AP2313A - Inhibitors of hepatitis C virus RNA-dependent RNA ploymerase, and compositions and treatments using the same. - Google Patents

Inhibitors of hepatitis C virus RNA-dependent RNA ploymerase, and compositions and treatments using the same.

Info

Publication number
AP2313A
AP2313A AP2007003918A AP2007003918A AP2313A AP 2313 A AP2313 A AP 2313A AP 2007003918 A AP2007003918 A AP 2007003918A AP 2007003918 A AP2007003918 A AP 2007003918A AP 2313 A AP2313 A AP 2313A
Authority
AP
ARIPO
Prior art keywords
rna
hepatitis
treatments
inhibitors
compositions
Prior art date
Application number
AP2007003918A
Other languages
English (en)
Other versions
AP2007003918A0 (en
Inventor
Javier Gonzalez
Tanya Michelle Jewell
Hui Li
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AP2007003918A0 publication Critical patent/AP2007003918A0/xx
Application granted granted Critical
Publication of AP2313A publication Critical patent/AP2313A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AP2007003918A 2004-08-18 2005-08-05 Inhibitors of hepatitis C virus RNA-dependent RNA ploymerase, and compositions and treatments using the same. AP2313A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60261804P 2004-08-18 2004-08-18
PCT/IB2005/002697 WO2006018725A1 (en) 2004-08-18 2005-08-05 Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same

Publications (2)

Publication Number Publication Date
AP2007003918A0 AP2007003918A0 (en) 2007-02-28
AP2313A true AP2313A (en) 2011-10-31

Family

ID=35429645

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2007003918A AP2313A (en) 2004-08-18 2005-08-05 Inhibitors of hepatitis C virus RNA-dependent RNA ploymerase, and compositions and treatments using the same.

Country Status (42)

