A AP 2014007401 A AP2014007401 A AP 2014007401A AP 2014007401 A0 AP2014007401 A0 AP 2014007401A0
- Authority
- AP
- ARIPO
- Prior art keywords
- asthma
- treating copd
- dihydrothienopyrimidine sulfoxides
- novel piperidino
- piperidino
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161526861P | 2011-08-24 | 2011-08-24 | |
| PCT/EP2012/066104 WO2013026797A1 (fr) | 2011-08-24 | 2012-08-17 | Nouveaux sulfoxydes de pipéridino-dihydrothiénopyrimidine et leur utilisation pour le traitement de la bpco et de l'asthme |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AP2014007401A0 true AP2014007401A0 (en) | 2014-01-31 |
Family
ID=46924393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2014007401A AP2014007401A0 (en) | 2011-08-24 | 2012-08-17 | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US20130059866A1 (fr) |
| EP (1) | EP2748156B1 (fr) |
| JP (1) | JP5851038B2 (fr) |
| KR (1) | KR101959194B1 (fr) |
| CN (1) | CN103889970B (fr) |
| AP (1) | AP2014007401A0 (fr) |
| AR (2) | AR087655A1 (fr) |
| AU (1) | AU2012298599B2 (fr) |
| BR (2) | BR112014003378B1 (fr) |
| CA (1) | CA2846183C (fr) |
| CL (1) | CL2014000296A1 (fr) |
| CO (1) | CO6900138A2 (fr) |
| DK (1) | DK2748156T5 (fr) |
| EA (1) | EA024033B1 (fr) |
| EC (1) | ECSP14013254A (fr) |
| ES (1) | ES2563028T3 (fr) |
| HU (1) | HUE028531T2 (fr) |
| IL (1) | IL230592A0 (fr) |
| MX (1) | MX358651B (fr) |
| PE (1) | PE20141532A1 (fr) |
| PH (1) | PH12014500395A1 (fr) |
| PL (1) | PL2748156T4 (fr) |
| TN (1) | TN2014000081A1 (fr) |
| TW (1) | TWI597283B (fr) |
| UY (1) | UY34285A (fr) |
| WO (1) | WO2013026797A1 (fr) |
| ZA (1) | ZA201400792B (fr) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE537175T1 (de) | 2007-10-19 | 2011-12-15 | Boehringer Ingelheim Int | Neue piperazino-dihydrothienopyrimidin-derivate |
| JP5341899B2 (ja) | 2007-10-19 | 2013-11-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ヘテロ環置換ピペラジノ−ジヒドロチエノピリミジン |
| ES2524910T3 (es) * | 2007-10-19 | 2014-12-15 | Boehringer Ingelheim International Gmbh | Piperidino-dihidrotienopirimidinas sustituidas |
| US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| WO2014124860A1 (fr) * | 2013-02-14 | 2014-08-21 | Boehringer Ingelheim International Gmbh | Inhibiteurs spécifiques de pde4b pour le traitement du diabète sucré |
| US11365204B2 (en) | 2017-09-20 | 2022-06-21 | UNION therapeutics A/S | Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors |
| BR112020003973A2 (pt) * | 2017-10-23 | 2020-09-01 | Boehringer Ingelheim International Gmbh | combinação de agentes ativos para o tratamento de doenças pulmonares intersticiais fibrosantes progressivas (pf-ild) |
| CN111712503B (zh) * | 2017-12-15 | 2024-04-09 | 联合疗法公司 | 取代的四氢吡喃二氢噻吩并嘧啶类化合物及其作为磷酸二酯酶抑制剂的用途 |
| US11292799B2 (en) | 2017-12-15 | 2022-04-05 | UNION therapeutics A/S | Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors |
| JP7203846B2 (ja) | 2017-12-15 | 2023-01-13 | ユニオン・セラピューティクス・アクティエセルスカブ | 置換アゼチジンジヒドロチエノピリジンおよびホスホジエステラーゼ阻害剤としてのそれらの使用 |
| US12171741B2 (en) | 2018-09-11 | 2024-12-24 | Nikang Therapeutics, Inc. | 2,3-dihydrobenzo[b]thiophene derivatives as hypoxia inducible factor-2(alpha) inhibitors |
| US12202490B2 (en) | 2019-06-25 | 2025-01-21 | Honda Motor Co., Ltd. | Vehicle, vehicle control method, and program |
| CN116438200A (zh) | 2020-09-10 | 2023-07-14 | 普雷西里克斯公司 | 针对fap的抗体片段 |
| EP4426307B1 (fr) | 2021-12-09 | 2025-07-02 | Boehringer Ingelheim International GmbH | Nouvelle composition pharmaceutique orale et schéma posologique pour le traitement de la maladie pulmonaire interstitielle fibrosante progressive |
| EP4494701A3 (fr) | 2021-12-09 | 2025-04-02 | Boehringer Ingelheim International GmbH | Nouvelles combinaisons thérapeutiques pour le traitement de maladies pulmonaires interstitielles fibrosantes progressives |
| WO2023150709A2 (fr) * | 2022-02-04 | 2023-08-10 | Aclaris Therapeutics, Inc. | Procédés de synthèse de composés pyridinone-pyridinyle substitués deutérés |
| WO2023203135A1 (fr) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Anticorps radiomarqué amélioré |
| JP2025517625A (ja) | 2022-05-02 | 2025-06-10 | プレシリックス・ナームローゼ・ベンノートシヤープ | プレターゲティング |
| US20250326765A1 (en) | 2022-06-02 | 2025-10-23 | Xizang Haisco Pharmaceutical Co., Ltd. | Pde4b inhibitor and use thereof |
| WO2023241683A1 (fr) * | 2022-06-16 | 2023-12-21 | 武汉人福创新药物研发中心有限公司 | Composé hétérocyclique contenant de l'azote agissant en tant qu'inhibiteur de pde4b |
| CN117247395A (zh) * | 2022-06-16 | 2023-12-19 | 武汉人福创新药物研发中心有限公司 | Pde4b抑制剂 |
| IL318673A (en) | 2022-08-09 | 2025-03-01 | Xizang Haisco Pharmaceutical Co Ltd | PDE4B inhibitor and its use |
| WO2024068386A1 (fr) | 2022-09-28 | 2024-04-04 | Boehringer Ingelheim International Gmbh | Utilisation de biomarqueurs dans le traitement d'états fibrotiques avec inhibiteur de la pde4b |
| US20260008788A1 (en) * | 2022-09-29 | 2026-01-08 | Suzhou Ark Biopharmaceutical Co., Ltd. | Aza-fused ring compound, preparation method therefor, and use thereof in medicine |
| CR20250111A (es) | 2022-10-28 | 2025-05-05 | Boehringer Ingelheim Int | Compuestos heterocíclicos como antagonistas de sting |
| EP4674852A1 (fr) | 2023-02-28 | 2026-01-07 | Innovstone Therapeutics Limited | Procédé de préparation et utilisation d'un dérivé de dihydrothiénopyrimidine |
| CN120897920A (zh) | 2023-03-20 | 2025-11-04 | 勃林格殷格翰国际有限公司 | 哌啶基-二氢噻吩并嘧啶亚砜的新型多晶型物 |
| WO2024208225A1 (fr) * | 2023-04-03 | 2024-10-10 | 上海壹迪生物技术有限公司 | Composé dihydrothiénopyrimidine, son procédé de préparation et son utilisation |
| EP4678644A1 (fr) | 2023-04-13 | 2026-01-14 | Shanghai Yidi Biotechnology Co., Ltd. | Composé dihydrothiénopyrimidine substitué, son procédé de préparation et son utilisation |
| CN116370640A (zh) * | 2023-04-26 | 2023-07-04 | 中国医学科学院基础医学研究所 | Pde4b抑制剂在制备预防和/或治疗肺动脉高压的药物中的应用 |
| GB202306663D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Combination therapy |
| CN116925099B (zh) * | 2023-07-21 | 2025-06-03 | 厦门大学 | 手性二氢噻吩并嘧啶亚砜的制备方法及其应用与其2、4位取代化合物 |
| WO2025067168A1 (fr) * | 2023-09-25 | 2025-04-03 | 苏州爱科百发生物医药技术有限公司 | Composé cyclique fusionné d'aza, son procédé de préparation et son utilisation |
| WO2025131986A1 (fr) | 2023-12-19 | 2025-06-26 | Boehringer Ingelheim International Gmbh | Nouvelles étapes de synthèse pour procédé de fabrication de 1-({(5r)-2-[4-(5-chloropyrimidine-2-yl)pipéridine-1-yl]-5-oxydo-6,7-dihydrothiéno[3,2-d]pyrimidine-4-yl}amino)cyclobutyl]méthanol inhibiteur de pde4b |
| CN120398908A (zh) * | 2024-02-01 | 2025-08-01 | 艾派克斯生物科技有限公司 | Pde4b抑制剂及其药物组合物和用途 |
| WO2025228895A1 (fr) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Indazoles et benzimidazoles à substitution hétaryle utilisés en tant qu'antagonistes de sting et leur utilisation en tant que médicament |
| WO2025228900A1 (fr) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Indazoles substitués par arylamide et leur utilisation en tant que médicament |
| US20250333398A1 (en) | 2024-04-30 | 2025-10-30 | Boehringer Ingelheim International Gmbh | Monoaryl and hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament |
| WO2025228889A1 (fr) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Composés hétérocycliques monoaryliques utilisés en tant qu'antagonistes de sting et leur utilisation en tant que médicament |
| WO2025228902A1 (fr) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Acides hétérocycliques en tant qu'antagonistes de sting et leur utilisation en tant que médicament |
| WO2025228899A1 (fr) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Autres composés hétérocycliques utilisés en tant qu'antagonistes de sting et leur utilisation en tant que médicament |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1470336A1 (de) | 1962-07-04 | 1969-03-20 | Thomae Gmbh Dr K | Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung |
| NL122810C (fr) | 1963-06-17 | |||
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2012
- 2012-02-23 US US13/402,996 patent/US20130059866A1/en not_active Abandoned
- 2012-03-15 US US14/239,818 patent/US9150586B2/en active Active
- 2012-08-17 PL PL12762543.2T patent/PL2748156T4/pl unknown
- 2012-08-17 AP AP2014007401A patent/AP2014007401A0/xx unknown
- 2012-08-17 PH PH1/2014/500395A patent/PH12014500395A1/en unknown
- 2012-08-17 WO PCT/EP2012/066104 patent/WO2013026797A1/fr not_active Ceased
- 2012-08-17 EP EP12762543.2A patent/EP2748156B1/fr active Active
- 2012-08-17 CN CN201280051868.3A patent/CN103889970B/zh active Active
- 2012-08-17 JP JP2014526455A patent/JP5851038B2/ja active Active
- 2012-08-17 BR BR112014003378-1A patent/BR112014003378B1/pt active IP Right Grant
- 2012-08-17 BR BR122022002799-7A patent/BR122022002799B1/pt active IP Right Grant
- 2012-08-17 AU AU2012298599A patent/AU2012298599B2/en active Active
- 2012-08-17 PE PE2014000242A patent/PE20141532A1/es not_active Application Discontinuation
- 2012-08-17 DK DK12762543.2T patent/DK2748156T5/da active
- 2012-08-17 EA EA201400252A patent/EA024033B1/ru not_active IP Right Cessation
- 2012-08-17 MX MX2014002025A patent/MX358651B/es active IP Right Grant
- 2012-08-17 KR KR1020147004639A patent/KR101959194B1/ko active Active
- 2012-08-17 HU HUE12762543A patent/HUE028531T2/en unknown
- 2012-08-17 ES ES12762543.2T patent/ES2563028T3/es active Active
- 2012-08-17 CA CA2846183A patent/CA2846183C/fr active Active
- 2012-08-23 TW TW101130693A patent/TWI597283B/zh active
- 2012-08-23 AR ARP120103115A patent/AR087655A1/es not_active Application Discontinuation
- 2012-08-23 UY UY0001034285A patent/UY34285A/es unknown
- 2012-08-23 US US13/592,664 patent/US8609670B2/en active Active
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2014
- 2014-01-22 IL IL230592A patent/IL230592A0/en unknown
- 2014-02-03 ZA ZA2014/00792A patent/ZA201400792B/en unknown
- 2014-02-06 CL CL2014000296A patent/CL2014000296A1/es unknown
- 2014-02-21 TN TNP2014000081A patent/TN2014000081A1/en unknown
- 2014-02-27 CO CO14042259A patent/CO6900138A2/es active IP Right Grant
- 2014-03-18 EC ECSP14013254 patent/ECSP14013254A/es unknown
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2022
- 2022-03-18 AR ARP220100644A patent/AR125150A2/es unknown
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