AP291A - Use of a guanine derivative in the treatment of viral infections. - Google Patents

Use of a guanine derivative in the treatment of viral infections. Download PDF

Info

Publication number: AP291A
Authority: AP; ARIPO
Prior art keywords: formula; compound; use according; hiv; drug
Prior art date: 1990-07-07

Application number

APAP/P/1991/000290A

Other languages

English (en)

Other versions

AP9100290A0 (en

Inventor

Martin David John Kenig

Richard Anthony Vere Hodge

Original Assignee

Novartis Int Pharmaceutical Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-07

Filing date

1991-07-05

Publication date

1993-12-29

1991-07-05 Application filed by Novartis Int Pharmaceutical Ltd filed Critical Novartis Int Pharmaceutical Ltd

1991-07-31 Publication of AP9100290A0 publication Critical patent/AP9100290A0/xx

1993-12-29 Application granted granted Critical

1993-12-29 Publication of AP291A publication Critical patent/AP291A/en

Links

238000011282 treatment Methods 0.000 title claims abstract description 19
230000009385 viral infection Effects 0.000 title abstract description 4
WJSVJNDMOQTICG-UHFFFAOYSA-N 2-amino-1-[(2-methyl-4-methylidene-5-oxooxolan-2-yl)methyl]-7h-purin-6-one Chemical compound NC1=NC=2N=CNC=2C(=O)N1CC1(C)CC(=C)C(=O)O1 WJSVJNDMOQTICG-UHFFFAOYSA-N 0.000 title abstract 2
208000036142 Viral infection Diseases 0.000 title abstract 2
229940002612 prodrug Drugs 0.000 claims abstract description 15
239000000651 prodrug Substances 0.000 claims abstract description 15
150000001875 compounds Chemical class 0.000 claims description 32
241001529453 unidentified herpesvirus Species 0.000 claims description 14
241000124008 Mammalia Species 0.000 claims description 10
150000003839 salts Chemical class 0.000 claims description 10
JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 claims description 9
239000003814 drug Substances 0.000 claims description 8
229960001179 penciclovir Drugs 0.000 claims description 8
125000002252 acyl group Chemical group 0.000 claims description 7
208000015181 infectious disease Diseases 0.000 claims description 7
229910052739 hydrogen Inorganic materials 0.000 claims description 6
239000001257 hydrogen Substances 0.000 claims description 6
229910019142 PO4 Inorganic materials 0.000 claims description 4
229960004396 famciclovir Drugs 0.000 claims description 4
GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 claims description 4
239000010452 phosphate Substances 0.000 claims description 4
-1 phosphate ester Chemical class 0.000 claims description 4
125000003545 alkoxy group Chemical group 0.000 claims description 3
239000011734 sodium Substances 0.000 claims description 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 2
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 claims description 2
150000002431 hydrogen Chemical group 0.000 claims description 2
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
229940079593 drug Drugs 0.000 claims 1
229910052708 sodium Inorganic materials 0.000 claims 1
241000725303 Human immunodeficiency virus Species 0.000 description 12
235000002639 sodium chloride Nutrition 0.000 description 12
102100034349 Integrase Human genes 0.000 description 10
108010092799 RNA-directed DNA polymerase Proteins 0.000 description 10
KGSIOVLUJYQLKR-UHFFFAOYSA-N [[4-(2-amino-6-oxo-3h-purin-9-yl)-2-(hydroxymethyl)butoxy]-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C=N2 KGSIOVLUJYQLKR-UHFFFAOYSA-N 0.000 description 9
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
210000004027 cell Anatomy 0.000 description 7
239000000203 mixture Substances 0.000 description 7
230000005764 inhibitory process Effects 0.000 description 6
239000003981 vehicle Substances 0.000 description 6
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
208000031886 HIV Infections Diseases 0.000 description 5
241000282412 Homo Species 0.000 description 5
HDRRAMINWIWTNU-NTSWFWBYSA-N [[(2s,5r)-5-(2-amino-6-oxo-3h-purin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@H]1CC[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 HDRRAMINWIWTNU-NTSWFWBYSA-N 0.000 description 5
239000011541 reaction mixture Substances 0.000 description 5
238000006243 chemical reaction Methods 0.000 description 4
238000010348 incorporation Methods 0.000 description 4
238000000034 method Methods 0.000 description 4
239000011780 sodium chloride Substances 0.000 description 4
239000001226 triphosphate Substances 0.000 description 4
LTFMZDNNPPEQNG-KVQBGUIXSA-N 2'-deoxyguanosine 5'-monophosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@H]1C[C@H](O)[C@@H](COP(O)(O)=O)O1 LTFMZDNNPPEQNG-KVQBGUIXSA-N 0.000 description 3
102000004190 Enzymes Human genes 0.000 description 3
108090000790 Enzymes Proteins 0.000 description 3
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 3
230000000840 anti-viral effect Effects 0.000 description 3
LTFMZDNNPPEQNG-UHFFFAOYSA-N deoxyguanylic acid Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1CC(O)C(COP(O)(O)=O)O1 LTFMZDNNPPEQNG-UHFFFAOYSA-N 0.000 description 3
239000003937 drug carrier Substances 0.000 description 3
239000003112 inhibitor Substances 0.000 description 3
239000000243 solution Substances 0.000 description 3
239000006188 syrup Substances 0.000 description 3
235000020357 syrup Nutrition 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