Country Link
US (3) US7151105B2 (es)
EP (1) EP1781662B1 (es)
JP (1) JP4372195B2 (es)
KR (1) KR100851178B1 (es)
CN (2) CN101006092B (es)
AP (1) AP2313A (es)
AR (1) AR050699A1 (es)
AT (1) ATE506364T1 (es)
AU (1) AU2005273619B2 (es)
BR (1) BRPI0514425A (es)
CA (1) CA2577525C (es)
CR (2) CR8935A (es)
CY (1) CY1111480T1 (es)
DE (1) DE602005027580D1 (es)
DK (1) DK1781662T3 (es)
EA (1) EA012605B1 (es)
EC (1) ECSP077264A (es)
ES (1) ES2361845T3 (es)
GE (2) GEP20094751B (es)
GT (1) GT200500221A (es)
HN (1) HN2005000449A (es)
HR (1) HRP20110458T1 (es)
IL (2) IL180933A (es)
MA (1) MA28803B1 (es)
MX (1) MX2007001527A (es)
MY (1) MY146123A (es)
NI (1) NI200700043A (es)
NL (1) NL1029755C2 (es)
NO (1) NO20071274L (es)
NZ (1) NZ552874A (es)
PE (1) PE20060677A1 (es)
PL (1) PL1781662T3 (es)
PT (1) PT1781662E (es)
RS (1) RS51794B (es)
SI (1) SI1781662T1 (es)
SV (1) SV2007002202A (es)
TN (1) TNSN07066A1 (es)
TW (1) TWI376379B (es)
UA (1) UA88909C2 (es)
UY (1) UY29068A1 (es)
WO (1) WO2006018725A1 (es)
ZA (1) ZA200700779B (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005273619B2 (en) * 2004-08-18 2009-05-28 Pfizer Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
WO2007023381A1 (en) * 2005-08-24 2007-03-01 Pfizer Inc. Methods for the preparation of hcv polymerase inhibitors
EP2142215B1 (en) 2007-05-04 2012-03-07 Vertex Pharmceuticals Incorporated Combination therapy for the treatment of hcv infection
EP2008996A1 (en) * 2007-06-27 2008-12-31 Syngeta Participations AG Process for the production of pyrazoles
CN102083852A (zh) 2008-06-06 2011-06-01 西尼克斯公司 环孢菌素类似物及其在治疗hcv感染中的应用
BRPI0917458A2 (pt) 2008-08-11 2015-12-01 Glaxosmithkline Llc composto, método de tratamento de doenças e condições, composição farmacêutica, método para tratar ou prevenir doença, e, uso de um composto
BRPI0917013A2 (pt) 2008-08-11 2016-02-16 Glaxosmithkline Llc métodos para tratar doenças alérgicas e outras condições inflamatórias, e para tratar ou prevenir doença, composto, composição farmacêutica, e, uso de um composto
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
UY32940A (es) 2009-10-27 2011-05-31 Bayer Cropscience Ag Amidas sustituidas con halogenoalquilo como insecticidas y acaricidas
EA201200650A1 (ru) 2009-10-30 2012-12-28 Бёрингер Ингельхайм Интернациональ Гмбх Курсы комбинированного лечения вируса гепатита с, включающие bi201335, интерферон-альфа и рибавирин
EP2325173A1 (de) 2009-11-19 2011-05-25 Bayer CropScience AG Verfahren zum Herstellen von 5-Fluor-1-alkyl-3-fluoralkyl-1H-pyrazol-4-carbonsäurechloriden
PH12012501216A1 (en) * 2009-12-18 2012-11-05 Boehringer Ingelheim Int Hcv combination therapy
DK2534149T3 (da) 2010-02-10 2015-01-05 Glaxosmithkline Llc 6-amino-2-{ [ (1s)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8h-purin-8-on-maleat
WO2011098451A1 (en) 2010-02-10 2011-08-18 Glaxosmithkline Llc Purine derivatives and their pharmaceutical uses
EP2571854B1 (en) * 2010-05-20 2014-11-05 Bayer Intellectual Property GmbH Method for manufacturing 1-alkyl-3-difluormethyl-5-hydroxypyrazoles
US8987307B2 (en) 2011-03-03 2015-03-24 Hoffmann-La Roche Inc. 3-amino-pyridines as GPBAR1 agonists
FR2972452B1 (fr) 2011-03-09 2013-03-15 Rhodia Operations Procede de preparation du difluoroacetonitrile et de ses derives
JP6101345B2 (ja) 2012-05-14 2017-03-22 バイエル・クロップサイエンス・アクチェンゲゼルシャフト １−アルキル−３−フルオロアルキル−１ｈ−ピラゾール−４−カルボニルクロライド類の製造方法
US9657024B2 (en) 2012-11-21 2017-05-23 Stategics, Inc. Substituted triazolo-pyrimidine compounds for modulating cell proliferation, differentiation and survival
ES2610380T3 (es) 2013-01-17 2017-04-27 Bayer Cropscience Ag Procedimiento de preparación de 5-fluoro-1-metil-3-difluorometil-1H-pirazol-4-carbaldehído
PL2953942T3 (pl) 2013-02-06 2018-03-30 Bayer Cropscience Aktiengesellschaft Podstawione halogenem pochodne pirazolu jako środki do zwalczania szkodników
MX2016008653A (es) 2014-01-03 2016-09-26 Bayer Animal Health Gmbh Nuevas pirazolil-heteroarilamidas como agentes plaguicidas.
JP6462703B2 (ja) 2014-01-24 2019-01-30 バイエル・クロップサイエンス・アクチェンゲゼルシャフト １−アルキル−３−ジフルオロメチル−５−フルオロ−１ｈ−ピラゾール−４−カルバルデヒド類及び１−アルキル−３−ジフルオロメチル−５−フルオロ−１ｈ−ピラゾール−４−カルボキシレート類を調製する方法
KR20160124157A (ko) 2014-02-20 2016-10-26 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 인간 인터페론의 유도인자로서의 피롤로[3,2]피리미딘 유도체
CN106414429B (zh) 2014-06-03 2020-01-03 爱杜西亚药品有限公司 吡唑化合物及其作为t型钙通道阻断剂的用途
MX2017006302A (es) 2014-11-13 2018-02-16 Glaxosmithkline Biologicals Sa Derivados de adenina que son utiles en el tratamiento de enfermedades alergicas u otras afecciones inflamatorias.
WO2017093180A1 (de) 2015-12-01 2017-06-08 Bayer Cropscience Aktiengesellschaft Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel
CN107849084B (zh) 2015-12-03 2021-09-14 葛兰素史密斯克莱知识产权发展有限公司 作为sting调节剂的环状嘌呤二核苷酸
PT3440076T (pt) 2016-04-07 2022-07-29 Glaxosmithkline Ip Dev Ltd Amidas heterocíclicas úteis como modeladores de proteína
