AP2227A - 5,7-diaminopyrazolo [4,3-d]pyrimidines with PDE-5 inhibiting activity. - Google Patents

5,7-diaminopyrazolo [4,3-d]pyrimidines with PDE-5 inhibiting activity.

Info

Publication number: AP2227A
Authority: AP; ARIPO
Prior art keywords: diaminopyrazolo; pde; pyrimidines; inhibiting activity; inhibiting
Prior art date: 2003-11-24

Application number

AP2006003591A

Other languages

English (en)

Other versions

AP2006003591A0 (en

Inventor

Andrew Simon Bell

David Graham Brown

Kevin Neil Dack

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-24

Filing date

2004-11-12

Publication date

2011-03-29

2004-11-12 Application filed by Pfizer filed Critical Pfizer

2006-04-30 Publication of AP2006003591A0 publication Critical patent/AP2006003591A0/xx

2011-03-29 Application granted granted Critical

2011-03-29 Publication of AP2227A publication Critical patent/AP2227A/xx

Links

ZTAWTRPFJHKMRU-UHFFFAOYSA-N 7-deaza-8-aza-2,6-diaminopurine Chemical class NC1=NC(N)=C2NN=CC2=N1 ZTAWTRPFJHKMRU-UHFFFAOYSA-N 0.000 title 1
101100296726 Caenorhabditis elegans pde-5 gene Proteins 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Dermatology (AREA)
Child & Adolescent Psychology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Immunology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AP2006003591A 2003-11-24 2004-11-12 5,7-diaminopyrazolo [4,3-d]pyrimidines with PDE-5 inhibiting activity. AP2227A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0327319.0A GB0327319D0 (en)	2003-11-24	2003-11-24	Novel pharmaceuticals
PCT/IB2004/003747 WO2005049616A1 (en)	2003-11-24	2004-11-12	5,7-DIAMINOPYRAZOLO [4,3-d] PYRIMIDINES WITH PDE-5 INHIBITING ACTIVITY

Publications (2)

Publication Number	Publication Date
AP2006003591A0 AP2006003591A0 (en)	2006-04-30
AP2227A true AP2227A (en)	2011-03-29

Family

ID=29764364

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2006003591A AP2227A (en)	2003-11-24	2004-11-12	5,7-diaminopyrazolo [4,3-d]pyrimidines with PDE-5 inhibiting activity.

Country Status (43)

