AP3337A - Aminoalcohol substituted 2,3-dihydroimidazo[1,2-C]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis - Google Patents

Aminoalcohol substituted 2,3-dihydroimidazo[1,2-C]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis

Info

Publication number: AP3337A
Authority: AP; ARIPO
Prior art keywords: dihydroimidazo; angiogenesis; diseases associated; proliferative disorders; derivatives useful
Prior art date: 2010-11-11

Application number

AP2013006921A

Other languages

English (en)

Other versions

AP2013006921A0 (en

Inventor

William Johnston Scott

Ursula Mönning

Andrea Hägebarth

Original Assignee

Bayer Intellectual Property

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-11-11

Filing date

2011-11-08

Publication date

2015-07-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44999756&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP3337(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2011-11-08 Application filed by Bayer Intellectual Property filed Critical Bayer Intellectual Property

2013-06-30 Publication of AP2013006921A0 publication Critical patent/AP2013006921A0/xx

2015-07-31 Application granted granted Critical

2015-07-31 Publication of AP3337A publication Critical patent/AP3337A/xx

Links

208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 2
NTTQCLSBWRKUIJ-UHFFFAOYSA-N 2,3-dihydroimidazo[1,2-c]quinazoline Chemical class C1=CC=C2C3=NCCN3C=NC2=C1 NTTQCLSBWRKUIJ-UHFFFAOYSA-N 0.000 title 1
150000001414 amino alcohols Chemical group 0.000 title 1
230000033115 angiogenesis Effects 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000035475 disorder Diseases 0.000 title 1
230000003463 hyperproliferative effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AP2013006921A 2010-11-11 2011-11-08 Aminoalcohol substituted 2,3-dihydroimidazo[1,2-C]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis AP3337A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41255610P	2010-11-11	2010-11-11
PCT/EP2011/069637 WO2012062748A1 (en)	2010-11-11	2011-11-08	Aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis

Publications (2)

Publication Number	Publication Date
AP2013006921A0 AP2013006921A0 (en)	2013-06-30
AP3337A true AP3337A (en)	2015-07-31

Family

ID=44999756

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2013006921A AP3337A (en)	2010-11-11	2011-11-08	Aminoalcohol substituted 2,3-dihydroimidazo[1,2-C]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis

Country Status (31)

Country	Link
US (2)	US8895549B2 (xx)
EP (1)	EP2638045B1 (xx)
JP (1)	JP6196156B2 (xx)
KR (1)	KR20140003436A (xx)
CN (1)	CN102906094B (xx)
AP (1)	AP3337A (xx)
AR (1)	AR083842A1 (xx)
AU (1)	AU2011328192B2 (xx)
BR (1)	BR112013011634A2 (xx)
CA (1)	CA2817317C (xx)
CL (1)	CL2013001295A1 (xx)
CO (1)	CO6761350A2 (xx)
CR (1)	CR20130213A (xx)
CU (1)	CU20130069A7 (xx)
DO (1)	DOP2013000105A (xx)
EA (1)	EA024406B1 (xx)
EC (1)	ECSP13012618A (xx)
GT (1)	GT201300121A (xx)
IL (1)	IL226066A0 (xx)
MA (1)	MA34655B1 (xx)
MX (1)	MX2013005305A (xx)
MY (1)	MY164730A (xx)
NZ (1)	NZ610018A (xx)
PE (1)	PE20140411A1 (xx)
PH (1)	PH12013500938A1 (xx)
SG (1)	SG190100A1 (xx)
TW (1)	TW201305170A (xx)
UA (1)	UA113280C2 (xx)
UY (1)	UY33719A (xx)
WO (1)	WO2012062748A1 (xx)
ZA (1)	ZA201304244B (xx)

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US9730943B2 (en) *	2010-11-11	2017-08-15	Bayer Intellectual Property Gmbh	Alkoxy-substituted 2,3-dihydroimidazo[1,2-C]quinazolines
UA113280C2 (xx) *	2010-11-11	2017-01-10		АМІНОСПИРТЗАМІЩЕНІ ПОХІДНІ 2,3-ДИГІДРОІМІДАЗО$1,2-c]ХІНАЗОЛІНУ, ПРИДАТНІ ДЛЯ ЛІКУВАННЯ ГІПЕРПРОЛІФЕРАТИВНИХ ПОРУШЕНЬ І ЗАХВОРЮВАНЬ, ПОВ'ЯЗАНИХ З АНГІОГЕНЕЗОМ
CN103370320B (zh) *	2010-11-11	2016-04-27	拜耳知识产权有限责任公司	芳基氨基醇取代的2,3-二氢咪唑并[1,2-c]喹啉
EP2508525A1 (en)	2011-04-05	2012-10-10	Bayer Pharma Aktiengesellschaft	Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts
JO3733B1 (ar)	2011-04-05	2021-01-31	Bayer Ip Gmbh	استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة
CN103214489B (zh) *	2013-02-25	2016-10-26	中国人民解放军第二军医大学	一类具有抗肿瘤活性的多靶点激酶抑制剂及其制备方法
UA119537C2 (uk) *	2013-04-08	2019-07-10	Байєр Фарма Акцієнгезелльшафт	ЗАСТОСУВАННЯ ЗАМІЩЕНИХ 2,3-ДИГІДРОІМІДАЗО[1,2-c]ХІНАЗОЛІНІВ ДЛЯ ЛІКУВАННЯ ЛІМФОМ
WO2015082376A2 (en)	2013-12-03	2015-06-11	Bayer Pharma Aktiengesellschaft	Use of pi3k-inhibitors
US10124007B2 (en)	2013-12-03	2018-11-13	Bayer Pharma Aktiengesellschaft	Combination of PI3K-inhibitors
JP6499657B2 (ja)	2013-12-03	2019-04-10	バイエルファーマアクチエンゲゼルシャフト	Ｐｉ３ｋ阻害剤の組み合わせ
WO2016071380A1 (en) *	2014-11-07	2016-05-12	Bayer Pharma Aktiengesellschaft	Synthesis of pi3k inhibitor and salts thereof
WO2016071382A1 (en) *	2014-11-07	2016-05-12	Bayer Pharma Aktiengesellschaft	Synthesis of pi3k inhibitor and salts thereof
WO2016087488A1 (en) *	2014-12-03	2016-06-09	Bayer Pharma Aktiengesellschaft	Administration regime for aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives
WO2016087490A1 (en) *	2014-12-03	2016-06-09	Bayer Pharma Aktiengesellschaft	Combination of pi3k-inhibitors
AU2016349632A1 (en)	2015-11-07	2018-05-24	Multivir Inc.	Compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer
CA3037626A1 (en)	2016-09-23	2018-03-29	Bayer Pharma Aktiengesellschaft	Combination of pi3k-inhibitors
CN110381997A (zh)	2016-12-12	2019-10-25	茂体外尔公司	用于治疗和预防癌症和感染性疾病的包含病毒基因治疗和免疫检查点抑制剂的方法和组合物
WO2018215282A1 (en)	2017-05-26	2018-11-29	Bayer Pharma Aktiengesellschaft	Combination of bub1 and pi3k inhibitors
EP3645005A1 (en)	2017-06-28	2020-05-06	Bayer Consumer Care AG	Combination of a pi3k-inhibitor with an androgen receptor antagonist
KR20200135986A (ko)	2018-03-19	2020-12-04	멀티비르 인코포레이티드	종양 억제인자 유전자 치료 및 cd122/cd132 작용제를 포함하는 암 치료를 위한 방법 및 조성물
CN108383849B (zh) *	2018-04-26	2020-11-06	浙江大学	咪唑并喹唑啉衍生物及其在抗肿瘤抗炎中的应用
MX2021010669A (es) *	2019-03-07	2021-09-28	BioNTech SE	Proceso para la preparacion de una imidazoquinolina sustituida.
US20230029385A1 (en) *	2019-10-15	2023-01-26	Bayer Aktiengesellschaft	2-methyl-aza-quinazolines
WO2021113644A1 (en)	2019-12-05	2021-06-10	Multivir Inc.	Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer
WO2021260443A1 (en)	2020-06-24	2021-12-30	Bayer Aktiengesellschaft	Combinations of 2,3-dihydroimidazo[1,2-c]quinazolines
CN115572256B (zh) *	2021-06-21	2025-01-24	武汉睿健医药科技有限公司	Oct4高选择性活化剂
CN113512040B (zh) *	2021-08-25	2023-10-13	河南牧业经济学院	一种血根碱仿生化合物及其制备方法
TW202404968A (zh) *	2022-04-20	2024-02-01	美商思諾維新醫藥公司	ＰＩ３Ｋα抑制劑
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AU2024361550A1 (en) *	2023-10-17	2026-04-09	Pikavation Therapeutics, Inc.	5-oxo-4,5-dihydroimidazo[1,5-a]quinazoline compounds as pi3k[alpha] inhibitors