JP2019510802A (ja) 2016-04-07 2019-04-18 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ タンパク質調節物質として有用な複素環アミド
MX2019001918A (es) 2016-08-15 2019-09-06 Bayer Cropscience Ag Derivados del heterociclo biciclico condensado como agentes de control de plagas.
EP3301094A1 (en) * 2016-09-30 2018-04-04 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
MX388586B (es) 2016-12-16 2025-03-20 Idorsia Pharmaceuticals Ltd Combinacion farmaceutica que comprende un bloqueador del canal de calcio de tipo t.
CA3050348A1 (en) 2017-02-06 2018-08-09 Idorsia Pharmaceuticals Ltd A novel process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes
USRE50663E1 (en) 2017-10-04 2025-11-18 Bayer Aktiengesellschaft Heterocycle derivatives as pesticides
CA3077337A1 (en) 2017-10-05 2019-04-11 Glaxosmithkline Intellectual Property Development Limited Modulators of stimulator of interferon genes (sting)
AU2018344902B2 (en) 2017-10-05 2021-06-03 Glaxosmithkline Intellectual Property Development Limited Modulators of stimulator of interferon genes (STING) useful in treating HIV
US11414432B2 (en) 2018-03-12 2022-08-16 Bayer Aktiengesellschaft Condensed bicyclic heterocyclic derivatives as pest control agents
WO2019201921A1 (de) 2018-04-20 2019-10-24 Bayer Aktiengesellschaft Heterocyclen-derivate als schädlingsbekämpfungsmittel
GB201807924D0 (en) 2018-05-16 2018-06-27 Ctxt Pty Ltd Compounds
AU2020210455B2 (en) 2019-01-25 2023-02-02 Beijing Scitech-Mq Pharmaceuticals Limited Acylamino bridged heterocyclic compound, and composition and application thereof
US20220227761A1 (en) 2019-05-16 2022-07-21 Stingthera, Inc. Oxoacridinyl acetic acid derivatives and methods of use
WO2020232378A1 (en) 2019-05-16 2020-11-19 Silicon Swat, Inc. Benzo[b][1,8]naphthyridine acetic acid derivatives and methods of use
GB201910305D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
GB201910304D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
EP4077318B1 (en) 2019-12-18 2025-10-15 Ctxt Pty Ltd Benzimidazole dimers as modulators of sting
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
CN112194620B (zh) * 2020-12-04 2021-02-26 苏州开元民生科技股份有限公司 一种2-乙基-4-氰基吡啶的制备方法
CN113563167B (zh) * 2021-07-16 2023-09-08 南通华祥医药科技有限公司 一种2-甲基-1-四氢萘酮的制备方法
WO2025094987A1 (ja) 2023-10-31 2025-05-08 日本農薬株式会社 スルホニル基を有する含窒素複素環化合物及び該化合物を含有する農園芸用除草剤並びにそれらの使用方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003095441A1 (en) * 2002-05-10 2003-11-20 Pfizer Inc. Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same
WO2004074270A2 (en) * 2003-02-21 2004-09-02 Pfizer Inc. Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3786063A (en) 1971-05-24 1974-01-15 Universal Oil Prod Co Thiazolethiosulfonates
DE2155360C3 (de) * 1971-11-08 1980-04-03 Cassella Ag, 6000 Frankfurt Verfahren zur Herstellung von Acylbernsteinsäuredialkylestern
CA1140049A (en) 1977-12-22 1983-01-25 Dke J.E. Helgstran Pharmaceutical preparations from derivatives of hydroxycarbonylphosphonic acid
US4326058A (en) 1979-02-05 1982-04-20 Sumitomo Chemical Company, Limited Organo-phosphoric esters and their production and use
US4489077A (en) 1983-03-23 1984-12-18 Warner-Lambert Company 3-Isoxa-zolyl-2H-1,2-benzothiazine-3-carboxamide, 1,1-dioxides
US6174868B1 (en) 1992-09-10 2001-01-16 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of hepatitis C virus-associated diseases
US5846964A (en) 1993-07-19 1998-12-08 Tokyo Tanabe Company Limited Hepatitis C virus proliferation inhibitor
RU2140917C1 (ru) 1993-11-19 1999-11-10 Парк, Дэвис энд Компани Производные 5,6-дигидропирона и фармацевтическая композиция на их основе
US5840751A (en) 1993-11-19 1998-11-24 Warner-Lambert Company 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
US6005103A (en) 1993-11-19 1999-12-21 Warner-Lambert Company Pyrone derivatives as protease inhibitors and antiviral agents
FI962021A7 (fi) 1993-11-19 1996-07-12 Parke Davis & Co 5,6-dihydropyronijohdannaiset proteaasi-inhibiittoreina ja antiviraali sina aineina
US5504104A (en) 1993-11-19 1996-04-02 Warner-Lambert Company Tricyclic pyrone derivatives as protease inhibitors and antiviral agents
US5834506A (en) 1996-11-01 1998-11-10 Warner-Lambert Company Dihydropyrones with improved antiviral activity
CA2339275A1 (en) 1998-09-11 2000-03-23 Warner-Lambert Company 5,6-dihydro-4-hydroxy-2-pyranones as hiv aspartyl protease inhibitors
US6512006B1 (en) 1999-12-09 2003-01-28 Warner-Lambert Company HIV protease inhibitors
EP1256628A3 (en) 2001-05-10 2003-03-19 Agouron Pharmaceuticals, Inc. Hepatitis c virus (hcv) ns5b rna polymerase and mutants thereof
AU2005273619B2 (en) * 2004-08-18 2009-05-28 Pfizer Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003095441A1 (en) * 2002-05-10 2003-11-20 Pfizer Inc. Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same
WO2004074270A2 (en) * 2003-02-21 2004-09-02 Pfizer Inc. Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same