Country	Link
EP (1)	EP1689751B1 (es)
JP (1)	JP4056015B2 (es)
KR (2)	KR100893999B1 (es)
CN (4)	CN101362765B (es)
AP (1)	AP2227A (es)
AR (1)	AR046711A1 (es)
AT (1)	ATE485297T1 (es)
AU (1)	AU2004290643B2 (es)
BR (1)	BRPI0416869A (es)
CA (1)	CA2546987C (es)
CR (1)	CR8416A (es)
CY (1)	CY1110933T1 (es)
DE (1)	DE602004029705D1 (es)
DK (1)	DK1689751T3 (es)
EA (1)	EA011772B1 (es)
EC (1)	ECSP066580A (es)
ES (1)	ES2351622T3 (es)
GB (1)	GB0327319D0 (es)
GE (1)	GEP20084528B (es)
HR (1)	HRP20100651T1 (es)
IL (1)	IL175433A (es)
IS (1)	IS8406A (es)
MA (1)	MA28172A1 (es)
ME (1)	ME01216B (es)
MX (1)	MXPA06005914A (es)
MY (1)	MY140872A (es)
NL (1)	NL1027568C2 (es)
NO (1)	NO336526B1 (es)
NZ (1)	NZ548097A (es)
OA (1)	OA13289A (es)
PA (1)	PA8617701A1 (es)
PE (1)	PE20051061A1 (es)
PL (1)	PL1689751T3 (es)
PT (1)	PT1689751E (es)
RS (1)	RS51556B (es)
SG (1)	SG133614A1 (es)
SI (1)	SI1689751T1 (es)
TN (1)	TNSN06154A1 (es)
TW (1)	TWI265031B (es)
UA (1)	UA81994C2 (es)
UY (1)	UY28625A1 (es)
WO (1)	WO2005049616A1 (es)
ZA (1)	ZA200602899B (es)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2005286728A1 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
BRPI0515482A (pt)	2004-09-20	2008-07-22	Xenon Pharmaceuticals Inc	derivados heterocìclicos e seus usos como agentes terapêuticos
CN101084211A (zh)	2004-09-20	2007-12-05	泽农医药公司	杂环衍生物及其作为治疗剂的用途
BRPI0515500A (pt)	2004-09-20	2008-07-29	Xenon Pharmaceuticals Inc	derivados piridazina para inibição de estearoil-coa-desaturase
AU2005286647A1 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
MX2007003318A (es)	2004-09-20	2007-05-18	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como agentes terapeuticos.
MX2007003332A (es)	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
EP1809632A2 (en) *	2004-10-28	2007-07-25	Pharmacia & Upjohn Company LLC	Pyrazolo[4,3-d]pyrimidine derivatives useful as pde-5 inhibitors
CA2608018C (en) *	2005-05-12	2010-07-13	Pfizer Inc.	Anhydrous crystalline forms of n-[1-(2-ethoxyethyl)-5-(n-ethyl-n-methylamino)-7-(4-methylpyridin-2-yl-amino)-1h-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide
CA2618646A1 (en)	2005-06-03	2007-11-15	Xenon Pharmaceuticals Inc.	Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
NL1029244C2 (nl) *	2005-06-10	2006-12-12	Ronald Silfried Marlin	Middel ter vergroting van het mannelijk geslachtsorgaan.
DE102005050377A1 (de) *	2005-10-21	2007-04-26	Bayer Healthcare Ag	Heterocyclische Verbindungen und ihre Verwendung
NL2000291C2 (nl)	2005-11-10	2009-02-17	Pfizer Prod Inc	1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
WO2007070872A1 (en)	2005-12-15	2007-06-21	Rigel Pharmaceuticals, Inc.	Kinase inhibitors and their uses
EP1820502A1 (en) *	2006-02-10	2007-08-22	Laboratorios Del Dr. Esteve, S.A.	Active substance combination comprising azolylcarbinol compounds
WO2007113243A2 (en) *	2006-03-31	2007-10-11	Investigación Y Clínica Andrológicas S.L.	Use of pde 5 inhibitors for the treatment of overactive bladder
WO2008132589A1 (en) *	2007-05-01	2008-11-06	Pfizer Limited	Combinations comprising pregabalin
WO2009050554A2 (en) *	2007-10-19	2009-04-23	Pfizer Inc.	Treatment of central nervous system disorders
DE102008063992A1 (de) *	2008-12-19	2010-09-02	Lerner, Zinoviy, Dipl.-Ing.	Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung
CA2830027C (en)	2011-03-31	2016-04-26	Pfizer Inc.	Novel bicyclic pyridinones
WO2012172449A1 (en)	2011-06-13	2012-12-20	Pfizer Inc.	Lactams as beta secretase inhibitors
JP6043355B2 (ja)	2011-08-31	2016-12-14	ファイザー・インク	ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
WO2013164730A1 (en)	2012-05-04	2013-11-07	Pfizer Inc.	Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin- 2 -amine compounds as inhibitors of app, bace1 and bace 2.
EP2897964A1 (en)	2012-09-20	2015-07-29	Pfizer Inc.	Alkyl-substituted hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds
UA110688C2 (uk)	2012-09-21	2016-01-25	Пфайзер Інк.	Біциклічні піридинони
EP2931731A1 (en)	2012-12-11	2015-10-21	Pfizer Inc.	Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