241000700588 Human alphaherpesvirus 1 Species 0.000 description 2
241000701074 Human alphaherpesvirus 2 Species 0.000 description 2
241000701085 Human alphaherpesvirus 3 Species 0.000 description 2
241000713772 Human immunodeficiency virus 1 Species 0.000 description 2
101900297506 Human immunodeficiency virus type 1 group M subtype B Reverse transcriptase/ribonuclease H Proteins 0.000 description 2
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
241000700584 Simplexvirus Species 0.000 description 2
239000013504 Triton X-100 Substances 0.000 description 2
229920004890 Triton X-100 Polymers 0.000 description 2
210000003719 b-lymphocyte Anatomy 0.000 description 2
239000002775 capsule Substances 0.000 description 2
HAAZLUGHYHWQIW-KVQBGUIXSA-N dGTP Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 HAAZLUGHYHWQIW-KVQBGUIXSA-N 0.000 description 2
230000000694 effects Effects 0.000 description 2
235000019441 ethanol Nutrition 0.000 description 2
239000012530 fluid Substances 0.000 description 2
238000009472 formulation Methods 0.000 description 2
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
239000007788 liquid Substances 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
238000002156 mixing Methods 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
239000000725 suspension Substances 0.000 description 2
UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical class OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 2
JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 1
208000030507 AIDS Diseases 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
108090000565 Capsid Proteins Proteins 0.000 description 1
102100023321 Ceruloplasmin Human genes 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
102000011412 Complement 3d Receptors Human genes 0.000 description 1
108010023729 Complement 3d Receptors Proteins 0.000 description 1
108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
239000004150 EU approved colour Substances 0.000 description 1
101710121417 Envelope glycoprotein Proteins 0.000 description 1
241000588724 Escherichia coli Species 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
239000005977 Ethylene Substances 0.000 description 1
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
108010024636 Glutathione Proteins 0.000 description 1
108010078851 HIV Reverse Transcriptase Proteins 0.000 description 1
208000007514 Herpes zoster Diseases 0.000 description 1
241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
102000014150 Interferons Human genes 0.000 description 1
108010050904 Interferons Proteins 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
240000007594 Oryza sativa Species 0.000 description 1
235000007164 Oryza sativa Nutrition 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
102000006601 Thymidine Kinase Human genes 0.000 description 1
108020004440 Thymidine kinase Proteins 0.000 description 1
241000711975 Vesicular stomatitis virus Species 0.000 description 1
241000700605 Viruses Species 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
239000003708 ampul Substances 0.000 description 1
230000003444 anaesthetic effect Effects 0.000 description 1
239000003443 antiviral agent Substances 0.000 description 1
238000003556 assay Methods 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
230000037396 body weight Effects 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
239000007979 citrate buffer Substances 0.000 description 1
VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013312 flour Nutrition 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000008103 glucose Substances 0.000 description 1
235000001727 glucose Nutrition 0.000 description 1
229960003180 glutathione Drugs 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
229940047124 interferons Drugs 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229910001629 magnesium chloride Inorganic materials 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
239000000463 material Substances 0.000 description 1
229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000003182 parenteral nutrition solution Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
150000003014 phosphoric acid esters Chemical class 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
230000003334 potential effect Effects 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000001566 pro-viral effect Effects 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
230000010076 replication Effects 0.000 description 1
238000002976 reverse transcriptase assay Methods 0.000 description 1
235000009566 rice Nutrition 0.000 description 1
238000007789 sealing Methods 0.000 description 1
BRPTUOYNOCSFRJ-FYZOBXCZSA-N sodium (2S)-4-(2-amino-6-oxo-1H-purin-9-yl)-2-(hydroxymethyl)butan-1-olate Chemical class [Na+].Nc1nc(=O)c2ncn(CC[C@H](CO)C[O-])c2[nH]1 BRPTUOYNOCSFRJ-FYZOBXCZSA-N 0.000 description 1
NASFKTWZWDYFER-UHFFFAOYSA-N sodium;hydrate Chemical compound O.[Na] NASFKTWZWDYFER-UHFFFAOYSA-N 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
239000003826 tablet Substances 0.000 description 1
238000013518 transcription Methods 0.000 description 1
230000035897 transcription Effects 0.000 description 1
235000011178 triphosphate Nutrition 0.000 description 1
238000009827 uniform distribution Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