Also Published As

Publication number Publication date
ZA200700779B (en) 2008-11-26
NL1029755C2 (nl) 2006-10-18
DK1781662T3 (da) 2011-06-27
US7151105B2 (en) 2006-12-19
GEP20115305B (en) 2011-10-10
HN2005000449A (es) 2009-10-30
GEP20094751B (en) 2009-08-10
WO2006018725A1 (en) 2006-02-23
AP2007003918A0 (en) 2007-02-28
US20060122399A1 (en) 2006-06-08
HK1109617A1 (en) 2008-06-13
CA2577525C (en) 2010-03-30
JP4372195B2 (ja) 2009-11-25
DE602005027580D1 (de) 2011-06-01
EP1781662B1 (en) 2011-04-20
PL1781662T3 (pl) 2011-08-31
CR8935A (es) 2007-07-24
UA88909C2 (ru) 2009-12-10
PT1781662E (pt) 2011-07-01
HRP20110458T1 (hr) 2011-07-31
ATE506364T1 (de) 2011-05-15
NO20071274L (no) 2007-05-14
TNSN07066A1 (fr) 2008-06-02
CA2577525A1 (en) 2006-02-23
MX2007001527A (es) 2007-03-27
US20090281122A1 (en) 2009-11-12
NZ552874A (en) 2010-04-30
EP1781662A1 (en) 2007-05-09
TW200612898A (en) 2006-05-01
NI200700043A (es) 2008-01-02
US8268835B2 (en) 2012-09-18
PE20060677A1 (es) 2006-08-11
CN101006092B (zh) 2013-04-17
TWI376379B (en) 2012-11-11
SI1781662T1 (sl) 2011-07-29
KR20070044057A (ko) 2007-04-26
US20070015764A1 (en) 2007-01-18
CN101538268B (zh) 2011-07-27
IL180933A (en) 2011-08-31
KR100851178B1 (ko) 2008-08-08
CN101538268A (zh) 2009-09-23
AU2005273619A1 (en) 2006-02-23
AU2005273619B2 (en) 2009-05-28
GT200500221A (es) 2006-06-21
ES2361845T3 (es) 2011-06-22
BRPI0514425A (pt) 2008-06-10
JP2008509984A (ja) 2008-04-03
NL1029755A1 (nl) 2006-02-21
AR050699A1 (es) 2006-11-15
US7622605B2 (en) 2009-11-24
UY29068A1 (es) 2006-03-31
ECSP077264A (es) 2007-04-26
CY1111480T1 (el) 2015-08-05
CR20110153A (es) 2011-04-26
MY146123A (en) 2012-06-29
IL180933A0 (en) 2007-07-04
SV2007002202A (es) 2007-03-20
EA200700338A1 (ru) 2007-08-31
RS51794B (sr) 2011-12-31
IL192919A0 (en) 2009-02-11
CN101006092A (zh) 2007-07-25
MA28803B1 (fr) 2007-08-01
EA012605B1 (ru) 2009-10-30

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