US9403846B2 (en)	2012-12-19	2016-08-02	Pfizer Inc.	Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
EP2956458B1 (en)	2013-02-13	2017-08-09	Pfizer Inc	Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
US9233981B1 (en)	2013-02-15	2016-01-12	Pfizer Inc.	Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
BR112015019276A2 (pt)	2013-02-19	2017-07-18	Pfizer	compostos de azabenzimidazol como inibidores de isoenzimas de pde4 para o tratamento de distúrbios do snc e outros distúrbios
JP6425717B2 (ja)	2013-10-04	2018-11-21	ファイザー・インク	ガンマセクレターゼモジュレーターとしての新規二環式ピリジノン
US20170037028A1 (en) *	2013-12-20	2017-02-09	Bayer Pharma Aktiengesellschaft	Glucose transport inhibitors
AP2016009465A0 (en)	2014-04-01	2016-09-30	Pfizer	Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators
KR20160138084A (ko) *	2014-04-04	2016-12-02	하. 룬드벡 아크티에셀스카브	Pde1 저해제인 할로겐화된 퀴나졸린-thf-아민
CN106459088A (zh)	2014-04-10	2017-02-22	辉瑞公司	2‑氨基‑6‑甲基‑4，4a，5，6‑四氢吡喃并[3，4‑d][1，3]噻嗪‑8a(8H)‑基‑1，3‑噻唑‑4‑基酰胺
WO2016012896A1 (en)	2014-07-24	2016-01-28	Pfizer Inc.	Pyrazolopyrimidine compounds
MD20170011A2 (ro)	2014-08-06	2017-08-31	Pfizer Inc.	Compuşi imidazopiridazinici
WO2016091774A1 (en) *	2014-12-08	2016-06-16	Janssen Sciences Ireland Uc	Piperidine substituted pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (rsv)
MX368391B (es)	2015-02-03	2019-09-30	Pfizer	Ciclopropabenzofuranil-piridopirazindionas novedosas.
CN107787322B (zh)	2015-06-17	2023-07-07	辉瑞大药厂	三环化合物以及它们作为磷酸二酯酶抑制剂的用途
JP2018531923A (ja)	2015-09-24	2018-11-01	ファイザー・インク	Ｎ−［２−（２−アミノ−６，６−二置換−４，４ａ，５，６−テトラヒドロピラノ［３，４−ｄ］［１，３］チアジン−８ａ（８Ｈ）−イル）−１，３−チアゾール−４−イル］アミド
WO2017051303A1 (en)	2015-09-24	2017-03-30	Pfizer Inc.	Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors
JP2018534251A (ja)	2015-09-24	2018-11-22	ファイザー・インク	Ｂａｃｅ阻害剤として有用なｎ−［２−（３−アミノ−２，５−ジメチル−１，１−ジオキシド−５，６−ジヒドロ−２ｈ−１，２，４−チアジアジン−５−イル）−１，３−チアゾール−４−イル］アミド
CN113332292A (zh)	2016-02-23	2021-09-03	辉瑞公司	6,7-二氢-5H-吡唑并[5,1-b][1,3]噁嗪-2-甲酰胺化合物
PT3478679T (pt)	2016-07-01	2021-06-30	Pfizer	Derivados de 5,7-dihidro-pirrolo-piridina para o tratamento de doenças neurológicas e neurodegenerativas
IL271290B2 (en)	2017-06-22	2023-11-01	Pfizer	Dihydro-pyrrolo-pyridine derivatives
PT3768669T (pt)	2018-03-23	2023-04-24	Pfizer	Derivados de piperazina azaspiro
CA3100923A1 (en)	2018-06-04	2019-12-12	Exscientia Ltd	Pyrazolopyrimidine compounds as adenosine receptor antagonists
CN112805005A (zh) *	2018-08-24	2021-05-14	拓臻股份有限公司	甲状腺素受体β促效剂化合物
CN111320609A (zh)	2018-12-13	2020-06-23	拓臻股份有限公司	一种THRβ受体激动剂化合物及其制备方法和用途
AU2020336272A1 (en)	2019-08-23	2022-04-14	Terns Pharmaceuticals, Inc.	Thyroid hormone receptor beta agonist compounds
WO2021050945A1 (en)	2019-09-12	2021-03-18	Terns, Inc.	Thyroid hormone receptor beta agonist compounds
KR20220132601A (ko) *	2020-01-27	2022-09-30	브리스톨-마이어스 스큅 컴퍼니	톨-유사 수용체 7 (TLR7) 효능제로서의 1H-피라졸로[4,3-d]피리미딘 화합물
US12144815B2 (en)	2021-02-23	2024-11-19	Hoth Therapeutics, Inc.	Use of aprepitant for treating Alzheimer's disease
JP7788056B2 (ja) *	2022-03-10	2025-12-18	積水化学工業株式会社	ウイルス感染阻止剤、ウイルス感染阻止製品、ウイルス感染阻止塗料及び樹脂組成物
WO2024118524A1 (en)	2022-11-28	2024-06-06	Cerevel Therapeutics, Llc	Azaindole compounds and their use as phosphodiesterase inhibitors
EP4568664B1 (en)	2023-04-07	2026-04-01	Terns Pharmaceuticals, Inc.	Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating obesity
WO2025145091A1 (en)	2023-12-29	2025-07-03	Pfizer Inc.	Crystalline forms of a muscarinic m4 receptor modulator and methods of treating diseases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000024745A1 (en) *	1998-10-23	2000-05-04	Pfizer Limited	PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION
WO2002000600A1 (de) *	2000-06-27	2002-01-03	Qiagen Gmbh	Verwendung von kompositionen aus kationischen verbindungen und protonendonoren zur stabilisierung und/oder isolierung von nukleinsäuren in bzw. aus mikroorganismen - wie prokaryonten, pilzen, protozoen oder algen
WO2004096810A1 (en) *	2003-04-29	2004-11-11	Pfizer Limited	5,7-diaminopyrazolo`4,3-d!pyrimidines useful in the treatment of hypertension