APAP/P/1991/000290A 1990-07-07 1991-07-05 Use of a guanine derivative in the treatment of viral infections. AP291A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909015051A GB9015051D0 (en)	1990-07-07	1990-07-07	Pharmaceutical treatment

Publications (2)

Publication Number	Publication Date
AP9100290A0 AP9100290A0 (en)	1991-07-31
AP291A true AP291A (en)	1993-12-29

Family

ID=10678814

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1991/000290A AP291A (en)	1990-07-07	1991-07-05	Use of a guanine derivative in the treatment of viral infections.

Country Status (17)

Country	Link
EP (1)	EP0538305B1 (da)
JP (1)	JP2764656B2 (da)
KR (1)	KR100196339B1 (da)
AP (1)	AP291A (da)
AT (1)	ATE151291T1 (da)
AU (1)	AU647807B2 (da)
CA (1)	CA2086756C (da)
DE (1)	DE69125610T2 (da)
DK (1)	DK0538305T3 (da)
ES (1)	ES2101747T3 (da)
GB (1)	GB9015051D0 (da)
GR (1)	GR3023611T3 (da)
HK (1)	HK1004527A1 (da)
IE (1)	IE912358A1 (da)
IL (1)	IL98749A (da)
WO (1)	WO1992000742A1 (da)
ZA (1)	ZA915214B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6124304A (en) *	1993-10-05	2000-09-26	Smithkline Beecham Plc	Penciclovir for the treatment of zoster associated pain
GB9326177D0 (en) *	1993-12-22	1994-02-23	Smithkline Beecham Plc	Pharmaceuticals
GB9323403D0 (en) *	1993-11-12	1994-01-05	Smithkline Beecham Plc	Pharmaceuticals
US6683084B1 (en)	1993-11-12	2004-01-27	Novartis International Pharmaceutical Ltd.	Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections
GB9323404D0 (en) *	1993-11-12	1994-01-05	Smithkline Beecham Plc	Pharmaceuticals
UA51640C2 (uk) *	1994-12-12	2002-12-16	Смітклайн Бічам Плс	Спосіб утруднення встановлення або реактивації латентної інфекції, яка викликається вірусами герпесу
US5840763A (en) *	1994-12-12	1998-11-24	Smithkline Beecham Plc	Treatment of a latent infection of herpes viruses
GB9504497D0 (en)	1995-03-07	1995-04-26	Smithkline Beecham Plc	Pharmaceuticals
US7045525B1 (en)	1995-04-24	2006-05-16	Novartis Ag	Use of (R)-peniciclovir triphosphate for the manufacture of a medicament for the treatment of viral diseases
GB9601544D0 (en)	1996-01-26	1996-03-27	Smithkline Beecham Plc	Pharmaceuticals