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CN103370320B (zh) *	2010-11-11	2016-04-27	拜耳知识产权有限责任公司	芳基氨基醇取代的2,3-二氢咪唑并[1,2-c]喹啉
UA113280C2 (xx) *	2010-11-11	2017-01-10		АМІНОСПИРТЗАМІЩЕНІ ПОХІДНІ 2,3-ДИГІДРОІМІДАЗО$1,2-c]ХІНАЗОЛІНУ, ПРИДАТНІ ДЛЯ ЛІКУВАННЯ ГІПЕРПРОЛІФЕРАТИВНИХ ПОРУШЕНЬ І ЗАХВОРЮВАНЬ, ПОВ'ЯЗАНИХ З АНГІОГЕНЕЗОМ
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2011
- 2011-08-11 UA UAA201307179A patent/UA113280C2/uk unknown
- 2011-11-08 CA CA2817317A patent/CA2817317C/en active Active
- 2011-11-08 CN CN201180023122.7A patent/CN102906094B/zh not_active Expired - Fee Related
- 2011-11-08 MA MA35889A patent/MA34655B1/fr unknown
- 2011-11-08 KR KR1020137014882A patent/KR20140003436A/ko not_active Ceased
- 2011-11-08 MY MYPI2013700753A patent/MY164730A/en unknown
- 2011-11-08 MX MX2013005305A patent/MX2013005305A/es unknown
- 2011-11-08 NZ NZ610018A patent/NZ610018A/en not_active IP Right Cessation
- 2011-11-08 PE PE2013001051A patent/PE20140411A1/es not_active Application Discontinuation
- 2011-11-08 US US13/885,122 patent/US8895549B2/en active Active
- 2011-11-08 AU AU2011328192A patent/AU2011328192B2/en not_active Ceased
- 2011-11-08 BR BR112013011634A patent/BR112013011634A2/pt not_active IP Right Cessation
- 2011-11-08 SG SG2013033634A patent/SG190100A1/en unknown
- 2011-11-08 JP JP2013538163A patent/JP6196156B2/ja active Active
- 2011-11-08 AP AP2013006921A patent/AP3337A/xx active
- 2011-11-08 WO PCT/EP2011/069637 patent/WO2012062748A1/en not_active Ceased
- 2011-11-08 PH PH1/2013/500938A patent/PH12013500938A1/en unknown
- 2011-11-08 EA EA201300556A patent/EA024406B1/ru not_active IP Right Cessation
- 2011-11-08 EP EP11784978.6A patent/EP2638045B1/en active Active
- 2011-11-10 UY UY0001033719A patent/UY33719A/es not_active Application Discontinuation
- 2011-11-11 TW TW100141328A patent/TW201305170A/zh unknown
- 2011-11-11 AR ARP110104216A patent/AR083842A1/es unknown
2013
- 2013-04-30 IL IL226066A patent/IL226066A0/en unknown
- 2013-05-10 EC ECSP13012618 patent/ECSP13012618A/es unknown
- 2013-05-10 CU CU2013000069A patent/CU20130069A7/es unknown
- 2013-05-10 GT GT201300121A patent/GT201300121A/es unknown
- 2013-05-10 CO CO13117697A patent/CO6761350A2/es not_active Application Discontinuation
- 2013-05-10 CL CL2013001295A patent/CL2013001295A1/es unknown
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MX2013005305A (es)	2013-06-13
CN102906094B (zh)	2016-06-22
AU2011328192B2 (en)	2016-09-01
US8895549B2 (en)	2014-11-25
BR112013011634A2 (pt)	2018-12-11
KR20140003436A (ko)	2014-01-09
AU2011328192A1 (en)	2013-05-02
MA34655B1 (fr)	2013-11-02
CU20130069A7 (es)	2013-09-27
AP2013006921A0 (en)	2013-06-30
GT201300121A (es)	2014-12-22
DOP2013000105A (es)	2013-09-30
CR20130213A (es)	2013-07-01
PH12013500938A1 (en)	2013-07-08
EA024406B1 (ru)	2016-09-30
JP6196156B2 (ja)	2017-09-13
CN102906094A (zh)	2013-01-30
UY33719A (es)	2012-06-29
TW201305170A (zh)	2013-02-01
ECSP13012618A (es)	2013-07-31
UA113280C2 (xx)	2017-01-10
JP2013542238A (ja)	2013-11-21
US9902727B2 (en)	2018-02-27
AR083842A1 (es)	2013-03-27
CA2817317A1 (en)	2012-05-18
IL226066A0 (en)	2013-06-27
US20130317004A1 (en)	2013-11-28
WO2012062748A1 (en)	2012-05-18
EP2638045A1 (en)	2013-09-18
EP2638045B1 (en)	2022-08-31
SG190100A1 (en)	2013-07-31
ZA201304244B (en)	2014-12-23
CA2817317C (en)	2020-07-14
CL2013001295A1 (es)	2013-10-04
NZ610018A (en)	2016-03-31
MY164730A (en)	2018-01-30
HK1180685A1 (zh)	2013-10-25
PE20140411A1 (es)	2014-04-13
CO6761350A2 (es)	2013-09-30
US20150080374A1 (en)	2015-03-19
EA201300556A1 (ru)	2013-10-30

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