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW370529B (en) *	1992-12-17	1999-09-21	Pfizer	Pyrazolopyrimidines
GB9823102D0 (en) *	1998-10-23	1998-12-16	Pfizer Ltd	Pharmaceutically active compounds
DE10031584A1 (de) *	2000-06-29	2002-01-10	Merck Patent Gmbh	5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
ATE478872T1 (de) *	2002-03-28	2010-09-15	Ustav Ex Botan Av Cr V V I I O	Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung

2003
- 2003-11-24 GB GBGB0327319.0A patent/GB0327319D0/en not_active Ceased
2004
- 2004-11-12 SI SI200431562T patent/SI1689751T1/sl unknown
- 2004-11-12 PT PT04798876T patent/PT1689751E/pt unknown
- 2004-11-12 ME MEP-2010-203A patent/ME01216B/me unknown
- 2004-11-12 GE GEAP20049412A patent/GEP20084528B/en unknown
- 2004-11-12 JP JP2006540647A patent/JP4056015B2/ja not_active Expired - Fee Related
- 2004-11-12 NZ NZ548097A patent/NZ548097A/en not_active IP Right Cessation
- 2004-11-12 AP AP2006003591A patent/AP2227A/xx active
- 2004-11-12 MX MXPA06005914A patent/MXPA06005914A/es active IP Right Grant
- 2004-11-12 WO PCT/IB2004/003747 patent/WO2005049616A1/en not_active Ceased
- 2004-11-12 SG SG200704860-6A patent/SG133614A1/en unknown
- 2004-11-12 CN CN200810085940XA patent/CN101362765B/zh not_active Expired - Fee Related
- 2004-11-12 CN CN200910151866A patent/CN101647802A/zh active Pending
- 2004-11-12 DE DE602004029705T patent/DE602004029705D1/de not_active Expired - Lifetime
- 2004-11-12 HR HR20100651T patent/HRP20100651T1/hr unknown
- 2004-11-12 OA OA1200600166A patent/OA13289A/en unknown
- 2004-11-12 KR KR1020087009034A patent/KR100893999B1/ko not_active Expired - Fee Related
- 2004-11-12 EA EA200600677A patent/EA011772B1/ru not_active IP Right Cessation
- 2004-11-12 AU AU2004290643A patent/AU2004290643B2/en not_active Ceased
- 2004-11-12 DK DK04798876.1T patent/DK1689751T3/da active
- 2004-11-12 ES ES04798876T patent/ES2351622T3/es not_active Expired - Lifetime
- 2004-11-12 CN CN2004800345707A patent/CN1882591B/zh not_active Expired - Fee Related
- 2004-11-12 CN CN2008100859397A patent/CN101362764B/zh not_active Expired - Fee Related
- 2004-11-12 EP EP04798876A patent/EP1689751B1/en not_active Expired - Lifetime
- 2004-11-12 RS RSP-2010/0534A patent/RS51556B/sr unknown
- 2004-11-12 BR BRPI0416869-0A patent/BRPI0416869A/pt not_active Application Discontinuation
- 2004-11-12 PL PL04798876T patent/PL1689751T3/pl unknown
- 2004-11-12 KR KR1020067010152A patent/KR100848216B1/ko not_active Expired - Fee Related
- 2004-11-12 AT AT04798876T patent/ATE485297T1/de active
- 2004-11-12 CA CA002546987A patent/CA2546987C/en not_active Expired - Fee Related
- 2004-11-22 MY MYPI20044834A patent/MY140872A/en unknown
- 2004-11-22 UY UY28625A patent/UY28625A1/es active IP Right Grant
- 2004-11-22 PE PE2004001138A patent/PE20051061A1/es not_active Application Discontinuation
- 2004-11-23 PA PA20048617701A patent/PA8617701A1/es unknown
- 2004-11-23 NL NL1027568A patent/NL1027568C2/nl not_active IP Right Cessation
- 2004-11-23 AR ARP040104331A patent/AR046711A1/es not_active Application Discontinuation
- 2004-11-23 TW TW093136019A patent/TWI265031B/zh not_active IP Right Cessation
- 2004-12-11 UA UAA200605669A patent/UA81994C2/uk unknown
2006
- 2006-04-10 IS IS8406A patent/IS8406A/is unknown
- 2006-04-10 ZA ZA200602899A patent/ZA200602899B/en unknown
- 2006-05-04 IL IL175433A patent/IL175433A/en not_active IP Right Cessation
- 2006-05-23 EC EC2006006580A patent/ECSP066580A/es unknown
- 2006-05-23 CR CR8416A patent/CR8416A/es unknown
- 2006-05-24 MA MA29050A patent/MA28172A1/fr unknown
- 2006-05-24 TN TNP2006000154A patent/TNSN06154A1/fr unknown
- 2006-06-23 NO NO20062950A patent/NO336526B1/no not_active IP Right Cessation
2010
- 2010-11-24 CY CY20101101062T patent/CY1110933T1/el unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000024745A1 (en) *	1998-10-23	2000-05-04	Pfizer Limited	PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION
WO2002000600A1 (de) *	2000-06-27	2002-01-03	Qiagen Gmbh	Verwendung von kompositionen aus kationischen verbindungen und protonendonoren zur stabilisierung und/oder isolierung von nukleinsäuren in bzw. aus mikroorganismen - wie prokaryonten, pilzen, protozoen oder algen
WO2004096810A1 (en) *	2003-04-29	2004-11-11	Pfizer Limited	5,7-diaminopyrazolo`4,3-d!pyrimidines useful in the treatment of hypertension