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0216459A1 (en) *	1985-07-27	1987-04-01	Beecham Group Plc	9-Substituted guanine monohydrates
EP0271270A2 (en) *	1986-12-02	1988-06-15	Beecham Group Plc	Pharmaceutical products
EP0306844A2 (de) *	1987-09-11	1989-03-15	Hoechst Aktiengesellschaft	Verwendung bestimmter 6-Mercaptopurine zur Herstellung eines Arzneimittels sowie Verfahren zur Herstellung des Arzneimittels
AT388500B (de) *	1987-10-27	1989-06-26	Wellcome Found	Antivirale 8-phenylxanthine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0141927B1 (en) *	1983-08-18	1991-10-30	Beecham Group Plc	Antiviral guanine derivatives

1990
- 1990-07-07 GB GB909015051A patent/GB9015051D0/en active Pending
1991
- 1991-07-03 DE DE69125610T patent/DE69125610T2/de not_active Expired - Lifetime
- 1991-07-03 JP JP3511884A patent/JP2764656B2/ja not_active Expired - Fee Related
- 1991-07-03 EP EP91912424A patent/EP0538305B1/en not_active Expired - Lifetime
- 1991-07-03 DK DK91912424.8T patent/DK0538305T3/da active
- 1991-07-03 CA CA002086756A patent/CA2086756C/en not_active Expired - Lifetime
- 1991-07-03 AU AU81032/91A patent/AU647807B2/en not_active Expired
- 1991-07-03 ES ES91912424T patent/ES2101747T3/es not_active Expired - Lifetime
- 1991-07-03 WO PCT/GB1991/001082 patent/WO1992000742A1/en not_active Ceased
- 1991-07-03 AT AT91912424T patent/ATE151291T1/de not_active IP Right Cessation
- 1991-07-03 HK HK98103626A patent/HK1004527A1/en not_active IP Right Cessation
- 1991-07-05 IE IE235891A patent/IE912358A1/en not_active IP Right Cessation
- 1991-07-05 ZA ZA915214A patent/ZA915214B/xx unknown
- 1991-07-05 IL IL9874991A patent/IL98749A/en not_active IP Right Cessation
- 1991-07-05 AP APAP/P/1991/000290A patent/AP291A/en active
- 1991-07-31 KR KR1019930700034A patent/KR100196339B1/ko not_active Expired - Fee Related
1997
- 1997-05-30 GR GR970401255T patent/GR3023611T3/el unknown

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Also Published As

Publication number	Publication date
WO1992000742A1 (en)	1992-01-23
ATE151291T1 (de)	1997-04-15
DE69125610D1 (de)	1997-05-15
AU647807B2 (en)	1994-03-31
GR3023611T3 (en)	1997-08-29
CA2086756C (en)	2003-04-08
KR100196339B1 (ko)	1999-06-15
DK0538305T3 (da)	1997-10-13
JP2764656B2 (ja)	1998-06-11
CA2086756A1 (en)	1992-01-08
ES2101747T3 (es)	1997-07-16
GB9015051D0 (en)	1990-08-29
IL98749A0 (en)	1992-07-15
DE69125610T2 (de)	1997-11-20
EP0538305B1 (en)	1997-04-09
ZA915214B (en)	1992-06-24
JPH05507719A (ja)	1993-11-04
EP0538305A1 (en)	1993-04-28
IL98749A (en)	1995-03-30
AP9100290A0 (en)	1991-07-31
AU8103291A (en)	1992-02-04
IE912358A1 (en)	1992-01-15
HK1004527A1 (en)	1998-11-27

Publication	Publication Date	Title
AP291A (en)	1993-12-29	Use of a guanine derivative in the treatment of viral infections.
HK1004527B (en)	1998-11-27	Penciclovir and famciclovir and related guanine derivatives for the treatment of the hiv-1 infections
US10463664B2 (en)	2019-11-05	Inhibitors of HSV nucleotidyl transferases and uses therefor
AU628137B2 (en)	1992-09-10	Pharmaceutical treatment
US5674869A (en)	1997-10-07	Pharmaceutical treatment
IE921156A1 (en)	1992-10-21	Pharmaceuticals
EP0728002B1 (en)	2001-12-12	Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 7 infection
EP0728001B1 (en)	2001-12-19	Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections
US20220348546A1 (en)	2022-11-03	Sulfur and amide tropolone inhibitors of nucleotidyl transferases and uses therefor
US6683084B1 (en)	2004-01-27	Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections
HK1012234B (en)	2002-08-09	Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 7 infection
HK1012233B (en)	2002-10-04	Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections