AP2227A - 5,7-diaminopyrazolo [4,3-d]pyrimidines with PDE-5 inhibiting activity. - Google Patents

5,7-diaminopyrazolo [4,3-d]pyrimidines with PDE-5 inhibiting activity.

Info

Publication number: AP2227A
Authority: AP; ARIPO
Prior art keywords: diaminopyrazolo; pde; pyrimidines; inhibiting activity; inhibiting
Prior art date: 2003-11-24

Application number

AP2006003591A

Other languages

English (en)

Other versions

AP2006003591A0 (en

Inventor

Andrew Simon Bell

David Graham Brown

Kevin Neil Dack

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-24

Filing date

2004-11-12

Publication date

2011-03-29

2004-11-12 Application filed by Pfizer filed Critical Pfizer

2006-04-30 Publication of AP2006003591A0 publication Critical patent/AP2006003591A0/xx

2011-03-29 Application granted granted Critical

2011-03-29 Publication of AP2227A publication Critical patent/AP2227A/xx

Links

ZTAWTRPFJHKMRU-UHFFFAOYSA-N 7-deaza-8-aza-2,6-diaminopurine Chemical class NC1=NC(N)=C2NN=CC2=N1 ZTAWTRPFJHKMRU-UHFFFAOYSA-N 0.000 title 1
101100296726 Caenorhabditis elegans pde-5 gene Proteins 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Child & Adolescent Psychology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Immunology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AP2006003591A 2003-11-24 2004-11-12 5,7-diaminopyrazolo [4,3-d]pyrimidines with PDE-5 inhibiting activity. AP2227A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0327319.0A GB0327319D0 (en)	2003-11-24	2003-11-24	Novel pharmaceuticals
PCT/IB2004/003747 WO2005049616A1 (en)	2003-11-24	2004-11-12	5,7-DIAMINOPYRAZOLO [4,3-d] PYRIMIDINES WITH PDE-5 INHIBITING ACTIVITY

Publications (2)

Publication Number	Publication Date
AP2006003591A0 AP2006003591A0 (en)	2006-04-30
AP2227A true AP2227A (en)	2011-03-29

Family

ID=29764364

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2006003591A AP2227A (en)	2003-11-24	2004-11-12	5,7-diaminopyrazolo [4,3-d]pyrimidines with PDE-5 inhibiting activity.

Country Status (43)

Country	Link
EP (1)	EP1689751B1 (es)
JP (1)	JP4056015B2 (es)
KR (2)	KR100848216B1 (es)
CN (4)	CN101647802A (es)
AP (1)	AP2227A (es)
AR (1)	AR046711A1 (es)
AT (1)	ATE485297T1 (es)
AU (1)	AU2004290643B2 (es)
BR (1)	BRPI0416869A (es)
CA (1)	CA2546987C (es)
CR (1)	CR8416A (es)
CY (1)	CY1110933T1 (es)
DE (1)	DE602004029705D1 (es)
DK (1)	DK1689751T3 (es)
EA (1)	EA011772B1 (es)
EC (1)	ECSP066580A (es)
ES (1)	ES2351622T3 (es)
GB (1)	GB0327319D0 (es)
GE (1)	GEP20084528B (es)
HR (1)	HRP20100651T1 (es)
IL (1)	IL175433A (es)
IS (1)	IS8406A (es)
MA (1)	MA28172A1 (es)
ME (1)	ME01216B (es)
MX (1)	MXPA06005914A (es)
MY (1)	MY140872A (es)
NL (1)	NL1027568C2 (es)
NO (1)	NO336526B1 (es)
NZ (1)	NZ548097A (es)
OA (1)	OA13289A (es)
PA (1)	PA8617701A1 (es)
PE (1)	PE20051061A1 (es)
PL (1)	PL1689751T3 (es)
PT (1)	PT1689751E (es)
RS (1)	RS51556B (es)
SG (1)	SG133614A1 (es)
SI (1)	SI1689751T1 (es)
TN (1)	TNSN06154A1 (es)
TW (1)	TWI265031B (es)
UA (1)	UA81994C2 (es)
UY (1)	UY28625A1 (es)
WO (1)	WO2005049616A1 (es)
ZA (1)	ZA200602899B (es)

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WO2005049616A8 (en)	2006-06-01
NZ548097A (en)	2008-12-24
CN101362765A (zh)	2009-02-11
PA8617701A1 (es)	2005-08-04
IS8406A (is)	2006-04-10
CA2546987A1 (en)	2005-06-02
NL1027568A1 (nl)	2005-05-26
HK1099286A1 (en)	2007-08-10
JP2007512314A (ja)	2007-05-17
IL175433A (en)	2011-08-31
HK1128917A1 (en)	2009-11-13
SG133614A1 (en)	2007-07-30
NO336526B1 (no)	2015-09-21
CN101362764A (zh)	2009-02-11
TWI265031B (en)	2006-11-01
MXPA06005914A (es)	2006-06-27
NL1027568C2 (nl)	2005-11-30
CN1882591B (zh)	2011-08-10
DE602004029705D1 (de)	2010-12-02
EA200600677A1 (ru)	2006-12-29
ATE485297T1 (de)	2010-11-15
CN101362764B (zh)	2011-04-20
PE20051061A1 (es)	2005-12-12
UY28625A1 (es)	2005-06-30
GEP20084528B (en)	2008-11-10
SI1689751T1 (sl)	2011-01-31
CR8416A (es)	2006-11-15
WO2005049616A1 (en)	2005-06-02
BRPI0416869A (pt)	2007-03-27
CN101362765B (zh)	2011-02-02
KR100848216B1 (ko)	2008-07-24
AU2004290643A1 (en)	2005-06-02
GB0327319D0 (en)	2003-12-24
CN101647802A (zh)	2010-02-17
CA2546987C (en)	2009-05-12
JP4056015B2 (ja)	2008-03-05
HRP20100651T1 (hr)	2011-01-31
MA28172A1 (fr)	2006-09-01
KR20070026334A (ko)	2007-03-08
AR046711A1 (es)	2005-12-21
OA13289A (en)	2007-01-31
NO20062950L (no)	2006-08-23
ECSP066580A (es)	2006-12-20
EP1689751A1 (en)	2006-08-16
TW200520758A (en)	2005-07-01
AU2004290643B2 (en)	2008-08-07
ME01216B (me)	2013-03-20
RS51556B (sr)	2011-06-30
CN1882591A (zh)	2006-12-20
AP2006003591A0 (en)	2006-04-30
ES2351622T3 (es)	2011-02-08
MY140872A (en)	2010-01-29
DK1689751T3 (da)	2011-01-17
ZA200602899B (en)	2007-07-25
PT1689751E (pt)	2010-11-29
CY1110933T1 (el)	2015-06-10
KR20080052666A (ko)	2008-06-11
IL175433A0 (en)	2006-09-05
EP1689751B1 (en)	2010-10-20
EA011772B1 (ru)	2009-06-30
UA81994C2 (en)	2008-02-25
KR100893999B1 (ko)	2009-04-20
TNSN06154A1 (fr)	2007-11-15
PL1689751T3 (pl)	2011-03-31

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NO20040540L (no)	2004-02-05	4-amino-6-fenylpyrrolo[2,3-D]pyrimidinderivater.
PL376916A1 (pl)	2006-01-09	Pochodne pirymido [4,5-d] pirymidyny o działaniu przeciwrakowym
AP2002002543A0 (en)	2002-06-30	Pyrrolo Ä2,3-dÜ pyrimidine compounds
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AP2005003365A0 (en)	2005-09-30	Hiv inhibiting 1, 2, 4-triazines.
IL170680A0 (en)	2009-02-11	8 - SUBSTITUTED - 6,7,8,9 -TETRAHYDROPYRIMIDO [1,2-a] PYRIMIDIN - 4 - ONE DERIVATIVES
IL164442A0 (en)	2005-12-18	Benzoxazinone-derived compounds, their preparationand use as medicaments
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