Also Published As

Publication number	Publication date
SI1689751T1 (sl)	2011-01-31
MXPA06005914A (es)	2006-06-27
CA2546987A1 (en)	2005-06-02
IL175433A (en)	2011-08-31
TW200520758A (en)	2005-07-01
KR100893999B1 (ko)	2009-04-20
WO2005049616A1 (en)	2005-06-02
IL175433A0 (en)	2006-09-05
CN101362764A (zh)	2009-02-11
RS51556B (sr)	2011-06-30
HRP20100651T1 (hr)	2011-01-31
AU2004290643B2 (en)	2008-08-07
BRPI0416869A (pt)	2007-03-27
TWI265031B (en)	2006-11-01
HK1128917A1 (en)	2009-11-13
ECSP066580A (es)	2006-12-20
UY28625A1 (es)	2005-06-30
DK1689751T3 (da)	2011-01-17
HK1099286A1 (en)	2007-08-10
EA200600677A1 (ru)	2006-12-29
CR8416A (es)	2006-11-15
EP1689751B1 (en)	2010-10-20
KR100848216B1 (ko)	2008-07-24
WO2005049616A8 (en)	2006-06-01
AP2006003591A0 (en)	2006-04-30
NL1027568A1 (nl)	2005-05-26
EA011772B1 (ru)	2009-06-30
MA28172A1 (fr)	2006-09-01
CA2546987C (en)	2009-05-12
NO20062950L (no)	2006-08-23
CN101362765A (zh)	2009-02-11
KR20080052666A (ko)	2008-06-11
AU2004290643A1 (en)	2005-06-02
PL1689751T3 (pl)	2011-03-31
JP4056015B2 (ja)	2008-03-05
UA81994C2 (en)	2008-02-25
SG133614A1 (en)	2007-07-30
CN1882591B (zh)	2011-08-10
NZ548097A (en)	2008-12-24
ES2351622T3 (es)	2011-02-08
KR20070026334A (ko)	2007-03-08
IS8406A (is)	2006-04-10
TNSN06154A1 (fr)	2007-11-15
ME01216B (me)	2013-03-20
MY140872A (en)	2010-01-29
GEP20084528B (en)	2008-11-10
OA13289A (en)	2007-01-31
NL1027568C2 (nl)	2005-11-30
CN101362765B (zh)	2011-02-02
PE20051061A1 (es)	2005-12-12
PA8617701A1 (es)	2005-08-04
PT1689751E (pt)	2010-11-29
NO336526B1 (no)	2015-09-21
CN101647802A (zh)	2010-02-17
AR046711A1 (es)	2005-12-21
ATE485297T1 (de)	2010-11-15
EP1689751A1 (en)	2006-08-16
CN1882591A (zh)	2006-12-20
DE602004029705D1 (de)	2010-12-02
ZA200602899B (en)	2007-07-25
CY1110933T1 (el)	2015-06-10
CN101362764B (zh)	2011-04-20
GB0327319D0 (en)	2003-12-24
JP2007512314A (ja)	2007-05-17

Publication	Publication Date	Title
AP2227A (en)	2011-03-29	5,7-diaminopyrazolo [4,3-d]pyrimidines with PDE-5 inhibiting activity.
IL182099A0 (en)	2007-07-24	Piperidinylamino-thieno[2,3-d] pyrimidine compounds
EP1599482A4 (en)	2008-10-01	PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES
NO20040540L (no)	2004-02-05	4-amino-6-fenylpyrrolo[2,3-D]pyrimidinderivater.
AP2005003403A0 (en)	2005-12-31	Substituted pyrimidinones.
PL376916A1 (pl)	2006-01-09	Pochodne pirymido [4,5-d] pirymidyny o działaniu przeciwrakowym
EG25273A (en)	2011-12-04	Substituted dihydroquinazolines.
AP2005003365A0 (en)	2005-09-30	Hiv inhibiting 1, 2, 4-triazines.
IL170680A0 (en)	2009-02-11	8 - SUBSTITUTED - 6,7,8,9 -TETRAHYDROPYRIMIDO [1,2-a] PYRIMIDIN - 4 - ONE DERIVATIVES
IL164442A0 (en)	2005-12-18	Benzoxazinone-derived compounds, their preparationand use as medicaments
MXPA03007320A (es)	2003-12-04	Nuevos compuestos de pirimidina.
ZA200507192B (en)	2007-03-28	Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido [1,2-A] pyrimidin-4-one derivatives
MXPA03007433A (es)	2003-11-18	Pirazolil pirimidinas.
ZA200501679B (en)	2005-09-06	Recreation range.
AP2006003497A0 (en)	2006-02-28	2-Substituted pyrimidines.
PL358551A1 (en)	2004-08-09	5-aminoalkyl-pyrazolo[4,3-d]pyrimidines
AP2006003539A0 (en)	2006-04-30	5-halogeno-[1,2,4]triazolo[1,5-A] pyrimidines for combating animal pests.
MXPA03004498A (es)	2003-09-05	Uso de pirazolo (4,3-d)pirimidinas.
GB0323137D0 (en)	2003-11-05	2,4,6- Trisubstituted pyrimidines and their different uses
PL361915A1 (en)	2004-10-04	Substituted 3.4-dihydro-pyrido[1,2-a]pyrimidines
PL375417A1 (en)	2005-11-28	2,3-dihydro-isoindol-1-ones with mao-b inhibiting activity
TWI372760B (en)	2012-09-21	A pyrazolo[1,5-a]pyrimidine compound
LU91022B1 (en)	2004-11-10	Sektionaltor.
ZA200600471B (en)	2007-04-25	7-substituted 3-nitro-pyrazolo[1,5-A] pyrimidines
TJ431B (en)	2007-06-05	2-Brom-7-methil-5-oxo-5h-1,3,4-thyodyazol-(3,2-a)pyrimidin, has antibacterial activity